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  • 山茱萸苷

    Cornin

    山茱萸苷
    产品编号 CFN98160
    CAS编号 548-37-8
    分子式 = 分子量 C17H24O10 = 388.37
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Iridoids
    植物来源 The fruits of Cornus officinalis Sieb. et Zucc.
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
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    山茱萸苷 CFN98160 548-37-8 10mg QQ客服:2159513211
    山茱萸苷 CFN98160 548-37-8 20mg QQ客服:2159513211
    山茱萸苷 CFN98160 548-37-8 50mg QQ客服:2159513211
    山茱萸苷 CFN98160 548-37-8 100mg QQ客服:2159513211
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • FORTH-IMBB (Greece)
  • Instituto de Investigaciones Agropecuarias (Chile)
  • Regional Crop Research Institute (Korea)
  • Shanghai University of TCM (China)
  • Massachusetts General Hospital (USA)
  • Universiti Malaysia Pahang (Malaysia)
  • Uniwersytet Medyczny w ?odzi (Poland)
  • University of the Basque Country (Spain)
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  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Anal Bioanal Chem.2023, 415(9):1641-1655.
  • Plants (Basel).2022, 11(16):2126.
  • Int J Mol Sci.2023, 24(3):2102.
  • The Japan Society for Analytical Chemistry2017, 613-617
  • J.the Korean Socie. Food Sci.&Nut.2023; 52(1):26-39.
  • Int J Med Sci.2020, 17(5):626-631
  • Int J Mol Sci.2021, 22(8):4211.
  • Sci Rep. 2018, 10590
  • Front Pharmacol.2021, 12:764297.
  • Phytochemistry.2017, 141:162-170
  • Front Pharmacol.2019, 10:1355
  • Phytochemistry Letters2015, 243-247
  • Front Pharmacol.2021, 12:770667.
  • Virus Res.2023, 335:199199.
  • Food Sci Biotechnol.2023, 32(9):1215-1223.
  • Evid Based Complement Alternat Med.2017, 2017:7383104
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  • J Ethnopharmacol.2017, 206:327-336
  • J Microbiol Biotechnol.2020, 30(2):178-186.
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  • Front Pharmacol.2017, 8:673
  • Phytochemistry Letters2017, 449-455
  • Chem. of Vegetable Raw Materials2020, 97-105
  • ...
  • 生物活性
    Description: Verbenalin has been reported to exhibit uterine stimulant activity and demonstrated cardioprotection against experimental myocardial ischemic injury and cerebral ischemia injury. Cornin induces angiogenesis in vitro via a programmed PI3K/Akt/eNOS/VEGF signaling axis, it also has antimitotic action on dividing cell.
    Targets: PI3K | Akt | NOS | VEGFR | ROS
    In vitro:
    Acta Med Okayama. 1977 Jun;31(3):203-9.
    Purification and some characteristics of liver cytosol cornin, an antimitotic substance from rat liver cytosol.[Pubmed: 144419]
    Further purification and characterization are reported on rat cytosol cornin (RLCC), an antimitotic substance.
    METHODS AND RESULTS:
    Fraction I (purified RLCC) was purified more than 10-fold from crude RLCC with Sephadex G-50 column chromatography and showed a remarkable inhibitory effect on division of inseminated sea urchin eggs and mouse fibroblast cells. Fraction I was observed as one spot, and the molecular weight was estimated to be about 25,000 by thin layer gel filtration. Fraction I contained protein (92%) and RNA (8%), but the antimitotic activity was scarcely affected by treatment by pancreatic RNase. The protein of Fraction I was separated into two bands by SDS-polyacrylamide gel electrophoresis, and the molecular weight was estimated as 10,000 and 15,000, respectively.
    CONCLUSIONS:
    The 50% inhibition dose of Fraction I on the first division of inseminated sea urchin eggs and on proliferation of mouse L cells was about 2.5 X 10(-5) g/ml and 5 X 10(-4) g/ml, respectively. The yield of fraction I was about 35 mg from 100 g rat liver.
    Acta Medicinae Okayama, 1965, 19(1):11-8.
    Antimitotic action of cornin as a biologically active polypeptide. I. Biochemical properties of cornin.[Reference: WebLink]
    Antimitotic action of cornin as a biologically active polypeptide. I. Biochemical properties of cornin.
    In vivo:
    Phytother Res. 2010 Apr;24(4):547-52.
    Cornin ameliorates cerebral infarction in rats by antioxidant action and stabilization of mitochondrial function.[Pubmed: 20041427]
    This study was conducted to investigate the efficacy of cornin, an iridoid glycoside, in an experimental cerebral ischemia induced by middle cerebral artery occlusion (MCAO) and reperfusion (I/R), and to elucidate the potential mechanism.
    METHODS AND RESULTS:
    Adult male Sprague-Dawley rats were subjected to MCAO for 1 h, then reperfusion for 23 h. Behavioral tests were used to evaluate the damage to central nervous system. The cerebral infarct volume and histopathological damage were assessed to evaluate the brain pathophysiological changes. Spectrophotometric assay methods were used to determine the activities of superoxide dismutase (SOD) and glutathione-peroxidase (GPx). Contents of malondialdehyde (MDA), the generation of reactive oxygen species (ROS) as well as respiratory control ratio and respiratory enzymes of the brain mitochondria were also determined. The results showed that cornin significantly decreased neurological deficit scores, and reduced cerebral infarct volume and degenerative neurons. Meanwhile, cornin significantly increased the brain ATP content, improved mitochondrial energy metabolism, inhibited the elevation of MDA content and ROS generation, and attenuated the decrease of SOD and GPx activities in brain mitochondria.
    CONCLUSIONS:
    These findings indicate that cornin has protective potential against cerebral ischemia injury and its protective effects may be due to amelioration of cerebral mitochondrial function and its antioxidant property.
    Braz J Med Biol Res. 2016 Feb;49(2):e5039.
    Cardioprotection against experimental myocardial ischemic injury using cornin.[Pubmed: 26871971 ]
    Phosphorylated-cyclic adenosine monophosphate response element-binding protein (Phospho-CREB) has an important role in the pathogenesis of myocardial ischemia. We isolated the iridoid glycoside cornin from the fruit of Verbena officinalis L, investigated its effects against myocardial ischemia and reperfusion (I/R) injury in vivo, and elucidated its potential mechanism in vitro.
    METHODS AND RESULTS:
    Effects of cornin on cell viability, as well as expression of phospho-CREB and phospho-Akt in hypoxic H9c2 cells in vitro, and myocardial I/R injury in vivo, were investigated. Cornin attenuated hypoxia-induced cytotoxicity significantly in H9c2 cells in a concentration-dependent manner. Treatment of H9c2 cells with cornin (10 µM) blocked the reduction of expression of phospho-CREB and phospho-Akt in a hypoxic condition. Treatment of rats with cornin (30 mg/kg, iv) protected them from myocardial I/R injury as indicated by a decrease in infarct volume, improvement in hemodynamics, and reduction of severity of myocardial damage. Cornin treatment also attenuated the reduction of expression of phospho-CREB and phospho-Akt in ischemic myocardial tissue.
    CONCLUSIONS:
    These data suggest that cornin exerts protective effects due to an increase in expression of phospho-CREB and phospho-Akt.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 2.5749 mL 12.8743 mL 25.7486 mL 51.4973 mL 64.3716 mL
    5 mM 0.515 mL 2.5749 mL 5.1497 mL 10.2995 mL 12.8743 mL
    10 mM 0.2575 mL 1.2874 mL 2.5749 mL 5.1497 mL 6.4372 mL
    50 mM 0.0515 mL 0.2575 mL 0.515 mL 1.0299 mL 1.2874 mL
    100 mM 0.0257 mL 0.1287 mL 0.2575 mL 0.515 mL 0.6437 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    7-去氧-10-羟基马钱苷元; 7-Deoxy-10-hydroxyloganetin CFN89296 76267-48-6 C11H16O5 = 228.24 5mg QQ客服:1457312923
    马钱苷; 番木鳖苷; Loganin CFN99858 18524-94-2 C17H26O10 = 390.4 20mg QQ客服:1457312923
    8-表马钱子苷; 8-Epiloganin CFN95478 79172-04-6 C17H26O10 = 390.4 20mg QQ客服:1413575084
    10-Carboxyloganin; 10-Carboxyloganin CFN95452 182172-02-7 C17H24O12 = 420.4 5mg QQ客服:1413575084
    山茱萸苷; Cornin CFN98160 548-37-8 C17H24O10 = 388.37 20mg QQ客服:1457312923
    戟叶马鞭草苷; Hastatoside CFN96588 50816-24-5 C17H24O11 = 404.37 20mg QQ客服:3257982914
    Griselinoside; Griselinoside CFN97199 71035-06-8 C18H24O12 = 432.4 5mg QQ客服:2159513211
    Garjasmin; Garjasmin CFN99492 144868-43-9 C11H12O5 = 224.2 5mg QQ客服:2056216494
    Gardenine; Gardenine CFN99447 139682-36-3 C11H13NO4 = 223.2 5mg QQ客服:1457312923
    栀子苷; Gardenoside CFN90237 24512-62-7 C17H24O11 = 404.37 10mg QQ客服:3257982914

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