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    异补骨脂素

    Angelicin

    异补骨脂素
    产品编号 CFN98854
    CAS编号 523-50-2
    分子式 = 分子量 C11H6O3 = 186.2
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Coumarins
    植物来源 The seeds of Psoralea grandulosa
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
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    异补骨脂素 CFN98854 523-50-2 10mg QQ客服:1457312923
    异补骨脂素 CFN98854 523-50-2 20mg QQ客服:1457312923
    异补骨脂素 CFN98854 523-50-2 50mg QQ客服:1457312923
    异补骨脂素 CFN98854 523-50-2 100mg QQ客服:1457312923
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • University of Maryland (USA)
  • University of Toronto (Canada)
  • University of Queensland (Australia)
  • Weizmann Institute of Science (Israel)
  • Aveiro University (Portugal)
  • Shanghai Institute of Biochemistry and Cell Biology (China)
  • Utrecht University (Netherlands)
  • MTT Agrifood Research Finland (Finland)
  • Griffith University (Australia)
  • Wroclaw Medical University (Poland)
  • Heinrich-Heine-University Düsseldorf (Germany)
  • University of Vienna (Austria)
  • Kitasato University (Japan)
  • University of Brasilia (Brazil)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Int J Mol Sci. 2014, 15(5):8443-57
  • Industrial Food Engineering2015, 19(4):408-413
  • Tea Res. Ins. Of China2017, 1-12
  • Exp Parasitol.2017, 183:160-166
  • Food Chem.2017, 221:1135-1144
  • LWT-Food Science and Technology2017, 75:488-496
  • Arch Toxicol.2017, 91(10):3225-3245
  • Neuropharmacology.2018, 131:68-82
  • Phys Chem Chem Phys.2018, 20(23):15986-15994
  • Biomol Ther (Seoul).2019, 10.4062
  • Food and Fermentation Industries2019, 45(7):45-51
  • J Asian Nat Prod Res.2019, 5:1-17
  • J of Ana. Chem.2019, 74(11):1113-1121
  • Biomed Chromatogr.2019, 8:e4774
  • Appl. Sci.2020, 10(16),5482.
  • Appl. Sci.2020, 10(5),1713.
  • Int J Biol Macromol.2020, 161:1230-1239.
  • J Ethnopharmacol.2020, 260:112988.
  • Biomol Ther (Seoul).2020, 28(6):542-548.
  • The Journal of Phytopharmacology2020, 9(1): 1-4
  • Antioxidants (Basel).2020, 9(6):466.
  • American Association for Anatomy2020, doi: 10.1002.
  • J of Pharmaceutical Analysis2020, doi: 10.1016
  • ...
  • 生物活性
    Description: Angelicin has anti-cancer, antiviral, and anti-inflammatory activities; it regulates LPS-induced inflammation via inhibiting MAPK/NF-κB pathways. Angelicin is a powerful inducer of erythroid differentiation and -globin mRNA accumulation of human leukemia K562 cells, it is a potential therapeutic approach in hematological disorders, including -beta-thalassemia and sickle cell anemia.
    Targets: p65 | NF-kB | IkB | p38MAPK | JNK | Bcl-2/Bax | Caspase | PI3K | Akt | GSK-3 | Antifection | IKK
    In vitro:
    J Surg Res. 2013 Nov;185(1):300-9.
    Angelicin regulates LPS-induced inflammation via inhibiting MAPK/NF-κB pathways.[Pubmed: 23816246]
    Angelicin is a furocoumarin found in Psoralea corylifolia L. fruit. The purpose of this study was to investigate the protective ability of angelicin against inflammation in lipopolysaccharide (LPS)-stimulated RAW 264.7 cells and LPS-induced in vivo acute lung injury model.
    METHODS AND RESULTS:
    The concentrations of tumor necrosis factor alpha (TNF-α) and interleukin (IL)-6 in the culture supernatants of RAW 264.7 cells were determined 24 h after LPS administration. ALI was induced by intratracheal instillation of LPS. Six hours after LPS inhalation, bronchoalveolar lavage fluid and lung tissue samples were obtained for enzyme-linked immunosorbent assay, histologic, and Western blotting analyses. The results showed that pretreatment with angelicin markedly downregulated TNF-α and IL-6 levels in vitro and in vivo, and significantly decreased the amount of inflammatory cells, lung wet-to-dry weight ratio, and myeloperoxidase activity in LPS-induced ALI mice. Furthermore, Western blotting analysis results demonstrated that angelicin blocked the phosphorylation of IκBα, NF-κBp65, p38 MAPK, and JNK in LPS-induced ALI.
    CONCLUSIONS:
    These results suggest that angelicin was potentially advantageous to prevent inflammatory diseases by inhibiting NF-κB and MAPK pathways. Our data indicated that angelicin might be a potential new agent for prevention of inflammatory reactions and diseases in the clinic.
    J. Med. Chem., 2010, 53(4):1519-33.
    Anti-influenza drug discovery: structure-activity relationship and mechanistic insight into novel angelicin derivatives.[Pubmed: 20092255 ]

    METHODS AND RESULTS:
    By using a cell-based high throughput screening campaign, a novel angelicin derivative 6a was identified to inhibit influenza A (H1N1) virus induced cytopathic effect in Madin-Darby canine kidney cell culture in low micromolar range. Detailed structure-activity relationship studies of 6a revealed that the angelicin scaffold is essential for activity in pharmacophore B, while meta-substituted phenyl/2-thiophene rings are optimal in pharmacophore A and C. The optimized lead 4-methyl-9-phenyl-8-(thiophene-2-carbonyl)-furo[2,3-h]chromen-2-one (8g, IC(50) = 70 nM) showed 64-fold enhanced activity compared to the high throughput screening (HTS) hit 6a. Also, 8g was found effective in case of influenza A (H3N2) and influenza B virus strains similar to approved anti-influenza drug zanamivir (4).
    CONCLUSIONS:
    Preliminary mechanistic studies suggest that these compounds act as anti-influenza agents by inhibiting ribonucleoprotein (RNP) complex associated activity and have the potential to be developed further, which could form the basis for developing additional defense against influenza pandemics.
    Eur J Haematol. 2003 Sep;71(3):189-95.
    Accumulation of gamma-globin mRNA in human erythroid cells treated with angelicin.[Pubmed: 12930320]
    The aim of the present study was to determine whether angelicin is able to increase the expression of gamma-globin genes in human erythroid cells. Angelicin is structurally related to psoralens, a well-known chemical class of photosensitizers used for their antiproliferative activity in treatment of different skin diseases (i.e., psoriasis and vitiligo).
    METHODS AND RESULTS:
    To verify the activity of angelicin, we employed two experimental cell systems, the human leukemic K562 cell line and the two-phase liquid culture of human erythroid progenitors isolated from normal donors. The results of our investigation suggest that angelicin, compared with cytosine arabinoside, mithramycin and cisplatin, is a powerful inducer of erythroid differentiation and gamma-globin mRNA accumulation of human leukemia K562 cells. In addition, when normal human erythroid precursors were cultured in the presence of angelicin, increases of gamma-globin mRNA accumulation and fetal hemoglobin (HbF) production, even higher than those obtained using hydroxyurea, were detected.
    CONCLUSIONS:
    These results could have practical relevance, as pharmacologically-mediated regulation of the expression of human gamma-globin genes, leading to HbF induction, is considered a potential therapeutic approach in hematological disorders, including beta-thalassemia and sickle cell anemia.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 5.3706 mL 26.8528 mL 53.7057 mL 107.4114 mL 134.2642 mL
    5 mM 1.0741 mL 5.3706 mL 10.7411 mL 21.4823 mL 26.8528 mL
    10 mM 0.5371 mL 2.6853 mL 5.3706 mL 10.7411 mL 13.4264 mL
    50 mM 0.1074 mL 0.5371 mL 1.0741 mL 2.1482 mL 2.6853 mL
    100 mM 0.0537 mL 0.2685 mL 0.5371 mL 1.0741 mL 1.3426 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    异补骨脂素; Angelicin CFN98854 523-50-2 C11H6O3 = 186.2 20mg QQ客服:1413575084
    6-甲氧基当归素; Sphondin CFN98763 483-66-9 C12H8O4 = 216.2 5mg QQ客服:1457312923
    异佛手柑内酯; Isobergapten CFN90231 482-48-4 C12H8O4 = 216.19 20mg QQ客服:2056216494
    茴芹内酯; Pimpinellin CFN99402 131-12-4 C13H10O5 = 246.2 20mg QQ客服:2159513211
    Moellendorffilin; Moellendorffilin CFN92638 105099-87-4 C26H20O10 = 492.4 5mg QQ客服:3257982914

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