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  • 大黄酚

    Chrysophanol

    大黄酚
    产品编号 CFN98751
    CAS编号 481-74-3
    分子式 = 分子量 C15H10O4 = 254.2
    产品纯度 >=98%
    物理属性 Yellow powder
    化合物类型 Anthraquinones
    植物来源 The roots and rhizomes of Rheum palmatum L.
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    大黄酚 CFN98751 481-74-3 10mg QQ客服:215959384
    大黄酚 CFN98751 481-74-3 20mg QQ客服:215959384
    大黄酚 CFN98751 481-74-3 50mg QQ客服:215959384
    大黄酚 CFN98751 481-74-3 100mg QQ客服:215959384
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • Universidad de Ciencias y Artes de Chiapas (Mexico)
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  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • J Microbiol Immunol Infect.2021, S1684-1182(21)00142-0.
  • Nutr Res Pract.2020, 14(3):203-217.
  • Int J Mol Sci.2020, 21(9):3392.
  • J Agric Food Chem.2021, 69(14):4210-4222.
  • Food Chem.2021, 360:130063.
  • J of the Korean Society of Food Science and Nutrition2019, 32(2):148-154
  • BMC Complement Altern Med.2019, 19(1):367
  • Phytother Res.2019, 33(5):1490-1500
  • Antioxidants (Basel).2020, 9(11):1121.
  • Plants (Basel).2021, 10(11):2525.
  • Viruses.2017, 9(10)
  • Srinagarind Medical Journal2017, 32(1)
  • J Ginseng Res.2020, 44(4):611-618.
  • Sci Rep.2015, 5:13194
  • Saf Health Work.2019, 10(2):196-204
  • Life Sci.2023, 317:121458.
  • J Mol Med (Berl).2018, 96(7):661-672
  • J Biomol Struct Dyn.2023, 1-21.
  • Heliyon.2023, 9(12):e22932.
  • Bioengineering2023, 10(10), 1113.
  • Molecules 2021, 26(4),1092.
  • Molecules.2021, 26(6):1635.
  • Sci Rep.2018, 8:9267
  • ...
  • 生物活性
    Description: Chrysophanol (Chrysophanic acid) is a natural anthraquinone, which inhibits EGF-induced phosphorylation of EGFR and suppresses activation of AKT and mTOR/p70S6K. Chrysophanol has anti-inflammatory, cytotoxicity and anti-diabetic properties, it can play metabolic roles in the insulin-stimulated glucose transport pathway; it can inhibit NALP3 inflammasome activation and ameliorate cerebral ischemia/reperfusion in mice; it also is active against plant powdery mildew.
    Targets: ROS | NF-kB | Caspase | Calcium Channel | GLUT | TNF-α | COX | IL Receptor | EGFR | mTOR
    In vitro:
    Environ Toxicol. 2014 May;29(7):740-9.
    Chrysophanol-induced cell death (necrosis) in human lung cancer A549 cells is mediated through increasing reactive oxygen species and decreasing the level of mitochondrial membrane potential.[Pubmed: 22848001]
    Chrysophanol (1,8-dihydroxy-3-methylanthraquinone) is one of the anthraquinone compounds, and it has been shown to induce cell death in different types of cancer cells. The effects of chrysophanol on human lung cancer cell death have not been well studied.
    METHODS AND RESULTS:
    The purpose of this study is to examine chrysophanol-induced cytotoxic effects and also to investigate such influences that involved apoptosis or necrosis in A549 human lung cancer cells in vitro. Our results indicated that chrysophanol decreased the viable A549 cells in a dose- and time-dependent manner. Chrysophanol also promoted the release of reactive oxygen species (ROS) and Ca(2+) and decreased the levels of mitochondria membrane potential (ΔΨm ) and adenosine triphosphate in A549 cells. Furthermore, chrysophanol triggered DNA damage by using Comet assay and DAPI staining. Importantly, chrysophanol only stimulated the cytocheome c release, but it did not activate other apoptosis-associated protein levels including caspase-3, caspase-8, Apaf-1, and AIF.
    CONCLUSIONS:
    In conclusion, human lung cancer A549 cells treated with chrysophanol exhibited a cellular pattern associated with necrotic cell death and not apoptosis in vitro.
    Pest Manag Sci. 2007 May;63(5):511-5.
    Synergistic interaction of physcion and chrysophanol on plant powdery mildew.[Pubmed: 17397111]
    The extract of the plant Rheum officinale Baill, mainly containing the anthraquinones physcion and chrysophanol, is highly active against plant powdery mildew.
    METHODS AND RESULTS:
    Experiments were conducted in the laboratory and greenhouse to determine the interaction of the two compounds on cucumber powdery mildew [Sphaerotheca fuliginea (Schlecht.) Poll] and on wheat powdery mildew [Blumeria graminis (DC.) Speer f. sp. tritici Marchal]. Physcion was much more bioactive than chrysophanol against these powdery mildews. There was a significant synergistic interaction between the two compounds on the diseases when the ratios of physcion to chrysophanol ranged from 1:9 to 5:5. The synergistic degree increased with increase in the chrysophanol proportion in the combination.
    CONCLUSIONS:
    The findings indicate that, in order to ensure constant efficacy of the extract on the disease, both the contents and the proportion of the main active ingredients physcion and chrysophanol have to be determined.
    Biol Pharm Bull. 2008 Nov;31(11):2154-7.
    Anti-diabetic properties of chrysophanol and its glucoside from rhubarb rhizome.[Pubmed: 18981591]
    An ethanol extract of rhubarb rhizome exhibited marked glucose transport activity in differentiated L6 rat myotubes. Activity-guided fractionation resulted in the isolation of two anthraquinones, chrysophanol-8-O-beta-D-glucopyranoside (1) and chrysophanol (2).
    METHODS AND RESULTS:
    The anti-diabetic effect was examined by glucose transport activity, glucose transporter 4 (Glut4) expression in myotubes, and the level of insulin receptor (IR) tyrosine phosphorylation as influenced by tyrosine phosphatase 1B, each of which is a major target of diabetes treatment. Chrysophanol-8-O-beta-D-glucopyranoside up to 25 microM dose-dependently activated glucose transport in insulin-stimulated myotubes. Increased tyrosine phosphorylation of IR due to tyrosine phosphatase 1B inhibitory activity with an IC50 value of 18.34+/-0.29 microM and unchanged Glut4 mRNA levels was observed following chrysophanol-8-O-beta-D-glucopyranoside treatment. Chrysophanol up to 100 microM exerted mild glucose transport activity and elevated the tyrosine phosphorylation of IR via tyrosine phosphatase 1B inhibition (IC50=79.86+/-0.12 microM); Glut4 mRNA expression was also significantly increased by 100 microM. The ED50 values of the two compounds were 59.38+/-0.66 and 79.69+/-0.03 microM, respectively.
    CONCLUSIONS:
    Therefore, these two anthraquinones from rhubarb rhizome, chrysophanol-8-O-beta-D-glucopyranoside and chrysophanol, have mild cytotoxicity and anti-diabetic properties and could play metabolic roles in the insulin-stimulated glucose transport pathway.
    2016 Dec 8;7:476.
    Chrysophanic Acid Suppresses Adipogenesis and Induces Thermogenesis by Activating AMP-Activated Protein Kinase Alpha In vivo and In vitro[Pubmed: 28008317]
    Chrysophanic acid (CA) is a member of the anthraquinone family abundant in rhubarb, a widely used herb for obesity treatment in Traditional Korean Medicine. Though several studies have indicated numerous features of CA, no study has yet reported the effect of CA on obesity. In this study, we tried to identify the anti-obesity effects of CA. By using 3T3-L1 adipocytes and primary cultured brown adipocytes as in vitro models, high-fat diet (HFD)-induced obese mice, and zebrafish as in vivo models, we determined the anti-obesity effects of CA. CA reduced weight gain in HFD-induced obese mice. They also decreased lipid accumulation and the expressions of adipogenesis factors including peroxisome proliferator-activated receptor gamma (PPARγ) and CCAAT/enhancer-binding protein alpha (C/EBPα) in 3T3-L1 adipocytes. In addition, uncoupling protein 1 (UCP1) and peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC1α), the brown fat specific thermogenic genes, were up-regulated in brown adipocytes by CA treatment. Furthermore, when co-treated with Compound C, the AMP-activated protein kinase (AMPK) inhibitor, the action of CA on AMPKα was nullified in both types of adipocytes, indicating the multi-controlling effect of CA was partially via the AMPKα pathway. Given all together, these results indicate that CA can ameliorate obesity by controlling the adipogenic and thermogenic pathway at the same time. On these bases, we suggest the new potential of CA as an anti-obese pharmacotherapy. Keywords: AMP-activated protein kinase alpha; adipogenesis; chrysophanic acid; obesity; thermogenesis.
    In vivo:
    Neural Regen Res. 2014 May 1;9(9):924-30.
    Chrysophanol attenuates lead exposure-induced injury to hippocampal neurons in neonatal mice.[Pubmed: 25206913]
    Previous studies have shown that chrysophanol protects against learning and memory impairments in lead-exposed adult mice.
    METHODS AND RESULTS:
    In the present study, we investigated whether chrysophanol can alleviate learning and memory dysfunction and hippocampal neuronal injury in lead-exposed neonatal mice. At the end of lactation, chrysophanol (0.1, 1.0, 10.0 mg/kg) was administered to the neonatal mice by intraperitoneal injection for 15 days. Chrysophanol significantly alleviated injury to hippocampal neurons and improved learning and memory abilities in the lead-poisoned neonatal mice. Chrysophanol also significantly decreased lead content in blood, brain, heart, spleen, liver and kidney in the lead-exposed neonatal mice. The levels of malondialdehyde in the brain, liver and kidney were significantly reduced, and superoxide dismutase and glutathione peroxidase activities were significantly increased after chrysophanol treatment.
    CONCLUSIONS:
    Collectively, these findings indicate that chrysophanol can significantly reduce damage to hippocampal neurons in lead-exposed neonatal mice.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 3.9339 mL 19.6696 mL 39.3391 mL 78.6782 mL 98.3478 mL
    5 mM 0.7868 mL 3.9339 mL 7.8678 mL 15.7356 mL 19.6696 mL
    10 mM 0.3934 mL 1.967 mL 3.9339 mL 7.8678 mL 9.8348 mL
    50 mM 0.0787 mL 0.3934 mL 0.7868 mL 1.5736 mL 1.967 mL
    100 mM 0.0393 mL 0.1967 mL 0.3934 mL 0.7868 mL 0.9835 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    橙黄决明素; Aurantio-obtusin CFN99732 67979-25-3 C17H14O7 = 330.29 20mg QQ客服:2056216494
    决明素; Obtusin CFN93032 70588-05-5 C18H16O7 = 344.31 5mg QQ客服:3257982914
    黄决明素; Chrysoobtusin CFN91661 70588-06-6 C19H18O7 = 358.34 5mg QQ客服:2159513211
    1,3,6,8-四羟基-2-(1-羟基己基)-蒽醌 ; Averantin CFN96721 5803-62-3 C20H20O7 = 372.37 5mg QQ客服:215959384
    大黄素; Emodin CFN98834 518-82-1 C15H10O5 = 270.2 20mg QQ客服:3257982914
    1-O-Methylnataloe-emodin; 1-O-Methylnataloe-emodin CFN96731 103392-51-4 C16H12O5 = 284.26 5mg QQ客服:2056216494
    大黄素甲醚; Physcion CFN98848 521-61-9 C16H12O5 = 284.3 20mg QQ客服:1413575084
    迷人醇; Fallacinol CFN91577 569-05-1 C16H12O6 = 300.3 5mg QQ客服:2159513211
    1,6-二羟基-8-甲氧基-3-甲基蒽-9,10-二酮; Questin CFN89155 3774-64-9 C16H12O5 = 284.26 5mg QQ客服:215959384
    Questinol; Questinol CFN89152 35688-09-6 C16H12O6 = 300.26 5mg QQ客服:3257982914

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