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  • 橙皮油内酯

    Auraptene

    橙皮油内酯
    产品编号 CFN98787
    CAS编号 495-02-3
    分子式 = 分子量 C19H22O3 = 298.4
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Coumarins
    植物来源 The peels of Poncirus trifoliata.
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    橙皮油内酯 CFN98787 495-02-3 10mg QQ客服:2159513211
    橙皮油内酯 CFN98787 495-02-3 20mg QQ客服:2159513211
    橙皮油内酯 CFN98787 495-02-3 50mg QQ客服:2159513211
    橙皮油内酯 CFN98787 495-02-3 100mg QQ客服:2159513211
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • Uniwersytet Gdański (Poland)
  • Julius Kühn-Institut (Germany)
  • Tohoku University (Japan)
  • University of Liège (Belgium)
  • Donald Danforth Plant Science Center (USA)
  • University of Hull (United Kingdom)
  • Universidad de Buenos Aires (Argentina)
  • University of Limpopo (South Africa)
  • Istanbul University (Turkey)
  • Korea Institute of Oriental Medicine (Korea)
  • University of Dicle (Turkey)
  • Charles Sturt University (Denmark)
  • Harvard University (USA)
  • Mahatma Gandhi University (India)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Nutrients.2019, 11(4):E936
  • Agronomy2020, 10(10),1489
  • Int J Mol Sci.2020, 21(7):2530.
  • Phytother Res.2016, 30(12):2020-2026
  • Reprod Toxicol.2020, 96:1-10.
  • bioRxiv-Pharm.&Toxi.2022, 2022.481203.
  • Acta horticulturae2017, 1158:257-268
  • Life (Basel).2021, 11(7):616.
  • Hum Exp Toxicol.2022, 41:9603271221143713.
  • PLoS One.2015, 10(5):e0127060
  • Academic J of Second Military Medical University2018, 39(11)
  • Life Sci.2021, 286:120019.
  • J Appl Biol Chem2023, 66:455−461
  • Analytical Letters.2020, doi 10.1008
  • Plants (Basel).2023, 12(1):163.
  • Food and Agriculture Org. Of the UN2019, 151-160
  • Life Sci.2022, 311(Pt A):121157.
  • Biology (Basel).2020, 9(11):363.
  • Appl Biol Chem2019, 62:46
  • Antioxidants (Basel).2022, 11(10):1929.
  • Korean J. of Food Sci. and Tech2016, 172-177
  • Food Funct.2022, 13(13):6923-6933.
  • Journal of Physiology & Pathology in Korean Medicine.2018, 32(2): 106-112
  • ...
  • 生物活性
    Description: Auraptene possesses anticarcinogenic, cardioprotective, anti-inflammatory, anti-oxidant, antihelicobacter, antigenotoxic, and neuroprotective effects. Auraptene has a potential to attenuate chronic inflammation in adipose tissue and to improve obesity-related insulin resistance, and has protective effects in transgenic rats developing adenocarcinoma of the prostate (TRAP) and human prostate carcinoma cells.
    Targets: IFN-γ | IL Receptor | PGE | COX | BACE | JNK | Beta Amyloid | TNF-α | p38MAPK | NO
    In vitro:
    Eur J Pharmacol. 2015 Mar 5;750:8-13.
    Auraptene has the inhibitory property on murine T lymphocyte activation.[Pubmed: 25620131]
    Auraptene, a citrus fruit-derived coumarin, has been reported to exert valuable pharmacological properties as anti-tumor, anti-inflammatory, and anti-oxidant agent. However, little is known about auraptene on immune responses.
    METHODS AND RESULTS:
    In this study, we conducted an investigation to evaluate auraptene as an anti-T lymphocyte proliferation agent using CD3/CD28-activated lymphocytes isolated from C57BL/6 mice. We found that administration of auraptene inhibited CD3/CD28-activated lymphocyte proliferation in a dose dependent manner, but the inhibition at a wide range of doses used in this study did not induce cytotoxicity or apoptosis. In addition, auraptene dose dependently decreased the CD3/CD28-activated T lymphocyte secreting T helper (Th)1 cytokines (interleukin (IL)-2 and interferon (IFN)-γ); whereas, auraptene could decrease Th2 cytokine (IL-4) at a higher level (40μM) but had not at lower levels (10 and 20μM). Further mechanistic study demonstrated that auraptene doses dependently suppressed T cell early and middle/late activation marker CD69 and CD25 expression, respectively. Finally, auraptene could suppress cell cycle progression which contributes to inhibiting T cell proliferation and cell division.
    CONCLUSIONS:
    These findings indicate that auraptene exhibits anti-inflammatory properties via inhibiting T cell proliferation and their inflammatory cytokine secretion that may mediate the interaction between T cells and autoimmune disorders, suggesting that auraptene is a potential food-derived compound with a benefit to those with abnormally over-activation T cell mediated response and chronic inflammation such as autoimmune and inflammatory diseases.
    Inflammation. 2013 Dec;36(6):1525-32.
    Anti-inflammatory effect of auraptene extracted from trifoliate orange (Poncirus trifoliate) on LPS-stimulated RAW 264.7 cells.[Pubmed: 23872723]
    Poncirus trifoliate is a traditional Chinese medicinal plant used for treating inflammation-related diseases for a long time and trifoliate orange contains abundant auraptene.
    METHODS AND RESULTS:
    The present study was to evaluate auraptene as a potential anti-inflammatory agent and investigate the mechanism of auraptene against prostaglandins E2 (PGE2) and cyclooxygenase-2 (COX-2) on lipopolysaccharide (LPS)-stimulated RAW 264.7 cells by comparing it with aspirin as a positive control group. The methods of enzyme-linked immunosorbent assay, reverse transcriptive polymerase chain reaction, real-time PCR, and western-blotting were used in the study. The results showed that auraptene exhibited better biocompatibility and lower cytotoxicity. At the same time, it significantly inhibited the production of PGE2 on LPS-stimulated macrophage cells. The auraptene-treated group had a higher COX-2 mRNA expression but relatively lower COX-2 protein level which implied that auraptene suppressed the post-transcriptional expression of COX-2 protein but not the transcriptional process.
    CONCLUSIONS:
    Compared with aspirin, the lower cytotoxicity of auraptene can make it a potential source for medicine that can benefit patients who are suffering from chronic inflammatory diseases and need long-term medication.
    In vivo:
    Iran J Basic Med Sci. 2015 Feb;18(2):153-8.
    Antihypertensive effect of auraptene, a monoterpene coumarin from the genus Citrus, upon chronic administration.[Pubmed: 25810889]
    Auraptene, a monoterpene coumarin from Citrus species, exhibits cardioprotective effects. In this study, the effects of auraptene administration were investigated on blood pressure of normotensive and desoxycorticosterone acetate (DOCA) salt induced hypertensive rats.
    METHODS AND RESULTS:
    Five weeks administration of auraptene (2, 4, 8 and 16 mg/kg/day) and nifedipine (0.25, 0.5, 1, 2 and 4 mg/kg/day) in different groups of normotensive and hypertensive rats (at the end of 3 weeks treatment by DOCA salt) was carried out and their effects on mean systolic blood pressure (MSBP) and mean heart rate (MHR) were evaluated using tail cuff method. Our results indicated that chronic administration of auraptene (2, 4, 8 and 16 mg/kg/day) significantly reduced the MSBP in DOCA salt treated rats in a dose and time dependent manner. The percent of decreases in MSBP levels by the highest dose of auraptene (16 mg/kg) at the end of 4 (th) to 8 (th) weeks, were 7.00%, 10.78%, 16.07%, 21.28% and 27.54% respectively (P<0.001). Moreover the antihypertensive effect of auraptene was less than nifedipine (ED50 value of nifedipine = 0.7 mg/kg at 8(th) week and ED50 value of auraptene = 5.64 mg/kg at 8 week).
    CONCLUSIONS:
    Auraptene considerably reduced MSBP in hypertensive rats, but not in normotensive (normal saline treated) rats. The results of MHR measurement showed that the increase in MHR was not significant in comparison with DOCA treated rats.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 3.3512 mL 16.756 mL 33.5121 mL 67.0241 mL 83.7802 mL
    5 mM 0.6702 mL 3.3512 mL 6.7024 mL 13.4048 mL 16.756 mL
    10 mM 0.3351 mL 1.6756 mL 3.3512 mL 6.7024 mL 8.378 mL
    50 mM 0.067 mL 0.3351 mL 0.6702 mL 1.3405 mL 1.6756 mL
    100 mM 0.0335 mL 0.1676 mL 0.3351 mL 0.6702 mL 0.8378 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    7-异戊烯氧基香豆素; 7-Prenylumbelliferone CFN90825 10387-50-5 C14H14O3 = 230.3 20mg QQ客服:1413575084
    橙皮油内酯; Auraptene CFN98787 495-02-3 C19H22O3 = 298.4 20mg QQ客服:215959384
    Marmin; Marmin CFN99621 14957-38-1 C19H24O5 = 332.4 20mg QQ客服:2056216494
    Marmin acetonide; Marmin acetonide CFN98408 320624-68-8 C22H28O5 = 372.5 5mg QQ客服:2056216494
    7'-O-Ethylmarmin; 7'-O-Ethylmarmin CFN97584 N/A C21H28O5 = 360.5 5mg QQ客服:1457312923
    Excavatin M; Excavatin M CFN98274 250293-31-3 C19H20O7 = 360.4 5mg QQ客服:215959384
    Diversoside; Diversoside CFN89254 55062-36-7 C25H34O10 = 494.53 10mg QQ客服:2056216494
    香豆素; Coumarin CFN99552 91-64-5 C9H6O2 = 146.15 20mg QQ客服:2056216494
    6-甲基香豆素; 6-Methylcoumarin CFN96597 92-48-8 C10H8O2 = 160.17 20mg QQ客服:215959384
    7-甲基香豆素; 7-Methylcoumarin CFN91113 2445-83-2 C10H8O2 = 160.17 30mg QQ客服:2056216494

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