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    Caffeic acid

    咖啡酸
    产品编号 CFN99190
    CAS编号 331-39-5
    分子式 = 分子量 C9H8O4 = 180.15
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Phenylpropanoids
    植物来源 The herbs of Boehmeria siamensis Craib.
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
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    咖啡酸 CFN99190 331-39-5 10mg QQ客服:1148253675
    咖啡酸 CFN99190 331-39-5 20mg QQ客服:1148253675
    咖啡酸 CFN99190 331-39-5 50mg QQ客服:1148253675
    咖啡酸 CFN99190 331-39-5 100mg QQ客服:1148253675
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • University of Maryland School of Medicine (USA)
  • Melbourne University (Australia)
  • Universidade de Franca (Brazil)
  • Universidade Católica Portuguesa (Portugal)
  • University of Virginia (USA)
  • Institute of Chinese Materia Medica (China)
  • Mahatma Gandhi University (India)
  • CSIRO - Agriculture Flagship (Australia)
  • Helmholtz Zentrum München (Germany)
  • Universidad Miguel Hernández (Spain)
  • Universidade da Beira Interior (Germany)
  • Siksha O Anusandhan University (India)
  • Universiti Sains Malaysia (Malaysia)
  • Leibniz Institute of Plant Biochemistry (Germany)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Acta Agriculturae Scandinavica2015, 381-383
  • Ind Crops Prod.2015, 67:185-191
  • Molecules.2016, 21(6)
  • PLoS One.2017, 12(8):e0181191
  • Int J Anal Chem.2017, 2017:1254721
  • Evid Based Complement Alternat Med.2017, 2017:6360836
  • FEMS Microbiol Lett.2017, 364(11)
  • Biol Pharm Bull.2017, 40(6):797-806
  • Nat Prod Commun.2018, 10.1177
  • Appl Microbiol Biotechnol.2018, 102(12):5105-5120
  • Microchemical Journal2018, 137:168-173
  • The Pharmaceutical Society of Japan2018, 138(4):571-579
  • Cell.2018, 172(1-2):249-261
  • Phytomedicine.2018, 40:37-47
  • J Sep Sci.2018, 41(11):2488-2497
  • Korean Journal of Pharmacognosy2018, 49(3):270-277
  • Food Res Int.2019, 123:125-134
  • J of Essential Oil Research2019, 1677272
  • BMC Complement Altern Med.2019, 19(1):367
  • Molecules.2019, 24(11):E2102
  • Molecules.2019, 24(12):E2286
  • Molecules.2019, 24(19):E3417
  • Phytother Res.2019, 33(7):1784-1793
  • ...
  • 生物活性
    Description: Caffeic acid has antidiabetic, antioxidant, anticarcinogenic, and anti-inflammatory activities, it can suppress ultraviolet B(UVB)-induced COX-2 expression by blocking Fyn kinase activity, inhibits HBV-DNA replication as well as HBsAg production, also reduces serum DHBV level in DHBV-infected duckling model. Caffeic acid may be used as designed novel therapeutic drugs for Parkinson's disease by inhibiting α-synuclein fibrillation.
    Targets: Estrogen receptor | IGF-1R | HBV | AP-1 | COX | MAPK | NF-kB | NO | NOS | IL Receptor | Progestogen receptor
    In vitro:
    Antiviral Res. 2009 Aug;83(2):186-90.
    Anti-hepatitis B virus activity of chlorogenic acid, quinic acid and caffeic acid in vivo and in vitro.[Pubmed: 19463857 ]
    Chlorogenic acid and its related compounds are abundant plant polyphenols that have a diverse antiviral activity.
    METHODS AND RESULTS:
    In this study, HepG2.2.15 cells and duck hepatitis B virus infection model were used as in vitro and in vivo models to evaluate their anti-HBV activity. In the cell model, all the three compounds inhibited HBV-DNA replication as well as HBsAg production. Chlorogenic acid and caffeic acid also reduced serum DHBV level in DHBV-infected duckling model. Moreover, the anti-HBV activity of crude extracts of coffee beans, which have a high content of chlorogenic acid, was studied.
    CONCLUSIONS:
    Both the extracts of regular coffee and that of decaffeinated coffee showed inhibitory effect on HBV replication.
    In vivo:
    J Pharmacol Exp Ther. 2006 Aug;318(2):476-83
    Antihyperglycemic and antioxidant properties of caffeic acid in db/db mice.[Pubmed: 16644902 ]
    This study investigated the blood glucose-lowering effect and antioxidant capacity of caffeic acid in C57BL/KsJ-db/db mice.
    METHODS AND RESULTS:
    Caffeic acid induced a significant reduction of the blood glucose and glycosylated hemoglobin levels than the control group. The plasma insulin, C-peptide, and leptin levels in caffeic acid group were significantly higher than those of the control group, whereas the plasma glucagon level was lower. Increased plasma insulin by caffeic acid was attributable to an antidegenerative effect on the islets. Caffeic acid also markedly increased glucokinase activity and its mRNA expression and glycogen content and simultaneously lowered glucose-6-phosphatase and phosphoenolpyruvate carboxykinase activities and their respective mRNA expressions, accompanied by a reduction in the glucose transporter 2 expression in the liver. In contrast to the hepatic glucose transporter 2, adipocyte glucose transporter 4 expression was greater than the control group. In addition, caffeic acid significantly increased superoxide dismutase, catalase, and glutathione peroxidase activities and their respective mRNA levels, while lowering the hydrogen peroxide and thiobarbituric acid reactive substances levels in the erythrocyte and liver of db/db mice.
    CONCLUSIONS:
    These results indicate that caffeic acid exhibits a significant potential as an antidiabetic agent by suppressing a progression of type 2 diabetic states that is suggested by an attenuation of hepatic glucose output and enhancement of adipocyte glucose uptake, insulin secretion, and antioxidant capacity.
    Free Radic Res. 2004 Nov;38(11):1241-53.
    Caffeic acid derivatives: in vitro and in vivo anti-inflammatory properties.[Pubmed: 15621702]
    Caffeic acid and some of its derivatives such as caffeic acid phenetyl ester (CAPE) and octyl caffeate are potent antioxidants which present important anti-inflammatory actions.
    METHODS AND RESULTS:
    The present study assessed the in vitro and in vivo effects of five caffeic acid derivatives (caffeic acid methyl, ethyl, butyl, octyl and benzyl esters) and compared their actions to those of CAPE. In the model of LPS-induced nitric oxide (NO) production in RAW 264.7 macrophages, the pre-incubation of all derivatives inhibited nitrite accumulation on the supernatant of stimulated cells, with mean IC50 (microM) values of 21.0, 12.0, 8.4, 2.4, 10.7 and 4.80 for methyl, ethyl, butyl, octyl, benzyl and CAPE, respectively. The effects of caffeic acid derivatives seem to be related to the scavenging of NO, as the compounds prevented SNAP-derived nitrite accumulation and decreased iNOS expression. In addition, butyl, octyl and CAPE derivatives significantly inhibited LPS-induced iNOS expression in RAW 264.7 macrophages. Extending the in vitro results, we showed that the pre-treatment of mice with butyl, octyl and CAPE derivatives inhibited carrageenan-induced paw edema and prevented the increase in IL-1beta levels in the mouse paw by 30, 24 and 36%, respectively. Butyl, octyl and CAPE derivatives also prevented carrageenan-induced neutrophil influx in the mouse paw by 28, 49 and 31%, respectively.
    CONCLUSIONS:
    Present results confirm and extend literature data, showing that caffeic acid derivatives exert in vitro and in vivo anti-inflammatory actions, being their actions mediated, at least in part by the scavenging of NO and their ability to modulate iNOS expression and probably that of other inflammatory mediators.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 5.5509 mL 27.7546 mL 55.5093 mL 111.0186 mL 138.7732 mL
    5 mM 1.1102 mL 5.5509 mL 11.1019 mL 22.2037 mL 27.7546 mL
    10 mM 0.5551 mL 2.7755 mL 5.5509 mL 11.1019 mL 13.8773 mL
    50 mM 0.111 mL 0.5551 mL 1.1102 mL 2.2204 mL 2.7755 mL
    100 mM 0.0555 mL 0.2775 mL 0.5551 mL 1.1102 mL 1.3877 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    天芥菜品碱N-氧化物; Heliosupine N-oxide CFN00454 31701-88-9 C20H31NO8 = 413.5 5mg QQ客服:2932563308
    氧化血根碱; Oxysanguinarine CFN91002 548-30-1 C20H13NO5 = 347.3 10mg QQ客服:2159513211
    Maculosidin; Maculosidin CFN95126 522-19-0 C14H13NO4 = 259.3 5mg QQ客服:2159513211
    Andropanolide; Andropanolide CFN97600 869807-57-8 C20H30O5 = 350.45 5mg QQ客服:2932563308

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