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  • 堇醇灵碱

    (+)-Corynoline

    堇醇灵碱
    产品编号 CFN99745
    CAS编号 18797-79-0
    分子式 = 分子量 C21H21NO5 = 367.40
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Alkaloids
    植物来源 The tubers of Corydalis ambigua
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    堇醇灵碱 CFN99745 18797-79-0 10mg QQ客服:3257982914
    堇醇灵碱 CFN99745 18797-79-0 20mg QQ客服:3257982914
    堇醇灵碱 CFN99745 18797-79-0 50mg QQ客服:3257982914
    堇醇灵碱 CFN99745 18797-79-0 100mg QQ客服:3257982914
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • Kitasato University (Japan)
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  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Nat Prod Commun.2017, 12(5):771-778
  • Inflammation2015, 38(1):445-55
  • Cell Physiol Biochem.2019, 52(6):1255-1266
  • Front Microbiol.2019, 10:2806
  • Int J Mol Sci.2020, 21(9):3392.
  • Biochem Biophys Res Commun.2017, 482(4):1095-1101
  • Front Pharmacol.2021, 12:762829.
  • Asian Pac J Cancer Prev.2021, 22(S1):97-106.
  • Separations2021, 8(1), 1.
  • Molecules.2021, 26(2):313.
  • Food Funct.2022, 13(13):6923-6933.
  • Pharmacogn Mag.2015, 11(43):562-6
  • Mol Pharm.2017, 14(9):3164-3177
  • Enzyme Microb Technol.2022, 161:110111.
  • Natural Product Communications2023, 18(9).
  • Biol Pharm Bull.2018, 41(1):65-72
  • Mol Med Rep.2022, 25(1):8.
  • Molecules.2019, 24(16):E2985
  • Free Radic Biol Med.2016, 97:307-319
  • Mediators Inflamm. 2016, 2016:6189590
  • Nutr Res Pract.2023, 17(4):670-681.
  • Toxicol Rep.2021, 8:1131-1142.
  • Int J Mol Sci.2022, 23(11):6104.
  • ...
  • 生物活性
    Description: Corynoline is a reversible and noncompetitive inhibitor of acetylcholinesterase(AChE) with the IC50 value of 30.6 microM, which exhibits the potent anti-inflammatory and/or immunosuppressive activity, the potent inhibitory activity of corynoline for the ICAM-1/LFA-1 adhesion and would be important on developing the clinically usable drugs for the inflammatory diseases.
    Targets: AChR
    In vitro:
    Bioorg Med Chem. 2005 Mar 1;13(5):1867-72.
    Cell adhesion inhibitory activity of (d)-corynoline, a hexahydrobenzo[c]phenanthridine-type alkaloid, and its structure-activity relationship, studied by X-ray crystal structure analysis and molecular docking study.[Pubmed: 15698804 ]
    Corynoline (1), a hexahydrobenzo[c]phenanthridine-type alkaloid, exhibited the concentration-dependent inhibition for the adhesion of human polymorphonuclear leukocyte and eosinophil to human umbilical vein cultured endothelial cell in the concentration range of showing no significant cytotoxicity for the cell: IC(50) value=72.4 microM for (d)-1 and 156.7 microM for (l)-1. This shows the potent anti-inflammatory and/or immunosuppressive activity of 1.
    METHODS AND RESULTS:
    To elucidate possible structure-activity relationship, the conformational/structural feature of (d)-1 was investigated by X-ray crystal structure analysis and molecular orbital energy calculations, and the docking study was performed for its interaction with the D1-domain of ICAM-1 (intracellular adhesion molecule-1). A plausible model was proposed, in which all polar atoms of (d)-1 are linked by hydrogen bonds or electrostatic interactions with the functional residues of ICAM-1, that have been supposed to be necessary for the binding with LFA-1 (leukocyte function-associated antigen-1).
    CONCLUSIONS:
    This suggests the potent inhibitory activity of 1 for the ICAM-1/LFA-1 adhesion and would be important on developing the clinically usable drugs for the inflammatory diseases.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 2.7218 mL 13.6091 mL 27.2183 mL 54.4366 mL 68.0457 mL
    5 mM 0.5444 mL 2.7218 mL 5.4437 mL 10.8873 mL 13.6091 mL
    10 mM 0.2722 mL 1.3609 mL 2.7218 mL 5.4437 mL 6.8046 mL
    50 mM 0.0544 mL 0.2722 mL 0.5444 mL 1.0887 mL 1.3609 mL
    100 mM 0.0272 mL 0.1361 mL 0.2722 mL 0.5444 mL 0.6805 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    6-乙酰甲基白屈菜红碱; 6-Acetonyldihydrochelerythrine CFN98233 22864-92-2 C24H23NO5 = 405.5 5mg QQ客服:1413575084
    8-乙酰甲基二氢血根碱; 8-Acetonyldihydrosanguinarine CFN98608 37687-34-6 C23H19NO5 = 389.4 5mg QQ客服:215959384
    8-乙酰甲基二氢勒樘碱; 8-Acetonyldihydroavicine CFN92338 348098-59-9 C23H19NO5 = 389.4 5mg QQ客服:215959384
    8-乙酰甲基二氢两面针碱; 8-Acetonyldihydronitidine CFN92339 80330-39-8 C24H23NO5 = 405.5 5mg QQ客服:3257982914
    bis[6-(5,6-dihydrochelerythrinyl)]amine; bis[6-(5,6-dihydrochelerythrinyl)]amine CFN91015 165393-48-6 C42H37N3O8 = 711.76 5mg QQ客服:215959384
    乙酰紫堇灵; Acetylcorynoline CFN99749 18797-80-3 C23H23NO6 = 409.43 20mg QQ客服:3257982914
    白屈菜碱; Chelidonine CFN90319 476-32-4 C20H19NO5 = 353.37 20mg QQ客服:2056216494
    二氢白屈菜红碱; Dihydrochelerythrine CFN90127 6880-91-7 C21H19NO4 = 349.38 20mg QQ客服:3257982914
    去甲白屈菜红碱; Norchelerythrine CFN92737 6900-99-8 C20H15NO4 = 333.3 5mg QQ客服:1413575084
    氧基白屈菜季铵碱; Oxychelerythrine CFN97999 28342-33-8 C21H17NO5 = 363.4 5mg QQ客服:3257982914

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