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  • 芍药内酯苷

    Albiflorin

    芍药内酯苷
    产品编号 CFN99774
    CAS编号 39011-90-0
    分子式 = 分子量 C23H28O11 = 480.46
    产品纯度 >=98%
    物理属性 White powder
    化合物类型 Monoterpenoids
    植物来源 The roots of Paeonia albiflora
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    芍药内酯苷 CFN99774 39011-90-0 10mg QQ客服:2932563308
    芍药内酯苷 CFN99774 39011-90-0 20mg QQ客服:2932563308
    芍药内酯苷 CFN99774 39011-90-0 50mg QQ客服:2932563308
    芍药内酯苷 CFN99774 39011-90-0 100mg QQ客服:2932563308
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • Harvard University (USA)
  • National Research Council of Canada (Canada)
  • University of Indonesia (Indonesia)
  • University of Otago (New Zealand)
  • CSIRO - Agriculture Flagship (Australia)
  • Universidade do Porto (Portugal)
  • Heidelberg University (Germany)
  • Johannes Gutenberg University Mainz (JGU) (Germany)
  • Wroclaw Medical University (Poland)
  • Martin Luther University of Halle-Wittenberg (Germany)
  • China Medical University (Taiwan)
  • St. Jude Children Research Hospital (USA)
  • Lodz University of Technology (Poland)
  • University of Melbourne (Australia)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Oncol Rep.2016, 35(3):1356-64
  • US20170000760 A12016, 42740
  • Bulletin of Health Research2016, 44(4):279-286
  • Int J Oncol.2016, 49(4):1497-504
  • J. of The Korean Society of Food Culture2017, 144-149
  • Int J Mol Sci.2017, 18(12)
  • J Ethnopharmacol.2017, 197:157-164
  • Food Chem.2017, 228:301-314
  • JPC-Journal of Planar Chromatography 2017, 30(4)
  • Food Res Int.2017, 96:40-45
  • Int J Mol Sci.2018, 19(9):E2601
  • Anat Rec2018, 24264
  • Phytother Res.2018, 32(12):2551-2559
  • Biol Pharm Bull.2018, 41(11):1645-1651
  • Nutr Metab (Lond).2019, 16:31
  • Food Engineering Progress2019, 23(3)209-216
  • Molecules.2019, 24(12):E2286
  • Phytomedicine.2019, 59:152785
  • Toxicol In Vitro.2019, 59:161-178
  • Plos One.2019, 15(2):e0220084
  • LWT-Food Sci Technol2020, 109163
  • J Pharmaceut Biomed2020, 178:112894
  • Cell Metab.2020, S1550-4131(20)30002-4
  • ...
  • 生物活性
    Description: Albiflorin has anti-inflammatory, and antidepressant-like effects. Albiflorin may reduce or prevent osteoblast degeneration in osteoporosis, and may promote the recovery of bone marrow hemopoietic function in a myelosuppressed mouse model, it has neuroprotective effect on primary hippocampal cells against β-amyloid induced toxicity.
    Targets: ROS | 5-HT Receptor | NO | PGE | TNF-α | NOS | COX | IL Receptor | p38MAPK | JNK | Beta Amyloid | Calcium Channel
    In vitro:
    Fitoterapia. 2013 Sep;89:33-41.
    Protective effect of albiflorin against oxidative-stress-mediated toxicity in osteoblast-like MC3T3-E1 cells.[Pubmed: 23707745 ]
    Albiflorin isolated from Paeoniae Radix was investigated for its ability to protect against antimycin A-induced osteoblast toxicity in the MC3T3-E1 cell line.
    METHODS AND RESULTS:
    MC3T3-E1 cells showed significantly reduced viability, increased apoptosis and lactate dehydrogenase release, elevated ROS/RNS levels, and decreased mitochondrial function after exposure to antimycin A. Pretreatment with albiflorin reversed the loss of cell viability in antimycin A-treated cultures. Similarly, pretreatment with albiflorin before antimycin A resulted in decreased apoptosis and lactate dehydrogenase release, decreased ROS/RNS levels, and increased mitochondrial function compared to antimycin A-treated cultures. In addition, albiflorin increased the mineralization reduced by antimycin A. Albiflorin reduced antimycin A-induced mitochondrial cytochrome c loss and cardiolipin peroxidation, conferring protection against ROS. These results confirmed the crucial role of cytochrome c and cardiolipin in the underlying mechanistic action of albiflorin. Therefore, the results suggest that albiflorin enhances mitochondrial function to suppress antimycin A-induced oxidative damage via the preservation of cytochrome c and cardiolipin.
    CONCLUSIONS:
    All of these data indicate that albiflorin may reduce or prevent osteoblast degeneration in osteoporosis.
    In vivo:
    Evid-based. Compl. Alt. , 2016, 2016(15):1-8.
    Paeoniflorin and Albiflorin Attenuate Neuropathic Pain via MAPK Pathway in Chronic Constriction Injury Rats[Pubmed: 27429639 ]
    Neuropathic pain remains as the most frequent cause of suffering and disability around the world. The isomers paeoniflorin (PF) and Albiflorin (AF) are major constituents extracted from the roots of Paeonia (P.) lactiflora Pall. Neuroprotective effect of PF has been demonstrated in animal models of neuropathologies. However, only a few studies are related to the biological activities of AF and no report has been published on analgesic properties of AF about neuropathic pain to date.
    METHODS AND RESULTS:
    The aim of this study was to compare the effects of AF and PF against CCI-induced neuropathic pain in rat and explore the underlying mechanism. We had found that both PF and AF could inhibit the activation of p38 mitogen-activated protein kinase (p38 MAPK) pathway in spinal microglia and subsequent upregulated proinflammatory cytokines (interleukin-1β (IL-1β) and tumor necrosis factor-α (TNF-α)). AF further displayed remarkable effects on inhibiting the activation of astrocytes, suppressing the overelevated expression of phosphorylation of c-Jun N-terminal kinases (p-JNK) in astrocytes, and decreasing the content of chemokine CXCL1 in the spinal cord.
    CONCLUSIONS:
    These results suggest that both PF and AF are potential therapeutic agents for neuropathic pain, which merit further investigation.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 2.0813 mL 10.4067 mL 20.8134 mL 41.6268 mL 52.0335 mL
    5 mM 0.4163 mL 2.0813 mL 4.1627 mL 8.3254 mL 10.4067 mL
    10 mM 0.2081 mL 1.0407 mL 2.0813 mL 4.1627 mL 5.2033 mL
    50 mM 0.0416 mL 0.2081 mL 0.4163 mL 0.8325 mL 1.0407 mL
    100 mM 0.0208 mL 0.1041 mL 0.2081 mL 0.4163 mL 0.5203 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    没食子酰芍药苷; Galloylpaeoniflorin CFN90831 122965-41-7 C30H32O15 = 632.6 10mg QQ客服:2159513211
    芍药苷元酮; Paeoniflorigenone CFN96022 80454-42-8 C17H18O6 = 318.3 5mg QQ客服:3257982914
    芍药内苷B; Paeonilactone B CFN96055 98751-78-1 C10H12O4 = 196.2 5mg QQ客服:2159513211
    芍药内苷C; Paeonilactone C CFN96056 98751-77-0 C17H18O6 = 318.3 5mg QQ客服:215959384
    芍药内苷A; Paeonilactone A CFN96059 98751-79-2 C10H14O4 = 198.2 5mg QQ客服:2159513211
    芍药苷; Paeoniflorin CFN99544 23180-57-6 C23H28O11 = 480.45 20mg QQ客服:1413575084
    氧化芍药苷; Oxypaeoniflorin CFN99589 39011-91-1 C23H28O12 = 496.46 20mg QQ客服:3257982914
    2'-O-苯甲酰基芍药甙; 2'-O-Benzoylpaeoniflorin CFN89529 1456598-64-3 C30H32O12 = 584.56 5mg QQ客服:1148253675
    苯甲酰芍药苷; Benzoylpaeoniflorin CFN99536 38642-49-8 C30H32O12 = 584.57 20mg QQ客服:2932563308
    苯甲酰氧化芍药苷; Benzoyloxypeoniflorin CFN90662 72896-40-3 C30H32O13 = 600.57 10mg QQ客服:1413575084

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