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  • 黄肉楠碱

    Actein

    黄肉楠碱
    产品编号 CFN99864
    CAS编号 18642-44-9
    分子式 = 分子量 C37H56O11 = 676.9
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Triterpenoids
    植物来源 The roots of Cimicifuga racemosa
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    黄肉楠碱 CFN99864 18642-44-9 1mg QQ客服:1457312923
    黄肉楠碱 CFN99864 18642-44-9 5mg QQ客服:1457312923
    黄肉楠碱 CFN99864 18642-44-9 10mg QQ客服:1457312923
    黄肉楠碱 CFN99864 18642-44-9 20mg QQ客服:1457312923
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • University of Toulouse (France)
  • Nanjing University of Chinese Medicine (China)
  • Max Rubner-Institut (MRI) (Germany)
  • University of Medicine and Pharmacy (Romania)
  • Weizmann Institute of Science (Israel)
  • Korea Institute of Oriental Medicine (Korea)
  • University of Vienna (Austria)
  • Korea Food Research Institute(KFRI) (Korea)
  • Guangzhou Institutes of Biomedicine and Health (China)
  • National Research Council of Canada (Canada)
  • Warszawski Uniwersytet Medyczny (Poland)
  • Wageningen University (Netherlands)
  • Wroclaw Medical University (Poland)
  • Chiang Mai University (Thailand)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Institute of Food Science & Technology2021, 18 December.
  • Chemistry of plant raw materials2021, 1:pp 139-150
  • Agronomy2023, 13(6), 1435.
  • Iranian Journal of Pharmaceutical Sciences2021, 17(2):25-36
  • Molecules.2015, 20(10):19172-88
  • Journal of Food Composition and Analysis2021, 100:103905.
  • J Agric Food Chem.2020, 68(43):12164-12172.
  • Int J Mol Sci.2021, 22(19):10220.
  • Molecules.2019, 24(6):E1155
  • University of Limpopo2016, 1777
  • Korean J. Medicinal Crop Sci.2018, 26(2):148-156
  • Mol Med Rep.2015, 12(5):7789-95
  • Int J Mol Sci.2019, 21(1):E265
  • Biomedicines.2021, 9(8):996.
  • Viruses.2021, 13(11):2118.
  • Microchemical Journal2018, 137:168-173
  • Srinagarind Medical Journal2019, 34(1)
  • Cell Physiol Biochem.2017, 43(4):1425-1435
  • Theranostics.2023, 13(9):3103-3116.
  • J Ethnopharmacol.2020, 249:112381
  • Biosci Rep.2020, 40(8):BSR20201219.
  • Molecules.2022, 27(7):2360.
  • Regul Toxicol Pharmacol.2023, 142:105433.
  • ...
  • 生物活性
    Description: Actein has a stimulatory effect on osteoblastic bone formation or has potential activity against osteoporosis, it also can prevent oxidative damage to osteoblasts in osteoporotic patients. Actein's ability to pathways involved in lipid disorders and carcinogenesis may make it a new agent for preventing and treating these major disorders, it has been shown to inhibit the proliferation of human breast cancer cells, by altering the activity of the ER IP3 receptor and Na,K-ATPase, inducing calcium release and modulating the NF-κB and MEK pathways.
    Targets: cAMP | TNF-α | NF-kB | Sodium Channel | ATPase | Potassium Channel | MEK | p53 | Akt | P450 (e.g. CYP17)
    In vitro:
    J Med Food. 2014 Apr;17(4):414-23.
    Actein isolated from black cohosh promotes the function of osteoblastic MC3T3-E1 cells.[Pubmed: 24552231]
    Actein, isolated from black cohosh, was subjected to in vitro experiments to investigate its functional bioactivities in osteoblastic MC3T3-E1 cells.
    METHODS AND RESULTS:
    Actein caused a significant elevation of alkaline phosphatase activity, collagen synthesis, osteocalcin production, mineralization, and glutathione content in the cells, suggesting that Actein has a stimulatory effect on osteoblastic bone formation or has potential activity against osteoporosis. We investigated the protective effects of Actein on mitochondrial electron transport inhibitor, antimycin A induced toxicity in osteoblastic MC3T3-E1 cells. Exposure of MC3T3-E1 cells to antimycin A caused significant decrease in cell viability and mineralization. However, pretreatment with Actein prior to antimycin A exposure significantly reduced antimycin A-induced cell damage by preventing mitochondrial membrane potential dissipation, complex IV inactivation, cardiolipin oxidation, ROS release, and nitrotyrosine increase, suggesting that Actein may be useful for protecting mitochondria against a burst of oxidative stress. In addition, Actein increased the phosphorylation of CREB (cAMP-response element-binding protein) inhibited by antimycin A and decreased the production of TNF-α induced by antimycin A.
    CONCLUSIONS:
    These findings suggest that Actein could prevent oxidative damage to osteoblasts in osteoporotic patients.
    In vivo:
    Fundam Clin Pharmacol. 2009 Jun;23(3):311-21.
    Actein activates stress- and statin-associated responses and is bioavailable in Sprague-Dawley rats.[Pubmed: 19527300]
    The purpose of this study was to assess in rats the pharmacological parameters and effects on gene expression in the liver of the triterpene glycoside Actein. Actein, an active component from the herb black cohosh, has been shown to inhibit the proliferation of human breast cancer cells.
    METHODS AND RESULTS:
    To conduct our assessment, we determined the molecular effects of Actein on livers from Sprague-Dawley rats treated with Actein at 35.7 mg/kg for 6 and 24 h. Chemogenomic analyses indicated that Actein elicited stress and statin-associated responses in the liver; Actein altered expression of cholesterol and fatty acid biosynthetic genes, p53 pathway genes, CCND1 and ID3. Real-time RT-PCR validated that Actein induced three time-dependent patterns of gene expression in the liver: (i) a decrease followed by a significant increase of HMGCS1, HMGCR, HSD17B7, NQO1, S100A9; (ii) a progressive increase of BZRP and CYP7A1 and (iii) a significant increase followed by a decrease of CCND1 and ID3. Consistent with Actein's statin- and stress-associated responses, Actein reduced free fatty acid and cholesterol content in the liver by 0.6-fold at 24 h and inhibited the growth of human HepG2 liver cancer cells. To determine the bioavailability of Actein, we collected serum samples for pharmacokinetic analysis at various times up to 24 h. The serum level of Actein peaked at 2.4 microg/mL at 6 h.
    CONCLUSIONS:
    Actein's ability to alter pathways involved in lipid disorders and carcinogenesis may make it a new agent for preventing and treating these major disorders.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 1.4773 mL 7.3866 mL 14.7732 mL 29.5465 mL 36.9331 mL
    5 mM 0.2955 mL 1.4773 mL 2.9546 mL 5.9093 mL 7.3866 mL
    10 mM 0.1477 mL 0.7387 mL 1.4773 mL 2.9546 mL 3.6933 mL
    50 mM 0.0295 mL 0.1477 mL 0.2955 mL 0.5909 mL 0.7387 mL
    100 mM 0.0148 mL 0.0739 mL 0.1477 mL 0.2955 mL 0.3693 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    异黄芪皂苷I; Isoastragaloside I CFN90977 84676-88-0 C45H72O16 = 869.1 10mg QQ客服:1457312923
    黄芪皂苷III; Astragaloside III CFN99174 84687-42-3 C41H68O14 = 784.97 20mg QQ客服:1457312923
    黄肉楠碱; Actein CFN99864 18642-44-9 C37H56O11 = 676.9 5mg QQ客服:215959384
    升麻素苷; Cimicifugoside CFN90481 66176-93-0 C37H54O11 = 674.81 5mg QQ客服:3257982914
    26-脱氧升麻苷; 26-Deoxycimicifugoside CFN90788 214146-75-5 C37H54O10 = 658.8 5mg QQ客服:215959384
    23-表-26-脱氧黄肉楠碱; 23-epi-26-Deoxyactein CFN91896 264624-38-6 C37H56O10 = 660.83 5mg QQ客服:215959384
    土荆皮内酯B; Pseudolarolide B CFN91878 151368-43-3 C30H42O4 = 466.65 5mg QQ客服:2159513211
    升麻内酯A; Cimilactone A CFN92971 468733-06-4 C33H50O9 = 590.74 5mg QQ客服:3257982914
    21,24-环氧基环安坦-3,25-二醇; 21,24-Epoxycycloartane-3,25-diol CFN97836 125305-73-9 C30H50O3 = 458.73 5mg QQ客服:215959384
    环黄芪醇; Cycloastragenol CFN99538 84605-18-5 C30H50O5 = 490.71 20mg QQ客服:2159513211

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