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  • 榄香酮酸

    Beta-Elemonic acid

    榄香酮酸
    产品编号 CFN90991
    CAS编号 28282-25-9
    分子式 = 分子量 C30H46O3 = 454.7
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Triterpenoids
    植物来源 The sclerotium of Poria cocos (Schw.) Wolf
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    榄香酮酸 CFN90991 28282-25-9 10mg QQ客服:1457312923
    榄香酮酸 CFN90991 28282-25-9 20mg QQ客服:1457312923
    榄香酮酸 CFN90991 28282-25-9 50mg QQ客服:1457312923
    榄香酮酸 CFN90991 28282-25-9 100mg QQ客服:1457312923
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • Sri Ramachandra University (India)
  • University of the Basque Country (Spain)
  • Heidelberg University (Germany)
  • Kyushu University (Japan)
  • University of Cincinnati (USA)
  • University of Illinois (USA)
  • Srinakharinwirot University (Thailand)
  • University of Oslo (Norway)
  • University of Vigo (Spain)
  • Georgia Institute of Technology (USA)
  • Michigan State University (USA)
  • Center for protein Engineering (CIP) (Belgium)
  • CSIRO - Agriculture Flagship (Australia)
  • Seoul National University of Science and Technology (Korea)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Drug Test Anal.2018, 10(10):1579-1589
  • J Ethnopharmacol.2022, 282:114574.
  • Biomolecules.2022, 12(12):1754.
  • Applied Biological Chemistry2023, 66:42.
  • Front Microbiol.2022, 13:835463.
  • Internoational J of Toxicology2020, 10.1177.
  • Bioorg Med Chem.2020, 28(12):115553.
  • Journal of Molecular Liquids2021, 334:116014.
  • J Ethnopharmacol.2020, 260:112988.
  • Antioxidants (Basel).2021, 10(9):1435.
  • J Appl Biol Chem2022, 65:343−348.
  • Applied Biological Chemistry 2021, 64(75)
  • Molecules.2019, 24(23):E4303
  • Molecules2022, 27(12):3824.
  • Integr Med Res.2021, 10(3):100723.
  • Environ Toxicol.2022, 37(3):514-526.
  • Bioengineering2023, 10(10), 1113.
  • Mol Pharmacol.2021, 99(2):163-174.
  • Neurotox Res.2022, 40(6):1937-1947.
  • BMC Microbiol.2019, 19(1):78
  • Anal Bioanal Chem. 2016, 408(15)
  • Plant Direct.2021, 5(12):e372.
  • Front Pharmacol.2021, 12:765521.
  • ...
  • 生物活性
    Description: Beta-Elemonic acid exhibits anti-inflammatory, and anti-cancer effects, it inhibits proliferation by inducing hypoploid cells and cell apoptosis, the anticancer effects of beta-Elemonic acid are related to the MAPK signaling pathway, ROS activation and glutathione depletion in human A549 lung cancer cells. Beta-Elemonic acid exhibits prolyl endopeptidase inhibitory activities.
    Targets: MAPK | ROS | COX | Bcl-2/Bax
    In vitro:
    Oncol Rep. 2016 Jan;35(1):227-34.
    β-Elemonic acid inhibits the cell proliferation of human lung adenocarcinoma A549 cells: The role of MAPK, ROS activation and glutathione depletion.[Pubmed: 26530631 ]
    Beta-Elemonic acid, a known triterpene, exhibits anti-inflammatory effects, yet research on the pharmacological effects of Beta-Elemonic acid is rare.
    METHODS AND RESULTS:
    We investigated the anticancer effects and the related molecular mechanisms of Beta-Elemonic acid on human non-small cell lung cancer (NSCLC) A549 cells. The effects of Beta-Elemonic acid on the growth of A549 cells were studied using a 3-(4,5)-2,5-diphenyltetrazolium bromide (MTT) assay. Apoptosis was detected using Annexin V staining. The effect of Beta-Elemonic acid on the cell cycle of A549 cells was assessed using the propidium iodide method. The change in reactive oxygen species (ROS) was detected using a dichlorodihydrofluorescein diacetate (DCFH-DA) assay with microscopic examination. The expression levels of Bcl-2 family proteins, mitogen-activated protein kinase (MAPK) family proteins and cyclooxygenase 2 (COX-2) were detected using western blot analysis. Our data revealed that β-elemonic acid strongly induced human A549 lung cancer cell death in a dose- and time-dependent manner as determined by the MTT assay. Beta-Elemonic acid-induced cell death was considered to be apoptotic when the phosphatidylserine exposure was observed using Annexin V staining. The death of human A549 lung cancer cells was caused by apoptosis induced by activation of ROS activity, increase in the sub-G1 proportion, downregulation of Bcl-2 expression, upregulation of Bax expression and inhibition of the MAPK signaling pathways.
    CONCLUSIONS:
    These results clearly demonstrated that Beta-Elemonic acid inhibits proliferation by inducing hypoploid cells and cell apoptosis. Moreover, the anticancer effects of Beta-Elemonic acid were related to the MAPK signaling pathway, ROS activation and glutathione depletion in human A549 lung cancer cells.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 2.1993 mL 10.9963 mL 21.9925 mL 43.985 mL 54.9813 mL
    5 mM 0.4399 mL 2.1993 mL 4.3985 mL 8.797 mL 10.9963 mL
    10 mM 0.2199 mL 1.0996 mL 2.1993 mL 4.3985 mL 5.4981 mL
    50 mM 0.044 mL 0.2199 mL 0.4399 mL 0.8797 mL 1.0996 mL
    100 mM 0.022 mL 0.11 mL 0.2199 mL 0.4399 mL 0.5498 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    金钱松呋喃酸; Pseudolarifuroic acid CFN91924 130825-79-5 C30H42O4 = 466.65 5mg QQ客服:3257982914
    3-氧代甘遂-7,24-二烯-21-酸; 3-Oxotirucalla-7,24-dien-21-oic acid CFN97609 82464-35-5 C30H46O3 = 454.69 5mg QQ客服:3257982914
    苦楝萜酸甲酯; Methyl kulonate CFN92975 22611-37-6 C31H48O4 = 484.71 5mg QQ客服:1413575084
    帕克醇; Parkeol CFN92825 514-45-4 C30H50O = 426.7 5mg QQ客服:1457312923
    葫芦二烯醇; Cucurbitadienol CFN92378 35012-08-9 C30H50O = 426.7 5mg QQ客服:215959384
    桦褐孔菌醇; Inotodiol CFN92367 35963-37-2 C30H50O2 = 442.7 5mg QQ客服:3257982914
    3beta-羟基羊毛甾-8,24-二烯-21-醛; 3beta-Hydroxylanosta-8,24-diene-21-al CFN92365 96574-03-7 C30H48O2 = 440.7 5mg QQ客服:2159513211
    3β-羟基-羊毛甾-8,24-二烯-21-酸; Trametenolic acid CFN92366 24160-36-9 C30H48O3 = 456.7 10mg QQ客服:2056216494
    Tsugaric acid A; Tsugaric acid A CFN90990 174391-64-1 C32H50O4 = 498.8 5mg QQ客服:3257982914
    榄香酮酸; Beta-Elemonic acid CFN90991 28282-25-9 C30H46O3 = 454.7 20mg QQ客服:2159513211

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