牛弥菜醇A

Conduritol A

	产品编号	CFN98868
	CAS编号	526-87-4
	分子式 = 分子量	C₆H₁₀O₄ = 146.1
	产品纯度	>=98%
	物理属性	Oil
	化合物类型	Miscellaneous
	植物来源	The barks of Marsdenia condurango
ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用

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产品名称	产品编号	CAS编号	包装	QQ客服
牛弥菜醇A	CFN98868	526-87-4	1mg	QQ客服：3257982914
牛弥菜醇A	CFN98868	526-87-4	5mg	QQ客服：3257982914
牛弥菜醇A	CFN98868	526-87-4	10mg	QQ客服：3257982914
牛弥菜醇A	CFN98868	526-87-4	20mg	QQ客服：3257982914

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ChemFaces的产品在许多优秀和顶级科学期刊中被引用

Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6.
doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)

PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206.
doi: 10.1038/nplants.2016.205.
IF=13.297(2019)

PMID: 28005066

Sci Adv. 2018 Oct 24;4(10): eaat6994.
doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)

PMID: 30417089

University of Stirling (United Kingdom)

Univerzita Karlova v Praze (Czech Republic)

University of Hertfordshire (United Kingdom)

Kazusa DNA Research Institute (Japan)

Charles University in Prague (Czech Republic)

MTT Agrifood Research Finland (Finland)

Helmholtz Zentrum München (Germany)

Indian Institute of Science (India)

University of Minnesota (USA)

Donald Danforth Plant Science Center (USA)

VIT University (India)

University of Fribourg (Switzerland)

Leibniz-Institut für Pflanzenbiochemie (IPB) (Germany)

Chulalongkorn University (Thailand)

More...

Description:

Conduritol A has a hypoglycemic effect, can have an effect on regulating the metabolism of blood lipid, free-radical scavenging, enhancing the antioxidant ability, potentiating immune function; it also can markedly prevent the diabetic rats from getting cataracts through the inhibition of lens aldose reductase.

Targets:

TNF-α | Lens aldose reductase

In vivo:

Zhongguo Zhong Yao Za Zhi. 2008 Dec;33(24):2961-5.

Experimental [corrected] study of hypoglycemic activity of conduritol A of stems of Gymnema sylvestre[Pubmed: 19294862]

To investigates the mechanism of hypooglycemic effect of conduritol A of stems of Gymnema sylvestre.
METHODS AND RESULTS:
Fourteen days later after administration, observation is taken on the change of these mice and rats weight, the FBG, TG, CHO, SOD, MDA, INS, TNF in serum were also detected with enzymology method and Radioimmuoassay method. Take the liver to determine the disposal of glucose. Take the pancreas to do the HE and immunohistochemistrial staining, and show pancreas islet beta-cell. Calulate thymus, pancreas, splenica index. Compared with diabetic model mice, high and middosage of conduritol A could remarkably reduce fasted blood sugar in diabetic rats induced by alloxan (P < 0.01). Significantly increase the level of serum insulin (P < 0.05). Activity of SOD was obviously increased, and amount of MDA was obviously decreased (P < 0.05). The amount of conduritol A disposal of glucose was obviously increased (P < 0.05). Significantly increase thymus, pancreas, splencia index (P < 0.01 or 0.05); inhibited the atrophy of thymus, pancreas, splencias of the diabetic rats induced by alloxan. Compared with diabetic model group, cell structure and form of conduritol A had been some way improved. The immunohistochemistry results showed that beta-cells numbers of pancreas in each conduritol A group were more than those in the model group.
CONCLUSIONS:
Conduritol A could have an effect on regulating the metabolism of blood lipid, free-radical scavenging, enhancing the antioxidant ability, potentiating immune function. Promoting synthesis of hepatic to decrease fasted blood suger.

产品名称	产品编号	CAS编号	分子式 = 分子量	位单	联系QQ
3,4-O-异亚丙基莽草酸; 3,4-O-Isopropylidene shikimic acid	CFN99852	183075-03-8	C₁₀H₁₄O₅ = 214.2	5mg	QQ客服：2056216494
3-O-咖啡酰莽草酸; 3-O-Caffeoylshikimic acid	CFN92951	180981-12-8	C₁₆H₁₆O₈ = 336.29	5mg	QQ客服：1457312923
4-O-咖啡酰莽草酸; 4-O-Caffeoylshikimic acid	CFN92952	180842-65-3	C₁₆H₁₆O₈ = 336.29	5mg	QQ客服：2056216494
5-O-咖啡酰莽草酸; 5-O-Caffeoylshikimic acid	CFN92950	73263-62-4	C₁₆H₁₆O₈ = 336.29	10mg	QQ客服：1457312923
腐殖酸钠; Humic acid sodium salt	CFN99794	68131-04-4	C₉H₈O₄Na₂ = 226.14	20mg	QQ客服：1457312923
去氧野艽霉素盐酸盐; Deoxynojirimycin hydrochloride	CFN90484	73285-50-4	C₆H₁₄ClNO₄ = 199.6	5mg	QQ客服：1457312923
环己五醇, L-栎醇; vibo-Quercitol	CFN98778	488-76-6	C₆H₁₂O₅ = 164.2	20mg	QQ客服：1457312923
肌醇; Inositol	CFN91718	87-89-8	C₆H₁₂O₆ = 180.16	20mg	QQ客服：2056216494
(E)-1-甲氧基-2-O-(p-香豆酰)-myo-肌醇; (E)-1-methoxy-2-O-(p-coumaroyl)-myo-inositol	CFN95609	1391715-18-6	C₁₆H₂₀O₈ = 340.3	20mg	QQ客服：2056216494
D-松醇; D-Pinitol	CFN99044	10284-63-6	C₇H₁₄O₆ = 194.2	20mg	QQ客服：1413575084

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	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	6.8446 mL	34.2231 mL	68.4463 mL	136.8925 mL	171.1157 mL
5 mM	1.3689 mL	6.8446 mL	13.6893 mL	27.3785 mL	34.2231 mL
10 mM	0.6845 mL	3.4223 mL	6.8446 mL	13.6893 mL	17.1116 mL
50 mM	0.1369 mL	0.6845 mL	1.3689 mL	2.7379 mL	3.4223 mL
100 mM	0.0684 mL	0.3422 mL	0.6845 mL	1.3689 mL	1.7112 mL