| In vitro: |
| China Medical Herald, 2016, 13(13):20-3. | | Anti-inflammatory constituents of Acanthopanax senticosus[Reference: WebLink] | To study the anti-inflammatory constituents of Acanthopanax senticosus.
METHODS AND RESULTS:
NO production in the activated RAW 264.7 macrophages induced by LPS and IFN-γ were used to evaluate anti-inflammatory activity. The compounds were isolated by HPD 100 resin, silica gel, ODS and HPLC methods, their structures were identified by Infrared TLC method and spectral imaging spectrum technology. The extraction of A. senticosus. had inhibitory activity on NO production. Seven compounds were isolated and identified as Syringin, Isofraxidin-7-O-glucoside(Calycanthoside),, Syringaresinoldi-O-β-D-glycoside, Sesamin, Daucosterol, β-sitosterol and Vanillic acid respectively.
CONCLUSIONS:
The extraction of A. senticosus. has the anti-inflammatory effect, and phenylpropanoids are the anti-inflammatory constituents. | | Zhongguo Zhong Yao Za Zhi,2008,33(15):1843-6. | | Studies on chemical constituents and antibacterial activity from n-butanol extract of Sarcandra glabra[Pubmed: 19007012] | To study the chemical constituents and the antibacterial activity from n-butanol extract of Sarcandra glabra.
METHODS AND RESULTS:
The compounds were isolated by Diaion HP-20, Sephadex LH-20, MCI CHP-20 and silica gel column chromatographic methods. Their structures were identified on the basis of physicochemical and spectroscopic analysis. The antibacterial effect of the compounds were measured against Staphylococcus aureus by filterpaper slice method, finally the antibacterial ring in each group was recorded after 24 hours. Seven constituents were isolated and elucidated as 5, 7, 3', 4'-tetrahydroxy-6-C-beta-D-glucopyranosylflavanone(1),kaempferol-3-O-beta-D-glucuronide (2),fraxidin (3),isofraxidin (4),isofraxidin-7-O-beta-D-glucopyranoside(Calycanthoside) (5),kaempferol (6), pinostrobin (7).
CONCLUSIONS:
Diameters (in mm) of antibacterial ring in the compounds 2, 5, 6 were orderly recorded as follows: 14.67 +/- 0.08, 11.14 +/- 1.06, 8.26 +/- 1.26 and the compound 4 is not effective. Compounds 1-3 and 5 were isolated from S. glabra for the first time. |
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Cell. 2018 Jan 11;172(1-2):249-261.e12. doi: 10.1016/j.cell.2017.12.019.IF=36.216(2019)
Cell Metab. 2020 Mar 3;31(3):534-548.e5. doi: 10.1016/j.cmet.2020.01.002.IF=22.415(2019)
Mol Cell. 2017 Nov 16;68(4):673-685.e6. doi: 10.1016/j.molcel.2017.10.022.IF=14.548(2019)
ACS Nano. 2018 Apr 24;12(4): 3385-3396. doi: 10.1021/acsnano.7b08969.IF=13.903(2019)
Nature Plants. 2016 Dec 22;3: 16206. doi: 10.1038/nplants.2016.205.IF=13.297(2019)
Sci Adv. 2018 Oct 24;4(10): eaat6994. doi: 10.1126/sciadv.aat6994.IF=12.804(2019)
