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  • 鸦胆子素 D

    Bruceine D

    鸦胆子素 D
    产品编号 CFN90771
    CAS编号 21499-66-1
    分子式 = 分子量 C20H26O9 = 410.4
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Diterpenoids
    植物来源 The barks of Ailanthus altissima
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
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    产品名称 产品编号 CAS编号 包装 QQ客服
    鸦胆子素 D CFN90771 21499-66-1 1mg QQ客服:1413575084
    鸦胆子素 D CFN90771 21499-66-1 5mg QQ客服:1413575084
    鸦胆子素 D CFN90771 21499-66-1 10mg QQ客服:1413575084
    鸦胆子素 D CFN90771 21499-66-1 20mg QQ客服:1413575084
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • Michigan State University (USA)
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  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Int J Mol Sci. 2014, 15(5):8443-57
  • SBRAS2016, 12
  • J. Soc. Cosmet. Sci. Korea2016, 163-171
  • Mediators Inflamm.2016, 2016:7216912
  • Molecules.2016, 21(6)
  • J Separation Science & Technology2016, 51:1579-1588
  • Int. Conference on Med. Sci. and Bio.2017, 17973
  • Molecules.2017, 22(2)
  • Cell Physiol Biochem.2017, 43(4):1425-1435
  • RSC Advances2017, 86
  • RSC Adv.2018, 32621-32636
  • Academic J of Second Military Medical University2018, 39(11)
  • J Liq Chromatogr R T2018, 41(12):761-769
  • Biochem Biophys Res Commun.2018, 505(1):261-266
  • Plant Cell Physiol.2018, 59(1):128-141
  • J Agric Food Chem.2018, 66(1):351-358
  • Food Res Int.2019, 123:125-134
  • ACS Chem Biol.2019, 14(5):873-881
  • Phytother Res.2019, 33(3):676-689
  • Pharmaceutical Chemistry Journal2019, 52(12):986-991
  • J Agric Food Chem.2019, 67(27):7748-7754
  • United States Patent Application2020, 20200038363
  • Biosci Biotechnol Biochem.2020, 84(3):621-632
  • ...
  • 生物活性
    Description: Bruceine D has anti-cancer activity, it inhibits the growth of three pancreatic cancer cell lines, i.e., PANC-1, SW1990 and CAPAN-1; induces cytotoxicity in Capan-2 cells via the induction of cellular apoptosis involving the mitochondrial pathway.Bruceine D may have the potential to be used as a natural viricide, or a lead compound for new viricides.
    Targets: Bcl-2/Bax | Caspase | p38MAPK
    In vitro:
    Int J Mol Med. 2012 Jul;30(1):93-9.
    Involvement of the mitochondrial pathway in bruceine D-induced apoptosis in Capan-2 human pancreatic adenocarcinoma cells.[Pubmed: 22552257]
    Our research group has previously identified Bruceine D (BD), a quassinoid found abundantly in B. javanica, to have potent cytotoxic effect on a number of pancreatic cancer cell lines, including Panc-1, SW1990 and Capan-1 cells.
    METHODS AND RESULTS:
    In the present study, we showed that Bruceine D was also able to inhibit the growth of the Capan-2 human pancreatic adenocarcinoma cell line, but it exerted only modest cytotoxicity on the WRL68 human hepatocyte cell line and a human pancreatic progenitor cell line. The antiproliferative effects of Bruceine D were comparable to those exhibited by camptothecin and gemcitabine in our culture system. We found a dose-dependent decrease of the mitochondrial membrane potential in Bruceine D-treated Capan-2 cells as measured by the JC-1 assay. Bruceine D exposure was able to attenuate the expression of Bcl-2 protein in Capan-2 cells as detected by western blot analysis. In addition, the expression of both caspase 9 and caspase 3 in Bruceine D-treated Capan-2 cells was significantly accentuated. Moreover, Bruceine D was capable of inducing the fragmentation of genomic DNA in Capan-2 cells as evidenced by Hoechst staining. Cell cycle analysis demonstrated that Bruceine D could increase the percentage of Capan-2 cells in the subG1 phase in a dose-related manner. An increase in the apoptosis of Capan-2 cells was also observed by Annexin V and PI staining.
    CONCLUSIONS:
    These results unequivocally indicate that Bruceine D induces cytotoxicity in Capan-2 cells via the induction of cellular apoptosis involving the mitochondrial pathway.
    Vet Parasitol. 2011 Apr 19;177(1-2):127-33.
    In vivo anthelmintic activity of bruceine A and bruceine D from Brucea javanica against Dactylogyrus intermedius (Monogenea) in goldfish (Carassius auratus).[Pubmed: 21196080]
    The present study was designated to ascertain the anthelmintic activity of the dried fruits of Brucea javanica and to isolate and characterise the active constituents. The methanol extract from the fruits of B. javanica showed significant anthelmintic activity against Dactylogyrus intermedius (EC(50) (median effective concentration) value=49.96 mg l(-1)).
    METHODS AND RESULTS:
    Based on this finding, the methanol extract was fractionated on silica gel column chromatography in a bioassay-guided fractionation affording two known quassinoids showing potent activity, bruceine A and bruceine D. Both bruceine A and D exhibited significant activity against D. intermedius with EC(50) values of 0.49 mg l(-1) and 0.57 mg l(-1), respectively, which were more effective than the positive control, mebendazole (EC(50) value=1.25 mg l(-1)). In addition, the 48-h median lethal concentration (LC(50)) for bruceine A and D against the host (Carassius auratus) was 10.6-fold and 9.7-fold higher than the EC(50) for D. intermedius.
    CONCLUSIONS:
    These results provide evidence that the isolated compounds might be potential sources of new anti-parasitic drugs for the control of Dactylogyrus. This is the first report on an in vivo anthelmintic investigation for B. javanica against D. intermedius.
    Pest Manag Sci. 2008 Feb;64(2):191-6.
    Antiphytoviral activity of bruceine-D from Brucea javanica seeds.[Pubmed: 17912689 ]
    Brucea javanica (L.) Merr. is widely distributed throughout the southern parts of China and has been used in traditional medicine to treat a variety of diseases. The objective of the present study was to identify the active antiphytoviral compound in the seeds of B. javanica and evaluate the inhibitory activity of the compound against plant virus.
    METHODS AND RESULTS:
    Bioassay-guided fractionation of the most active extract from the seeds led to the isolation of an antiphytoviral compound which was identified as bruceine-D by conventional spectroscopy methods. The compound exhibited significant inhibitory activity against the infection and replication of tobacco mosaic virus (TMV), with IC(50) values of 13.98 and 7.13 mg L(-1) respectively. The compound also showed a strong inhibitory effect on the infectivity of potato virus Y (PVY) and cucumber mosaic virus (CMV). Furthermore, the compound could effectively inhibit systemic TMV infection in the host tobacco plant under glasshouse conditions.
    CONCLUSIONS:
    The results suggested that bruceine-D from Brucea javanica may have the potential to be used as a natural viricide, or a lead compound for new viricides.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 2.4366 mL 12.1832 mL 24.3665 mL 48.7329 mL 60.9162 mL
    5 mM 0.4873 mL 2.4366 mL 4.8733 mL 9.7466 mL 12.1832 mL
    10 mM 0.2437 mL 1.2183 mL 2.4366 mL 4.8733 mL 6.0916 mL
    50 mM 0.0487 mL 0.2437 mL 0.4873 mL 0.9747 mL 1.2183 mL
    100 mM 0.0244 mL 0.1218 mL 0.2437 mL 0.4873 mL 0.6092 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    鸦胆亭醇B; Bruceantinol B CFN95216 1822332-33-1 C27H34O12 = 550.6 5mg QQ客服:1148253675
    鸦胆亭醇; Bruceantinol A CFN91971 948038-36-6 C29H36O13 = 592.59 5mg QQ客服:2932563308
    鸦胆子素J; Bruceine J CFN91973 948038-38-8 C25H32O11 = 508.51 5mg QQ客服:1148253675
    鸦胆子素A; Bruceine A CFN89338 25514-31-2 C26H34O11 = 522.54 5mg QQ客服:2159513211
    鸦胆子苦醇; Brusatol CFN93119 14907-98-3 C26H32O11 = 520.53 10mg QQ客服:1413575084
    鸦胆亭; Bruceantin CFN89339 41451-75-6 C28H36O11 = 548.57 5mg QQ客服:1413575084
    鸦胆子酸C; Bruceanic acid C CFN91975 132587-60-1 C29H38O14 = 610.60 5mg QQ客服:2932563308
    宽缨酮; Eurycomanone CFN92008 84633-29-4 C20H24O9 = 408.4 10mg QQ客服:1148253675
    Pasakbumin B; Pasakbumin B CFN92009 138809-10-6 C20H24O10 = 424.4 5mg QQ客服:1148253675
    鸦胆子素 D; Bruceine D CFN90771 21499-66-1 C20H26O9 = 410.4 10mg QQ客服:2159513211

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