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  • 短叶老鹤草素A

    Brevilin A

    短叶老鹤草素A
    产品编号 CFN99694
    CAS编号 16503-32-5
    分子式 = 分子量 C20H26O5 = 346.4
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Sesquiterpenoids
    植物来源 The herbs of Centipeda minima
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    短叶老鹤草素A CFN99694 16503-32-5 10mg QQ客服:2159513211
    短叶老鹤草素A CFN99694 16503-32-5 20mg QQ客服:2159513211
    短叶老鹤草素A CFN99694 16503-32-5 50mg QQ客服:2159513211
    短叶老鹤草素A CFN99694 16503-32-5 100mg QQ客服:2159513211
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • Stanford University (USA)
  • Imperial College London (United Kingdom)
  • Sanford Burnham Medical Research Institute (USA)
  • Nanjing University of Chinese Medicine (China)
  • Indian Institute of Science (India)
  • Macau University of Science and Technology (China)
  • Istanbul University (Turkey)
  • Universita' Degli Studi Di Cagliari (Italy)
  • Heinrich-Heine-University Düsseldorf (Germany)
  • Chinese University of Hong Kong (China)
  • Florida International University (USA)
  • The Ohio State University (USA)
  • Julius Kühn-Institut (Germany)
  • Universidade Federal de Santa Catarina (Brazil)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Int J Mol Sci.2022, 23(23):14826.
  • Journal of Applied Pharmaceutical Science2022, 0(00), pp:001-007
  • Natural Product Communications2020, doi: 10.1177.
  • Evid-Based Compl Alt2020, 7202519:13
  • ACS Synth Biol.2020, 9(9):2282-2290.
  • J Agric Food Chem.2021, 69(11):3496-3510.
  • LWT - Food Science and Technology2022, 164:113627
  • Key Engineering Materials2022, 931(47-53).
  • Vietnam Journal of Food Control.2022, 5(3):pp.488-497.
  • J Ethnopharmacol.2019, 236:31-41
  • Food and Fermentation Industries2019, 45(7):45-51
  • Korean J. Medicinal Crop Sci.2021, 29(6):425-433
  • Journal of Functional Foods2019, 52:430-441
  • Food Chem.2016, 191:81-90
  • Arch Biochem Biophys.2020, 687:108363.
  • Nutrients.2018, 10(12)
  • World J Mens Health.2019, 10.5534
  • Chem Res Toxicol.2023, 36(2):213-229.
  • Front Microbiol.2019, 10:2806
  • Current Enzyme Inhibition2023, 19(1):55-64(10)
  • New Zealand J. Forestry Sci.2014, 44:17
  • Food Chem Toxicol.2023, 176:113785.
  • Food Chem.2022, 378:131975.
  • ...
  • 生物活性
    Description: Brevilin A is a strong impetus for the development of selective JAK-STAT inhibitors and therapeutic drugs in order to improve survival of patients with hyperactivated JAKs and STATs. Brevilin A shows antigiardial activity (IC50 = 16.1 μM) and is similarly active in vitro against Entamoeba histolytica (IC50 between 4.5 and 9 μM) and against Plasmodium falciparum (IC50 = 9.42 μM).
    Targets: JAK | STAT | Antifection
    In vitro:
    Phytother. Res., 1994, 8(8):436-8.
    Antiprotozoal activities of Centipeda minima.[Reference: WebLink]

    METHODS AND RESULTS:
    In vitro activity against Giardia intestinalis was used for bioassay-guided fractionation of crude extracts from C. minima. The sesquiterpene lactone, Brevilin A was isolated and found to have antigiardial activity (IC50 = 16.1 μM) and was similarly active in vitro against Entamoeba histolytica (IC50 between 4.5 and 9 μM) and against Plasmodium falciparum (IC50 = 9.42 μM).
    CONCLUSIONS:
    Three flavonoids, quercetin, quercetin 3-methyl ether and kaempferol 7-glucosylrhamnoside were also isolated.
    PLoS One . 2013 May 21;8(5):e63697.
    Brevilin A, a novel natural product, inhibits janus kinase activity and blocks STAT3 signaling in cancer cells[Pubmed: 23704931]
    Abstract Signal abnormalities in human cells usually cause unexpected consequences for individual health. We focus on these kinds of events involved in JAK-STAT signal pathways, especially the ones triggered by aberrant activated STAT3, an oncoprotein which participates in essential processes of cell survival, growth and proliferation in many types of tumors, as well as immune diseases. By establishing a STAT3 signal based high-throughput drug screening system in human lung cancer A549 cells, we have screened a library from natural products which contained purified compounds from medicinal herbs. One compound, named Brevilin A, exhibited both strong STAT3 signal inhibition and STAT3 signal dependent cell growth inhibition. Further investigations revealed that Brevilin A not only inhibits STAT3 signaling but also STAT1 signaling for cytokines induced phosphorylation of STAT3 and STAT1 as well as the expression of their target genes. In addition, we found Brevilin A could attenuate the JAKs activity by blocking the JAKs tyrosine kinase domain JH1. The levels of cytokine induced phosphorylation of STATs and other substrates were dramatically reduced by treatment of Brevilin A. The roles of Brevilin A targeting on JAKs activity indicate that Brevilin A may not only be used as a STAT3 inhibitor but also a compound blocking other JAK-STAT hyperactivation. Thus, these findings provided a strong impetus for the development of selective JAK-STAT inhibitors and therapeutic drugs in order to improve survival of patients with hyperactivated JAKs and STATs.
    Biomed Pharmacother . 2018 Feb;98:619-625.
    Brevilin A induces apoptosis and autophagy of colon adenocarcinoma cell CT26 via mitochondrial pathway and PI3K/AKT/mTOR inactivation[Pubmed: 29289836]
    Abstract Brevilin A is a sesquiterpene lactone isolated from Centipeda minima and possesses inhibitory effects on proliferation of various tumor cells. In this study, Brevilin A inhibitory effect on proliferation and its molecular mechanism of action were investigated both in vivo and in vitro in colon adenocarcinoma CT26 cells. The results indicated that the inhibitory effect of Brevilin A in CT26 proliferation was dose-dependent and this effect was due to apoptosis. Furthermore, Brevilin A increased ROS levels, decreased mitochondrial membrane potential (MMP) and induced apoptosis of CT26 cell in a dose-dependent manner. Apoptosis induced by Brevilin A was higher than that induced by adriamycin under the same dose. Cleaved-caspase-8, cleaved-caspase-9 and cleaved-caspase-3 were up-regulated after Brevilin A treatment, together with an increase of Bax protein expression, while Bcl-2 was reduced. Further investigation revealed that Brevilin A inhibited the phosphorylation of PI3K, AKT and mTOR and promoted the expressions of autophagy-related proteins LC3-II, Beclin1 and Atg5 and consequent formation of autophagosomes, whereas 3-methyladenine (3-MA), a type III PI3K inhibitor, inhibited autophagosomes formation induced by Brevilin A. In vivo investigation suggested that Brevilin A significantly inhibited the growth of CT26 tumor compared to adriamycin and concurrently promoted the expressions of LC3-II and cleaved-caspase-3 in tumor tissues. Our results demonstrated that the anti-tumor activity of Brevilin A was mainly achieved by the induction of cell apoptosis and autophagy, suggesting a promising potential as antitumor drug against colon adenocarcinoma.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 2.8868 mL 14.4342 mL 28.8684 mL 57.7367 mL 72.1709 mL
    5 mM 0.5774 mL 2.8868 mL 5.7737 mL 11.5473 mL 14.4342 mL
    10 mM 0.2887 mL 1.4434 mL 2.8868 mL 5.7737 mL 7.2171 mL
    50 mM 0.0577 mL 0.2887 mL 0.5774 mL 1.1547 mL 1.4434 mL
    100 mM 0.0289 mL 0.1443 mL 0.2887 mL 0.5774 mL 0.7217 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    8-表-密花豚草素; 8-epi-Confertin CFN95509 110115-60-1 C15H20O3 = 248.3 5mg QQ客服:3257982914
    Dihydroconfertin; Dihydroconfertin CFN95523 68832-40-6 C15H22O3 = 250.3 5mg QQ客服:2056216494
    5-Hydroxy-4a,8-dimethyl-3-methylen-decahydroazuleno[6,5-b]furan-2(3H)-on; 5-Hydroxy-4a,8-dimethyl-3-methylen-decahydroazuleno[6,5-b]furan-2(3H)-on CFN95522 114579-31-6 C15H22O3 = 250.3 5mg QQ客服:1457312923
    2-去氧-4-表-天人菊灵; 2-Desoxy-4-epi-pulchellin CFN99345 122872-03-1 C15H22O3 = 250.3 20mg QQ客服:1413575084
    Carabrolactone B; Carabrolactone B CFN99287 1187925-31-0 C15H22O4 = 266.3 5mg QQ客服:1457312923
    旋覆花内酯; Britannin CFN90220 33627-28-0 C19H26O7 = 366.41 20mg QQ客服:1457312923
    麦角内酯; Ergolide CFN91552 54999-07-4 C17H22O5 = 306.4 10mg QQ客服:1457312923
    锦鸡菊素; Helenalin CFN91899 6754-13-8 C15H18O4 = 262.30 5mg QQ客服:2056216494
    山金草内酯C; Arnicolide C CFN91996 34532-67-7 C19H26O5 = 334.41 5mg QQ客服:2056216494
    山金草内酯D; Arnicolide D CFN91999 34532-68-8 C19H24O5 = 332.39 10mg QQ客服:1457312923

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