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  • Artanin

    Artanin

    Artanin
    产品编号 CFN97547
    CAS编号 96917-26-9
    分子式 = 分子量 C16H18O5 = 290.3
    产品纯度 >=98%
    物理属性 Cryst.
    化合物类型 Coumarins
    植物来源 The herbs of Toddalia asiatica
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    Artanin CFN97547 96917-26-9 1mg QQ客服:3257982914
    Artanin CFN97547 96917-26-9 5mg QQ客服:3257982914
    Artanin CFN97547 96917-26-9 10mg QQ客服:3257982914
    Artanin CFN97547 96917-26-9 20mg QQ客服:3257982914
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • University of Medicine and Pharmacy (Romania)
  • University of Amsterdam (Netherlands)
  • Ain Shams University (Egypt)
  • University of Perugia (Italy)
  • Texas A&M University (USA)
  • Universidad Miguel Hernández (Spain)
  • University of Illinois (USA)
  • Funda??o Universitária de Desenvolvimento (Brazil)
  • University of Liège (Belgium)
  • Institute of Bioorganic Chemistry Polish Academy of Sciences (Poland)
  • Heinrich-Heine-University Düsseldorf (Germany)
  • Instytut Nawozów Sztucznych w Pu?awach (Poland)
  • Nanjing University of Chinese Medicine (China)
  • National Hellenic Research Foundation (Greece)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Journal of Functional Foods2022, 99: 105331.
  • bioRxiv - Molecular Biology2023, 535548.
  • Sci Rep.2018, 8:15059
  • Front Immunol.2017, 8:1542
  • Sci Rep.2017, 7:467-479
  • Korea Institute of Oriental Medicine2020, doi: 10.21203.
  • Int J Biol Macromol.2019, 126:653-661
  • Fitoterapia.2021, 153:104995.
  • Evid-Based Compl Alt2020, 7202519:13
  • Korean J. Food Preserv.2023, 30(4):663-668.
  • Research Square2023, 2883170.
  • J Nat Sc Biol Med2019, 10(2):149-156
  • Acta Physiologiae Plantarum2015, 37:1736
  • Nutrients.2019, 11(11):E2694
  • Journal of Ginseng Research2019, 10.1016
  • Nat Prod Commun.2017, 12(5):771-778
  • Molecules.2022, 27(22):7997.
  • Molecules.2020, 25(23):5636.
  • Environ Toxicol.2019, 34(4):513-520.
  • Korean Journal of Medicinal Crop Science2018, 26(5):382-390
  • American Association for Anatomy2020, doi: 10.1002.
  • Int Immunopharmacol.2021, 101(Pt A):108181.
  • Front Pharmacol.2020, 11:683.
  • ...
  • 生物活性
    Description: Artanin displays promising inhibition against both MSSA and MRSA with minimal inhibitory concentrations (MICs) of 8-64 ug/ml, but very weak against Gram-negative pathogen and yeast with MICs of 256 to ≥1024 ug/ml.
    Targets: Antifection
    In vitro:
    Phytomedicine. 2016 Dec 15;23(14):1814-1820.
    Synergism of coumarins from the Chinese drug Zanthoxylum nitidum with antibacterial agents against methicillin-resistant Staphylococcus aureus (MRSA).[Pubmed: 27912884 ]
    This study is to present in-depth evaluations of in vitro antimicrobial activities of four natural coumarins 5-geranyloxy-7-methoxycoumarin (Gm, 1), (5,7-dimethoxy-8-prenyloxycoumarin (Artanin, Ar, 2)), isopimpinellin (Is, 3) and phellopterin (Ph, 4) from Zanthoxylum nitidum (Roxb.) DC. (Rutaceae) extracts, focusing on their potential restoration the activity of conventional antibacterial agents against clinical MRSA strains.
    METHODS AND RESULTS:
    Bioactivity-guided fractionation and spectral analyses were used to isolate the coumarins and identify the structures, respectively. The double broth microdilution method was used to assay the coumarins' alone activity. The classic checkerboard microdilution and dynamic time-killing methods were used to evaluate combinatory effects. The four plant coumarins Gm (1), Ar (2), Is (3) and Ph (4) were isolated and identified from Z. nitidum extracts. Coumarins 1-4 displayed promising inhibition against both MSSA and MRSA with minimal inhibitory concentrations (MICs) of 8-64μg/ml, but very weak against Gram-negative pathogen and yeast with MICs of 256 to ≥1024μg/ml. The geranyloxy and prenyloxy substitutions showed to be more active than the methoxy substitution on the coumarin skeletons. 1-4 also showing different extent of synergism with a total of eight conventional antibacterial agents, i.e. chloramphenicol (CL), gentamicin (CN), fosfomycin (FF), levofloxacin (LE), minocycline (MI), piperacillin/tazobactam (P/T), teicoplanin (TE) and vancomycin (VA) against ten clinical MRSA strains.
    CONCLUSIONS:
    Four to ten of the tested MRSA strains showed bacteriostatic synergy in the eleven combinations.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 3.4447 mL 17.2236 mL 34.4471 mL 68.8942 mL 86.1178 mL
    5 mM 0.6889 mL 3.4447 mL 6.8894 mL 13.7788 mL 17.2236 mL
    10 mM 0.3445 mL 1.7224 mL 3.4447 mL 6.8894 mL 8.6118 mL
    50 mM 0.0689 mL 0.3445 mL 0.6889 mL 1.3779 mL 1.7224 mL
    100 mM 0.0344 mL 0.1722 mL 0.3445 mL 0.6889 mL 0.8612 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    Artanin; Artanin CFN97547 96917-26-9 C16H18O5 = 290.3 5mg QQ客服:3257982914
    Neoartanin; Neoartanin CFN91660 104196-69-2 C16H18O5 = 290.31 5mg QQ客服:3257982914
    8-香叶基氧基-5,7-二甲氧基香豆素; 8-Geranyloxy-5,7-dimethoxycoumarin CFN99344 1228175-65-2 C21H26O5 = 358.4 5mg QQ客服:1457312923
    Arteminin; Arteminin CFN92736 466639-11-2 C11H10O5 = 222.2 5mg QQ客服:1413575084
    白蜡树精; Fraxinol CFN98768 486-28-2 C11H10O5 = 222.2 5mg QQ客服:215959384
    5-甲氧基莨菪亭; Umckalin CFN70362 43053-62-9 C11H10O5 = 222.2 5mg QQ客服:215959384
    5-羟基-6,7-二甲氧基香豆素; Tomentin CFN98347 28449-62-9 C11H10O5 = 222.2 5mg QQ客服:3257982914
    5,6,7-三甲氧基香豆素; 5,6,7-Trimethoxycoumarin CFN89309 55085-47-7 C12H12O5 = 236.22 5mg QQ客服:1457312923
    5-羟基-6,7,8-甲氧基香豆素; 5-Hydroxy-6,7,8-trimethoxycoumarin CFN89182 1581248-32-9 C12H12O6 = 252.22 5mg QQ客服:215959384
    5,6,7,8-四甲氧基香豆素; 5,6,7,8-Tetramethoxycoumarin CFN98941 56317-15-8 C13H14O6 = 266.3 5mg QQ客服:1457312923

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