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    青蒿酸

    Artemisinic acid

    青蒿酸
    产品编号 CFN97276
    CAS编号 80286-58-4
    分子式 = 分子量 C15H22O2 = 234.3
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Sesquiterpenoids
    植物来源 The herbs of Artemisia annua L.
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    青蒿酸 CFN97276 80286-58-4 10mg QQ客服:2159513211
    青蒿酸 CFN97276 80286-58-4 20mg QQ客服:2159513211
    青蒿酸 CFN97276 80286-58-4 50mg QQ客服:2159513211
    青蒿酸 CFN97276 80286-58-4 100mg QQ客服:2159513211
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • FORTH-IMBB (Greece)
  • Utah State University (USA)
  • Universidade Federal de Pernambuco (UFPE) (Brazil)
  • Universidade de Franca (Brazil)
  • University of Maryland School of Medicine (USA)
  • The University of Newcastle (Australia)
  • Uniwersytet Gdański (Poland)
  • Siksha O Anusandhan University (India)
  • University of Vienna (Austria)
  • Wroclaw Medical University (Poland)
  • Regional Crop Research Institute (Korea)
  • Centrum Menselijke Erfelijkheid (Belgium)
  • Washington State University (USA)
  • Universitas Airlangga (Indonesia)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • New Zealand J. Forestry Sci.2014, 44:17
  • PLoS One.2015, 10(5):e0127060
  • Inflammation.2015, 38(4):1502-16
  • Acta Agriculturae Scandinavica2015, 381-383
  • University of Central Lancashire2017, 20472
  • Biochem Biophys Res Commun.2017, 494(3-4):587-593
  • PLoS One.2018, 13(11):e0208055
  • Microchemical Journal2018, 137:168-173
  • Korean J of Medicinal Crop Science2018, 220-226
  • Journal of Life Science2018, 917-922
  • Biorxiv2019, 10.1101
  • Molecules.2019, 24(6):E1155
  • Food Chem.2019, 290:286-294
  • Chem Biol Interact.2019, 298:1-7
  • Aquaculture2019, 510:392-399
  • Biochem Biophys Res Commun.2020, 522(4):1052-1058
  • Dent Mater J.2020, 39(4):690-695
  • Pharmaceutics.2020, 12(9):882.
  • Biochem Pharmacol.2020, 178:114083
  • Int J Mol Sci.2020, 21(19),7070.
  • Int J Mol Sci.2020, 21(19):7209.
  • Asian Pac J Cancer Prev. 2020, 21(4):935-941.
  • Molecules.2020, 25(18):4283.
  • ...
  • 生物活性
    Description: Artemisinic acid, is the immediate precursor of the semi-synthesis artemisinin, could be a cost-effective, environmentally friendly, high-quality and reliable source of artemisinin. Artemisinic acid has a variety of pharmacological activity, such as antimalarial, anti-tumor, antipyretic, antibacterial, allelopathy and anti-adipogenesis effects. Artemisinic acid is a regulator of adipocyte differentiation and C/EBP δ expression, it inhibits adipogenic differentiation of hAMSCs through reduced expression of C/EBP δ; it inhibits melanogenesis through downregulation of C/EBP α-dependent expression of HMG-CoA reductase gene.
    Targets: Tyrosinase | cAMP | PKA | HMG-CoA Reductase | PPAR | JNK | VEGFR | P450 (e.g. CYP17) | Antifection | C/EBP δ
    In vitro:
    J Cell Biochem. 2012 Jul;113(7):2488-99.
    Artemisinic acid is a regulator of adipocyte differentiation and C/EBP δ expression.[Pubmed: 22396222]
    Adipocyte dysfunction is associated with the development of obesity. In this study, artemisinic acid, which was isolated from Artemisia annua L., inhibited adipogenic differentiation of human adipose tissue-derived mesenchymal stem cells (hAMSCs) and its mechanism of action was determined.
    METHODS AND RESULTS:
    The mRNA levels of peroxidase proliferation-activated receptor (PPAR) γ and CCAAT/enhancer binding protein (C/EBP) α, late adipogenic factors, were reduced by artemisinic acid. Moreover, the mRNA levels of the PPAR γ target genes lipoprotein lipase, CD36, adipocyte protein, and liver X receptor were down-regulated by artemisinic acid. Artemisinic acid reduced expression of the C/EBP δ gene without impacting C/EBP β. In addition, attempts to elucidate a possible mechanism underlying the artemisinic acid-mediated effects revealed that reduced expression of the C/EBP δ gene was mediated by inhibiting Jun N-terminal kinase (JNK). Additionally, artemisinic acid also reduced the expression of the adipogenesis-associated genes glucose transporter-4 and vascular endothelial growth factor. In addition to the interference of artemisinic acid with adipogenesis, artemisinic acid significantly attenuated tumor necrosis factor-α-induced secretion of interleukin-6 by undifferentiated hAMSCs, thus influencing insulin resistance and the inflammatory state characterizing obesity.
    CONCLUSIONS:
    Taken together, these findings indicate that inhibiting adipogenic differentiation of hAMSCs by artemisinic acid occurs primarily through reduced expression of C/EBP δ, which is mediated by the inhibition of JNK and suggest that aremisinic acid may be used as a complementary treatment option for obesity associated with metabolic syndrome.
    Current Science, 2000 , 78 (6) :709-713.
    Antimicrobial activity of artemisinin and its precursors.[Reference: WebLink]
    Artemisinic acid and Arteannuin B are biogenetic precursors of Artemisinin, an important antimalarial produced by the herb Artemisia annua. These compounds have been screened for antimicrobial activity against a range of organisms.
    CONCLUSIONS:
    All the three compounds are active against different bacteria and certain fungal species
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 4.268 mL 21.3402 mL 42.6803 mL 85.3606 mL 106.7008 mL
    5 mM 0.8536 mL 4.268 mL 8.5361 mL 17.0721 mL 21.3402 mL
    10 mM 0.4268 mL 2.134 mL 4.268 mL 8.5361 mL 10.6701 mL
    50 mM 0.0854 mL 0.4268 mL 0.8536 mL 1.7072 mL 2.134 mL
    100 mM 0.0427 mL 0.2134 mL 0.4268 mL 0.8536 mL 1.067 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    青蒿素A; Arteannuin A CFN97308 82442-48-6 C13H18O2 = 206.3 5mg QQ客服:2159513211
    青蒿素M; Arteannuin M CFN98044 207446-90-0 C15H24O4 = 268.4 5mg QQ客服:3257982914
    青蒿素L; Arteannuin L CFN98043 207446-89-7 C15H22O3 = 250.3 5mg QQ客服:2932563308
    青蒿素B; Arteannuin B CFN98807 50906-56-4 C15H20O3 = 248.3 20mg QQ客服:1457312923
    8alpha-Methacryloyloxy-13-ethoxyvernojalcanolide; 8alpha-Methacryloyloxy-13-ethoxyvernojalcanolide CFN89154 142891-14-3 C25H34O11 = 510.53 5mg QQ客服:2159513211
    10beta-Hydroxycadina-4,11(13)-dien-12,8beta-olide; 10beta-Hydroxycadina-4,11(13)-dien-12,8beta-olide CFN89143 35001-23-1 C15H20O3 = 248.32 5mg QQ客服:2932563308
    二氢青蒿酸; Dihydroartemisinic acid CFN93295 85031-59-0 C15H24O2 = 236.35 5mg QQ客服:2932563308
    青蒿素N; Arteannuin N CFN98045 207446-92-2 C15H22O3 = 250.3 5mg QQ客服:3257982914
    4,5-环氧青蒿酸; 4,5-Epoxyartemisinic acid CFN97486 92466-31-4 C15H22O3 = 250.3 5mg QQ客服:2932563308
    alpha-环氧二氢青蒿酸; alpha-Epoxydihydroartemisinic acid CFN98613 380487-65-0 C15H24O3 = 252.4 5mg QQ客服:1457312923

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