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  • 毛蕊异黄酮-7-O-beta-D-葡萄糖苷; 毛蕊异黄酮苷


    毛蕊异黄酮-7-O-beta-D-葡萄糖苷; 毛蕊异黄酮苷
    产品编号 CFN99141
    CAS编号 20633-67-4
    分子式 = 分子量 C22H22O10 = 446.40
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Flavonoids
    植物来源 The herbs of Astragalus membranaceus Bge. var. mongholicus.
    产品名称 产品编号 CAS编号 包装 QQ客服
    毛蕊异黄酮-7-O-beta-D-葡萄糖苷; 毛蕊异黄酮苷 CFN99141 20633-67-4 10mg QQ客服:2932563308
    毛蕊异黄酮-7-O-beta-D-葡萄糖苷; 毛蕊异黄酮苷 CFN99141 20633-67-4 20mg QQ客服:2932563308
    毛蕊异黄酮-7-O-beta-D-葡萄糖苷; 毛蕊异黄酮苷 CFN99141 20633-67-4 50mg QQ客服:2932563308
    毛蕊异黄酮-7-O-beta-D-葡萄糖苷; 毛蕊异黄酮苷 CFN99141 20633-67-4 100mg QQ客服:2932563308
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    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
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    Nature Plants. 2016 Dec 22;3: 16206.
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    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
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    PMID: 30417089
  • Shanghai Institute of Organic Chemistry (China)
  • University of Limpopo (South Africa)
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  • Srinakharinwirot University (Thailand)
  • University of Malaya (Malaysia)
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  • 国外学术期刊发表的引用ChemFaces产品的部分文献
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  • Org Biomol Chem.2017, 15(31):6483-6492
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  • Evid Based Complement Alternat Med.2017, 2017:9764843
  • Hum Exp Toxicol.2017, 36(11):1169-1176
  • FEMS Microbiol Lett.2017, 364(11)
  • Integr Med Res.2017, 6(4):395-403
  • J Food Compos Anal2017, 62:197-204
  • The Japan Society for Analy. Chem.2017, 66(8):613-617
  • Sci Rep.2017, 7:46299
  • J Ethnopharmacol.2018, 210:88-94
  • Molecules.2018, 23(7):E1659
  • Food Chem.2018, 252:207-214
  • Biol Pharm Bull.2018, 41(11):1645-1651
  • Front Cell Infect Microbiol.2018, 8:292
  • Nutr Res Pract2019, 13:e45
  • Food Engineering Progress2019, 23(3)209-216
  • Molecules.2019, 24(4):E709
  • Cell Mol Biol(Noisy-le-grand)2019, 65(7):77-83
  • Planta Med.2019, 85(3):217-224
  • Biosci. Rep.2020, 10.1024
  • ...
  • 生物活性
    Description: Calycosin-7-O-beta-D-glucoside, a melanin biosynthesis inhibitor, can protect BBB integrity in experimental cerebral ischemia–reperfusion injury via regulating NO/cav-1/MMPs pathway. It attenuates ischemia-reperfusion injuryin vivovia activation of the PI3K/Akt pathway, and has effects on cell apoptosis in cervical cancer HeLa cells and expression of Bcl-2/Bax.
    Targets: NO | MMP(e.g.TIMP) | Bcl-2/Bax | PI3K | VEGFR | Akt | Rho | ROCK | Caspase | ROS
    In vitro:
    Bmc Compl. Altern. M., 2015, 15(1):1-11.
    Calycosin-7-O-β-D-glucoside promotes oxidative stress-induced cytoskeleton reorganization through integrin-linked kinase signaling pathway in vascular endothelial cells.[Pubmed: 26346982 ]
    Dysfunction of vascular endothelium is implicated in many pathological situations. Cytoskeleton plays an importance role in vascular endothelial permeability barrier and inflammatory response. Many Chinese herbs have the endothelial protective effect, of which, "Astragalus membranaceus" is a highly valued herb for treatment of cardiovascular and renal diseases in traditional Chinese medicine, In this study, we tested whether calycosin-7-O-β-D-glucoside (Calycosin), a main effective monomer component of "Astragalus membranaceus", could protect endothelial cells from bacterial endotoxin (LPS)-induced cell injury.
    Endothelial cell injury was induced by exposing human umbilical vein endothelial cells (HUVECs) to LPS. The effects of calycosin on LPS-induced changes in cell viability, apoptosis rate, cell migration, nitric oxide synthase (NOS), generationof intracellular reactive oxygen species (ROS) and cytoskeleton organization were determined. Microarray assay was employed to screen the possible gene expression change. Based on the results of microarray assay, the expression profile of genes involved in Rho/ROCK pathway and AKT pathway were further evaluated with quantitative real-time RT-PCR or western blot methods. Calycosin improved cell viability, suppressed apoptosis and protected the cells from LPS-induced reduction in cell migration and generation of ROS, protein level of NOS at a comparable magnitude to that of Y27632 and valsartan. Similar to Y27632 and valsartan, Calycosin, also neutralized LPS-induced actomyosin contraction and vinculin protein aggregation. Microarray assay, real-time PCR and western blot results revealed that LPS induced expression of FN, ITG A5, RhoA, PI3K (or PIP2 in western blotting), FAK, VEGF and VEGF R2, and inhibited expression of MLCP. We believed multiple pathways involved in the regulation of calycosin on HUVECs. Calycosin are considered to be able to activate MLCP through promoting the generation of NO, decreasing PMLC, suppressing the cytoskeleton remodeling caused by activation of Rho/ROCK pathway and inhibiting AKT pathway by decreasing VEGF, VEGF R2 and PI3K level.
    Calycosin protected HUVEC from LPS-induced endothelial injury, possibly through suppression of Rho/ROCK pathway and regulation of AKT pathway.
    In vivo:
    Mol Med Rep. 2016 Jan; 13(1): 633–640.
    Calycosin-7-O-β-d-glucoside attenuates ischemia-reperfusion injury in vivo via activation of the PI3K/Akt pathway[Pubmed: 26648122]
    The aim of the present study was to investigate the effects and mechanisms of calycosin‑7‑O‑β‑D‑glucoside (CG) on ischemia‑reperfusion (I/R) injury in vivo.
    Hemodynamic parameters, including ejection fraction (EF), fractional shortening (FS), left ventricular end‑systolic pressure (LVESP) and left ventricular end‑diastolic pressure (LVEDP) were monitored using an ultrasound system, and infarct size was measured using Evans blue/tetrazolium chloride double staining. The activities of serum creatine kinase (CK), lactate dehydrogenase (LDH) and superoxide dismutase (SOD), and the levels of malondialdehyde (MDA) were determined to assess the degree of myocardial injury and oxidative stress‑induced damage. The protein expression levels of cleaved‑caspase‑3, cleaved‑caspase‑9, phosphorylated (p)‑phosphatidylinositol 3‑kinase (PI3K) p85, PI3K p85, p‑Akt and Akt were determined using western blotting. The results demonstrated that pretreatment with high dose (H)‑CG markedly improved cardiac function, as evidenced by upregulated EF, FS and LVESP, and downregulated LVEDP. In addition, administration of CG resulted in significant decreases in infarct size in the I/R+low dose‑CG and I/R+H‑CG groups, compared with the I/R group. The activities of CK and LDH, and the levels of MDA in the I/R+H‑CG group were reduced, compared with those in the I/R group, whereas SOD activity was elevated. Treatment with CG inhibited the cleavage and activity of caspase‑3 and caspase‑9, and enhanced the phosphorylation of PI3K p85 and Akt. Notably, administration of the PI3K inhibitor, LY294002, markedly lowered the levels of p‑PI3K p85/p‑Akt, and eradicated the inhibitory effects of H‑CG on infarct size, myocardial injury and oxidative stress‑induced damage.
    Taken together, the results suggested that CG may alleviate I/R injury by activating the PI3K/Akt signaling pathway.
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 2.2401 mL 11.2007 mL 22.4014 mL 44.8029 mL 56.0036 mL
    5 mM 0.448 mL 2.2401 mL 4.4803 mL 8.9606 mL 11.2007 mL
    10 mM 0.224 mL 1.1201 mL 2.2401 mL 4.4803 mL 5.6004 mL
    50 mM 0.0448 mL 0.224 mL 0.448 mL 0.8961 mL 1.1201 mL
    100 mM 0.0224 mL 0.112 mL 0.224 mL 0.448 mL 0.56 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    澳白檀苷; Lanceolarin CFN95166 15914-68-8 C27H30O14 = 578.5 5mg QQ客服:1148253675
    鸡豆黄素配糖物; 印度黄檀苷; Sissotrin CFN97005 5928-26-7 C22H22O10 = 446.4 5mg QQ客服:2932563308
    染料木素-7,4'-二-O-β-D-葡萄糖苷; Genistein 7,4'-di-O-beta-D-glucopyranoside CFN90953 36190-98-4 C27H30O15 = 594.52 20mg QQ客服:1148253675
    丙二酰染料木苷; 6''-O-Malonylgenistin CFN90631 51011-05-3 C24H22O13 = 518.42 10mg QQ客服:215959384
    黄豆黄苷; Glycitin CFN99105 40246-10-4 C22H22O10 = 446.41 20mg QQ客服:1413575084
    6”-O-乙酰黄豆黄苷 ; 6''-O-Acetylglycitin CFN93455 134859-96-4 C24H24O11 = 488.44 5mg QQ客服:215959384
    6″-O-木糖黄豆黄苷; 6''-O-xylosyl-glycitin CFN80151 231288-18-9 C27H30O14 = 578.16 5mg QQ客服:215959384
    Odoratin-7-O-beta-D-glucopyranoside; Odoratin-7-O-beta-D-glucopyranoside CFN91882 210413-47-1 C23H24O11 = 476.43 5mg QQ客服:215959384
    射干苷; Tectoridin CFN99921 611-40-5 C22H22O11 = 462.40 20mg QQ客服:2932563308
    鸢尾黄素-7-O-木糖基葡萄糖苷; Tectorigenin 7-O-xylosylglucoside CFN90784 231288-19-0 C27H30O15 = 594.5 5mg QQ客服:1148253675





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