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  • 白当归脑

    Byakangelicol

    白当归脑
    产品编号 CFN98167
    CAS编号 26091-79-2
    分子式 = 分子量 C17H16O6 = 316.31
    产品纯度 >=98%
    物理属性 White cryst.
    化合物类型 Coumarins
    植物来源 The roots of Angelica dahurica
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    白当归脑 CFN98167 26091-79-2 10mg QQ客服:2056216494
    白当归脑 CFN98167 26091-79-2 20mg QQ客服:2056216494
    白当归脑 CFN98167 26091-79-2 50mg QQ客服:2056216494
    白当归脑 CFN98167 26091-79-2 100mg QQ客服:2056216494
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • University of Ioannina (Greece)
  • Universitas islam negeri Jakarta (Indonesia)
  • University of Toulouse (France)
  • Universita' Degli Studi Di Cagliari (Italy)
  • Shanghai Institute of Biochemistry and Cell Biology (China)
  • Mahatma Gandhi University (India)
  • University of Bordeaux (France)
  • University of Liège (Belgium)
  • Seoul National University of Science and Technology (Korea)
  • Lodz University of Technology (Poland)
  • Universiti Malaysia Pahang (Malaysia)
  • Amity University (India)
  • University of Illinois (USA)
  • Complutense University of Madrid (Spain)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • QASCF2022, 14(4).
  • J Phys Chem Lett.2021, 12(7):1793-1802.
  • J of Apicultural Research2020, 10.1080
  • Biochem Biophys Res Commun.2020, 527(4):889-895.
  • Biochemistry.2018, 57(40):5886-5896
  • Horticulture Research2023, uhad164.
  • Int J Cosmet Sci.2019, 41(1):12-20
  • J Pharmaceut Biomed2020, 182:113110
  • Sci Rep.2023, 13(1):21690.
  • Journal of Functional Foods2022, 99: 105331.
  • Appl. Sci.2020, 10,1304
  • J Mol Med (Berl).2018, 96(7):661-672
  • Foods.2021, 10(12):2929.
  • Applied Biological Chemistry2023, 66:85.
  • Agronomy 2021, 11(3),502.
  • Korean Journal of Pharmacognosy.2015, 46(4):352-364
  • Separation Science Plus2022, sscp.202200048.
  • Molecules.2016, 21(10)
  • Int J Mol Sci.2022, 23(15):8687.
  • Cell Biochem Funct.2018, 36(6):303-311
  • Molecular & Cellular Toxicology2017, 13(3):271-278
  • Inflammation.2021, doi: 10.1007
  • Processes 2021, 9(5),894.
  • ...
  • 生物活性
    Description: Byakangelicol exhibits hepatoprotective activities on tacrine-induced cytotoxicity in Hep G2 cells, with EC(50) values of 112.7 +/- 5.35 microM. Byakangelicol may have therapeutic potential as an anti-inflammatory drug on airway inflammation, it can inhibit IL-1beta-induced PGE2 release in A549 cells; this inhibition may be mediated by suppression of COX-2 expression and the activity of COX-2 enzyme, it also can inhibit P-gp expressed. Byakangelicol shows a significant inhibition on the proliferation of cultured human tumor cells.
    Targets: COX | PGE | IL Receptor | MAPK | p65 | P-gp | NF-kB
    In vitro:
    J Pharm Pharmacol. 2002 Sep;54(9):1271-8.
    Byakangelicol, isolated from Angelica dahurica, inhibits both the activity and induction of cyclooxygenase-2 in human pulmonary epithelial cells.[Pubmed: 12356282]
    We examined the inhibitory mechanism of byakangelicol, isolated from Angelica dahurica, on interleukin-1beta (IL-1beta)-induced cyclooxygenase-2 (COX-2) expression and prostaglandin E2 (PGE2) release in human pulmonary epithelial cell line (A549).
    METHODS AND RESULTS:
    Byakangelicol (10-50 microM) concentration-dependently attenuated IL-1beta-induced COX-2 expression and PGE2 release. The selective COX-2 inhibitor, NS-398 (0.01-1 microM), and byakangelicol (10-50 microM) both concentration-dependently inhibited the activity of the COX-2 enzyme. Byakangelicol, at a concentration up to 200 microM, did not affect the activity and expression of COX-1 enzyme. IL-1beta-induced p44/42 mitogen-activated protein kinase (MAPK) activation was inhibited by the MAPK/extracellular signal-regulated protein kinase (MEK) inhibitor, PD 98059 (30 microM), while byakangelicol (50 microM) had no effect. Treatment of cells with byakangelicol (50 microM) or pyrrolidine dithiocarbamate (PDTC; 50 microM) partially inhibited IL-1beta-induced degradation of IkappaB-alpha in the cytosol, translocation of p65 NF-kappaB from the cytosol to the nucleus and the NF-kappaB-specific DNA-protein complex formation.
    CONCLUSIONS:
    Taken together, we have demonstrated that byakangelicol inhibits IL-1beta-induced PGE2 release in A549 cells; this inhibition may be mediated by suppression of COX-2 expression and the activity of COX-2 enzyme. The inhibitory mechanism of byakangelicol on IL-1beta-induced COX-2 expression may be, at least in part, through suppression of NF-kappaB activity. Therefore, byakangelicol may have therapeutic potential as an anti-inflammatory drug on airway inflammation.
    Phytother Res. 2007 Mar;21(3):288-90.
    Antiproliferative effect of furanocoumarins from the root of Angelica dahurica on cultured human tumor cell lines.[Pubmed: 17143927 ]
    A bioassay-guided fractionation of the root extract of Angelica dahurica (Umbelliferae) led to the isolation of six furanocoumarins as active ingredients responsible for the antitumoral property.
    METHODS AND RESULTS:
    The hexane soluble part of the extract demonstrated a significant inhibition on the proliferation of cultured human tumor cells such as A549 (non small cell lung), SK-OV-3 (ovary), SK-MEL-2 (melanoma), XF498 (central nervous system) and HCT-15 (colon) in vitro, whereas the remaining water soluble part exhibited poor inhibition.
    CONCLUSIONS:
    Intensive investigation of the hexane soluble part of the extract yielded six furanocoumarins, i.e. isoimperatorin, cnidicin, imperatorin, oxypeucedanin, byakangelicol, oxypeucedanin hydrate, all of which exhibited a significant inhibition on cell proliferation in a dose-dependent manner.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 3.1615 mL 15.8073 mL 31.6146 mL 63.2291 mL 79.0364 mL
    5 mM 0.6323 mL 3.1615 mL 6.3229 mL 12.6458 mL 15.8073 mL
    10 mM 0.3161 mL 1.5807 mL 3.1615 mL 6.3229 mL 7.9036 mL
    50 mM 0.0632 mL 0.3161 mL 0.6323 mL 1.2646 mL 1.5807 mL
    100 mM 0.0316 mL 0.1581 mL 0.3161 mL 0.6323 mL 0.7904 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    别异欧前胡素; Alloisoimperatorin CFN95012 35214-83-6 C16H14O4 = 270.3 5mg QQ客服:3257982914
    别欧前胡素; Alloimperatorin CFN93037 642-05-7 C16H14O4 = 270.28 10mg QQ客服:1457312923
    珊瑚菜素; Phellopterin CFN90495 2543-94-4 C17H16O5 = 300.3 20mg QQ客服:3257982914
    白当归脑; Byakangelicol CFN98167 26091-79-2 C17H16O6 = 316.31 20mg QQ客服:2159513211
    白当归素; Byakangelicin CFN98152 482-25-7 C17H18O7 = 334.32 20mg QQ客服:3257982914
    新比克白芷内酯; Neobyakangelicol CFN98462 35214-82-5 C17H16O6 = 316.3 5mg QQ客服:2159513211

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