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  • 鸭脚木碱

    Alstonine

    鸭脚木碱
    产品编号 CFN97709
    CAS编号 642-18-2
    分子式 = 分子量 C21H21N2O3 = 349.4
    产品纯度 >=98%
    物理属性 Yellow powder
    化合物类型 Alkaloids
    植物来源 The herbs of Catharanthus roseus
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    鸭脚木碱 CFN97709 642-18-2 1mg QQ客服:2159513211
    鸭脚木碱 CFN97709 642-18-2 5mg QQ客服:2159513211
    鸭脚木碱 CFN97709 642-18-2 10mg QQ客服:2159513211
    鸭脚木碱 CFN97709 642-18-2 20mg QQ客服:2159513211
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • University of Auckland (New Zealand)
  • Institute of Bioorganic Chemistry Polish Academy of Sciences (Poland)
  • Univerzita Karlova v Praze (Czech Republic)
  • Rio de Janeiro State University (Brazil)
  • Max Rubner-Institut (MRI) (Germany)
  • Deutsches Krebsforschungszentrum (Germany)
  • Macau University of Science and Technology (China)
  • University of the Basque Country (Spain)
  • Osmania University (India)
  • Technical University of Denmark (Denmark)
  • University of Hawaii Cancer Center (USA)
  • Instituto de Investigaciones Agropecuarias (Chile)
  • University of Leipzig (Germany)
  • Medical University of Gdansk (Poland)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • J Breast Cancer.2015, 18(2):112-118
  • Evid Based Complement Alternat Med.2015, 2015:165457
  • BMC Complement Altern Med.2016, 16:213
  • Korean J. of Food Sci. and Tech2016, 172-177
  • ARPN Journal of Eng.& Applied Sci.2016, 2199-2204
  • Food and Bioprocess Technology2017, 10(6):1074-1092
  • J Ethnopharmacol.2017, 196:75-83
  • Molecules.2017, 22(2)
  • Chin. Med.J.Res. Prac.2017, 31(4)
  • Integr Med Res.2017, 6(4):395-403
  • J Agric Food Chem.2017, 65(13):2670-2676
  • Front Aging Neurosci.2018, 10:269
  • J Cell Biochem.2018, 119(2):2231-2239
  • Neuropharmacology.2018, 131:68-82
  • J Sep Sci.2018, 41(9):1938-1946
  • Eur J Pharmacol.2018, 832:96-103
  • Nat Commun.2019, 10(1):5169
  • Int J Immunopathol Pharmacol.2019, 33:2058738419857537
  • Phytomedicine.2019, 65:153089
  • J Mater Chem B.2019, 7(39):5896-5919
  • Planta Med.2019, 85(9-10):766-773
  • Appl. Sci.2020, 10,1304
  • Antioxidants (Basel).2020, 9(2): E119
  • ...
  • 生物活性
    Description: Alstonine is an indole alkaloid that has an antipsychotic activity, by decreasing glutamate uptake and using the step-down inhibitory avoidance paradigm and MK801-induced working memory deficits in mice. Alstonine prevents the expected fasting-induced decrease in glucose levels.
    Targets: Dopamine Receptor | 5-HT Receptor
    In vitro:
    Neurochem Int. 2012 Dec;61(7):1144-50.
    Effects of the putative antipsychotic alstonine on glutamate uptake in acute hippocampal slices.[Pubmed: 22940693]
    A dysfunctional glutamatergic system is thought to be central to the negative symptoms and cognitive deficits recognized as determinant to the poor quality of life of people with schizophrenia. Modulating glutamate uptake has, thus, been suggested as a novel target for antipsychotics. Alstonine is an indole alkaloid sharing with atypical antipsychotics the profile in animal models relevant to schizophrenia, though divergent in its mechanism of action. The aim of this study was to evaluate the effects of Alstonine on glutamate uptake. Additionally, the effects on glutathione content and extracellular S100B levels were assessed.
    METHODS AND RESULTS:
    Acute hippocampal slices were incubated with haloperidol (10μM), clozapine (10 and 100μM) or Alstonine (1-100μM), alone or in combination with apomorphine (100μM), and 5-HT(2) receptor antagonists (0.01μM altanserin and 0.1μM SB 242084). A reduction in glutamate uptake was observed with Alstonine and clozapine, but not haloperidol. Apomorphine abolished the effect of clozapine, whereas 5-HT(2A) and 5-HT(2C) antagonists abolished the effects of Alstonine. Increased levels of glutathione were observed only with Alstonine, also the only compound that failed to decrease the release of S100B. This study shows that Alstonine decreases glutamate uptake, which may be beneficial to the glutamatergic deficit observed in schizophrenia. Noteworthily, the decrease in glutamate uptake is compatible with the reversal of MK-801-induced social interaction and working memory deficits. An additional potential benefit of
    CONCLUSIONS:
    Alstonine as an antipsychotic is its ability to increase glutathione, a key cellular antioxidant reported to be decreased in the brain of patients with schizophrenia. Adding to the characterization of the novel mechanism of action of Alstonine, the lack of effect of apomorphine in Alstonine-induced changes in glutamate uptake reinforces that D(2) receptors are not primarily implicated. Though clearly mediated by 5-HT(2A) and 5-HT(2C) serotonin receptors, the precise mechanisms that result in the effects of Alstonine on glutamate uptake warrant elucidation.
    In vivo:
    Phytomedicine. 2015 Jan 15;22(1):52-5.
    Original mechanisms of antipsychotic action by the indole alkaloid alstonine(Picralima nitida).[Pubmed: 25636871]
    Alstonine is the major component of plant based remedies that traditional psychiatrists use in Nigeria. Alstonine is an indole alkaloid that has an antipsychotic experimental profile comparable with that of clozapine and is compatible with the alleged effects in mental patients. Representing a desirable innovation in the pharmacodynamics of antipsychotic medications, the evidence indicates that Alstonine does not bind to D2 dopamine receptors (D2R) and differentially regulates dopamine in the cortical and limbic areas.
    METHODS AND RESULTS:
    The purpose of this study was to further investigate the effects of Alstonine on D2R binding in specific brain regions using quantitative autoradiography (QAR) and its effects on dopamine (DA) uptake in mouse striatal synaptosomes. The effects of Alstonine on D2R binding were determined in the nucleus accumbens and caudate-putamen using QAR in mice treated with Alstonine doses that have antipsychotic effects. The effects of Alstonine [3H]DA uptake were assessed in synaptosomes prepared from striatal tissue obtained from mice treated acutely or for 7 days with Alstonine. Alstonine did not change the D2R binding densities in the studied regions. DA uptake was increased after acute (but not after 7 days) treatment with Alstonine.
    CONCLUSIONS:
    Consistent with the Alstonine behavioral profile, these results indicate that Alstonine indirectly modulates DA receptors, specifically by modulating DA uptake. This unique mechanism for DA transmission modulation contributes to the antipsychotic-like effects of Alstonine and is compatible with its behavioral profile in mice and alleged effects in patients. These results may represent an innovation in the antipsychotic development field.
    Evid Based Complement Alternat Med. 2011;2011:418597.
    Alstonine as an antipsychotic: effects on brain amines and metabolic changes.[Pubmed: 19189988]
    Managing schizophrenia has never been a trivial matter. Furthermore, while classical antipsychotics induce extrapyramidal side effects and hyperprolactinaemia, atypical antipsychotics lead to diabetes, hyperlipidaemia, and weight gain. Moreover, even with newer drugs, a sizable proportion of patients do not show significant improvement. Alstonine is an indole alkaloid identified as the major component of a plant-based remedy used in Nigeria to treat the mentally ill. Alstonine presents a clear antipsychotic profile in rodents, apparently with differential effects in distinct dopaminergic pathways.
    METHODS AND RESULTS:
    The aim of this study was to complement the antipsychotic profile of Alstonine, verifying its effects on brain amines in mouse frontal cortex and striatum. Additionally, we examined if Alstonine induces some hormonal and metabolic changes common to antipsychotics. HPLC data reveal that Alstonine increases serotonergic transmission and increases intraneuronal dopamine catabolism. In relation to possible side effects, preliminary data suggest that Alstonine does not affect prolactin levels, does not induce gains in body weight, but prevents the expected fasting-induced decrease in glucose levels.
    CONCLUSIONS:
    Overall, this study reinforces the proposal that Alstonine is a potential innovative antipsychotic, and that a comprehensive understanding of its neurochemical basis may open new avenues to developing newer antipsychotic medications.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 2.862 mL 14.3102 mL 28.6205 mL 57.241 mL 71.5512 mL
    5 mM 0.5724 mL 2.862 mL 5.7241 mL 11.4482 mL 14.3102 mL
    10 mM 0.2862 mL 1.431 mL 2.862 mL 5.7241 mL 7.1551 mL
    50 mM 0.0572 mL 0.2862 mL 0.5724 mL 1.1448 mL 1.431 mL
    100 mM 0.0286 mL 0.1431 mL 0.2862 mL 0.5724 mL 0.7155 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    阿立新碱; Aricine CFN98760 482-91-7 C22H26N2O4 = 382.5 5mg QQ客服:2159513211
    萝巴新; 阿吗碱; Ajmalicine CFN98761 483-04-5 C21H24N2O3 = 352.4 5mg QQ客服:1413575084
    蛇纹石素; Serpentine CFN99867 18786-24-8 C21H21N2O3 = 349.4 5mg QQ客服:1413575084
    Rauvotetraphylline E; Rauvotetraphylline E CFN96746 1422506-53-3 C20H19N2O3 = 335.4 5mg QQ客服:215959384
    鸭脚木碱; Alstonine CFN97709 642-18-2 C21H21N2O3 = 349.4 5mg QQ客服:2159513211
    阿枯米精; Akuammigine CFN97710 642-17-1 C21H24N2O3 = 352.43 5mg QQ客服:1148253675
    Serpentinic acid; Serpentinic acid CFN97721 605-14-1 C20H19N2O3 = 335.38 5mg QQ客服:215959384
    19-表阿马碱; Mayumbine CFN98283 25532-45-0 C21H24N2O3 = 352.4 5mg QQ客服:2159513211
    蛇根亭碱; Serpentinine CFN98499 36519-42-3 C42H44N4O5 = 684.8 5mg QQ客服:1148253675
    (4R)-阿马碱N-氧化物; 4,R-ajmalicine N-oxide CFN98652 41590-29-8 C21H24N2O4 = 368.4 5mg QQ客服:3257982914

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