异鼠李亭 3-龙胆二糖甙

Astragaloside

	产品编号	CFN99170
	CAS编号	17429-69-5
	分子式 = 分子量	C₂₈H₃₂O₁₇ = 640.55
	产品纯度	>=98%
	物理属性	Yellow powder
	化合物类型	Flavonoids
	植物来源	The roots of Astragalus membranaceus (Fisch.) Bunge
ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用

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产品名称	产品编号	CAS编号	包装	QQ客服
异鼠李亭 3-龙胆二糖甙	CFN99170	17429-69-5	1mg	QQ客服：215959384
异鼠李亭 3-龙胆二糖甙	CFN99170	17429-69-5	5mg	QQ客服：215959384
异鼠李亭 3-龙胆二糖甙	CFN99170	17429-69-5	10mg	QQ客服：215959384
异鼠李亭 3-龙胆二糖甙	CFN99170	17429-69-5	20mg	QQ客服：215959384

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ChemFaces的产品在许多优秀和顶级科学期刊中被引用

Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6.
doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)

PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206.
doi: 10.1038/nplants.2016.205.
IF=13.297(2019)

PMID: 28005066

Sci Adv. 2018 Oct 24;4(10): eaat6994.
doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)

PMID: 30417089

Universidade de Franca (Brazil)

Fraunhofer-Institut für Molekularbiologie und Angewandte ?kologie IME (Germany)

Guangzhou Institutes of Biomedicine and Health (China)

The Australian National University (Australia)

Charles University in Prague (Czech Republic)

University of Otago (New Zealand)

Lodz University of Technology (Poland)

Michigan State University (USA)

Weizmann Institute of Science (Israel)

Universidade Federal de Pernambuco (UFPE) (Brazil)

University of Ioannina (Greece)

University of Wuerzburg (Germany)

Amity University (India)

Leibniz Institute of Plant Biochemistry (Germany)

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Description:

Astragaloside may protect against brain contusion and neuronal apoptosis after TBI by attenuating microglia activation in male rats. Astragalosides-induced apoptosis in NB4 cells may be associated with down-regulation of the expression of BCL-2 and NF-κB, finally the relative activity of caspase-3 activated. Astragaloside has several pharmacological actions on cardiovascular system, including positive inotropic, anti-arrhythmia and anti-oxidant activities; it also has anti-apoptotic activity, which may contribute to the improvement of clinical outcomes in treating myocarditis with pharmaceutics of Astragalus membranaceus.

Targets:

In vivo:

Am J Chin Med. 2010;38(3):517-27.

Protective effect of astragaloside on focal cerebral ischemia/reperfusion injury in rats.[Pubmed: 20503469 ]

This study was to observe the neurological protective effects of Astragalosides (AST) on focal cerebral ischemia-reperfusion (I/R) injury in rats and to explore its possible mechanism.
METHODS AND RESULTS:
Male SD rats received right middle cerebral artery occlusion for 120 min and AST (40 mg/kg) was orally administered. The rats were decapitated 1, 3, 7, and 14 days after reperfusion. The neurological deficit score, infarct volume and water content of brain were measured; the activity of superoxide dismutase (SOD), lactate dehydrogenase (LDH) and nitric oxide synthase (NOS), and the content of malondialdehyde (MDA), lactate (LD) and nitric oxide (NO) of brain tissue were detected too. The expression of inducible nitric synthase (iNOS), nerve growth factor (NGF) and tropomyosin receptor kinase A (TrkA) mRNA were measured by RT-PCR or real-time PCR. AST could significantly reduce the neurological deficit score; infract volume and water content, increase SOD and LDH activities, decrease NOS activity and MDA, LD and NO content. AST treatment could down-regulate expression of iNOS mRNA, while, NGF and TrkA mRNA were up-regulated.
CONCLUSIONS:
Our data suggest that AST have the protective effects on focal cerebral ischemia in rats at the different reperfusion time points, the mechanism may be related to the antioxidation, regulated the expressions of iNOS, NGF and TrkA mRNA.

产品名称	产品编号	CAS编号	分子式 = 分子量	位单	联系QQ
Polygalin J; Polygalin J	CFN95175	N/A	C₄₁H₄₆O₂₁ = 874.8	5mg	QQ客服：1413575084
商陆苷; Ombuoside	CFN92808	20188-85-6	C₂₉H₃₄O₁₆ = 638.6	5mg	QQ客服：1413575084
柽柳黄素 7-O-新橙皮糖苷; Tamarixetin 7-O-neohesperidoside	CFN91527	28283-76-3	C₂₈H₃₂O₁₆ = 624.6	5mg	QQ客服：1457312923
异鼠李素-7-O-葡萄糖苷; Isorhamnetin 7-O-glucoside	CFN91115	6743-96-0	C₂₂H₂₂O₁₂ = 478.4	5mg	QQ客服：3257982914
异鼠李素-3-O-葡萄糖-7-O-鼠李糖苷; Isorhamnetin 3-glucoside-7-rhamnoside	CFN90739	17331-71-4	C₂₈H₃₂O₁₆ = 624.54	5mg	QQ客服：3257982914
异鼠李素-3,7-O-二葡萄糖苷; Isorhamnetin 3,7-O-diglucoside	CFN91130	6758-51-6	C₂₈H₃₂O₁₇ = 640.6	5mg	QQ客服：1457312923
异鼠李素-3-O-芸香苷-7-O-葡萄糖苷; Isorhamnetin-3-O-rutinoside-7-O-glucoside	CFN95494	55481-91-9	C₃₄H₄₂O₂₁ = 786.7	5mg	QQ客服：3257982914
异鼠李素-3-O-β-D-葡萄糖-7-O-β-D-龙胆双糖苷; Isorhamnetin 3-O-beta-D-glucose-7-O-beta-D-gentiobioside	CFN91845	60778-00-9	C₃₄H₄₂O₂₂ = 802.7	5mg	QQ客服：1413575084
异鼠李素-3-O-槐二糖-7-O-鼠李糖苷; Isorhamnetin 3-sophoroside-7-rhamnoside	CFN90735	41328-75-0	C₃₄H₄₂O₂₁ = 786.68	5mg	QQ客服：1457312923
柠檬黄素-3-O-β-D-葡萄糖苷; Limocitrin 3-O-beta-D-glucopyranoside	CFN91697	38836-51-0	C₂₃H₂₄O₁₃ = 508.4	5mg	QQ客服：3257982914

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	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	1.5612 mL	7.8058 mL	15.6116 mL	31.2232 mL	39.029 mL
5 mM	0.3122 mL	1.5612 mL	3.1223 mL	6.2446 mL	7.8058 mL
10 mM	0.1561 mL	0.7806 mL	1.5612 mL	3.1223 mL	3.9029 mL
50 mM	0.0312 mL	0.1561 mL	0.3122 mL	0.6245 mL	0.7806 mL
100 mM	0.0156 mL	0.0781 mL	0.1561 mL	0.3122 mL	0.3903 mL