Info: Read More
  • 中药标准品生产商,产品定制服务
  • 紫堇块茎碱

    Corytuberine

    紫堇块茎碱
    产品编号 CFN90528
    CAS编号 517-56-6
    分子式 = 分子量 C19H21NO4 = 327.37
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Alkaloids
    植物来源 The herbs of Caltha palustris L.
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    紫堇块茎碱 CFN90528 517-56-6 1mg QQ客服:2056216494
    紫堇块茎碱 CFN90528 517-56-6 5mg QQ客服:2056216494
    紫堇块茎碱 CFN90528 517-56-6 10mg QQ客服:2056216494
    紫堇块茎碱 CFN90528 517-56-6 20mg QQ客服:2056216494
    存储与注意事项
    1. 在您收到产品后请检查产品。如无问题,请将产品存入冰霜并且样品瓶保持密封,产品可以存放长达24个月(2-8摄氏度)。

    2. 只要有可能,产品溶解后,您应该在同一天应用于您的实验。 但是,如果您需要提前做预实验,或者需要全部溶解,我们建议您将溶液以等分试样的形式存放在-20℃的密封小瓶中。 通常,这些可用于长达两周。 使用前,打开样品瓶前,我们建议您将产品平衡至室温至少1小时。

    3. 需要更多关于溶解度,使用和处理的建议? 请发送电子邮件至:service@chemfaces.com
    订购流程
  • 1. 在线订购
  • 请联系我们QQ客服

  • 2. 电话订购
  • 请拨打电话:
    027-84237683 或 027-84237783

  • 3. 邮件或传真订购
  • 发送电子邮件到: manager@chemfaces.com 或
    发送传真到:027-84254680

  • 提供订购信息
  • 为了方便客户的订购,请需要订购ChemFaces产品的客户,在下单的时候请提供下列信息,以供我们快速为您建立发货信息。
  •  
  • 1. 产品编号(CAS No.或产品名称)
  • 2. 发货地址
  • 3. 联系方法 (联系人,电话)
  • 4. 开票抬头 (如果需要发票的客户)
  • 5. 发票地址(发货地址与发票地址不同)
  • 发货时间
    1. 付款方式为100%预付款客户,我们将在确认收到货款后当天或1-3个工作日发货。

    2. 付款方式为月结的客户,我们承诺在收到订单后当天或1-3个工作日内发货。

    3. 如果客户所需要的产品,需要重新生产,我们有权告知客户,交货时间需要延期。
    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • Universidad Industrial de Santander (Colombia)
  • Rio de Janeiro State University (Brazil)
  • Colorado State University (USA)
  • Shanghai Institute of Organic Chemistry (China)
  • Medical University of South Carolina (USA)
  • University of Sao Paulo (Brazil)
  • Aveiro University (Portugal)
  • Warszawski Uniwersytet Medyczny (Poland)
  • Center for protein Engineering (CIP) (Belgium)
  • Celltrion Chemical Research Institute (Korea)
  • Universite Libre de Bruxelles (Belgium)
  • Sanford Burnham Prebys Medical Discovery Institute (USA)
  • University of East Anglia (United Kingdom)
  • Srinakharinwirot University (Thailand)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • J of the Korean Society of Food Science and Nutrition2019, 32(2):148-154
  • Front Pharmacol.2016, 7:460
  • Food Research2021, 5(1):65-71
  • J Ethnopharmacol.2019, 244:112074
  • J Korean Society of Food Science & Nutrition2021, 50(9): 962-970
  • Cell Physiol Biochem.2019, 52(6):1255-1266
  • J Appl Biol Chem2023, 66:455−461
  • Kor. J. Herbol.2022, 37(5): 89-96.
  • Sci Rep. 2018, 10590
  • Front Neurosci.2019, 13:1091
  • Food Sci Nutr.2023, 11(9):5532-5542.
  • Plants (Basel).2021, 10(11):2317.
  • Int. J. Mol. Sci. 2022, 23(3),1696.
  • Evid Based Complement Alternat Med.2021, 2021:8707280.
  • Viruses.2021, 13(11):2118.
  • Mol Med Rep.2023 Oct;28(4):193.
  • Biomed Pharmacother.2022, 145:112474.
  • Sci Rep.2021, 11(1):14180.
  • J Mass Spectrom.2022, 57(2):e4810.
  • Am J Chin Med.2016, 44(6):1255-1271
  • Synthetic and Systems Biotechnology2023, j.synbio.
  • Molecules.2020, 25(23):5636.
  • Research Square2023, 2883170.
  • ...
  • 生物活性
    Description: Corytuberine was inhibited only by naloxone and that of bulbocapnine preferentially by yohimbine.
    In vivo:
    Arch Int Pharmacodyn Ther. 1988 Nov-Dec;296:255-81.
    Neuroleptic-like, anticonvulsant and antinociceptive effects of aporphine alkaloids: bulbocapnine, corytuberine, boldine and glaucine.[Pubmed: 2907279]

    METHODS AND RESULTS:
    The aporphine alkaloids bulbocapnine, Corytuberine, boldine and glaucine were studied in mice and compared with haloperidol, phenobarbital and morphine. All aporphines inhibited the exploratory rearing activity and elicited palpebral ptosis, catalepsy, hypothermia, and prolonged anesthesia by thiopental. They also reduced nociception (hot plate; phenylquinone-induced writhing) and (except for Corytuberine) were anticonvulsant against harman and picrotoxin, but not against bicuculline and pentetrazol; Corytuberine was proconvulsant. The aporphines (except for Corytuberine) antagonized the apomorphine- and methylphenidate-induced stereotyped gnawing and also the apomorphine-induced climbing activity; Corytuberine was prostereotypic. The antignawing effects (including those of haloperidol) were stronger when the antagonists were administered after the agonists (gnawing full-fletched) rather than before them: this led to the speculation of a metaphilic interaction at central site(s). Clonazepam inhibited the antistereotypic effect (vs apomorphine) more potently with the aporphines than with haloperidol. The antinociceptive effect (writhing) of the aporphines was, in contrast to that of morphine, resistant to both naloxone and yohimbine. The latter applied also to the antilicking action in the hot plate test; the antijumping effect of boldine was (like that of morphine) antagonized by both yohimbine and naloxone, whereas that of Corytuberine was inhibited only by naloxone and that of bulbocapnine preferentially by yohimbine.
    METHODS AND RESULTS:
    Hence, opioid and adrenergic mechanisms are unequally involved in the antinociceptive effects of the aporphines. The present results also showed that licking and jumping (in the hot plate test) are pharmacologically different phenomena. In low doses, the aporphines and haloperidol antagonized the antinociceptive effect of morphine (hot plate); hence, these drugs may be considered partial agonists or partial antagonists, respectively.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 3.0546 mL 15.2732 mL 30.5465 mL 61.093 mL 76.3662 mL
    5 mM 0.6109 mL 3.0546 mL 6.1093 mL 12.2186 mL 15.2732 mL
    10 mM 0.3055 mL 1.5273 mL 3.0546 mL 6.1093 mL 7.6366 mL
    50 mM 0.0611 mL 0.3055 mL 0.6109 mL 1.2219 mL 1.5273 mL
    100 mM 0.0305 mL 0.1527 mL 0.3055 mL 0.6109 mL 0.7637 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    N-甲基钓樟卡品; N-Methyllindcarpine CFN99454 14028-97-8 C19H21NO4 = 327.4 5mg QQ客服:2159513211
    异紫堇定碱; (+)-Isocorynoline CFN90215 475-67-2 C20H23NO4 = 341.40 20mg QQ客服:2056216494
    紫菫定酚; Corydine CFN90527 476-69-7 C20H23NO4 = 341.40 5mg QQ客服:215959384
    紫堇块茎碱; Corytuberine CFN90528 517-56-6 C19H21NO4 = 327.37 5mg QQ客服:2159513211
    N-甲基-O10-甲基莲叶桐文; Litseglutine B CFN98279 25368-01-8 C20H23NO4 = 341.4 5mg QQ客服:215959384
    波尔定碱; Boldine CFN98718 476-70-0 C19H21NO4 = 327.4 20mg QQ客服:3257982914
    无根藤辛; Cassythicine CFN98998 5890-28-8 C19H19NO4 = 325.4 5mg QQ客服:215959384
    海罂粟碱; Glaucine CFN90408 475-81-0 C21H25NO4 = 355.43 20mg QQ客服:3257982914
    波尔定碱 2-甲醚; Lauroscholtzine CFN98078 2169-44-0 C20H23NO4 = 341.4 5mg QQ客服:215959384
    Nantenine; Nantenine CFN89514 2565-01-7 C20H21NO4 = 339.38 5mg QQ客服:215959384

    信息支持


    公司简介
    订购流程
    付款方式
    退换货政策

    ChemFaces提供的产品仅用于科学研究使用,不用于诊断或治疗程序。

    联系方式


    电机:027-84237783
    传真:027-84254680
    在线QQ: 1413575084
    E-Mail:manager@chemfaces.com

    湖北省武汉沌口经济技术开区车城南路83号1号楼第三层厂房


    ChemFaces为科学家,科研人员与企业提供快速的产品递送。我们通过瑞士SGS ISO 9001:2008质量体系认证天然化合物与对照品的研发和生产