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  • 重楼皂苷VII

    Chonglou Saponin VII

    重楼皂苷VII
    产品编号 CFN97162
    CAS编号 68124-04-9
    分子式 = 分子量 C51H82O21 = 1031.2
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Steroids
    植物来源 The roots of Paris polyphylla
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    重楼皂苷VII CFN97162 68124-04-9 10mg QQ客服:1457312923
    重楼皂苷VII CFN97162 68124-04-9 20mg QQ客服:1457312923
    重楼皂苷VII CFN97162 68124-04-9 50mg QQ客服:1457312923
    重楼皂苷VII CFN97162 68124-04-9 100mg QQ客服:1457312923
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • Shanghai Institute of Organic Chemistry (China)
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  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Chinese Medicine2019, 14(1)
  • Preprints2022, 2022030063.
  • EXCLI J.2023, 22:482-498.
  • Universidade Estadual Paulista2017, 42785
  • Journal of Third Military Medical University2018, 40(12):1073-1078
  • J Clin Med.2019, 8(10):E1664
  • Food Chem.2022, 373(Pt B):131364.
  • Int J Mol Sci.2019, 20(23):E6071
  • Nat Prod Sci.2014, 20(3):182-190
  • Food Funct.2021, 12(13):5892-5902.
  • Int J Mol Med.2019, 43(6):2516-2522
  • New Zealand J. Forestry Sci.2014, 44:17
  • Foods.2022, 11(12):1773.
  • Applied Biological Chemistry2023, 66:42.
  • Chemistry of Natural Compounds2020, 56,423-426
  • Toxins (Basel).2019, 11(10):E575
  • Molecules.2020, 25(3):734
  • Front Pharmacol.2020, 11:683.
  • Int J Cosmet Sci.2023, 45(2):155-165.
  • Functional Ecology2020, doi: 10.1111.
  • Front Pharmacol.2018, 9:236
  • Sci Rep.2019, 9:12132
  • J Food Sci Technol.2022, 59(1):212-219.
  • ...
  • 生物活性
    Description: Chonglou saponin VII shows inhibitory effects on cell proliferation.
    In vitro:
    Zhonghua yi xue za zhi, 01 Jun 2015,95(23):1859-1861.
    Effects of Paris polyphylla saponin VII plus silica nano composite on ovarian cancer drug resistance in vitro.[Pubmed: 26712407]
    To explore the drug resistance of Chonglou Saponin VII plus silica nano complex for ovarian cancer.
    METHODS AND RESULTS:
    The method of thiazolyl blue tetrazolium blue (MTT) was employed for determining the proliferation inhibition rate of Chonglou Saponin VII plus silica nano composite for SKOV3/DDP drug-resistant human ovarian cancer cell. Flow cytometry and Hoechst 33342 staining were used for detecting apoptosis rate and cell cycle phase distribution. And the changes of apoptosis-related protein were examined by immunoblot assay.There were obvious inhibitory effects of Chonglou Saponin VII on cell proliferation. The inhibition rate increased with rising drug concentration with an obvious dose-effect relationship (P < 0.05). At the same time, the cell proliferation inhibition rate significantly improved at 48 h versus 24 h (P < 0.05). Flow cytometry and Hoechst 33342 staining showed that, after a 24 h treatment of SKOV3/DDP cells with 50 and 100 μmol/L Chonglou Saponin VII, early apoptotic cell ratio significantly increased compared with control group.
    CONCLUSIONS:
    The composite of Paris polyphylla saponin VII and silica nano has obvious proliferation inhibitory effects on SKOV3/DDP cells. And there is a significant concentration dependence and it also has some correlation with time. The above composite can increased the proportion of early apoptotic cell ratio.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 0.9697 mL 4.8487 mL 9.6974 mL 19.3949 mL 24.2436 mL
    5 mM 0.1939 mL 0.9697 mL 1.9395 mL 3.879 mL 4.8487 mL
    10 mM 0.097 mL 0.4849 mL 0.9697 mL 1.9395 mL 2.4244 mL
    50 mM 0.0194 mL 0.097 mL 0.1939 mL 0.3879 mL 0.4849 mL
    100 mM 0.0097 mL 0.0485 mL 0.097 mL 0.1939 mL 0.2424 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    重楼皂苷VI; Polyphyllin VI CFN99954 55916-51-3 C39H62O13 = 738.91 20mg QQ客服:215959384
    Mannioside A; Mannioside A CFN99055 1038922-95-0 C39H62O13 = 738.9 5mg QQ客服:1457312923
    麦冬皂苷Ra,麦冬皂苷1,麦冬苷元-3-O-新橙皮糖苷; Ophiogenin-3-O-alpha-L-rhaMnopyranosyl-(1->2)-beta-D-glucopyranoside CFN90638 128502-94-3 C39H62O14 = 754.9 10mg QQ客服:2056216494
    天冬宁B; Shatavarin IV CFN70458 84633-34-1 C45H74O17 = 887.1 5mg QQ客服:3257982914
    14-羟基麦冬皂苷C; 14-Hydroxy sprengerinin C CFN90636 1111088-89-1 C44H70O17 = 871.02 10mg QQ客服:1413575084
    17-羟基麦冬皂苷C; 17-Hydroxy sprengerinin C CFN90614 1029017-75-1 C44H70O17 = 871.02 10mg QQ客服:2056216494
    麦冬皂苷 C; Sprengerinin C CFN96366 88861-91-0 C44H70O16 = 855.0 5mg QQ客服:1457312923
    2''-O-乙酰麦冬皂苷 C; 2''-O-Acetylsprengerinin C CFN96364 1220707-33-4 C46H72O17 = 897.1 5mg QQ客服:215959384
    Glucopyranoside,(3beta,25R)-17-hydroxyspirost-5-en-3-yl; Glucopyranoside,(3beta,25R)-17-hydroxyspirost-5-en-3-yl CFN92807 84914-58-9 C44H70O17 = 870.5 10mg QQ客服:2056216494
    重楼皂苷H; Polyphyllin H CFN90701 81917-50-2 C44H70O17 = 871.0 5mg QQ客服:1413575084

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