黄芪皂苷I

Astragaloside I

	产品编号	CFN99172
	CAS编号	84680-75-1
	分子式 = 分子量	C₄₅H₇₂O₁₆ = 869.1
	产品纯度	>=98%
	物理属性	Powder
	化合物类型	Triterpenoids
	植物来源	The roots of Astragalus membranaceus (Fisch.) Bunge.
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产品名称	产品编号	CAS编号	包装	QQ客服
黄芪皂苷I	CFN99172	84680-75-1	10mg	QQ客服：2056216494
黄芪皂苷I	CFN99172	84680-75-1	20mg	QQ客服：2056216494
黄芪皂苷I	CFN99172	84680-75-1	50mg	QQ客服：2056216494
黄芪皂苷I	CFN99172	84680-75-1	100mg	QQ客服：2056216494

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Description:

Astragaloside Ι may protect the cerebral tissue against the free radical damage in ischemia and inhibit the activation of BV-2 cells induced by LPS through suppressing the activation of PI3K/Akt/NF-κB pathway. It stimulates osteoblast differentiation through the Wnt/β-catenin signaling pathway, which also activates the BMP pathway and RANK pathway.

Targets:

Wnt/β-catenin | HIF | TNF-α | NO | NOS | COX | NF-kB | PI3K | Akt | NF-kB | IkB | IL Receptor | IKK

In vitro:

Phytother Res. 2016 Oct;30(10):1680-8.

Astragaloside I Stimulates Osteoblast Differentiation Through the Wnt/β-catenin Signaling Pathway.[Pubmed: 27397144 ]

Astragaloside I (As-I), one of the main active ingredients in Astragalus membranaceus, is believed to have osteogenic properties, but this hypothesis has not been investigated in detail.
METHODS AND RESULTS:
In the present work, the As-I-induced osteogenic effects and its underlying mechanism were studied in MC3T3-E1 cells. The results indicated that the cellular levels of ALP and extracellular matrix calcium increased in a dose-dependent manner by As-I. To clarify the mechanisms involved in this process, the effect of As-I on the key osteogenic-related genes was investigated. We found that As-I stimulated the expression of β-catenin and Runx2 in MC3T3-E1 cells, which play central roles in the Wnt/β-catenin signaling pathway, suggesting that As-I could promote osteoblastic differentiation by regulating the Wnt/β-catenin signaling pathway. Moreover, the osteogenic effect of As-I could be inhibited by DKK-1, which is the classical inhibitor of Wnt/β-catenin-signaling pathway. Furthermore, As-I also increased BMP-2, BGP and OPG/RANKL expression, which are also activated by Wnt/β-catenin signaling pathway.
CONCLUSIONS:
Taken together, our findings show that As-I stimulates osteoblast differentiation through the Wnt/β-catenin signaling pathway, which also activates the BMP pathway and RANK pathway, thus highlighting the As-I for pharmaceutical and medicinal applications such as treating bone disease.

In vivo:

Chin Med J (Engl). 2013;126(8):1551-4.

Protective effects of astragalus extract against intermittent hypoxia-induced hippocampal neurons impairment in rats.[Pubmed: 23595393]

Intermittent hypoxia is the main pathophysiological cause of the obstructive sleep apnea syndrome. Astragalus shows improvement of spatial learning and memory abilities under intermittent hypoxia. Our study aimed to investigate the protective effect of astragalus against intermittent hypoxia induced-hippocampal neurons impairment in rats and lay the theoretical foundation for the sleep apnea improvement in cognitive function by astragalus.
METHODS AND RESULTS:
Male Wistar rats were divided into 4 groups: blank control group, normoxia group, intermittent hypoxia group and astragalus treated intermittent hypoxia group. After 6-week treatment, apoptosis of neurons was evaluated by terminal deoxynucleotidyl-transferase-mediated dUTP nick end-labeling (TUNEL) assay. Furthermore, the expression of HIF-1a was detected by real-time reverse transcription polymerase chain reaction (RT-PCR) at the mRNA level as well as by immunohistochemistry (IHC) and Western blotting at the protein level. HPLC analysis indicated that astragaloside IV, astragaloside II and astragaloside I were the main compounds in astragals extract. Astragalus extract reduced the apoptosis of hippocampal neurons (P < 0.05) and decreased the expression of HIF-1a at both the mRNA and protein levels in hippocampus compared with non-treated groups (P < 0.05).
CONCLUSIONS:
Astragalus protects against intermittent hypoxia-induced hippocampal neurons impairment in rats.

产品名称	产品编号	CAS编号	分子式 = 分子量	位单	联系QQ
21,24-环氧基环安坦-3,25-二醇; 21,24-Epoxycycloartane-3,25-diol	CFN97836	125305-73-9	C₃₀H₅₀O₃ = 458.73	5mg	QQ客服：1413575084
环黄芪醇; Cycloastragenol	CFN99538	84605-18-5	C₃₀H₅₀O₅ = 490.71	20mg	QQ客服：2056216494
黄芪甲苷IV; 黄芪皂苷Ⅳ; 黄芪甲苷; 黄芪甲甙; Astragaloside IV	CFN99171	84687-43-4	C₄₁H₆₈O₁₄ = 784.98	20mg	QQ客服：3257982914
黄芪甲苷 VII; Astrasieversianin VII	CFN90648	86764-11-6	C₄₃H₇₀O₁₅ = 827.01	10mg	QQ客服：2056216494
黄芪皂苷II; Astragaloside II	CFN99173	84676-89-1	C₄₃H₇₀O₁₅ = 827.02	20mg	QQ客服：3257982914
黄芪皂苷I; Astragaloside I	CFN99172	84680-75-1	C₄₅H₇₂O₁₆ = 869.1	20mg	QQ客服：2159513211
异黄芪皂苷I; Isoastragaloside I	CFN90977	84676-88-0	C₄₅H₇₂O₁₆ = 869.1	10mg	QQ客服：215959384
黄芪皂苷III; Astragaloside III	CFN99174	84687-42-3	C₄₁H₆₈O₁₄ = 784.97	20mg	QQ客服：3257982914
黄肉楠碱; Actein	CFN99864	18642-44-9	C₃₇H₅₆O₁₁ = 676.9	5mg	QQ客服：3257982914
升麻素苷; Cimicifugoside	CFN90481	66176-93-0	C₃₇H₅₄O₁₁ = 674.81	5mg	QQ客服：3257982914

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	1.1506 mL	5.7531 mL	11.5062 mL	23.0123 mL	28.7654 mL
5 mM	0.2301 mL	1.1506 mL	2.3012 mL	4.6025 mL	5.7531 mL
10 mM	0.1151 mL	0.5753 mL	1.1506 mL	2.3012 mL	2.8765 mL
50 mM	0.023 mL	0.1151 mL	0.2301 mL	0.4602 mL	0.5753 mL
100 mM	0.0115 mL	0.0575 mL	0.1151 mL	0.2301 mL	0.2877 mL

黄芪皂苷I

Astragaloside I

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