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  • Bonducellin

    Bonducellin

    Bonducellin
    产品编号 CFN96509
    CAS编号 83162-84-9
    分子式 = 分子量 C17H14O4 = 282.29
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Flavonoids
    植物来源 The herbs of Caesalpinia spinosa
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    Bonducellin CFN96509 83162-84-9 1mg QQ客服:215959384
    Bonducellin CFN96509 83162-84-9 5mg QQ客服:215959384
    Bonducellin CFN96509 83162-84-9 10mg QQ客服:215959384
    Bonducellin CFN96509 83162-84-9 20mg QQ客服:215959384
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • Calcutta University (India)
  • Nicolaus Copernicus Uniwersity (Poland)
  • Heidelberg University (Germany)
  • Uniwersytet Medyczny w ?odzi (Poland)
  • Martin Luther University of Halle-Wittenberg (Germany)
  • Universite Libre de Bruxelles (Belgium)
  • University of Sao Paulo (Brazil)
  • Universidad Industrial de Santander (Colombia)
  • National Chung Hsing University (Taiwan)
  • University of Wollongong (Australia)
  • University of Dicle (Turkey)
  • Shanghai Institute of Organic Chemistry (China)
  • University of Hertfordshire (United Kingdom)
  • Universitas islam negeri Jakarta (Indonesia)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Appl. Sci.2022, 12(17), 8646.
  • Korean Journal of Pharmacognosy.2020, 51(2):100-106
  • JEJU National University2022, 10478.
  • Korean Journal of Pharmacognosy2019, 50(4):285-290
  • J.Pharm. & Biome. Anal.2023, 2: 100018.
  • Nutrients.2019, 12(1):E40
  • Phytochem Anal.2013, 24(5):493-503
  • Phytomedicine.2019, 55:229-237
  • Molecules.2021, 26(6):1738.
  • Front Pharmacol.2022, 13:972825.
  • ACS Omega.2021, 6(36):23460-23474.
  • J AOAC Int.2023, 106(1):56-64.
  • Kor. J. Herbol.2019, 34(2):59-66
  • Plant Physiol Biochem.2019, 144:355-364
  • Molecules.2019, 24(24),4583
  • Plant Sci.2021, 313:111069.
  • Toxins (Basel).2020, 12(4):210.
  • Horticulturae2022, 8(10), 975.
  • Cosmetics2021, 8(3),91.
  • Metabolites2022, 12(6),507.
  • J of the Korean Society of Cosmetics and Cosmetology2019, 225-231
  • Neurochem Res.2021, s11064-021-03449-0
  • Food Chem.2020, 332:127412
  • ...
  • 生物活性
    Description: Bonducellin has anti-inflammatory activities, it can significantly and dose-dependently inhibit the inflammatory mediators; nitric oxide (NO), and cytokines [tumor necrosis factor (TNF)-alpha and interleukin (IL)-12. Bonducellin shows weak antimalarial activity against Plasmodium falciparum with the IC50 value of 26 uM; it also shows weak antiproliferative against A2780 human ovarian cancer cell line , with the IC50 value of 10.6 uM. Bonducellin shows modulation in the MIC of EtBr by eight fold at a concentration of 62.5 mg/L and also shows significant efflux pump inhibitory activity.
    Targets: NO | NF-kB | IL Receptor | IFN-γ | TNF-α | Antifection
    In vitro:
    Bioorg Med Chem. 2013 Dec 15;21(24):7591-4.
    Bioactive compounds from Stuhlmannia moavi from the Madagascar dry forest.[Pubmed: 24239390 ]

    METHODS AND RESULTS:
    Bioassay-directed fractionation of the leaf and root extracts of the antiproliferative Madagascar plant Stuhlmannia moavi afforded 6-acetyl-5,8-dihydroxy-2-methoxy-7-methyl-1,4-naphthoquinone (stuhlmoavin, 1) as the most active compound, with an IC50 value of 8.1 μM against the A2780 human ovarian cancer cell line, as well as the known homoisoflavonoid Bonducellin (2) and the stilbenoids 3,4,5'-trihydroxy-3'-methoxy-trans-stilbene (3), piceatannol (4), resveratrol (5), rhapontigenin (6), and isorhapontigenin (7). The structure elucidation of all compounds was based on NMR and mass spectroscopic data, and the structure of 1 was confirmed by a single crystal X-ray analysis.
    CONCLUSIONS:
    Compounds 2-5 showed weak A2780 activities, with IC50 values of 10.6, 54.0, 41.0, and 74.0 μM, respectively. Compounds 1-3 also showed weak antimalarial activity against Plasmodium falciparum with IC50 values of 23, 26, and 27 μM, respectively.
    Eur J Med Chem. 2013 Aug;66:499-507.
    7-Hydroxy-(E)-3-phenylmethylene-chroman-4-one analogues as efflux pump inhibitors against Mycobacterium smegmatis mc2 155.[Pubmed: 23832254]
    Efflux pump (EP) induces resistance in mycobacteria and hence could be explored as a new target for the discovery of anti-TB agents. In search for efflux pump inhibitors from natural products, bonducellin, a homoisoflavonoid was isolated from Caesalpinia digyna roots and evaluated for modulation and EP inhibitory activity.
    METHODS AND RESULTS:
    Bonducellin showed modulation in the MIC of EtBr by eight fold at a concentration of 62.5 mg/L and also showed significant EP inhibitory activity. A synthetic scheme was designed to prepare analogues of 7-hydroxy-(E)-3-phenylmethylene-chroman-4-one by modification at the phenylmethylene-ring and the synthesized compounds were evaluated in accumulation and efflux assays.
    CONCLUSIONS:
    Analogues 1, 7-11, 13-15, 17 and 19 were found to be good modulators and decreased the MIC of EtBr by ≥4 fold at sub-inhibitory concentration. The compounds 8, 13 and 17 were the most potent inhibitors of ethidium bromide efflux in Mycobacterium smegmatis mc(2) 155.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 3.5425 mL 17.7123 mL 35.4246 mL 70.8491 mL 88.5614 mL
    5 mM 0.7085 mL 3.5425 mL 7.0849 mL 14.1698 mL 17.7123 mL
    10 mM 0.3542 mL 1.7712 mL 3.5425 mL 7.0849 mL 8.8561 mL
    50 mM 0.0708 mL 0.3542 mL 0.7085 mL 1.417 mL 1.7712 mL
    100 mM 0.0354 mL 0.1771 mL 0.3542 mL 0.7085 mL 0.8856 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    7-羟基-3-(4-羟基亚苄基)色满-4-酮; 7-Hydroxy-3-(4-hydroxybenzylidene)chroman-4-one CFN99099 110064-50-1 C16H12O4 = 268.3 5mg QQ客服:3257982914
    Bonducellin; Bonducellin CFN96509 83162-84-9 C17H14O4 = 282.29 5mg QQ客服:215959384
    Isobonducellin; Isobonducellin CFN97042 610778-85-3 C17H14O4 = 282.3 5mg QQ客服:2159513211
    8-Methoxybonducellin; 8-Methoxybonducellin CFN97475 90996-27-3 C18H16O5 = 312.3 5mg QQ客服:3257982914
    4'-Demethyleucomin; 4'-Demethyleucomin CFN98457 34818-83-2 C16H12O5 = 284.3 5mg QQ客服:215959384
    3-(4-羟基苯亚甲基)-5-羟基-7-甲氧基色满-4-酮; 5-Hydroxy-7-methoxy-3-(4-hydroxybenzylidene)chroman-4-one CFN98291 259653-54-8 C17H14O5 = 298.3 5mg QQ客服:1413575084
    Hispidol; Hispidol CFN91694 5786-54-9 C15H10O4 = 254.2 5mg QQ客服:215959384
    硫黄菊素; Sulfuretin CFN97844 120-05-8 C15H10O5 = 270.24 5mg QQ客服:1457312923
    Mesopsin; Mesopsin CFN91922 5989-16-2 C15H12O6 = 288.25 5mg QQ客服:1413575084
    苦杏碱醇A; Amaronol A CFN98225 226560-96-9 C15H12O8 = 320.3 5mg QQ客服:2056216494

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