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  • 桂木黄素; 2',4',5-三羟基-7-甲氧基-6-(3-甲基-1-丁烯基)-3-(3-甲基-2-丁烯基)黄酮

    Artocarpin

    桂木黄素; 2',4',5-三羟基-7-甲氧基-6-(3-甲基-1-丁烯基)-3-(3-甲基-2-丁烯基)黄酮
    产品编号 CFN97239
    CAS编号 7608-44-8
    分子式 = 分子量 C26H28O6 = 436.5
    产品纯度 >=98%
    物理属性 Yellow powder
    化合物类型 Flavonoids
    植物来源 The heartwoods of Artocarpus incisus.
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
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    产品名称 产品编号 CAS编号 包装 QQ客服
    桂木黄素; 2',4',5-三羟基-7-甲氧基-6-(3-甲基-1-丁烯基)-3-(3-甲基-2-丁烯基)黄酮 CFN97239 7608-44-8 1mg QQ客服:2056216494
    桂木黄素; 2',4',5-三羟基-7-甲氧基-6-(3-甲基-1-丁烯基)-3-(3-甲基-2-丁烯基)黄酮 CFN97239 7608-44-8 5mg QQ客服:2056216494
    桂木黄素; 2',4',5-三羟基-7-甲氧基-6-(3-甲基-1-丁烯基)-3-(3-甲基-2-丁烯基)黄酮 CFN97239 7608-44-8 10mg QQ客服:2056216494
    桂木黄素; 2',4',5-三羟基-7-甲氧基-6-(3-甲基-1-丁烯基)-3-(3-甲基-2-丁烯基)黄酮 CFN97239 7608-44-8 20mg QQ客服:2056216494
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • Universidad de Buenos Aires (Argentina)
  • Yale University (USA)
  • Griffith University (Australia)
  • Michigan State University (USA)
  • Universiti Sains Malaysia (Malaysia)
  • John Innes Centre (United Kingdom)
  • Deutsches Krebsforschungszentrum (Germany)
  • VIT University (India)
  • University of Fribourg (Switzerland)
  • Aarhus University (Denmark)
  • Kyoto University (Japan)
  • University of Indonesia (Indonesia)
  • Nicolaus Copernicus Uniwersity (Poland)
  • Institute of Pathophysiology Medical University of Vienna (Austria)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Biochem Systematics and Ecology2017, 11-18
  • Oxid Med Cell Longev2020, 12
  • J Ethnopharmacol.2020, 254:112733.
  • Appl Microbiol Biotechnol.2016, 100(9):3965-77
  • QASCF2022, 14(4).
  • iScience.2020, 23(2):100849.
  • Food Addit Contam Part A.2021, 38(12):1985-1994.
  • J Nat Med.2021, doi: 10.1007.
  • J Herbmed Pharmacol.2018, 7(4):280-286
  • J Ethnopharmacol.2016, 192:370-381
  • Toxins (Basel).2021, 13(12):898.
  • Research on Crops.2017, 18(3):569
  • Phytomedicine.2018, 38:12-23
  • Acta Chromatographica2016, 29(3)
  • Process Biochemistry2019, 85:106-115
  • J Am Soc Mass Spectrom.2021, 32(5):1205-1214.
  • LWT2020, 110397
  • Molecules.2021, 26(23):7390.
  • Horticulture Research2020, 7:111.
  • PLoS One.2018, 13(4):e0195642
  • Biochem Biophys Res Commun.2018, 495(1):1271-1277
  • J Sci Food Agric.2017, 97(5):1656-1662
  • Front Pharmacol.2019, 10:1226
  • ...
  • 生物活性
    Description: Artocarpin has anti- bactericidal effect, can reduce the viability of pneumococci by a factor of >1000, without obvious harm to lung epithelial cells. Artocarpin can prevent skin damage from UVB irradiation-induced photodamage in hairless mice and this is likely mediated through its antioxidant and anti-inflammation mechanisms.Artocarpin possesses potent 5alpha reductase inhibitory effect, it induces apoptosis in HSC-1 and T47D cells through modulation of MAPK and Akt/mTOR pathways, an extrinsic pathway, respectively. Artocarpin has an efficient lightening effect on UV-stimulated hyperpigmented dorsal skins of brownish guinea pigs.
    Targets: COX | TNF-α | IL Receptor | Caspase | ERK | JNK | Akt | mTOR | p38MAPK
    In vitro:
    Evid Based Complement Alternat Med. 2015;2015:236159.
    Artocarpin Induces Apoptosis in Human Cutaneous Squamous Cell Carcinoma HSC-1 Cells and Its Cytotoxic Activity Is Dependent on Protein-Nutrient Concentration.[Pubmed: 25648333]
    Artocarpin, a natural prenylated flavonoid, has been shown to have various biological properties. However, its effects on human cutaneous squamous cell carcinoma (SCC) have not been previously investigated.
    METHODS AND RESULTS:
    We set out to determine whether Artocarpin has cytotoxic effects on SCC cells and whether its pharmacological activity is dependent on protein-nutrient concentration. Our results showed that treatment of HSC-1 cells (a human cutaneous SCC cell line) with Artocarpin decreased cell viability and induced cell apoptosis by increasing caspase 3/7 activity. These effects were more pronounced at low fetal bovine serum (FBS) concentrations. Artocarpin induced an increase in the level of phospho-p38 and a decrease in the levels of phospho-ERK, phospho-JNK, phospho-Akt, phospho-mTOR, and phospho-S6K. High FBS concentrations in the culture media inhibited and delayed the uptake of Artocarpin from the extracellular compartment (culture media) into the intracellular compartment, as determined by high performance liquid chromatography (HPLC) analysis.
    CONCLUSIONS:
    In conclusion, Artocarpin induces apoptosis in HSC-1 cells through modulation of MAPK and Akt/mTOR pathways. Binding of Artocarpin to proteins in the FBS may inhibit cellular uptake and reduce the cytotoxic activity of Artocarpin on HSC-1 cells. Therefore, Artocarpin may have potential use in the future as a form of treatment for cutaneous SCC.
    Int J Med Microbiol. 2015 May;305(3):289-97.
    Antipneumococcal activity of neuraminidase inhibiting artocarpin.[Pubmed: 25592264]
    Streptococcus (S.) pneumoniae is a major cause of secondary bacterial pneumonia during influenza epidemics. Neuraminidase (NA) is a virulence factor of both pneumococci and influenza viruses.
    METHODS AND RESULTS:
    Bacterial neuraminidases (NAs) are structurally related to viral NA and susceptible to oseltamivir, an inhibitor designed to target viral NA. This prompted us to evaluate the antipneumococcal potential of two NA inhibiting natural compounds, the diarylheptanoid katsumadain A and the isoprenylated flavone artocarpin. Chemiluminescence, fluorescence-, and hemagglutination-based enzyme assays were applied to determine the inhibitory efficiency (IC(50) value) of the tested compounds towards pneumococcal NAs. The mechanism of inhibition was studied via enzyme kinetics with recombinant NanA NA. Unlike oseltamivir, which competes with the natural substrate of NA, artocarpin exhibits a mixed-type inhibition with a Ki value of 9.70 μM.
    CONCLUSIONS:
    Remarkably, artocarpin was the only NA inhibitor (NAI) for which an inhibitory effect on pneumococcal growth (MIC: 0.99-5.75 μM) and biofilm formation (MBIC: 1.15-2.97 μM) was observable. In addition, we discovered that the bactericidal effect of artocarpin can reduce the viability of pneumococci by a factor of >1000, without obvious harm to lung epithelial cells. This renders artocarpin a promising natural product for further investigations.
    In vivo:
    Eur J Pharm Biopharm. 2007 Nov;67(3):639-45.
    Targeted transfollicular delivery of artocarpin extract from Artocarpus incisus by means of microparticles.[Pubmed: 17493791 ]
    Artocarpin (Ar), an extract of heartwood of Artocarpus incisus, possesses potent 5alpha reductase inhibitory effect. The penetration of Ar into the deeper layers of the skin where androgen receptors are present is limited. Therefore, this study was aimed to prepare alginate/chitosan (ACS) microparticles for targeted transfollicular delivery.
    METHODS AND RESULTS:
    It was found that a suitable particle size ranging from 2 to 6 microm can be prepared using the ionotropic gelation technique. Entrapment efficiency of Ar in ACS microparticles was 18.7+/-1.7%. The release of Ar from the ACS microparticles over 6 h was 0.7% of the loading dose suitable for a long-term release of Ar in the follicular ducts. The optimal growth suppression of the hamster flank organs could be achieved by topical application of Ar-ACS microparticles with a content of 0.1 mg in 5 mg microparticles to one hamster flank while the other flank (intraspecies control) showed the normal growth of the flank organs and Ar at the same concentration in solution form could not suppress the growth of the flank organs to the same extent.
    CONCLUSIONS:
    The efficiency of Ar 0.1 mg loaded in ACS microparticles was shown to be comparable to a dose of 1 mg Ar applied as solution. However, Ar formulated in microparticles did not show significant systemic action compared to the dermal application of an Ar solution and a flutamide preparation (1 mg) as positive control.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 2.291 mL 11.4548 mL 22.9095 mL 45.819 mL 57.2738 mL
    5 mM 0.4582 mL 2.291 mL 4.5819 mL 9.1638 mL 11.4548 mL
    10 mM 0.2291 mL 1.1455 mL 2.291 mL 4.5819 mL 5.7274 mL
    50 mM 0.0458 mL 0.2291 mL 0.4582 mL 0.9164 mL 1.1455 mL
    100 mM 0.0229 mL 0.1145 mL 0.2291 mL 0.4582 mL 0.5727 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    3-香叶基-5,7,2',4'-四羟基黄酮; 5,7,2',4'-Tetrahydroxy-3-geranylflavone CFN92322 376361-87-4 C25H26O6 = 422.5 5mg QQ客服:1413575084
    桑黄酮; 桑皮黄素; Mulberrin CFN97085 62949-79-5 C25H26O6 = 422.5 20mg QQ客服:1457312923
    桑辛素; Morusin CFN97083 62596-29-6 C25H24O6 = 420.5 20mg QQ客服:2159513211
    桑根皮醇; Morusinol CFN97086 62949-93-3 C25H26O7 = 438.5 5mg QQ客服:215959384
    8-Isomulberrin hydrate; 8-Isomulberrin hydrate CFN97581 N/A C25H28O7 = 440.5 5mg QQ客服:2056216494
    桂木黄素; 2',4',5-三羟基-7-甲氧基-6-(3-甲基-1-丁烯基)-3-(3-甲基-2-丁烯基)黄酮; Artocarpin CFN97239 7608-44-8 C26H28O6 = 436.5 5mg QQ客服:2056216494
    3'-牻牛儿基-3-异戊烯基-5,7,2',4'-四羟基黄酮; 3'-Geranyl-3-prenyl-2',4',5,7-tetrahydroxyflavone CFN97892 1334309-44-2 C30H34O6 = 490.6 5mg QQ客服:1413575084
    桑皮酮A; Kuwanon A CFN90834 62949-77-3 C25H24O6 = 420.5 5mg QQ客服:2056216494
    桑根酮K; Sanggenone K CFN92416 86450-77-3 C30H32O6 = 488.6 5mg QQ客服:3257982914
    桑皮酮G; Kuwanon G CFN93278 75629-19-5 C40H36O11 = 692.71 20mg QQ客服:2159513211

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