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  • 马兜铃酸A

    Aristolochic acid A

    马兜铃酸A
    产品编号 CFN99505
    CAS编号 313-67-7
    分子式 = 分子量 C17H11O7N = 341.27
    产品纯度 >=98%
    物理属性 Yellow powder
    化合物类型 Alkaloids
    植物来源 The herbs of Aristolochia debilis Sieb. et Zucc.
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
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    产品名称 产品编号 CAS编号 包装 QQ客服
    马兜铃酸A CFN99505 313-67-7 10mg QQ客服:2159513211
    马兜铃酸A CFN99505 313-67-7 20mg QQ客服:2159513211
    马兜铃酸A CFN99505 313-67-7 50mg QQ客服:2159513211
    马兜铃酸A CFN99505 313-67-7 100mg QQ客服:2159513211
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
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    PMID: 29328914

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    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
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    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
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    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

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  • 国外学术期刊发表的引用ChemFaces产品的部分文献
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  • ...
  • 生物活性
    Description: Aristolochic acid A is a potent nephrotoxin, which strongly induced toxic damage during ovarian maturation by inhibiting Akt phosphorylation-mediated suppression of apoptosis.
    Targets: Bcl-2/Bax | Caspase | PARP | Akt
    In vitro:
    Chem Res Toxicol. 2014 Dec 15;27(12):2128-35.
    Aristolochic Acid A induces ovarian toxicity by inhibition of akt phosphorylation.[Pubmed: 25406029]
    Aristolochic acids are natural products found in Chinese herbs of the Aristolochiaceae family. Aristolochic acid I (Aristolochic acid A,AAI) is a potent carcinogen and was found to be toxic in animal and clinical studies. Apoptosis is a rapid, selective process of physiological cell deletion that regulates the balance between cell proliferation and cell death and is induced by various kinds of damage. However, the toxicity of AAI during ovarian maturation in the mouse is unclear and is the subject of the present investigation.
    METHODS AND RESULTS:
    We used Chinese hamster ovary-K1 (CHO-K1) cells and an AAI injection mouse model: MTT assay was used to assess AA toxicity to cells; ovary size and weight were measured to determine the toxicity of AA to mouse ovary; western blot was used to assess apoptosis; TUNEL assay was used to evaluate apoptotic cell death; and immunohistochemistry was used to examine the local expression of apoptotic proteins in ovary tissue. We found that AAI significantly inhibits the viability of CHO-K1 cells and strongly induces apoptotic cell death in CHO-K1 cells and in mouse ovary. In addition, we observed that AAI markedly increases the expression of pro-apoptotic proteins, including Bax, caspase-3, caspase-9, and poly(ADP) ribose polymerase (PARP). In contrast, anti-apoptotic proteins, such as Bcl-2 and survivin, were decreased by AAI treatment. Furthermore, we observed that ovary size and weight were significantly reduced and that the number of ovulated oocytes was markedly suppressed in AAI-treated mice.
    CONCLUSIONS:
    These results suggest that AAI strongly induces toxic damage during ovarian maturation by inhibiting Akt phosphorylation-mediated suppression of apoptosis.
    Toxicol Lett . 2018 Jul;291:129-137.
    Aristolochic acid I interferes with the expression of BLCAP tumor suppressor gene in human cells[Pubmed: 29655784]
    Abstract Aristolochic acid I (AAI) is a phytocompound that is linked to the progressive renal disease and development of human urothelial carcinoma. The bladder cancer-associated protein (BLCAP) gene exhibits a tumor suppressor function in various tumors, including bladder carcinoma. This study evaluated the effect of AAI on BLCAP expression and its associated mechanism in human cells. Administering AAI to human embryonic kidney cells (HEK293), human proximal tubule epithelial cells (HK-2) and urinary bladder cancer cells (HT-1376) significantly reduced the expression of BLCAP mRNA and protein. AAI also effectively suppressed the luciferase activities driven by BLCAP promoters of various lengths in HEK293 cells. AAI significantly reduced both activator protein 1 (AP-1) and nuclear factor-κB (NF-κB) activities in reporter assays, but further point mutations revealed that Ap-1 and NF-κB binding sites on the BLCAP promoter were not AAI-responsive elements. Application of the DNA methyltransferase inhibitor, 5-aza-2'-deoxycytidine (5-aza-dC), reversed the decline of BLCAP expression that had been induced by AAI. However, AAI exposure did not alter hypermethylation of the BLCAP promoter, determined by methyl-specific polymerase chain reaction (PCR) and bisulfate sequencing. Knocking down BLCAP in HEK293 cell line enhanced the potential for cellular migration, invasion, and proliferation, along with the induction of a capacity for anchorage-independent growth. In conclusion, AAI down-regulated the expression of BLCAP gene and the deficiency in BLCAP expression contributed to the malignant transformation of human cells, implying that BLCAP may have a role in mediating AAI-associated carcinogenesis. Keywords: Aristolochic acid; BLCAP; Bladder cancer associated protein; Carcinogenesis; HEK293.
    In vivo:
    Zhong Yao Cai. 2010 Aug;33(8):1228-33.
    The determination of aristolochic acid A in different processed Aristolochia manshuriensis and the test of influence about renal function in rats.[Pubmed: 21213532]
    To study and approach the processing methods and mechanism which can markedly reduce the content of aristolochic acid in Aristolochia manshuriensis and lighten the nephrotoxicity of aristolochic acid.
    METHODS AND RESULTS:
    A traditional "attenuation" processing method was used and 30 types of samples which contain one crude and 29 types of processed sample were obtained. The contents of aristolochic acid A in every sample were determined by HPLC. According to the Rat's acute renal injury test, the influence of animal's renal function was investigated for representative samples. The content of aristolochic acid in six types of samples depressed markedly (30% or more depressed) which processing with boiling in the limewater, steaming with limewater, boiling in the juice of liquorice, boiling in the decoction of black soybean, boiling in the soda water and stir-baked with talcum powder, the content of aristolochic acid in other processed samples also depressed with a large discrepancy. The toxicology test results showed that the above-mentioned 6 samples all can relieve renal injury of rats. There could be some associativity between the degree of renal injury relieving and the content of aristolochic acid A in the samples.
    CONCLUSIONS:
    The content of aristolochic acid can be reduced and the nephrotoxicity for animals can be lightened with some eligible processing methods for the traditional Chinese medicines containing aristolochic acid with the representative of Aristolochia manshuriensis.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 2.9302 mL 14.6512 mL 29.3023 mL 58.6046 mL 73.2558 mL
    5 mM 0.586 mL 2.9302 mL 5.8605 mL 11.7209 mL 14.6512 mL
    10 mM 0.293 mL 1.4651 mL 2.9302 mL 5.8605 mL 7.3256 mL
    50 mM 0.0586 mL 0.293 mL 0.586 mL 1.1721 mL 1.4651 mL
    100 mM 0.0293 mL 0.1465 mL 0.293 mL 0.586 mL 0.7326 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    阿戈美拉汀; Agomelatine CFN90003 138112-76-2 C15H17NO2 = 243.3 5mg QQ客服:215959384
    7-甲氧基-1-萘乙酸; 7-Methoxy-1-naphthaleneacetic acid CFN90088 6836-22-2 C13H12O3 = 216.23 5mg QQ客服:3257982914
    7-甲氧基-1-萘基乙酸乙酯; 7-Methoxy-1-naphthaleneacetic acid ethyl ester CFN90087 6836-21-1 C15H16O3 = 244.29 5mg QQ客服:2159513211
    红根草内酯; Salpriolactone CFN92248 132278-72-9 C15H14O3 = 242.3 5mg QQ客服:2159513211
    羊蹄素; Nepodin CFN96584 3785-24-8 C13H12O3 = 216.24 5mg QQ客服:2056216494
    芦荟大黄素 8-葡萄糖甙; Torachrysone 8-O-glucoside CFN97101 64032-49-1 C20H24O9 = 408.4 20mg QQ客服:1457312923
    Cassiaglycoside II; Cassiaglycoside II CFN95130 2241081-56-9 C25H32O14 = 556.5 5mg QQ客服:3257982914
    Torosachrysone 8-O-beta-gentiobioside; Torosachrysone 8-O-beta-gentiobioside CFN95131 94356-13-5 C28H36O15 = 612.6 5mg QQ客服:2159513211
    马兜铃酸C; Aristolochic acid C CFN90516 4849-90-5 C16H9NO7 = 327.25 20mg QQ客服:1457312923
    马兜铃酸A; Aristolochic acid A CFN99505 313-67-7 C17H11O7N = 341.27 20mg QQ客服:1457312923

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