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  • 番荔枝碱

    (-)-Anonaine

    番荔枝碱
    产品编号 CFN91018
    CAS编号 1862-41-5
    分子式 = 分子量 C17H15NO2 = 265.31
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Alkaloids
    植物来源 The leaves of Nelumbo nucifera
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    番荔枝碱 CFN91018 1862-41-5 1mg QQ客服:2159513211
    番荔枝碱 CFN91018 1862-41-5 5mg QQ客服:2159513211
    番荔枝碱 CFN91018 1862-41-5 10mg QQ客服:2159513211
    番荔枝碱 CFN91018 1862-41-5 20mg QQ客服:2159513211
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • Martin Luther University of Halle-Wittenberg (Germany)
  • Universite de Lille1 (France)
  • University of Liège (Belgium)
  • Osmania University (India)
  • MTT Agrifood Research Finland (Finland)
  • The Vancouver Prostate Centre (VPC) (Canada)
  • Institute of Tropical Disease Universitas Airlangga (Indonesia)
  • Ain Shams University (Egypt)
  • Research Unit Molecular Epigenetics (MEG) (Germany)
  • FORTH-IMBB (Greece)
  • Warszawski Uniwersytet Medyczny (Poland)
  • Anna University (India)
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  • University of Bonn (Germany)
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  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Front Pharmacol.2022, 13:919230.
  • Heliyon2020, 6(6):e04337.
  • Molecules.2020, 25(3):734
  • Nat Commun.2021, 12(1):681.
  • Bull. Pharm. Sci., Assiut University2020, 43(2):149-155.
  • Chinese J of Tissue Engineering Res.2022, 26(17): 2636-2641.
  • J Nat Med.2017, 71(2):380-388
  • Environ Toxicol.2021, doi: 10.1002
  • ACS Nano.2018, 12(4):3385-3396
  • JEJU National University2022, 24032.
  • Plant Pathology2022, 10.1111:ppa.13651.
  • J Traditional Thai Medical Res.2022, 8(1):pp1-14.
  • BMC Complement Altern Med.2019, 19(1):367
  • Cell.2018, 172(1-2):249-261
  • PLoS One.2021, 16(9):e0257243.
  • Antioxidants (Basel).2021, 10(10):1638.
  • Mediators Inflamm. 2016, 2016:6189590
  • BMB Rep.2020, 53(4):218-222.
  • Heliyon.2023, 9(12):e22932.
  • Biomedicines.2022, 10(3):583.
  • Korean Herb. Med. Inf.2020, 8(2):205-213
  • Int J Mol Sci.2021, 22(12):6466.
  • Applied Biological Chemistry2022, 65(12)
  • ...
  • 生物活性
    Description: (-)-Anonaine has some anticancer activity, it induces apoptosis through Bax- and caspase-dependent pathways in human cervical cancer (HeLa) cells, it induces DNA damage and inhibits growth and migration of human lung carcinoma h1299 cells. (-)-Anonaine may be considered a potent compound for chemotherapy against cervical cancer or a health food supplement for cancer chemoprevention. (-)-Anonaine has vasorelaxant effect.
    Targets: Bcl-2/Bax | Caspase | p53 | PARP | PDE | Calcium Channel
    In vitro:
    Planta Med. 2004 Jul;70(7):603-9.
    Vascular activity of (-)-anonaine, (-)-roemerine and (-)-pukateine, three natural 6a(R)-1,2-methylenedioxyaporphines with different affinities for alpha1-adrenoceptor subtypes.[Pubmed: 15254852 ]
    We have studied the mechanism of action of three 6a( R)-1,2-methylenedioxyaporphines as vasorelaxant compounds.
    METHODS AND RESULTS:
    The alkaloids assayed showed different affinities for the three human cloned alpha (1)-adrenoceptor (AR) subtypes stably expressed in rat-1 fibroblasts, showing lower affinity for alpha(1B)-AR with regard to the alpha(1A)- or alpha(1D)-subtypes. These three natural compounds are more potent inhibitors of [ (3)H]-prazosin binding than of [ (3)H]-diltiazem binding to rat cerebral cortical membranes. As all these alkaloids inhibited noradrenaline (NA)-induced [ (3)H]-inositol phosphate formation in cerebral cortex and rat tail artery, they may be safely viewed as alpha (1)-AR antagonists, as is demonstrated by the vasorelaxant responses observed in isolated rat tail artery and/or aorta precontracted with NA. The alkaloids also inhibited the contractile response evoked by KCl (80 mM) but with a lower potency than that shown against NA-induced contraction. We have also examined their ability to inhibit the different forms of cyclic nucleotide phosphodiesterases (PDE) isolated from bovine aortic smooth muscle and endothelial cells, with negative results.
    CONCLUSIONS:
    We conclude that N-methylation favours the interaction of (R)-aporphines with all alpha (1)-AR subtypes, and that the topography of the binding site recognizing the basic or protonated nitrogen atom is similar in all three alpha (1)-AR subtypes. The presence of a hydroxy group at C-11 has different effects on the affinity for each alpha (1)-AR subtype but decreases the affinity for Ca (2+) channels. These results confirm and extend the view that subtle changes in the hydroxylation patterns on the aromatic ring of the aporphine structure affect the interactions of these compounds with the three alpha (1)-AR subtypes in different ways, suggesting that the binding site recognizing the aporphine skeleton is different in each of the three subtypes..
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 3.7692 mL 18.8459 mL 37.6918 mL 75.3835 mL 94.2294 mL
    5 mM 0.7538 mL 3.7692 mL 7.5384 mL 15.0767 mL 18.8459 mL
    10 mM 0.3769 mL 1.8846 mL 3.7692 mL 7.5384 mL 9.4229 mL
    50 mM 0.0754 mL 0.3769 mL 0.7538 mL 1.5077 mL 1.8846 mL
    100 mM 0.0377 mL 0.1885 mL 0.3769 mL 0.7538 mL 0.9423 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    10-O-甲基汝兰碱; 1,2-Methylenedioxy-3,10,11-trimethoxynoraporphine CFN96039 14050-90-9 C20H21NO5 = 355.4 5mg QQ客服:215959384
    阿朴雷因; Aporheine CFN97932 2030-53-7 C18H17NO2 = 279.3 5mg QQ客服:215959384
    新木姜子素; Neolitsine CFN97947 2466-42-4 C19H17NO4 = 323.4 5mg QQ客服:215959384
    氧代海罂粟碱; Oxoglaucine CFN90508 5574-24-3 C20H17NO5 = 351.34 5mg QQ客服:215959384
    鹅掌楸碱; Liriodenine CFN98715 475-75-2 C17H9NO3 = 275.3 5mg QQ客服:2159513211
    Lauterine; Lauterine CFN96757 28200-65-9 C18H11NO4 = 305.28 5mg QQ客服:1457312923
    观音莲明碱; Lysicamine CFN93254 15444-20-9 C18H13NO3 = 291.3 5mg QQ客服:2159513211
    3-Methoxyoxohernandaline; 3-Methoxyoxohernandaline CFN89535 872729-34-5 C29H25NO9 = 531.51 5mg QQ客服:215959384
    1,2,3,10-Tetramethoxy-9-(2-hydroxy-4,5-dimethoxybenzyloxy)oxoaporphine; 1,2,3,10-Tetramethoxy-9-(2-hydroxy-4,5-dimethoxybenzyloxy)oxoaporphine CFN89548 872729-33-4 C29H27NO9 = 533.52 5mg QQ客服:215959384
    去甲头花千金藤二酮B; Norcepharadione B CFN98975 57576-41-7 C18H13NO4 = 307.3 5mg QQ客服:2056216494

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