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  • Aflavarin

    Aflavarin

    Aflavarin
    产品编号 CFN89117
    CAS编号 144429-67-4
    分子式 = 分子量 C24H22O9 = 454.43
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Coumarins
    植物来源 The secondary metabolites of Aspergillus flavus
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    Aflavarin CFN89117 144429-67-4 1mg QQ客服:2159513211
    Aflavarin CFN89117 144429-67-4 5mg QQ客服:2159513211
    Aflavarin CFN89117 144429-67-4 10mg QQ客服:2159513211
    Aflavarin CFN89117 144429-67-4 20mg QQ客服:2159513211
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • Utrecht University (Netherlands)
  • John Innes Centre (United Kingdom)
  • Colorado State University (USA)
  • Macau University of Science and Technology (China)
  • Medical University of Gdansk (Poland)
  • Institute of Bioorganic Chemistry Polish Academy of Sciences (Poland)
  • National Chung Hsing University (Taiwan)
  • University of Illinois (USA)
  • Monash University Sunway Campus (Malaysia)
  • University of Medicine and Pharmacy (Romania)
  • National Hellenic Research Foundation (Greece)
  • Charles University in Prague (Czech Republic)
  • Gyeongsang National University (Korea)
  • Molecular Biology Institute of Barcelona (IBMB)-CSIC (Spain)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Pharmacognosy Journal.2020, 12(2), p232-235.
  • J Anal Methods Chem.2022, 2022:2229500.
  • European Journal of Integrative Medicine2018, 20:165-172
  • Oncol Rep.2016, 35(3):1356-64
  • Appl. Sci.2021, 11(19),9343.
  • Separations2023, 10(11), 567;
  • Toxicol Appl Pharmacol.2021, 427:115668.
  • Int J Mol Sci.2021, 22(9):5012.
  • The Japan Society for Analy. Chem.2017, 66(8):613-617
  • Fitoterapia.2021, 153:104995.
  • Food Chem.2019, 290:286-294
  • Biomed Chromatogr.2020, e5021.
  • PLoS One.2017, 12(3):e0173585
  • Molecules.2021, 26(9):2765.
  • Academic J of Second Military Medical University2019, 40(1)
  • Fitoterapia.2015, 100:179-86
  • Braz J Med Biol Res.2021, 54(12):e11183.
  • Front Plant Sci.2021, 12:673337.
  • Int J Mol Sci.2020, 21(24):9369.
  • Front Pharmacol.2018, 9:236
  • Natural Product Res.&Deve.2022, 1001-6880.
  • Mol Microbiol.2019, 112(1):317-332
  • Cardiovasc Toxicol.2021, 21(11):947-963.
  • ...
  • 生物活性
    Description: Aflavarin exhibits potent antifeedant activity against the fungivorous beetle Carpophilus hemipterus.
    In vitro:
    Fungal Genet Biol. 2017 Jul;104:29-37.
    Aspergillus flavus aswA, a gene homolog of Aspergillus nidulans oefC, regulates sclerotial development and biosynthesis of sclerotium-associated secondary metabolites.[Pubmed: 28442441]

    METHODS AND RESULTS:
    Aspergillus flavus aswA (AFLA_085170) is a gene encoding a Zn(II)2Cys6 DNA-binding domain and a transcriptional activation domain, DUF3468. Disruption of aswA yielded strains that made a truncated gene transcript and generated a fungus that produced a greatly increased number of sclerotia. These sclerotia were odd-shaped and non-pigmented (white) and different from oval and pigmented (dark brown to black) mature sclerotia. Transcriptomic analysis of the ΔaswA strain grown on potato dextrose agar plates and Wickerham agar plates showed that expression of clustering genes involved in the biosynthesis of three sclerotium-associated secondary metabolites was down-regulated. These included gene clusters of asparasone, aflatrem, and Aflavarin. In contrast, those of aflatoxin, cyclopiazonic acid and kojic acid were not affected.
    CONCLUSIONS:
    Metabolite analyses confirmed that the non-pigmented sclerotia contained aflatoxin and cyclopiazonic acid but not other aforementioned metabolites, three asparasone analogs and dihydroxyaflavinine commonly present in mature sclerotia. Impairment in aswA gene function stalls normal sclerotial development, which in turn prevents biosynthesis and accumulation of sclerotium-specific metabolites.
    Journal of Natural Products, 1992, 55(8):1080-1086.
    Aflavarin and β-Aflatrem: New Anti-Insectan Metabolites from the Sclerotia of Aspergillus flavus[Reference: WebLink]

    METHODS AND RESULTS:
    Aflavarin [3], a new bicoumarin, and beta-aflatrem [11], an isomer of the tremorgen aflatrem, were isolated from the sclerotia of Aspergillus flavus. The structures were determined through a series of 1D and 2D nmr experiments, assisted by spectral comparisons with known compounds. Aflavarin exhibits potent antifeedant activity against the fungivorous beetle Carpophilus hemipterus. Beta-aflatrem causes a significant reduction in the growth rate of the corn earworm Helicoverpa zea.
    CONCLUSIONS:
    The presence of nominine [13] as a minor metabolite of A. flavus is reported for the first time.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 2.2006 mL 11.0028 mL 22.0056 mL 44.0112 mL 55.014 mL
    5 mM 0.4401 mL 2.2006 mL 4.4011 mL 8.8022 mL 11.0028 mL
    10 mM 0.2201 mL 1.1003 mL 2.2006 mL 4.4011 mL 5.5014 mL
    50 mM 0.044 mL 0.2201 mL 0.4401 mL 0.8802 mL 1.1003 mL
    100 mM 0.022 mL 0.11 mL 0.2201 mL 0.4401 mL 0.5501 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    Aflavarin; Aflavarin CFN89117 144429-67-4 C24H22O9 = 454.43 5mg QQ客服:215959384
    松风草内酯; Matsukaze-lactone CFN89298 3153-73-9 C20H14O6 = 350.32 5mg QQ客服:1457312923
    7-甲氧基-4-甲基香豆素; 7-Methoxy-4-methylcoumarin CFN94405 2555-28-4 C11H10O3 = 190.20 20mg QQ客服:2159513211
    6-甲氧基-4-甲基香豆素; 6-Methoxy-4-methylcoumarin CFN94425 6295-35-8 C11H10O3 = 190.20 20mg QQ客服:215959384
    4,6-二甲氧基-2H-1-苯并吡喃-2-酮; 4,6-Dimethoxy-2H-1-benzopyran-2-one CFN92538 53666-78-7 C11H10O4 = 206.2 5mg QQ客服:1457312923
    4,6,7-三甲氧基-5-甲基香豆素; 4,6,7-Trimethoxy-5-methylcoumarin CFN97084 62615-63-8 C13H14O5 = 250.3 5mg QQ客服:2159513211
    结香素; Edgeworin CFN96263 120028-43-5 C18H10O6 = 322.3 5mg QQ客服:1457312923
    西瑞香素; Daphnoretin CFN90329 2034-69-7 C19H12O7 = 352.3 20mg QQ客服:2159513211
    异西瑞香素 B; Isodaphnoretin B CFN96604 944824-29-7 C20H14O8 = 382.32 5mg QQ客服:2159513211
    异双七叶内酯;异千金子素; Isoeuphorbetin CFN95207 50677-55-9 C18H10O8 = 354.3 5mg QQ客服:2159513211

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