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  • 赤桐甾醇

    Clerosterol

    赤桐甾醇
    产品编号 CFN90787
    CAS编号 2364-23-0
    分子式 = 分子量 C29H48O = 412.7
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Steroids
    植物来源 The herbs of Cleredendrum cwtophyllum Turcz.
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    赤桐甾醇 CFN90787 2364-23-0 1mg QQ客服:2056216494
    赤桐甾醇 CFN90787 2364-23-0 5mg QQ客服:2056216494
    赤桐甾醇 CFN90787 2364-23-0 10mg QQ客服:2056216494
    赤桐甾醇 CFN90787 2364-23-0 20mg QQ客服:2056216494
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • Universidad Industrial de Santander (Colombia)
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  • University of Canterbury (New Zealand)
  • Guangzhou Institutes of Biomedicine and Health (China)
  • University of Vienna (Austria)
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  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Antioxidants (Basel).2020, 9(4):284.
  • Oncol Rep.2021, 46(1):143.
  • Asian Journal of Chemistry2014, 26(22):7811-7816
  • Biomed Pharmacother.2023, 166:115329.
  • VNU Journal of Science: Med.& Pharm. Sci.2022, 38(2):2588-1132.
  • Int J Biol Macromol.2018, 112:1093-1103
  • Food Chem.2020, 332:127412
  • Plant Cell Tiss Org2020, 1-16
  • Int J Mol Med.2020, 45(5):1514-1524.
  • Mol Plant Pathol.2022, 10.1111:mpp.13280.
  • Chemistry of plant raw materials2021, 1:pp 139-150
  • Antioxidants.2022, 11(3):592.
  • Journal of Ginseng Research2019, 10.1016
  • PLoS One.2015, 10(5):e0127060
  • Postharvest Biol Tec2019, 149:18-26
  • Curr Eye Res.2018, 43(1):27-34
  • Front Pharmacol.2019, 10:1355
  • LWT2020, 130:109535
  • Cell Signal.2022, 99:110433.
  • Molecules.2021, 26(4):817.
  • Anal Bioanal Chem. 2016, 408(15)
  • Am J Chin Med.2015, 30:1-22
  • International. J. of Food Properties 2017, 20:S131-S140
  • ...
  • 生物活性
    Description: Clerosterol as a precursor of cyasterone, isocyasterone and 29-norcyasterone in biosynthesis of phytoecdysteroids of Ajuga hairy roots. Clerosterol exerts its cytotoxic effect in A2058 human melanoma cells by caspases-dependent apoptosis.
    Targets: Bcl-2/Bax | Caspase
    In vitro:
    Marine Drugs, 2013, 11(2):418-30.
    Cytotoxic Effect of Clerosterol Isolated from Codium fragile on A2058 Human Melanoma Cells[Pubmed: PMC3640389]
    The cytotoxic effects and mechanism of action of clerosterol, isolated from the marine alga Codium fragile, were investigated in A2058 human melanoma cells.
    METHODS AND RESULTS:
    Clerosterol inhibited the growth of A2058 cells with an IC(50) of 150 µM and induced apoptotic cell death, as evidenced by DNA fragmentation, an increase in the number of sub-G(1) hypodiploid cells and the presence of apoptotic bodies. Clerosterol treatment caused the loss of mitochondrial membrane potential. Alterations in the expression of apoptosis-associated proteins in response to clerosterol treatment included upregulation of Bax, downregulation of Bcl-2 and activation of caspases 3 and 9. The pan-caspase inhibitor treatment attenuated the expression of the active form of caspases and cell death induced by clerosterol.
    CONCLUSIONS:
    The present results show that clerosterol exerts its cytotoxic effect in A2058 human melanoma cells by caspases-dependent apoptosis.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 2.4231 mL 12.1153 mL 24.2307 mL 48.4614 mL 60.5767 mL
    5 mM 0.4846 mL 2.4231 mL 4.8461 mL 9.6923 mL 12.1153 mL
    10 mM 0.2423 mL 1.2115 mL 2.4231 mL 4.8461 mL 6.0577 mL
    50 mM 0.0485 mL 0.2423 mL 0.4846 mL 0.9692 mL 1.2115 mL
    100 mM 0.0242 mL 0.1212 mL 0.2423 mL 0.4846 mL 0.6058 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    Delta 5-avenasterol; Delta 5-avenasterol CFN92239 18472-36-1 C29H48O = 412.7 5mg QQ客服:215959384
    Delta 7-avenasterol; Delta 7-avenasterol CFN92240 23290-26-8 C29H48O = 412.7 5mg QQ客服:3257982914
    赤桐甾醇; Clerosterol CFN90787 2364-23-0 C29H48O = 412.7 5mg QQ客服:2056216494
    22-脱氢赤桐甾醇; 22-Dehydroclerosterol CFN98304 26315-07-1 C29H46O = 410.7 5mg QQ客服:2056216494
    22-去氢赤桐甾乙酸酯; 22-Dehydroclerosteryl acetate CFN98350 28594-00-5 C31H48O2 = 452.7 5mg QQ客服:2056216494
    3beta-Hydroxyporiferast-5-en-7-one; 3beta-Hydroxyporiferast-5-en-7-one CFN99498 145163-97-9 C29H48O2 = 428.7 5mg QQ客服:1457312923
    柠檬二烯醇; Citrostadienol CFN89063 474-40-8 C30H50O = 426.72 5mg QQ客服:1413575084

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