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  • 积雪草酸

    Asiatic acid

    积雪草酸
    产品编号 CFN98688
    CAS编号 464-92-6
    分子式 = 分子量 C30H48O5 = 488.7
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Triterpenoids
    植物来源 The herbs of Centella asiatica.
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    积雪草酸 CFN98688 464-92-6 10mg QQ客服:1413575084
    积雪草酸 CFN98688 464-92-6 20mg QQ客服:1413575084
    积雪草酸 CFN98688 464-92-6 50mg QQ客服:1413575084
    积雪草酸 CFN98688 464-92-6 100mg QQ客服:1413575084
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • St. Jude Children Research Hospital (USA)
  • S.N.D.T. Women's University (India)
  • Uniwersytet Jagielloński w Krakowie (Poland)
  • University of Hertfordshire (United Kingdom)
  • Institute of Tropical Disease Universitas Airlangga (Indonesia)
  • Shanghai Institute of Biochemistry and Cell Biology (China)
  • Kazusa DNA Research Institute (Japan)
  • Universidade de Franca (Brazil)
  • FORTH-IMBB (Greece)
  • University of Maryland (USA)
  • Institute of Chinese Materia Medica (China)
  • Universite de Lille1 (France)
  • University of Leipzig (Germany)
  • Tokyo Woman's Christian University (Japan)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Nat Prod Sci.2014, 20(3):182-190
  • Appl Microbiol Biotechnol.2016, 100(9):3965-77
  • J Ethnopharmacol.2016, 192:370-381
  • Evid Based Complement Alternat Med.2016, 2016:1230294
  • Pharm Biol.2016, 54(7):1255-62
  • Oncotarget.2016, 8(51):88386-88400
  • J Chromatogr B Analyt Technol Biomed Life Sci. 2017, 1064:115-123
  • Free Radic Biol Med.2017, 112:191-199
  • Evid Based Complement Alternat Med.2017, 2017:6360836
  • J Ethnopharmacol.2017, 206:73-77
  • Br J Pharmacol.2018, 175(6):902-923
  • Anat Rec2018, 24264
  • J Mol Med (Berl).2018, 96(7):661-672
  • Nat Commun.2019, 10(1):5169
  • Int J Biol Macromol.2019, 126:653-661
  • Molecules.2019, 24(4):E709
  • Journal of Apiculture2019, 34(2):131-136
  • Chinese Pharmacological Bulletin2019, 35(8):1120-1125
  • J Funct Foods2019, 54:449-456
  • Int Immunopharmacol.2019, 71:361-371
  • Antioxidants (Basel).2019, 8(8):E307
  • J Pharmaceut Biomed2020, 178:112894
  • Antioxidants (Basel).2020, 9(2): E119
  • ...
  • 生物活性
    Description: Asiatic acid shows antihyperlipidemic, anti-inflammatory, antioxidant, and anti-tumorigenesis effects, it inhibits NLRP3 inflammasome activation, NO and COX-2 signals. Asiatic acid inhibits the expression NDR1/2 kinase and promotes the stability of p21WAF1/CIP1 protein through attenuating NDR1/2 dependent phosphorylation of p21WAF1/CIP1 in HepG2 cells.
    Targets: TNF-α | IFN-γ | IL Receptor | Caspase | p21 | NOS | NADPH-oxidase | NO | HMG-CoA reductase | COX
    In vivo:
    Int Immunopharmacol. 2015 Feb;24(2):232-8.
    Asiatic acid ameliorates dextran sulfate sodium-induced murine experimental colitis via suppressing mitochondria-mediated NLRP3 inflammasome activation.[Pubmed: 25523461]
    In the present study, the effect of asiatic acid, a natural triterpenoid compound, on murine experimental colitis induced by dextran sulfate sodium (DSS) and its possible mechanism were examined in vivo and vitro.
    METHODS AND RESULTS:
    Oral administration of asiatic acid dose-dependently attenuated the loss of body weight and shortening of colon length induced by DSS. The disease activity index, histopathologic scores of musco and myeloperoxidase activity were also significantly reduced by asiatic acid treatment. Protein and mRNA levels of DSS-induced pro-inflammatory cytokines in colon, including TNF-α, IL-1β, IL-6 and IFN-γ, were markedly suppressed by asiatic acid. At the same time, decreased activation of caspase-1 in peritoneal macrophages was detected in asiatic acid-treated mice, which suggested that the NLRP3 inflammasome activation was suppressed. In addition, we also found that asiatic acid dose-dependently inhibited IL-1β secretion, caspase-1 activation as well as inflammasome assembling in vitro. Furthermore, the mechanism of asiatic acid was related to the inhibition of mitochondrial reactive oxygen species generation and prevention of mitochondrial membrane potential collapse.
    CONCLUSIONS:
    Taken together, our results demonstrate the ability of asiatic acid to inhibit NLRP3 inflammasome activation and its potential usage in the treatment of inflammatory bowel diseases.
    Nutrients. 2014 Jan 16;6(1):355-70.
    Asiatic acid alleviates hemodynamic and metabolic alterations via restoring eNOS/iNOS expression, oxidative stress, and inflammation in diet-induced metabolic syndrome rats.[Pubmed: 24441717 ]
    Asiatic acid is a triterpenoid isolated from Centella asiatica. The present study aimed to investigate whether Asiatic acid could lessen the metabolic, cardiovascular complications in rats with metabolic syndrome (MS) induced by a high-carbohydrate, high-fat (HCHF) diet.
    METHODS AND RESULTS:
    Male Sprague-Dawley rats were fed with HCHF diet with 15% fructose in drinking water for 12 weeks to induce MS. MS rats were treated with Asiatic acid (10 or 20 mg/kg/day) or vehicle for a further three weeks. Plasma nitrate and nitrite (NOx) were markedly high with upregulation of inducible nitric oxide synthase (iNOS) expression, but dowregulation of endothelial nitric oxide synthase (eNOS) expression (p<0.05). Asiatic acid significantly improved insulin sensitivity, lipid profiles, hemodynamic parameters, oxidative stress markers, plasma TNF-α, NOx, and recovered abnormality of eNOS/iNOS expressions in MS rats (p<0.05).
    CONCLUSIONS:
    In conclusion, Asiatic acid improved metabolic, hemodynamic abnormalities in MS rats that could be associated with its antioxidant, anti-inflammatory effects and recovering regulation of eNOS/iNOS expression.
    Phytomedicine. 2014 Feb 15;21(3):225-32.
    Antidiabetic and antihyperlipidemic activity of asiatic acid in diabetic rats, role of HMG CoA: in vivo and in silico approaches.[Pubmed: 24075211]
    Hyperlipidemia is an associated complication of diabetes and also a major risk factor for cardiovascular diseases.
    METHODS AND RESULTS:
    The present study was designed to examine the antihyperlipidemic effect of asiatic acid (AA) in streptozotocin (STZ) induced diabetic rats. Diabetes was induced in male Wistar rats by a single intraperitoneal injection of STZ (40 mg/kg b.w.). Diabetic rats show increased plasma glucose, total cholesterol, triglycerides, free fatty acids, phospholipids, low density lipoprotein, very low density liprotein, atherogenic index and decreased insulin and high density lipoprotein in diabetic rats. The activity of 3-hydroxy 3-methylglutaryl coenzyme A (HMG CoA) reductase increased significantly in contrast to the activities of lipoprotein lipase and lecithin cholesterol acyltransferase. In addition, the molecular docking of AA against HMG CoA reductase involved in cholesterol biosynthesis using Argus software. Diabetic rats were treated with AA shifted all these parameters towards normalcy. AA has shown best ligand binding energy 11.8122 kcal/mol. The antihyperlipidemic effect of AA was compared with glibenclamide; a well-known antihyperglycemic drug.
    CONCLUSIONS:
    In conclusion, this study indicates that AA showed an antihyperlipidemic effect in addition to its antidiabetic effect in experimental diabetes.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 2.0462 mL 10.2312 mL 20.4625 mL 40.9249 mL 51.1561 mL
    5 mM 0.4092 mL 2.0462 mL 4.0925 mL 8.185 mL 10.2312 mL
    10 mM 0.2046 mL 1.0231 mL 2.0462 mL 4.0925 mL 5.1156 mL
    50 mM 0.0409 mL 0.2046 mL 0.4092 mL 0.8185 mL 1.0231 mL
    100 mM 0.0205 mL 0.1023 mL 0.2046 mL 0.4092 mL 0.5116 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    去羟加利果酸; Esculentic acid CFN99059 103974-74-9 C30H48O5 = 488.7 5mg QQ客服:215959384
    (2ALPHA,3BETA,4ALPHA)-2,3,23-三羟基乌苏-12,20(30)-二烯-28-酸; Actinidic acid CFN98444 341971-45-7 C30H46O5 = 486.7 5mg QQ客服:215959384
    积雪草酸; Asiatic acid CFN98688 464-92-6 C30H48O5 = 488.7 20mg QQ客服:215959384
    3-O-香豆酰积雪草酸; 3-O-Coumaroylasiatic acid CFN96830 143773-52-8 C39H54O7 = 634.85 5mg QQ客服:1148253675
    积雪草苷; Asiaticoside CFN99912 16830-15-2 C48H78O19 = 959.12 20mg QQ客服:2932563308
    羟基积雪草苷; Madecassoside CFN99913 34540-22-2 C48H78O20 = 975.13 20mg QQ客服:1413575084
    积雪草苷B; Asiaticoside B CFN95124 125265-68-1 C48H78O20 = 975.13 20mg QQ客服:2932563308
    羟基积雪草酸; Madecassic acid CFN99914 18449-41-7 C30H48O6 = 504.70 20mg QQ客服:215959384
    2,24-二羟基熊果酸; 2,24-Dihydroxyursolic acid CFN99481 143839-02-5 C30H48O5 = 488.7 5mg QQ客服:2159513211
    马尾柴酸; Barbinervic acid CFN96162 64199-78-6 C30H48O5 = 488.7 5mg QQ客服:2932563308

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