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  • Borapetoside E

    Borapetoside E

    Borapetoside E
    产品编号 CFN96274
    CAS编号 151200-49-6
    分子式 = 分子量 C27H36O11 = 536.6
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Diterpenoids
    植物来源 The vines of Tinospora crispa.
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    Borapetoside E CFN96274 151200-49-6 1mg QQ客服:2056216494
    Borapetoside E CFN96274 151200-49-6 5mg QQ客服:2056216494
    Borapetoside E CFN96274 151200-49-6 10mg QQ客服:2056216494
    Borapetoside E CFN96274 151200-49-6 20mg QQ客服:2056216494
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • Chungnam National University (Korea)
  • Melbourne University (Australia)
  • Research Unit Molecular Epigenetics (MEG) (Germany)
  • University of Limpopo (South Africa)
  • University of Melbourne (Australia)
  • Sri Sai Aditya Institute of Pharmaceutical Sciences and Research (India)
  • Wageningen University (Netherlands)
  • Utrecht University (Netherlands)
  • Institute of Pathophysiology Medical University of Vienna (Austria)
  • Amity University (India)
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  • University of Illinois at Chicago (USA)
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  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Anal Bioanal Chem.2018, 410(5):1561-1569
  • Vietnam Journal of Science2022,64(2):69-75.
  • J Sep Sci.2020, 43(22):4148-4161.
  • J Food Compos Anal2017, 62:197-204
  • Molecules.2017, 22(2)
  • Phytomedicine Plus2022, 2(1):100207.
  • Foods.2022, 11(12):1773.
  • Antioxidants (Basel).2021, 10(9):1435.
  • Universidade Estadual Paulista2017, 11449
  • Antioxidants (Basel).2021, 10(1):112.
  • Environ Toxicol.2021, doi: 10.1002
  • Appl Biochem Biotechnol.2020, 190(2):732-744
  • Heliyon.2023, e12778.
  • Phytomedicine.2017, 24:77-86
  • J Traditional Thai Medical Res.2022, 8(1):pp1-14.
  • J Biol Chem.2014, 289(3):1723-31
  • Molecular & Cellular Toxicology2017, 13(3):271-278
  • BMC Microbiol.2019, 19(1):78
  • Oncol Rep.2021, 46(1):143.
  • Applied Physics B2021, 127(92).
  • Pharmaceutics.2021, 13(11):1839.
  • Biomedicine & Pharmacotherapy2020, 125:109950
  • Appl. Sci.2020, 10(23), 8729
  • ...
  • 生物活性
    Description: Borapetoside E has anti-hyperglycemic activity, it can significantly reduce serum glucose levels at dose-dependent manners in alloxan-induced hyperglycemic mice and db/db type 2 diabetic mice.
    In vitro:
    J Ethnopharmacol. 2013 Aug 26;149(1):123-32.
    Crude extract and purified components isolated from the stems of Tinospora crispa exhibit positive inotropic effects on the isolated left atrium of rats.[Pubmed: 23778316 ]
    Tinospora crispa has been used in folkloric medicine for the control of blood pressure. We previously found that an extract of Tinospora crispa and its constituents effect the heart rate and blood pressure in anesthetized rats.The aim was to investigate the effects and mechanisms of the Tinospora crispa extract and bioactive components on the rat isolated left atria.
    METHODS AND RESULTS:
    Air-dried stems of Tinospora crispa were extracted with water, followed by partitioning with chloroform, ethyl acetate, and finally by n-butanol. The n-butanol soluble material was concentrated and dried under reduced pressure and lyophilized to obtain a crude powder (Tinospora crispa extract). The active components of Tinospora crispa extract were separated by column chromatography and preparative HPLC. The effects and mechanisms of the n-butanol extract and the bioactive purified components (adenine, uridine, adenosine, salsolinol, tyramine, higenamine, syringin, (-)-litcubinine, borapetoside A, borapetoside B, borapetoside D and borapetoside E) were studied in isolated left atria from normal and reserpinized rats. Tinospora crispa extract caused an increase in the force of contraction of the electrical field stimulated left atrium. This effect was inhibited by propranolol, atenolol, ICI-118,551, phentolamine and atropine. The positive inotropic effect on the reserpenized isolated left atrium of the Tinospora crispa extract was significantly inhibited by propranolol, atenolol and ICI-118,551. Phentolamine, on the other hand, caused potentiation and the effect was inhibited when propranolol was also added. Higenamine caused an increase in the force of contraction of the electrical field stimulated left atrium and this effect was significantly inhibited by ICI-118,551 and atenolol but not by phentolamine. Reserpine did not significantly shift the concentration-response curve (C-R curve) of the inotropic effect of the higenamine. ICI-118,551 and atenolol caused a parallel shift of the C-R curve to the right of about 8 and 33 fold, respectively. At low concentrations salsolinol caused a slight increase in the force of contraction of the left atrium, but at higher concentrations a decrease was observed. The negative inotropic effect of salsolinol was significantly inhibited by propranolol and atropine. In the reserpinized isolated left atrium, the negative inotropic effect of salsolinol was potentiated and again this effect was significantly inhibited by propranolol and atropine. Tyramine caused a positive inotropic effect, and this effect was inhibited by propranolol or by pretreatment of the rat with reserpine. Adenosine caused a negative inotropic effect, while uridine caused a slight positive inotropic effect on the left atrium. This effect was significantly inhibited by DPCPX.
    CONCLUSIONS:
    Crude extract of Tinospora crispa exert a positive inotropic effect on the electrical field stimulated isolated left atria that results from the concerted action of 5 bioactive compounds: higenamine, salsolinol, tyramine, adenosine and uridine. Higenamine, salsolinol (at low concentration) and tyramine acted via the adrenergic receptors to increase the force of the atrial contraction, whereas a high concentration of salsolinol acted indirectly by stimulating the release of acetylcholine. Adenosine and uridine acted via the purinergic pathways to cause negative inotropic effects on the isolated left atria.
    In vivo:
    Nat Prod Bioprospect. 2016 Oct;6(5):247-55.
    Clerodane Diterpenoids with Anti-hyperglycemic Activity from Tinospora crispa.[Pubmed: 27752986 ]

    METHODS AND RESULTS:
    Four new clerodane diterpenoids, tinosporols A-C (2-4) and tinosporoside A (5), together with six known analogues were isolated from the vines of Tinospora crispa. Their structures were established by extensive spectroscopic analysis. The relative configuration at C-12 in the known diterpenoid Borapetoside E (1), the major component of the plant, was firstly established with the aid of molecular model.
    CONCLUSIONS:
    Compound 1 significantly reduced serum glucose levels at dose-dependent manners in alloxan-induced hyperglycemic mice and db/db type 2 diabetic mice.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 1.8636 mL 9.3179 mL 18.6359 mL 37.2717 mL 46.5896 mL
    5 mM 0.3727 mL 1.8636 mL 3.7272 mL 7.4543 mL 9.3179 mL
    10 mM 0.1864 mL 0.9318 mL 1.8636 mL 3.7272 mL 4.659 mL
    50 mM 0.0373 mL 0.1864 mL 0.3727 mL 0.7454 mL 0.9318 mL
    100 mM 0.0186 mL 0.0932 mL 0.1864 mL 0.3727 mL 0.4659 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    黄独素I; Diosbulbin I CFN99288 1187951-05-8 C29H30O8 = 506.6 5mg QQ客服:2056216494
    黄独素 L; Diosbulbin L CFN89003 1236285-87-2 C19H22O7 = 362.37 5mg QQ客服:2056216494
    黄独素J; Diosbulbin J CFN99289 1187951-06-9 C19H22O8 = 378.4 5mg QQ客服:2159513211
    Borapetoside A; Borapetoside A CFN95658 100202-29-7 C26H34O12 = 538.6 10mg QQ客服:215959384
    Borapetoside B; Borapetoside B CFN96298 104901-05-5 C27H36O12 = 552.6 5mg QQ客服:2159513211
    Dehydroborapetoside B; Dehydroborapetoside B CFN96306 1221178-16-0 C27H34O12 = 550.6 5mg QQ客服:2159513211
    Borapetoside F; Borapetoside F CFN96279 151200-50-9 C27H34O11 = 534.6 5mg QQ客服:2056216494
    Borapetoside E; Borapetoside E CFN96274 151200-49-6 C27H36O11 = 536.6 10mg QQ客服:2159513211
    Borapetoside D; Borapetoside D CFN96317 151200-48-5 C33H46O16 = 698.7 5mg QQ客服:2056216494
    黄独素C; Diosbulbin C CFN98015 20086-07-1 C19H22O7 = 362.4 5mg QQ客服:215959384

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