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  • 木通苯乙醇苷A

    Calceolarioside A

    木通苯乙醇苷A
    产品编号 CFN98522
    CAS编号 84744-28-5
    分子式 = 分子量 C23H26O11 = 478.44
    产品纯度 >=98%
    物理属性 White powder
    化合物类型 Phenylpropanoids
    植物来源 The herbs of Ajuga becumbens Thunb.
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    木通苯乙醇苷A CFN98522 84744-28-5 1mg QQ客服:215959384
    木通苯乙醇苷A CFN98522 84744-28-5 5mg QQ客服:215959384
    木通苯乙醇苷A CFN98522 84744-28-5 10mg QQ客服:215959384
    木通苯乙醇苷A CFN98522 84744-28-5 20mg QQ客服:215959384
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • Fraunhofer-Institut für Molekularbiologie und Angewandte ?kologie IME (Germany)
  • VIT University (India)
  • University of Padjajaran (Indonesia)
  • Pennsylvania State University (USA)
  • Worcester Polytechnic Institute (USA)
  • Wroclaw Medical University (Poland)
  • Cancer Research Initatives Foundation(CARIF) (Malaysia)
  • Leibniz-Institut für Pflanzenbiochemie (IPB) (Germany)
  • FORTH-IMBB (Greece)
  • Kazusa DNA Research Institute (Japan)
  • University of Bonn (Germany)
  • Florida International University (USA)
  • Medical University of Gdansk (Poland)
  • Institute of Tropical Disease Universitas Airlangga (Indonesia)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • British Jou. Med.&Med. Research2014, 1802-1811
  • Clin Exp Pharmacol Physiol.2015, 42(11):1189-97
  • Am J Chin Med.2016, 44(6):1255-1271
  • Biochem Systematics and Ecology2017, 11-18
  • Tea Res. Ins. Of China2017, 1-12
  • Molecules.2017, 22(12)
  • Biol Pharm Bull.2017, 40(6):797-806
  • Cytotechnology.2017, 69(5):765-773
  • Nutrients.2018, 10(12):E1998
  • Neuropharmacology.2018, 131:68-82
  • Mol Pharm.2018, 15(8):3285-3296
  • Journal of functional foods2018, 171-182
  • J Ethnopharmacol.2018, 210:88-94
  • Molecules.2018, 23(7):E1659
  • J Nat Prod.2018, 81(4):966-975
  • Nutr Metab (Lond).2019, 16:31
  • Exp Ther Med.2019, 18(6):4388-4396
  • J Ethnopharmacol.2019, 228:132-141
  • J Ethnopharmacol.2019, 241:112025
  • Food Chem.2019, 290:286-294
  • Journal of Functional Foods2019, 52:430-441
  • Molecules2020, 25(4):892
  • Antioxidants (Basel).2020, 9(2): E119
  • ...
  • 生物活性
    Description: Calceolarioside A shows potent activity against visceral leishmaniasis. It can induce a dose-related aggregant effect on rabbit platelets, which may be partly related to a calcium-dependent mechanism. Calceolarioside A also has potent antioxidative activity, it displays stronger scavenging potential with IC50 values of (4.15 +/- 0.07, 40.32 +/- 0.09, 2.26 +/- 0.03 microM) for OH, total ROS and scavenging of ONOO(-), respectively.
    Targets: Calcium Channel | Antifection
    In vitro:
    Planta Med. 1993 Aug;59(4):337-9.
    Platelet aggregation induced by calceolarioside A in vitro: role of platelet intracellular calcium.[Pubmed: 8372152]
    The effect of calceolarioside A, a phenylpropanoid glycoside (PhG), isolated from Calceolaria hypericina, was studied on rabbit platelets in vitro.
    METHODS AND RESULTS:
    Calceolarioside A induced a dose-related aggregant effect on rabbit platelets. Indomethacin did not modify the calceolarioside A-induced aggregant effect. Furthermore, no modification was exerted by phenoxybenzamine, BW 577C, and WEB 2086 on the PhG aggregant effect. On the contrary, TMB-8, an intracellular calcium blocker, significantly reduced the PhG effect.
    CONCLUSIONS:
    The latter result suggests that calceolarioside A aggregation may be partly related to a calcium-dependent mechanism.
    J Enzyme Inhib Med Chem. 2009 Aug;24(4):993-7.
    Antioxidant phenylpropanoid glycosides from Buddleja davidii.[Pubmed: 19548780]

    METHODS AND RESULTS:
    Phytochemical investigations on the n-BuOH-soluble fraction of the whole plant of Buddleja davidii led to the isolation of the phenylpropanoid glycosides 1-10. Their structures were determined by 1D and 2D NMR spectroscopic techniques. All the compounds showed potent antioxidative activity in three different tests, with IC(50) values in the range 4.15-9.47 microM in the hydroxyl radical ( OH) inhibitory activity test, 40.32-81.15 microM in the total ROS (reactive oxygen species) inhibitory activity test, and 2.26-7.79 microM in the peroxynitrite (ONOO(-)) scavenging activity test.
    CONCLUSIONS:
    Calceolarioside A (1) displayed the strongest scavenging potential with IC(50) values of (4.15 +/- 0.07, 40.32 +/- 0.09, 2.26 +/- 0.03 microM) for OH, total ROS and scavenging of ONOO(-), respectively.
    In vivo:
    Planta Med. 2008 Apr;74(5):503-8.
    In vivo efficacy of calceolarioside A against experimental visceral leishmaniasis.[Pubmed: 18543147]

    METHODS AND RESULTS:
    Bioactivity-guided fractionation has led to the successful isolation of Calceolarioside A ( 1) from the methanolic extract of night jasmine leaves. The in vitro antileishmanial activity of Calceolarioside A was determined (IC (50) = 20 microg/mL). Its IN VIVO efficacy was noted at 20 mg/kg body weight when it reduced the hepatic and splenic parasite burden by 79 and 84 %, respectively, in an established model of L. donovani Ag83 infected golden hamster. Furthermore, synergistic potentiations of Calceolarioside A at 20 mg/kg body weight and SAG at 5 mg/kg body weight showed a significant reduction of hepatic and splenic parasite burden. No cytotoxicity was observed against the U937 cell line.
    CONCLUSIONS:
    This is the first report describing the isolation of Calceolarioside A from N. arbor-tristis L. and the first demonstration of its potent activity against visceral leishmaniasis.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 2.0901 mL 10.4506 mL 20.9013 mL 41.8025 mL 52.2532 mL
    5 mM 0.418 mL 2.0901 mL 4.1803 mL 8.3605 mL 10.4506 mL
    10 mM 0.209 mL 1.0451 mL 2.0901 mL 4.1803 mL 5.2253 mL
    50 mM 0.0418 mL 0.209 mL 0.418 mL 0.8361 mL 1.0451 mL
    100 mM 0.0209 mL 0.1045 mL 0.209 mL 0.418 mL 0.5225 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    去鼠李糖地黄苷; Desrhamnosylmartynoside CFN89370 136055-64-6 C25H30O11 = 506.49 5mg QQ客服:1148253675
    连翘酯苷B; Forsythoside B CFN99715 81525-13-5 C34H44O19 = 756.70 20mg QQ客服:1148253675
    金石蚕苷; Poliumoside CFN99714 94079-81-9 C35H46O19 = 770.73 20mg QQ客服:3257982914
    2'-乙酰基金石蚕苷; Brandioside CFN90882 133393-81-4 C37H48O20 = 812.8 10mg QQ客服:2159513211
    松果菊苷; Echinacoside CFN98105 82854-37-3 C35H46O20 = 786.72 20mg QQ客服:1413575084
    2'-鼠李糖松果菊苷; 2'-Rhamnoechinacoside CFN95035 1422390-59-7 C41H56O24 = 932.9 10mg QQ客服:1413575084
    紫地黄甙C; Purpureaside C CFN93410 108648-07-3 C35H46O20 = 786.7 5mg QQ客服:1413575084
    焦地黄苯乙醇甙A1; Jionoside A1 CFN90809 120444-60-2 C36H48O20 = 800.8 10mg QQ客服:1148253675
    焦地黄苯乙醇甙B1; Jionoside B1 CFN90729 120406-37-3 C37H50O20 = 814.78 10mg QQ客服:1148253675
    管花苷A; Tubuloside A CFN90669 112516-05-9 C37H48O21 = 828.76 20mg QQ客服:215959384

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