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  • 诃子林鞣酸

    Chebulinic acid

    诃子林鞣酸
    产品编号 CFN92296
    CAS编号 18942-26-2
    分子式 = 分子量 C41H32O27 = 956.7
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Phenols
    植物来源 The fruits of Terminalia chebula.
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
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    产品名称 产品编号 CAS编号 包装 QQ客服
    诃子林鞣酸 CFN92296 18942-26-2 10mg QQ客服:3257982914
    诃子林鞣酸 CFN92296 18942-26-2 20mg QQ客服:3257982914
    诃子林鞣酸 CFN92296 18942-26-2 50mg QQ客服:3257982914
    诃子林鞣酸 CFN92296 18942-26-2 100mg QQ客服:3257982914
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • Universidade Federal de Santa Catarina (Brazil)
  • Universite de Lille1 (France)
  • National Cancer Center Research Institute (Japan)
  • Universiti Sains Malaysia (Malaysia)
  • Seoul National University (Korea)
  • Instituto Politécnico de Bragan?a (Portugal)
  • Universidad de Antioquia (Colombia)
  • FORTH-IMBB (Greece)
  • Chungnam National University (Korea)
  • Technical University of Denmark (Denmark)
  • University Medical Center Mainz (Germany)
  • Center for protein Engineering (CIP) (Belgium)
  • Uniwersytet Medyczny w ?odzi (Poland)
  • Shanghai University of TCM (China)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Journal of Analytical Chemistry2017, 854-861
  • Food and Agriculture Org. Of the UN2019, 151-160
  • BMC Pharmacol Toxicol.2018, 19(1):5
  • Korean J. Medicinal Crop Sci.2021, 29(1):45-50.
  • Int J Mol Sci.2022, 23(21):13112.
  • Plant Foods Hum Nutr.2020, 10.1007
  • Biomol Ther (Seoul).2023, 31(1):40-47.
  • Metabolites.2020, 11(1):E11.
  • Applied Biological Chemistry2023, 66:42.
  • Nutr Res Pract.2020, 14(5):478-489.
  • Oxid Med Cell Longev.2022, 2022:9139338.
  • Sci Rep. 2017, 12953(7)
  • J Herbmed Pharmacol.2018, 7(4):280-286
  • J of the Korean Society of Cosmetics and Cosmetology2019, 225-231
  • J-STAGE2015, 249-255
  • Nat Plants.2016, 3:16205
  • Environ Toxicol.2023, 23929.
  • J Agric Food Chem.2017, 65(13):2670-2676
  • J Adv Res.2021, 35:245-257.
  • Nutrients.2018, 10(12)
  • Anal Bioanal Chem.2023, 415(9):1641-1655.
  • Phytomedicine.2018, 41:62-66
  • Anesth Pain Med (Seoul).2020, 15(4):478-485.
  • ...
  • 生物活性
    Description: Chebulinic acid is a potent natural inhibitor of M. tuberculosis DNA gyrase, also can inhibit SMAD-3 phosphorylation, inhibit H+ K+-ATPase activity; it also is a natural inhibitor of vascular endothelial growth factor-A mediated angiogenesis. Chebulinic acid has hypotensive, antioxidant, anti-HIV, and anti-ulcer activities. Chebulinic acid has inhibitory effect on erythroid differentiation likely through changing transcriptional activation of differentiation relative genes, it or other tannins might influence the efficiency of some anti-tumor drugs-induced differentiation or the hematopoiesis processes.
    Targets: ATPase | Potassium Channel | VEGFR | HIV | Antifection | GATA-1 | PBGD | NF-E2
    In vitro:
    Toxicol In Vitro. 2009 Jun;23(4):667-73.
    Chebulinic acid and tellimagrandin I inhibit DNA strand breaks by hydroquinone/Cu(II) and H(2)O(2)/Cu(II), but potentiate DNA strand breaks by H(2)O(2)/Fe(II).[Pubmed: 19328845]

    METHODS AND RESULTS:
    The effects of two polyphenols, chebulinic acid and tellimagrandin I, on DNA strand breaks mediated by H(2)O(2)/Cu(II), hydroquinone (HQ)/Cu(II) and H(2)O(2)/Fe(II) in pBR322 plasmid DNA and genomic DNA of cultured MRC-5 human embryo lung fibroblasts were examined. The results demonstrated that chebulinic acid and tellimagrandin I obviously inhibited HQ/Cu(II)- and H(2)O(2)/Cu(II)-mediated pBR322 DNA strand breaks. When MRC-5 cells were treated with HQ/Cu(II), the presence of chebulinic acid or tellimagrandin I inhibited HQ/Cu(II)-mediated double strand breaks of genomic DNA. The presence of chebulinic acid or tellimagrandin I did not affect the H(2)O(2)- and HQ-mediated reduction of Cu(II) to Cu(I). Both polyphenols could slightly inhibit H(2)O(2)/Fe(II)-mediated plasmid DNA strand break at the lower concentration (1-10 microM), but potentiate the DNA strand break at the higher concentration (over 50 microM).
    CONCLUSIONS:
    These results demonstrated that chebulinic acid and tellimagrandin I possessed antioxidant action in certain conditions and exerted prooxidant action on DNA strand breaks in other conditions.
    In vivo:
    Clin Exp Pharmacol Physiol. 1996 Aug;23(8):747-50.
    In vitro inhibitory effects of chebulinic acid on the contractile responses of cardiovascular muscles.[Pubmed: 8886502]
    1. The effects of chebulinic acid, which has been shown to elicit blood pressure lowering effect in rats, on aortic vascular contraction as well as cardiac contraction were studied in rats.
    METHODS AND RESULTS:
    2. Chebulinic acid had no effect on KCl-induced aortic contraction, but irreversibly inhibited the contractile responses to phenylephrine in an apparently non-competitive manner. Chebulinic acid also inhibited contractile responses of rat aorta to 5-hydroxytryptamine and angiotensin II. 3. Chebulinic acid inhibited the binding of [3H]-prazosin to dog aortic microsomal membranes in a concentration-dependent manner with an IC50 value of 0.34 mmol/L. Results of saturation binding experiments suggest a mixed mode of inhibition by chebulinic acid (i.e. a decrease in both the maximal number of binding sites and the affinity for prazosin). 4. Chebulinic acid concentration-dependently and reversibly inhibited the maximal left ventricular pressure of rat heart in a Langendorff preparation with 50% inhibition occurring at a concentration of 0.3 nmol/L. 5. We conclude that chebulinic acid exerts non-specific inhibitory actions in vascular preparations. Its inhibitory effect on cardiac contraction was reversible and three orders of magnitude more potent than that on vascular contraction.
    CONCLUSIONS:
    We suggest that the hypotensive effect of chebulinic acid is probably mediated via the decrease in cardiac output resulting from reduced left ventricular contraction.
    Phytomedicine. 2013 Apr 15;20(6):506-11.
    Anti-secretory and cyto-protective effects of chebulinic acid isolated from the fruits of Terminalia chebula on gastric ulcers.[Pubmed: 23462212]
    In continuation of our drug discovery program on Indian medicinal plants, the gastro protective mechanism of chebulinic acid isolated from Terminalia chebula fruit was investigated.
    METHODS AND RESULTS:
    Chebulinic acid was evaluated against cold restraint (CRU), aspirin (AS), alcohol (AL) and pyloric ligation (PL) induced gastric ulcer models in rats. Potential anti-ulcer activity of chebulinic acid was observed against CRU (62.9%), AS (55.3%), AL (80.67%) and PL (66.63%) induced ulcer models. The reference drug omeprazole (10 mg/kg, p.o.) showed 77.73% protection against CRU, 58.30% against AS and 70.80% against PL model. Sucralfate, another reference drug (500 mg/kg, p.o.) showed 65.67% protection in AL induced ulcer model. Chebulinic acid significantly reduced free acidity (48.82%), total acidity (38.29%) and upregulated mucin secretion by 59.75% respectively.
    CONCLUSIONS:
    Further, chebulinic acid significantly inhibited H(+) K(+)-ATPase activity in vitro with IC50 of 65.01 μg/ml as compared to the IC50 value of omeprazole (30.24 μg/ml) confirming its anti-secretory activity.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 1.0453 mL 5.2263 mL 10.4526 mL 20.9052 mL 26.1315 mL
    5 mM 0.2091 mL 1.0453 mL 2.0905 mL 4.181 mL 5.2263 mL
    10 mM 0.1045 mL 0.5226 mL 1.0453 mL 2.0905 mL 2.6131 mL
    50 mM 0.0209 mL 0.1045 mL 0.2091 mL 0.4181 mL 0.5226 mL
    100 mM 0.0105 mL 0.0523 mL 0.1045 mL 0.2091 mL 0.2613 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    新诃黎勒鞣花酸甲酯; Methyl neochebulinate CFN95201 1236310-34-1 C42H36O28 = 988.7 5mg QQ客服:215959384
    月见草素 B; Oenothein B CFN91651 104987-36-2 C68H48O44 = 1569.1 5mg QQ客服:2159513211
    1,2,3,6-四-O-没食子酰-β-D-葡萄糖; 1,2,3,6-Tetragalloylglucose CFN00447 79886-50-3 C34H28O22 = 788.57 10mg QQ客服:3257982914
    1,3,4,6-四没食子酰葡萄糖; 1,3,4,6-Tetragalloylglucose CFN95425 26922-99-6 C34H28O22 = 788.6 10mg QQ客服:2056216494
    1,3,6-三没食子酰葡萄糖; 1,3,6-Tri-O-galloylglucose CFN95043 18483-17-5 C27H24O18 = 636.5 10mg QQ客服:1457312923
    6-O-没食子酰葡萄糖; 6-O-Galloylglucose CFN95638 13186-19-1 C13H16O10 = 332.3 10mg QQ客服:1457312923
    葡萄糖没食子鞣苷; beta-Glucogallin CFN70245 13405-60-2 C13H16O10 = 332.3 5mg QQ客服:3257982914
    1-O-没食子酰-6-O-肉桂酰葡萄糖; 1-O-galloyl-6-O-cinnamoylglucose CFN95053 115746-69-5 C22H22O11 = 462.4 5mg QQ客服:3257982914
    2-肉桂酰-1-没食子酰葡萄糖; 2-Cinnamoyl-1-galloylglucose CFN95098 56994-83-3 C22H22O11 = 462.4 5mg QQ客服:1457312923
    香草酸葡萄糖酯; 1-O-Vanilloylglucose CFN95663 68985-14-8 C14H18O9 = 330.3 5mg QQ客服:1413575084

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