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    Corosolic acid

    科罗索酸
    产品编号 CFN98685
    CAS编号 4547-24-4
    分子式 = 分子量 C30H48O4 = 472.7
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Triterpenoids
    植物来源 The barks of Lagerstroemia speciosa
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    科罗索酸 CFN98685 4547-24-4 10mg QQ客服:2159513211
    科罗索酸 CFN98685 4547-24-4 20mg QQ客服:2159513211
    科罗索酸 CFN98685 4547-24-4 50mg QQ客服:2159513211
    科罗索酸 CFN98685 4547-24-4 100mg QQ客服:2159513211
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • Biotech R&D Institute (USA)
  • Chiang Mai University (Thailand)
  • Chinese University of Hong Kong (China)
  • Copenhagen University (Denmark)
  • Imperial College London (United Kingdom)
  • University of Dicle (Turkey)
  • Medical University of South Carolina (USA)
  • Universiti Sains Malaysia (Malaysia)
  • University of Padjajaran (Indonesia)
  • Universidade Católica Portuguesa (Portugal)
  • Shanghai University of TCM (China)
  • The Ohio State University (USA)
  • Seoul National University (Korea)
  • Korea Food Research Institute(KFRI) (Korea)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Molecules.2015, 20(11):20014-30
  • University of Limpopo2016, 1-237
  • Evid Based Complement Alternat Med.2016, 2016:1739760
  • PLoS One.2017, 12(8):e0181191
  • J Ethnopharmacol.2017, 198:205-213
  • Nutrients.2018, 10(10)
  • Int J Mol Sci.2018, 19(9):E2601
  • Molecules.2018, 23(9):E2121
  • Industrial Crops and Products2018, 353-362
  • Mol Cells.2018, 41(8):771-780
  • Sci Rep.2018, 8(1)
  • Front Pharmacol.2018, 9:236
  • Saf Health Work.2019, 10(2):196-204
  • Biomol Ther (Seoul).2019, 10.4062
  • Plant Physiol Biochem.2019, 144:355-364
  • BMC Complement Altern Med.2019, 19(1):367
  • Molecules.2019, 24(7):E1290
  • Saudi Pharm J.2019, 27(1):145-153
  • Anal Sci.2019, 35(12):1317-1325
  • The Malaysian journal of pathology2019, 41(3):243-251
  • Appl. Sci.2020, 10,1304
  • Drug Des Devel Ther.2020, 14:61-71
  • Biosci Biotechnol Biochem.2020, 84(3):621-632
  • ...
  • 生物活性
    Description: Corosolic acid has antitumor, anti-inflammatory and hypoglycemic activities, it can ameliorate hypertension, abnormal lipid metabolism, and oxidative stress as well as the inflammatory state in SHR-cp rats; it can improve glucose metabolism by reducing insulin resistance, it inhibits the enzymatic activities of several diabetes-related non-receptor protein tyrosine phosphatases (PTPs) in vitro, such as PTP1B, T-cell-PTP, src homology phosphatase-1 and src homology phosphatase-2. Corosolic acid can suppress the M2 polarization of macrophages and tumor cell proliferation by inhibiting both STAT3 and NF-κB activation, it also can enhance the antitumor effects of adriamycin and cisplatin in in vitro.
    Targets: FAK | ERK | Caspase | PARP | VEGFR | Src | Bcl-2/Bax | NF-κB | STAT | PTPs
    In vitro:
    Nat Prod Res. 2014;28(21):1879-86.
    Microbial transformation of the anti-diabetic agent corosolic acid.[Pubmed: 25190540]

    METHODS AND RESULTS:
    Biotransformation of corosolic acid (1) by Cochliobolus lunatus and Streptomyces asparaginoviolaceus afforded four metabolites, which were identified by using (1)H NMR, (13)C NMR, DEPT, HSQC, HMBC and NOESY spectral data. Biotransformation of corosolic acid by C. lunatus R.R. Nelson & Haasis CGMCC 3.4381 produced three metabolites: 2α,3β,21β-trihydroxyurs-12-en-28-oic acid (2), 2α,3β,7β,21β-tetrahydroxy-urs-12-en-28-oic acid (3) and 2α,3β-dihydroxy-21-oxours-12-en-28-oic acid (4). Incubation of corosolic acid with growing cultures of S. asparaginoviolaceus CGMCC 4.0175 afforded metabolite 2α,3β,30-trihydroxyurs-12-en-28-oic acid (5). All the metabolites were reported for the first time.
    CONCLUSIONS:
    The substrate and four metabolites, along with four products obtained previously, were evaluated for their inhibitory effects on α-glucosidase; all the triterpenes tested showed potent inhibitory effects.
    In vivo:
    Phytother Res. 2015 May;29(5):714-23.
    Corosolic Acid Exhibits Anti-angiogenic and Anti-lymphangiogenic Effects on In Vitro Endothelial Cells and on an In Vivo CT-26 Colon Carcinoma Animal Model.[Pubmed: 25644809]
    We describe the anti-angiogenic and anti-lymphangiogenic effects of corosolic acid, a pentacyclic triterpenoid isolated from Cornus kousa Burg.
    METHODS AND RESULTS:
    A mouse colon carcinoma CT-26 animal model was employed to determine the in vivo anti-angiogenic and anti-lymphangiogenic effects of corosolic acid. Corosolic acid induced apoptosis in CT-26 cells, mediated by the activation of caspase-3. In addition, it reduced the final tumor volume and the blood and lymphatic vessel densities of tumors, indicating that it suppresses in vivo angiogenesis and lymphangiogenesis. Corosolic acid inhibited the proliferation and tube formation of human umbilical vein endothelial cells and human dermal lymphatic microvascular endothelial cells. In addition, corosolic acid decreased the proliferation and migration of human umbilical vein endothelial cells stimulated by angiopoietin-1.
    CONCLUSIONS:
    Pretreatment with corosolic acid decreased the phosphorylation of focal adhesion kinase (FAK) and ERK1/2, suggesting that corosolic acid contains anti-angiogenic activity that can suppress FAK signaling induced by angiopoietin-1.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 2.1155 mL 10.5775 mL 21.1551 mL 42.3101 mL 52.8877 mL
    5 mM 0.4231 mL 2.1155 mL 4.231 mL 8.462 mL 10.5775 mL
    10 mM 0.2116 mL 1.0578 mL 2.1155 mL 4.231 mL 5.2888 mL
    50 mM 0.0423 mL 0.2116 mL 0.4231 mL 0.8462 mL 1.0578 mL
    100 mM 0.0212 mL 0.1058 mL 0.2116 mL 0.4231 mL 0.5289 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    高加蓝花楹三萜酸; Jacoumaric acid CFN92274 63303-42-4 C39H54O6 = 618.9 5mg QQ客服:215959384
    3-表熊果酸; 3-Epiursolic acid CFN92196 989-30-0 C30H48O3 = 456.7 10mg QQ客服:1413575084
    熊果酸; Ursolic acid CFN97259 77-52-1 C30H48O3 = 456.7 20mg QQ客服:2932563308
    熊果酸乙酸酯; Acetylursolic acid CFN97219 7372-30-7 C32H50O4 = 498.8 5mg QQ客服:1148253675
    3-氧代-12-烯-28-乌苏酸; Ursonic acid CFN97078 6246-46-4 C30H46O3 = 454.7 20mg QQ客服:3257982914
    Randialic acid B; Randialic acid B CFN91138 14021-14-8 C30H46O3 = 454.7 5mg QQ客服:3257982914
    地榆皂苷元; Sanguisorbigenin CFN91139 6812-98-2 C30H46O3 = 454.7 5mg QQ客服:2159513211
    Obtusilin; Obtusilin CFN90556 105870-59-5 C30H46O4 = 470.69 5mg QQ客服:2159513211
    全草含茜草萜酸; Rubifolic acid CFN97281 80489-65-2 C30H48O4 = 472.7 5mg QQ客服:1413575084
    3beta-羟基乌苏-30-对羟基肉桂酰基-12-烯-28-酸; Zamanic acid CFN98292 260393-05-3 C39H54O6 = 618.9 5mg QQ客服:2159513211

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