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  • 二氢莰非醇; 香橙素

    Aromadendrin

    二氢莰非醇; 香橙素
    产品编号 CFN98736
    CAS编号 480-20-6
    分子式 = 分子量 C15H12O6 = 288.3
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Flavonoids
    植物来源 The barks of Eucalyptus calophylla
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    二氢莰非醇; 香橙素 CFN98736 480-20-6 1mg QQ客服:2159513211
    二氢莰非醇; 香橙素 CFN98736 480-20-6 5mg QQ客服:2159513211
    二氢莰非醇; 香橙素 CFN98736 480-20-6 10mg QQ客服:2159513211
    二氢莰非醇; 香橙素 CFN98736 480-20-6 20mg QQ客服:2159513211
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • Kyushu University (Japan)
  • Sanford Burnham Medical Research Institute (USA)
  • Universidade Federal de Santa Catarina (Brazil)
  • Universidade de Franca (Brazil)
  • University of Auckland (New Zealand)
  • Universiti Malaysia Pahang (Malaysia)
  • Lund University (Sweden)
  • Weizmann Institute of Science (Israel)
  • Universidade do Porto (Portugal)
  • Imperial College London (United Kingdom)
  • Pennsylvania State University (USA)
  • Universiti Putra Malaysia(UPM) (Malaysia)
  • Chungnam National University (Korea)
  • Gyeongsang National University (Korea)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Asian J Beauty Cosmetol2016, 14(3):249-257
  • J Drug Target.2016, 24:1-28
  • Am J Chin Med.2016, 44(6):1255-1271
  • J Chromatogr A.2017, 1518:46-58
  • J Ethnopharmacol.2017, 206:73-77
  • Molecules.2017, 22(2)
  • JPC-Journal of Planar Chromatography 2017, 30(4)
  • Plant Cell Tiss Org2017, 479-486
  • J Pharm Biomed Anal.2018, 151:32-41
  • Molecules.2018, 23(7):E1659
  • Phytother Res.2018, 32(12):2551-2559
  • Biochem Biophys Res Commun.2018, 495(1):1271-1277
  • Asian J Beauty Cosmetol2019, 17(3):287-294
  • J Adv Res.2019, 17:85-94
  • Molecules.2019, 24(16):E3003
  • Molecules.2019, 24(23):E4303
  • Chin J Pharm Anal.2019, 39(7):1217-1228
  • Journal of Third Military Medical University2019, 41(2):110-115
  • J Nat Prod.2019, 82(4):1002-1008
  • Sci Rep.2019, 9(1):4342
  • Biomolecules.2019, 9(11):E696
  • Food Chem.2020, 313:126079
  • Biochem Biophys Res Commun.2020, 522(1):40-46
  • ...
  • 生物活性
    Description: Aromadendrin possesses anti-inflammatory, antioxidant, and anti-diabetic properties, it exhibits anti-inflammatory activity through the suppression of nuclear translocation of NF-κB and phosphorylation of JNK in LPS-stimulated RAW 264.7 macrophage cells. Aromadendrin treatment induces adipogenesis by increases in PPARγ2 expression, resulting in stimulation of glucose uptake and ameliorated insulin resistance, suggests that it may represent a potential therapeutic candidate for the management of type 2 DM. Aromadendrin has inhibitory activity on aldose reductase and the formation of advanced glycation end products.
    Targets: NO | PGE | NOS | COX | NF-kB | JNK | ERK | p38MAPK | PPAR | PI3K | Akt | IkB | IKK
    In vitro:
    Pharmacology. 2011;88(5-6):266-74.
    Stimulation of glucose uptake and improvement of insulin resistance by aromadendrin.[Pubmed: 22056597]
    Agents that stimulate glucose uptake and improve insulin resistance may be useful in the management of type 2 diabetes mellitus (DM). Thus, the aims of this study were to assess the effects of aromadendrin, a flavonoid from Gleditsia sinensis Lam., on stimulation of glucose uptake and improvement of insulin resistance and to characterize the molecular mechanisms underlying these activities.
    METHODS AND RESULTS:
    Insulin-stimulated glucose uptake was measured in HepG2 cells and in differentiated 3T3-L1 adipocytes using 2-[N-(7-nitrobenz-2-oxa-1,3-diazol-4-yl)amino]-2-deoxy-D-glucose (2-NBDG), a fluorescent D-glucose analog. Expression of the peroxisome proliferator-activated receptor-γ2 (PPARγ2) and adipocyte-specific fatty acid binding protein (aP2) mRNAs and the PPARγ2 protein was analyzed in adipocytes using RT-PCR and immunoblotting, respectively. Insulin-stimulated protein kinase B (Akt/PKB) phosphorylation was measured in high glucose-induced, insulin-resistant HepG2 cells. Similar to 30 μmol/l rosiglitazone, treatment with 30 μmol/l aromadendrin significantly stimulated insulin-sensitive glucose uptake in both HepG2 cells and 3T3-L1 adipocytes. Aromadendrin treatment also enhanced adipogenesis and caused increases in the expression of PPARγ2 and aP2 mRNAs and the PPARγ2 protein in differentiated 3T3-L1 adipocytes. In high glucose-induced, insulin-resistant HepG2 cells, aromadendrin reversed the inhibition of Akt/PKB phosphorylation in response to insulin, which could be abrogated by pretreatment with LY294002, a phosphatidylinositol 3-kinase (PI3K) inhibitor. Aromadendrin treatment induced adipogenesis by increases in PPARγ2 expression, resulting in stimulation of glucose uptake and ameliorated insulin resistance.
    CONCLUSIONS:
    These findings suggest that aromadendrin may represent a potential therapeutic candidate for the management of type 2 DM.
    Food Sci. Biotechnol., 2011, 20(5):1283-8.
    Inhibitory Activity of Aromadendrin from Prickly Pear (Opuntia ficus-indica) Root on Aldose Reductase and the Formation of Advanced Glycation End Products.[Reference: WebLink]
    Prickly pear (Opuntia ficus-indica) is a longdomesticated crop plant of arid and semiarid parts of the world.
    METHODS AND RESULTS:
    The efficacy of extracts of prickly pear root for managing diabetes and diabetes complications was evaluated using a variety of in vitro bioassays. The ethyl acetate-soluble fraction was most effective in the prevention of diabetes and its complications via the inhibition of rat lens aldose reductase activity, the formation of advanced glycation end products, and α-glucosidase activity.
    CONCLUSIONS:
    MS and NMR were used to identify the bioactive compound from the ethyl acetate-soluble fraction as 3,5,7,4′-tetrahydroxyflavanone (Aromadendrin).
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 3.4686 mL 17.343 mL 34.6861 mL 69.3722 mL 86.7152 mL
    5 mM 0.6937 mL 3.4686 mL 6.9372 mL 13.8744 mL 17.343 mL
    10 mM 0.3469 mL 1.7343 mL 3.4686 mL 6.9372 mL 8.6715 mL
    50 mM 0.0694 mL 0.3469 mL 0.6937 mL 1.3874 mL 1.7343 mL
    100 mM 0.0347 mL 0.1734 mL 0.3469 mL 0.6937 mL 0.8672 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    3,4',7-三羟基黄烷酮; Garbanzol CFN96497 1226-22-8 C15H12O5 = 272.25 5mg QQ客服:2159513211
    二氢莰非醇; 香橙素; Aromadendrin CFN98736 480-20-6 C15H12O6 = 288.3 5mg QQ客服:1148253675
    (2R,3R)-2,3-二氢-3-羟基-5,7-二甲氧基-2-(4-甲氧基苯基)-4H-1-苯并吡喃-4-酮; 3-Hydroxy-4',5,7-trimethoxyflavanone CFN97247 76792-94-4 C18H18O6 = 330.3 5mg QQ客服:3257982914
    6-甲基-7-O-甲氧基香橙素; 6-Methyl-7-O-methylaromadendrin CFN96109 852385-13-8 C17H16O6 = 316.3 5mg QQ客服:215959384
    Gericudranin E; Gericudranin E CFN91902 172104-07-3 C22H18O7 = 394.37 5mg QQ客服:1148253675
    2-羟基柚皮素; 2-Hydroxynaringenin CFN97950 58124-18-8 C15H12O6 = 288.3 5mg QQ客服:3257982914

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