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  • 苍术酮

    Atractylone

    苍术酮
    产品编号 CFN92066
    CAS编号 6989-21-5
    分子式 = 分子量 C15H20O = 216.3
    产品纯度 >=98%
    物理属性 Soild
    化合物类型 Sesquiterpenoids
    植物来源 The roots of Atractylodes macrocephala
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    苍术酮 CFN92066 6989-21-5 1mg QQ客服:2159513211
    苍术酮 CFN92066 6989-21-5 5mg QQ客服:2159513211
    苍术酮 CFN92066 6989-21-5 10mg QQ客服:2159513211
    苍术酮 CFN92066 6989-21-5 20mg QQ客服:2159513211
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
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  • Florida International University (USA)
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  • University of Virginia (USA)
  • Massachusetts General Hospital (USA)
  • University of Wollongong (Australia)
  • The Vancouver Prostate Centre (VPC) (Canada)
  • University of Lodz (Poland)
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  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Advances in Traditional Medicine 2021, 21:779-789.
  • J Formos Med Assoc.2020, S0929-6646(20)30425-3
  • Pak J Pharm Sci.2019, 32(6):2879-2885
  • Appl. Sci. 2021, 11(10),4666.
  • J Nat Sc Biol Med2019, 10(2):149-156
  • Elife.2021, 10:e68058.
  • Pak J Pharm Sci.2019, 32(6)
  • Spectrochim Acta A2019, 210:372-380
  • J Pharmaceutical and Biomedical Analysis2022, 114631.
  • Oncotarget.2017, 8(53):90925-90947
  • Antioxidants (Basel).2021, 10(9):1435.
  • J Ethnopharmacol.2019, 241:112025
  • J.of Traditional&Complementary Med.2022, 10.1016:j.jtcme.
  • Cell Death Dis.2019, 10(12):882
  • Nutrients.2022, 14(16):3393.
  • J of the Society of Cosmetic Scientists of Korea2018, 44(4):407-417
  • J Ginseng Res.2020, 44(4):611-618.
  • Phytother Res.2022, 35844057.
  • J Cosmet Dermatol.2022, 21(1):396-402.
  • Food Funct.2022, 13(14):7638-7649.
  • Int J Mol Sci.2019, 20(16):E4015
  • Int Immunopharmacol.2023, 123:110572.
  • Sci Rep.2015, 5:13194
  • ...
  • 生物活性
    Description: Atractylone has inhibitory effects on mast cell-mediated allergic reactions, it regulates the degranulation of mast cell, proves its potential in the treatment of mast cell-mediated allergic reactions.
    Targets: IL Receptor | VEGFR | Histamine Receptor
    In vitro:
    World J Microbiol Biotechnol. 2012 Feb;28(2):575-84.
    Comparison of the effects of fungal endophyte Gilmaniella sp. and its elicitor on Atractylodes lancea plantlets.[Pubmed: 22806853]
    The effects of the endophytic fungus Gilmaniella sp. and its elicitor on the defense and metabolic responses of host plants Atractylodes lancea were investigated, in order to understand how to utilize endophytic fungi and their elicitor resources better.
    METHODS AND RESULTS:
    The results showed that the promotion effect of the fungus on the growth of host plantlets was much better than that of its elicitor. Both fungus and elicitor enhanced defense-related enzyme activities. In fungus-inoculated groups, phenylalanine ammonia lyase and polyphenol oxidase activities increased slowly, and reached a maximum level during the later stages, whereas peroxidase activity peaked in the first few days. Additionally, the activities of chitinase and β-1,3-glucanase were significantly higher than those of the control plants. In elicitor-treated groups, however, most of the enzymes were activated during the early stage, and their highest levels were generally lower than those of the fungus-inoculated groups. Compared with the elicitor, fungal infection improved the photosynthetic rate of the host, and increased carbohydrate levels as well as chlorophyll content in host leaves. The total content of the four main components of volatile oil was also increased in elicitor-treated groups, but there was no particular pattern in this increase. Meanwhile, in the fungus-inoculated groups, the content of Atractylone significantly increased with time, while the content of β-eudesmol decreased.
    CONCLUSIONS:
    These results indicated that fungal elicitor could substantially improve the total content of volatile oil, while the fungus could more effectively enhance the quality of herbal medicines.
    Chem.Biol. Interact., 2016, 258:59–68
    Inhibitory effects of atractylone on mast cell-mediated allergic reactions.[Pubmed: 27553716 ]
    This study investigated a salutary effect of Atractylone (Atr) which is an active constituent of Pyeongwee-San (KMP6) on mast cell-mediated allergic reactions. Our previous report indicated that KMP6 regulated allergic reactions.
    METHODS AND RESULTS:
    Thus, this study sought to determine the potential of Atr in vitro models, compound 48/80-stimulated rat peritoneal mast cells (RPMCs), phorbol 12-myristate 13-acetate (PMA) plus A23187-stimulated human mast cell line (HMC-1) cells, and stem cell factor (SCF)-stimulated RPMCs as well as in vivo models, IgE-mediated passive cutaneous anaphylaxis (PCA), compound 48/80-induced systemic anaphylaxis, and compound 48/80-induced ear swelling. The results showed that Atr inhibited compound 48/80-induced RPMCs degranulation, intracellular calcium level, tryptase release, and histamine release. Atr inhibited the up-regulation of p56(lck) tyrosine kinase activity by compound 48/80. And Atr reduced tryptase and histamine releases from PMA plus A23187-stimulated HMC-1 cells. In addition, Atr decreased histidine decarboxylase activity and expression in the activated HMC-1 cells. Atr inhibited SCF-induced morphological alteration and filamentous actin formation in RPMCs. Atr improved IgE-induced PCA reaction by decreasing the levels of histamine, IgE, interleukin (IL)-4, IL-5, IL-6, vascular endothelial growth factor, and IL-13 in the serum of PCA-induced mice. Furthermore, Atr mitigated compound 48/80-induced systemic anaphylaxis and ear swelling.
    CONCLUSIONS:
    Taken together, these results of this study indicate that Atr regulates the degranulation of mast cell, proving its potential in the treatment of mast cell-mediated allergic reactions.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 4.6232 mL 23.116 mL 46.2321 mL 92.4642 mL 115.5802 mL
    5 mM 0.9246 mL 4.6232 mL 9.2464 mL 18.4928 mL 23.116 mL
    10 mM 0.4623 mL 2.3116 mL 4.6232 mL 9.2464 mL 11.558 mL
    50 mM 0.0925 mL 0.4623 mL 0.9246 mL 1.8493 mL 2.3116 mL
    100 mM 0.0462 mL 0.2312 mL 0.4623 mL 0.9246 mL 1.1558 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    Zedoarofuran; Zedoarofuran CFN92619 213833-34-2 C15H20O4 = 264.3 5mg QQ客服:2159513211
    Curcolonol; Curcolonol CFN92650 217817-09-9 C15H20O4 = 264.3 5mg QQ客服:1413575084
    1beta,10beta-Epoxy-6beta-isobutyryloxy-9-oxofuranoeremophilane; 1beta,10beta-Epoxy-6beta-isobutyryloxy-9-oxofuranoeremophilane CFN89321 59742-11-9 C19H24O5 = 332.39 5mg QQ客服:2159513211
    6beta-Angeloyloxy-1beta,10beta-epoxy-9-oxofuranoeremophilane; 6beta-Angeloyloxy-1beta,10beta-epoxy-9-oxofuranoeremophilane CFN89320 59780-08-4 C20H24O5 = 344.40 5mg QQ客服:3257982914
    莪术呋喃烯酮; Curzerenone CFN92027 20493-56-5 C15H18O2 = 230.3 20mg QQ客服:2159513211
    表莪术呋喃烯酮; Epicurzerenone CFN92613 20085-85-2 C15H18O2 = 230.3 5mg QQ客服:2056216494
    异乌药内酯; Isolinderalactone CFN99762 957-66-4 C15H16O3 = 244.29 10mg QQ客服:215959384
    苍术酮; Atractylone CFN92066 6989-21-5 C15H20O = 216.3 5mg QQ客服:1457312923
    乌药醇; Linderene CFN90639 26146-27-0 C15H18O2 = 230.3 10mg QQ客服:215959384
    乌药醇乙酸酯; Linderene acetate CFN91930 26146-28-1 C17H20O3 = 272.34 5mg QQ客服:1457312923

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