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  • 当归醇A

    Angelol A

    当归醇A
    产品编号 CFN90999
    CAS编号 19625-17-3
    分子式 = 分子量 C20H24O7 = 376.4
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Coumarins
    植物来源 The roots of Angelica sinensis.
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    当归醇A CFN90999 19625-17-3 1mg QQ客服:1413575084
    当归醇A CFN90999 19625-17-3 5mg QQ客服:1413575084
    当归醇A CFN90999 19625-17-3 10mg QQ客服:1413575084
    当归醇A CFN90999 19625-17-3 20mg QQ客服:1413575084
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
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    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
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    IF=13.297(2019)

    PMID: 28005066

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  • ...
  • 生物活性
    Description: Angelol A and angelol B are passive diffusion as the dominating process in Caco-2 cell monolayer model.
    In vitro:
    Zhong Xi Yi Jie He Xue Bao. 2008 Apr;6(4):392-8.
    Absorption and transport of 6 coumarins isolated from the roots of Angelica pubescens f. biserrata in human Caco-2 cell monolayer model.[Pubmed: 18405608]
    To study the absorption and transepithelial transport of six coumarins (umbelliferone, osthole, columbianadin, columbianetin acetate, angelol A and angelol B, isolated from the roots of Angelica pubescens f. biserrata) in the human Caco-2 cell monolayer model.
    METHODS AND RESULTS:
    The in vitro cultured human colon carcinoma cell line, Caco-2 cell monolayer model, was applied to study the absorption and transport of the six coumarins from apical (AP) to basolateral (BL) side and from BL to AP side. The six coumarins were measured by reversed-phase high-performance liquid chromatography (HPLC) coupled with ultraviolet absorption detector. Transport parameters and apparent permeability coefficients (P(app)) were calculated and compared with those of propranolol as a control substance of high permeability and atenolol as a control substance of poor permeability. The transport mechanism of angelol B was assayed by using iodoacetamide as a reference standard to inhibit ATP-dependent transport and MK571 as a well-known inhibitor of MRP2. The absorption and transport of six coumarins were passive diffusion as the dominating process. The P(app) values of umbelliferone, osthole, columbianadin, columbianetin acetate, angelol A and angelol B from AP to BL side were (2.679+/-0.263) x 10(-5), (1.306+/-0.324) x 10(-5), (0.595+/-0.086) x 10(-6), (2.930+/-0.410) x 10(-6), (1.532+/-0.444) x 10(-5) and (1.413+/-0.243) x 10(-5) cm/s, and from BL to AP side were (3.381+/-0.410) x 10(-5), (0.898+/-0.134) x 10(-5), (0.510+/-0.183) x 10(-6), (0.222+/-0.025) x 10(-6), (1.203+/-0.280) x 10(-5) and (0.754+/-0.092) x 10(-5) cm/s, respectively. In this assay, the P(app) value of propranolol was 2.18 x 10(-5) cm/s and the P(app) value of atenolol was 2.77 x 10(-7) cm/s. Among the 6 coumarins, the P(app) values of umbelliferone, osthole, angelol A and angelol B from AP to BL side were identical with that of propranolol, and columbianadin and columbianetin acetate lied between propranolol and atenolol. When replaced the HBSS with EBSS, and iodoacetamide or MK-591 were used in the experiment, the P(app) of angelol-B had no statistical difference as compared with the control group. In the mean total recoveries, umbelliferone was (83.31+/-3.52)%, angelol A was (77.39+/-7.38)%, osthole, columbianadin and angelol B were between 50% to 65%, and columbianetin acetate was lower than 10%. The accumulation rates of osthole and columbianadin in the Caco-2 cells were (36.15+/-5.87)% and (53.90+/-4.39)%, respectively.
    CONCLUSIONS:
    The absorption and transport of umbelliferone, osthole, columbianadin, columbianetin acetate, angelol A and angelol B are passive diffusion as the dominating process in Caco-2 cell monolayer model. Umbelliferone, osthole, angelol A and angelol B are estimated to be highly absorbed compounds, and columbianadin and columbianetin acetate are estimated to be moderately absorbed compounds. In the Caco-2 cells, osthol and columbianadin appear to accumulate, and columbianetin acetate may be metabolized. The absorption and transport of angelol B are not influenced by the change of pH and the presence of iodoacetamide or MK571.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 2.6567 mL 13.2837 mL 26.5675 mL 53.135 mL 66.4187 mL
    5 mM 0.5313 mL 2.6567 mL 5.3135 mL 10.627 mL 13.2837 mL
    10 mM 0.2657 mL 1.3284 mL 2.6567 mL 5.3135 mL 6.6419 mL
    50 mM 0.0531 mL 0.2657 mL 0.5313 mL 1.0627 mL 1.3284 mL
    100 mM 0.0266 mL 0.1328 mL 0.2657 mL 0.5313 mL 0.6642 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    6-(1,2-二羟基-3-甲基-3-丁烯基)-7-甲氧基-2H-1-苯并吡喃-2-酮; Thamnosmonin CFN96622 60094-90-8 C15H16O5 = 276.28 5mg QQ客服:2159513211
    白花前胡醇; Peucedanol CFN99738 28095-18-3 C15H18O5 = 278.30 5mg QQ客服:3257982914
    (R)-白花前胡醇 3'-O-beta-D-吡喃葡萄糖苷; Peucedanol 3'-O-glucoside CFN89411 65891-61-4 C20H26O10 = 426.41 5mg QQ客服:215959384
    (R)-白花前胡醇 7-O-beta-D-吡喃葡萄糖苷; Peucedanol 7-O-glucoside CFN89412 65853-04-5 C20H26O10 = 426.41 5mg QQ客服:2056216494
    Peujaponiside; Peujaponiside CFN93412 155740-16-2 C25H34O14 = 558.5 5mg QQ客服:1413575084
    当归醇A; Angelol A CFN90999 19625-17-3 C20H24O7 = 376.4 10mg QQ客服:1457312923
    当归醇M; Angelol M CFN95060 1092952-64-1 C20H24O7 = 376.4 5mg QQ客服:1413575084
    当归醇B; Angelol B CFN91000 83156-04-1 C20H24O7 = 376.4 10mg QQ客服:3257982914
    当归醇K; Angelol K CFN80136 169736-93-0 C20H24O7 = 376.15 5mg QQ客服:3257982914
    当归醇G; Angelol G CFN92988 83199-38-6 C20H24O7 = 376.40 10mg QQ客服:1413575084

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