• 中药标准品生产商,产品定制服务
  • Science | Nature | Cell | View More

    猫眼草黄素

    Chrysosplenetin

    猫眼草黄素
    产品编号 CFN97026
    CAS编号 603-56-5
    分子式 = 分子量 C19H18O8 = 374.4
    产品纯度 >=98%
    物理属性 Yellow powder
    化合物类型 Flavonoids
    植物来源 The herbs of Laggera pterodonta
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    猫眼草黄素 CFN97026 603-56-5 10mg QQ客服:1148253675
    猫眼草黄素 CFN97026 603-56-5 20mg QQ客服:1148253675
    猫眼草黄素 CFN97026 603-56-5 50mg QQ客服:1148253675
    猫眼草黄素 CFN97026 603-56-5 100mg QQ客服:1148253675
    存储与注意事项
    1. 在您收到产品后请检查产品。如无问题,请将产品存入冰霜并且样品瓶保持密封,产品可以存放长达24个月(2-8摄氏度)。

    2. 只要有可能,产品溶解后,您应该在同一天应用于您的实验。 但是,如果您需要提前做预实验,或者需要全部溶解,我们建议您将溶液以等分试样的形式存放在-20℃的密封小瓶中。 通常,这些可用于长达两周。 使用前,打开样品瓶前,我们建议您将产品平衡至室温至少1小时。

    3. 需要更多关于溶解度,使用和处理的建议? 请发送电子邮件至:service@chemfaces.com
    订购流程
  • 1. 在线订购
  • 请联系我们QQ客服

  • 2. 电话订购
  • 请拨打电话:
    027-84237683 或 027-84237783

  • 3. 邮件或传真订购
  • 发送电子邮件到: manager@chemfaces.com 或
    发送传真到:027-84254680

  • 提供订购信息
  • 为了方便客户的订购,请需要订购ChemFaces产品的客户,在下单的时候请提供下列信息,以供我们快速为您建立发货信息。
  •  
  • 1. 产品编号(CAS No.或产品名称)
  • 2. 发货地址
  • 3. 联系方法 (联系人,电话)
  • 4. 开票抬头 (如果需要发票的客户)
  • 5. 发票地址(发货地址与发票地址不同)
  • 发货时间
    1. 付款方式为100%预付款客户,我们将在确认收到货款后当天或1-3个工作日发货。

    2. 付款方式为月结的客户,我们承诺在收到订单后当天或1-3个工作日内发货。

    3. 如果客户所需要的产品,需要重新生产,我们有权告知客户,交货时间需要延期。
    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • Warszawski Uniwersytet Medyczny (Poland)
  • Uniwersytet Gdański (Poland)
  • Florida A&M University (USA)
  • University of Melbourne (Australia)
  • The Ohio State University (USA)
  • Sanford Burnham Medical Research Institute (USA)
  • University of Indonesia (Indonesia)
  • CSIRO - Agriculture Flagship (Australia)
  • Kazusa DNA Research Institute (Japan)
  • Mahidol University (Thailand)
  • Universite Libre de Bruxelles (Belgium)
  • Deutsches Krebsforschungszentrum (Germany)
  • Universidade Federal de Santa Catarina (Brazil)
  • University of East Anglia (United Kingdom)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Scientific World Journal.2014, 2014:654193
  • J-STAGE2015, 249-255
  • Polytechnic University of Catalonia2017, 105826
  • Sci Rep. 2017, 17332(7)
  • Preprints2017, 2017120176
  • Food Chem.2017, 228:301-314
  • Plant Cell Tiss Org2017, 479-486
  • Aquaculture2017, 481:94-102
  • J Food Compos Anal2017, 62:197-204
  • BMC Complement Altern Med.2018, 18(1):303
  • Exp Neurobiol.2018, 27(3):200-209
  • Phytother Res.2018, 32(5):923-932
  • Phytomedicine.2018, 38:45-56
  • J of the Korean Society of Cosmetics and Cosmetology2018, 399-406
  • Sci Rep. 2018, 462(8)
  • Pharmacognosy Journal2019, 11(2): 369-373
  • Drug Invention Today2019, 12(6):1303-1306
  • J of Essential Oil Research2019, 1677272
  • Korean J of Crop Science2019, 452-458
  • Anal Biochem.2019, 569:10-15
  • Cell Mol Biol(Noisy-le-grand)2019, 65(7):77-83
  • Plos One.2019, 15(2):e0220084
  • J of Applied Pharmaceutical Science2020, 10(1):077-082
  • ...
  • 生物活性
    Description: Chrysosplenetin is a metabolic inhibitor of artemisinin, it has strong activity in vitro against EV71 with low cytotoxicity. Co-administration of artemisinin(ART) with chrysosplenetin(CHR) in ratio of 1:2 achieved a synergic anti-malarial effect partly because of the noncompetitive or uncompetitive inhibition of CHR of drug-metabolism enzymes, especially CYP3A which is closely related to the auto-induction of ART.
    Targets: P450 (e.g. CYP17) | Antifection
    In vitro:
    Zhongguo Zhong Yao Za Zhi. 2013 Oct;38(19):3363-7.
    Determination of chrysosplenetin, metabolic inhibitor of artemisinin, in rat plasma by UPLC-ms/MS and study on its pharmacokinetics.[Pubmed: 24422409]

    METHODS AND RESULTS:
    The study aimed to develop the assay of Chrysosplenetin (CHR), a metabolic inhibitor of artemisinin by UPLC-MS/MS in rat plasma and investigate the pharmacokinetics parameters of Chrysosplenetin.The assay was linear in the range 5-5 000 microg L-1 (r =0. 999 3) with recoveries in the range from 69. 0% to 81.2% and satisfied inter-, intra- precision and accuracy. Chrysosplenetin after oral administration is not easy to absorb with double or multimodal peak phenomenon. The t1/2 of Chrysosplenetin after intravenous injection was very short and that of low, medium, and high dosage was (17. 01 +/- 8. 06) , (24. 62 +/- 4. 59), (28. 46+/- 4. 63) min, respectively.
    CONCLUSIONS:
    The developed method was special, rapid, and sensitive for determination of Chrysosplenetin pharmacokinetics.
    Eur J Pharm Sci. 2011 Oct 9;44(3):392-8.
    Inhibition of enterovirus 71 replication by chrysosplenetin and penduletin.[Pubmed: 21914477]
    In recent years, enterovirus 71 (EV71) infections have caused an increasing epidemic in young children, accompanying with more severe nervous system disease and more deaths. Unfortunately, there is no specific medication for it so far.
    METHODS AND RESULTS:
    Here we investigated the anti-EV71 activity of Chrysosplenetin and penduletin, two o-methylated flavonols isolated from the leaves of Laggera pterodonta. These two compounds were found to have strong activity in vitro against EV71 with low cytotoxicity. In the cytopathic effect (CPE) inhibition assays, both plaque reduction assay and virus yield inhibition assay, the compounds showed a similar 50% inhibitory concentration (IC(50)) value of about 0.20 μM.
    CONCLUSIONS:
    The selectivity indices (SI) of Chrysosplenetin and penduletin were 107.5 and 655.6 in African green monkey kidney (Vero) cells, and 69.5 and 200.5 in human rhabdomyosarcoma (RD) cells, accordingly.
    In vivo:
    Malaria J., 2015, 14(1):1-13.
    Impact of chrysosplenetin on the pharmacokinetics and anti-malarial efficacy of artemisinin against Plasmodium berghei as well as in vitro CYP450 enzymatic activities in rat liver microsome.[Pubmed: 26537009]
    Artemisinin (ART) is an efficacious and safe anti-malarial drugs but has low oral bioavailability and auto-induction profiles during multiple dosing. The pharmacokinetic disadvantages have been found to partially depend on the induction of cytochrome P-450 enzymes by ART and resulted in the therapeutic failure due to insufficient drug levels.
    METHODS AND RESULTS:
    The present study, therefore, investigated the impacts of Chrysosplenetin (CHR), a polymethoxylated flavonoid from Artemisia annua, on the pharmacokinetics and the anti-malarial efficacy of ART against Plasmodium berghei. The inhibition of CHR on enzymatic activity of CYP1A2, CYP2A, CYP2C19, CYP2D6, CYP2E1, and CYP3A in rat liver microsome was also investigated. IC50, Km, Ki, and inhibitory type of CHR were respectively calculated. Co-administration of ART with CHR in ratio of 1:2 achieved a synergic anti-malarial effect partly because of the noncompetitive or uncompetitive inhibition of CHR of drug-metabolism enzymes, especially CYP3A which is closely related to the auto-induction of ART.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 2.6709 mL 13.3547 mL 26.7094 mL 53.4188 mL 66.7735 mL
    5 mM 0.5342 mL 2.6709 mL 5.3419 mL 10.6838 mL 13.3547 mL
    10 mM 0.2671 mL 1.3355 mL 2.6709 mL 5.3419 mL 6.6774 mL
    50 mM 0.0534 mL 0.2671 mL 0.5342 mL 1.0684 mL 1.3355 mL
    100 mM 0.0267 mL 0.1335 mL 0.2671 mL 0.5342 mL 0.6677 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    栎精-3,7,3’,4’-四甲醚; Retusin CFN89520 1245-15-4 C19H18O7 = 358.34 5mg QQ客服:215959384
    槲皮素3,5,7,3',4'-五甲基醚; Quercetin 3,5,7,3,4-pentamethyl ether CFN70262 1247-97-8 C20H20O7 = 372.4 5mg QQ客服:2932563308
    艾黄素; Artemetin CFN98731 479-90-3 C20H20O8 = 388.4 20mg QQ客服:2932563308
    乙酰艾黄素; 乙酸六棱菊亭酯; Artemetin acetate CFN97530 95135-98-1 C22H22O9 = 430.4 5mg QQ客服:1413575084
    槲皮素; Quercetin CFN99272 117-39-5 C15H10O7 = 302.2 20mg QQ客服:3257982914
    杜鹃黄素; Azaleatin CFN91007 529-51-1 C16H12O7 = 316.3 10mg QQ客服:3257982914
    3-O-甲基槲皮素; 3-O-Methylquercetin CFN99616 1486-70-0 C16H12O7 = 316.3 5mg QQ客服:2932563308
    四乙酸3-O-甲基槲皮素酯; 3-O-Methylquercetin tetraacetate CFN99615 1486-69-7 C24H20O11 = 484.4 5mg QQ客服:2932563308
    beta-鼠李素; beta-Rhamnocitrin CFN92328 90-19-7 C16H12O7 = 316.3 5mg QQ客服:2159513211
    3,7-二-O-甲基槲皮素; 3,7-Di-O-methylquercetin CFN96221 2068-02-2 C17H14O7 = 330.3 5mg QQ客服:215959384

    信息支持


    公司简介
    订购流程
    付款方式
    退换货政策

    ChemFaces提供的产品仅用于科学研究使用,不用于诊断或治疗程序。

    联系方式


    电机:027-84237783
    传真:027-84254680
    在线QQ: 215959384
    E-Mail:manager@chemfaces.com

    湖北省武汉沌口经济技术开区车城南路83号1号楼第三层厂房


    ChemFaces为科学家,科研人员与企业提供快速的产品递送。我们通过瑞士SGS ISO 9001:2008质量体系认证天然化合物与对照品的研发和生产