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  • 猫眼草黄素

    Chrysosplenetin

    猫眼草黄素
    产品编号 CFN97026
    CAS编号 603-56-5
    分子式 = 分子量 C19H18O8 = 374.4
    产品纯度 >=98%
    物理属性 Yellow powder
    化合物类型 Flavonoids
    植物来源 The herbs of Laggera pterodonta
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    猫眼草黄素 CFN97026 603-56-5 1mg QQ客服:2932563308
    猫眼草黄素 CFN97026 603-56-5 5mg QQ客服:2932563308
    猫眼草黄素 CFN97026 603-56-5 10mg QQ客服:2932563308
    猫眼草黄素 CFN97026 603-56-5 20mg QQ客服:2932563308
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • Weizmann Institute of Science (Israel)
  • Centrum Menselijke Erfelijkheid (Belgium)
  • Centralised Purchases Unit (CPU), B.I.T.S (India)
  • University of South Australia (Australia)
  • Mahidol University (Thailand)
  • Universidad Miguel Hernández (Spain)
  • Universite de Lille1 (France)
  • National Cancer Institute (USA)
  • Harvard University (USA)
  • University of East Anglia (United Kingdom)
  • Universidad de La Salle (Mexico)
  • Nanjing University of Chinese Medicine (China)
  • Indian Institute of Science (India)
  • The Vancouver Prostate Centre (VPC) (Canada)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Scientific World Journal.2014, 2014:654193
  • PLoS One.2015, 10(5):e0127060
  • Mol Med Rep.2015, 12(5):7789-95
  • J. Soc. Cosmet. Sci. Korea2016, 163-171
  • Int J Mol Med.2016, 37(2):501-8
  • Int. Conference on Med. Sci. and Bio.2017, 17973
  • Int J Mol Sci.2017, 19(1)
  • Phytochemistry Letters2017, 449-455
  • Cytotechnology.2017, 69(5):765-773
  • Oncotarget.2017, 8(53):90925-90947
  • Oncotarget.2017, 9(3):4161-4172
  • Analytical Methods2018, 10(27)
  • Anal Chim Acta.2018, 1039:162-171
  • Nat Prod Sci.2018, 24(3):206
  • Korean J Dent Mater.2018, 45(2):139-146
  • Biochem Biophys Res Commun.2018, 505(1):194-200
  • The Japan Society for Analytical Chemistry2018, 67(4):201-206
  • Cell Death Dis.2019, 10(12):882
  • Molecules.2019, 24(11):E2044
  • Molecules.2019, 24(24):E4536
  • Anal Sci.2019, 35(12):1317-1325
  • The Malaysian journal of pathology2019, 41(3):243-251
  • Genes Genomics.2020, 10.1007
  • ...
  • 生物活性
    Description: Chrysosplenetin is a metabolic inhibitor of artemisinin, it has strong activity in vitro against EV71 with low cytotoxicity. Co-administration of artemisinin(ART) with chrysosplenetin(CHR) in ratio of 1:2 achieved a synergic anti-malarial effect partly because of the noncompetitive or uncompetitive inhibition of CHR of drug-metabolism enzymes, especially CYP3A which is closely related to the auto-induction of ART.
    Targets: P450 (e.g. CYP17) | Antifection
    In vitro:
    Zhongguo Zhong Yao Za Zhi. 2013 Oct;38(19):3363-7.
    Determination of chrysosplenetin, metabolic inhibitor of artemisinin, in rat plasma by UPLC-ms/MS and study on its pharmacokinetics.[Pubmed: 24422409]

    METHODS AND RESULTS:
    The study aimed to develop the assay of Chrysosplenetin (CHR), a metabolic inhibitor of artemisinin by UPLC-MS/MS in rat plasma and investigate the pharmacokinetics parameters of Chrysosplenetin.The assay was linear in the range 5-5 000 microg L-1 (r =0. 999 3) with recoveries in the range from 69. 0% to 81.2% and satisfied inter-, intra- precision and accuracy. Chrysosplenetin after oral administration is not easy to absorb with double or multimodal peak phenomenon. The t1/2 of Chrysosplenetin after intravenous injection was very short and that of low, medium, and high dosage was (17. 01 +/- 8. 06) , (24. 62 +/- 4. 59), (28. 46+/- 4. 63) min, respectively.
    CONCLUSIONS:
    The developed method was special, rapid, and sensitive for determination of Chrysosplenetin pharmacokinetics.
    Eur J Pharm Sci. 2011 Oct 9;44(3):392-8.
    Inhibition of enterovirus 71 replication by chrysosplenetin and penduletin.[Pubmed: 21914477]
    In recent years, enterovirus 71 (EV71) infections have caused an increasing epidemic in young children, accompanying with more severe nervous system disease and more deaths. Unfortunately, there is no specific medication for it so far.
    METHODS AND RESULTS:
    Here we investigated the anti-EV71 activity of Chrysosplenetin and penduletin, two o-methylated flavonols isolated from the leaves of Laggera pterodonta. These two compounds were found to have strong activity in vitro against EV71 with low cytotoxicity. In the cytopathic effect (CPE) inhibition assays, both plaque reduction assay and virus yield inhibition assay, the compounds showed a similar 50% inhibitory concentration (IC(50)) value of about 0.20 μM.
    CONCLUSIONS:
    The selectivity indices (SI) of Chrysosplenetin and penduletin were 107.5 and 655.6 in African green monkey kidney (Vero) cells, and 69.5 and 200.5 in human rhabdomyosarcoma (RD) cells, accordingly.
    In vivo:
    Malaria J., 2015, 14(1):1-13.
    Impact of chrysosplenetin on the pharmacokinetics and anti-malarial efficacy of artemisinin against Plasmodium berghei as well as in vitro CYP450 enzymatic activities in rat liver microsome.[Pubmed: 26537009]
    Artemisinin (ART) is an efficacious and safe anti-malarial drugs but has low oral bioavailability and auto-induction profiles during multiple dosing. The pharmacokinetic disadvantages have been found to partially depend on the induction of cytochrome P-450 enzymes by ART and resulted in the therapeutic failure due to insufficient drug levels.
    METHODS AND RESULTS:
    The present study, therefore, investigated the impacts of Chrysosplenetin (CHR), a polymethoxylated flavonoid from Artemisia annua, on the pharmacokinetics and the anti-malarial efficacy of ART against Plasmodium berghei. The inhibition of CHR on enzymatic activity of CYP1A2, CYP2A, CYP2C19, CYP2D6, CYP2E1, and CYP3A in rat liver microsome was also investigated. IC50, Km, Ki, and inhibitory type of CHR were respectively calculated. Co-administration of ART with CHR in ratio of 1:2 achieved a synergic anti-malarial effect partly because of the noncompetitive or uncompetitive inhibition of CHR of drug-metabolism enzymes, especially CYP3A which is closely related to the auto-induction of ART.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 2.6709 mL 13.3547 mL 26.7094 mL 53.4188 mL 66.7735 mL
    5 mM 0.5342 mL 2.6709 mL 5.3419 mL 10.6838 mL 13.3547 mL
    10 mM 0.2671 mL 1.3355 mL 2.6709 mL 5.3419 mL 6.6774 mL
    50 mM 0.0534 mL 0.2671 mL 0.5342 mL 1.0684 mL 1.3355 mL
    100 mM 0.0267 mL 0.1335 mL 0.2671 mL 0.5342 mL 0.6677 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    菠叶素; Spinacetin CFN95194 3153-83-1 C17H14O8 = 346.3 5mg QQ客服:1413575084
    棕鳞矢车菊黄酮素; Jaceidin CFN99032 10173-01-0 C18H16O8 = 360.3 5mg QQ客服:2932563308
    三乙酸棕鳞矢车菊黄酮素酯; Jaceidin triacetate CFN99482 14397-69-4 C24H22O11 = 486.4 5mg QQ客服:2159513211
    猫眼草黄素; Chrysosplenetin CFN97026 603-56-5 C19H18O8 = 374.4 10mg QQ客服:1413575084
    3',4',7,8-四甲氧基黄酮; 3',4',7,8-Tetramethoxyflavone CFN70432 65548-55-2 C19H18O6 = 342.4 5mg QQ客服:1148253675
    5,7,3',4'-四甲氧基黄酮; 5,7,3',4'-Tetramethoxyflavone CFN91116 855-97-0 C19H18O6 = 342.3 10mg QQ客服:2932563308
    栎精-3,7,3’,4’-四甲醚; Retusin CFN89520 1245-15-4 C19H18O7 = 358.34 5mg QQ客服:215959384
    槲皮素3,5,7,3',4'-五甲基醚; Quercetin 3,5,7,3,4-pentamethyl ether CFN70262 1247-97-8 C20H20O7 = 372.4 5mg QQ客服:1413575084
    艾黄素; Artemetin CFN98731 479-90-3 C20H20O8 = 388.4 20mg QQ客服:215959384
    乙酰艾黄素; 乙酸六棱菊亭酯; Artemetin acetate CFN97530 95135-98-1 C22H22O9 = 430.4 5mg QQ客服:1148253675

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