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  • 氧杂蒽酮I

    9-Hydroxycalabaxanthone

    氧杂蒽酮I
    产品编号 CFN98467
    CAS编号 35349-68-9
    分子式 = 分子量 C24H24O6 = 408.5
    产品纯度 >=98%
    物理属性 Yellow powder
    化合物类型 Xanthones
    植物来源 The fruits of Garcinia mangostana L.
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    氧杂蒽酮I CFN98467 35349-68-9 1mg QQ客服:3257982914
    氧杂蒽酮I CFN98467 35349-68-9 5mg QQ客服:3257982914
    氧杂蒽酮I CFN98467 35349-68-9 10mg QQ客服:3257982914
    氧杂蒽酮I CFN98467 35349-68-9 20mg QQ客服:3257982914
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • Hamdard University (India)
  • Universidade do Porto (Portugal)
  • University of Medicine and Pharmacy (Romania)
  • University of Oslo (Norway)
  • Universidad Industrial de Santander (Colombia)
  • Regional Crop Research Institute (Korea)
  • Chang Gung University (Taiwan)
  • Univerzita Karlova v Praze (Czech Republic)
  • Universidad de Buenos Aires (Argentina)
  • Institute of Tropical Disease Universitas Airlangga (Indonesia)
  • University of Toulouse (France)
  • Sri Sai Aditya Institute of Pharmaceutical Sciences and Research (India)
  • University of Toronto (Canada)
  • Universiti Sains Malaysia (Malaysia)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Evid Based Complement Alternat Med.2016, 2016:4357656
  • Horticulture Research2023, uhad164.
  • Spectrochim Acta A2019, 210:372-380
  • Plant Physiol Biochem.2023, 201:107795.
  • Nutrients.2017, 10(1)
  • Int. J. Mol. Sci. 2022, 23(3),1696.
  • Korean J. of Horticultural Sci. & Tech. 2017, 793-804
  • Sci Adv.2018, 4(10)
  • FEBS Lett.2021, 595(20):2608-2615.
  • Mol Biol Rep.2022, doi: 10.1007
  • Korean Journal of Pharmacognosy2018, 49(4):349-361
  • J Health Sci Med Res.2023, 31584.
  • Pharmaceutics.2020, 12(9):882.
  • Phytochem Anal.2022, doi: 10.1002
  • PLoS One.2017, 12(8):e0181191
  • Molecules.2019, 24(2):E343
  • Int. J. of Pha. and Phy. Res.2015, 7(1):144-149
  • J Agric Food Chem.2021, 69(46):14037-14047.
  • J Am Soc Mass Spectrom.2021, 32(9):2451-2462.
  • Plos One.2019, 15(2):e0220084
  • Food Chem.2022, 378:131975.
  • J Immunol.2023, ji2200727.
  • Natural Product Res.&Deve.2022, 1001-6880.
  • ...
  • 生物活性
    Description: 9-Hydroxycalabaxanthone exhibits cytotoxicity against the HT-29 cell line with ED50 values of 9.1 microM. The combination of 9-hydroxycalabaxanthone with α-mangostin shows the synergistic antimalarial interaction in both clones.
    Targets: Antifection
    In vitro:
    Fitoterapia. 2014 Oct;98:215-21.
    Mangostanaxanthones I and II, new xanthones from the pericarp of Garcinia mangostana.[Pubmed: 25128900 ]
    Two new xanthones: mangostanaxanthones I (3) and II (5) were isolated from the pericarp of Garcinia mangostana, along with four known xanthones: 9-hydroxycalabaxanthone (1), parvifolixanthone C (2), α-mangostin (4), and rubraxanthone (6).
    METHODS AND RESULTS:
    Their structures were elucidated on the basis of IR, UV, 1D, 2D NMR, and MS spectroscopic data, in addition to comparison with literature data. The isolated compounds were evaluated for their antioxidant, antimicrobial, and quorum-sensing inhibitory activities. Compounds 3 and 5 displayed promising antioxidant activity with IC50 12.07 and 14.12 μM, respectively using DPPH assay. Compounds 4-6 had weak to moderate activity against Escherichia coli and Staphylococcus aureus, while demonstrated promising action against Bacillus cereus with MICs 0.25, 1.0, and 1.0mg/mL, respectively.
    CONCLUSIONS:
    The tested compounds were inactive against Candida albicans. However, they showed selective antifungal potential toward Aspergillus fumigatus. Compounds 3 and 4 possessed quorum-sensing inhibitory activity against Chromobacterium violaceum ATCC 12472.
    Acta Parasitol. 2014 Mar;60(1):105-11.
    The in vitro antimalarial interaction of 9-hydroxycalabaxanthone and α-mangostin with mefloquine/artesunate.[Pubmed: 26204026]
    Multidrug resistance Plasmodium falciparum is the major health problem in Thailand. Discovery and development of new antimalarial drugs with novel modes of action is urgently required. The aim of the present study was to investigate the antimalarial interaction of 9-hydroxycalabaxanthone and α-mangostin with the standard antimalarial drugs mefloquine and artesunate in chloroquine sensitive (3D7) and chloroquine resistant (K1) P. falciparum clones in vitro.
    METHODS AND RESULTS:
    Median (range) IC50 (drug concentration which produces 50% parasite growth inhibition) values of the 9-hydroxycalabaxanthone, α-mangostin, artesunate and mefloquine for 3D7 vs K1 clones were 1.5 (0.9-2.1) vs 1.2 (1.1-1.6) μM, 17.9 (15.7.0-20.0) vs 9.7 (6.0-14.0) μM, 1.0 (0.4-3.0) vs 1.7 (1.0-2.5) nM, and 13.3 (11.1-13.3) vs 7.1 (6.7-12.2) nM, respectively. Analysis of isobologram and combination index (CI) of 9-hydroxycalabaxanthone with artesunate or mefloquine showed synergistic and indifference antimalarial interaction, respectively. α-mangostin-artesunate combination exhibited a slight antagonistic effect of antimalarial interaction, whereas α-mangostin and mefloquine combination showed indifference interaction in both clones.
    CONCLUSIONS:
    The combination of 9-hydroxycalabaxanthone with α-mangostin showed the synergistic antimalarial interaction in both clones.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 2.448 mL 12.2399 mL 24.4798 mL 48.9596 mL 61.1995 mL
    5 mM 0.4896 mL 2.448 mL 4.896 mL 9.7919 mL 12.2399 mL
    10 mM 0.2448 mL 1.224 mL 2.448 mL 4.896 mL 6.12 mL
    50 mM 0.049 mL 0.2448 mL 0.4896 mL 0.9792 mL 1.224 mL
    100 mM 0.0245 mL 0.1224 mL 0.2448 mL 0.4896 mL 0.612 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    锰黄原酮IV; Mangostanaxanthone IV CFN91525 2182593-73-1 C24H26O7 = 426.5 5mg QQ客服:3257982914
    1-异倒捻子素; 1-Isomangostin CFN95114 19275-44-6 C24H26O6 = 410.5 5mg QQ客服:1413575084
    11-羟基-1-异倒棯子素; 11-hydroxy-1-isomangostin CFN91523 164365-71-3 C24H26O7 = 426.5 5mg QQ客服:3257982914
    1-异倒捻子素水合物; 1-Isomangostin hydrate CFN98294 26063-95-6 C24H28O7 = 428.5 5mg QQ客服:2056216494
    异去甲倒捻子素; Isonormangostin CFN99645 15404-80-5 C23H24O6 = 396.4 5mg QQ客服:1457312923
    9-Hydroxycalabaxanthone hydrate; 9-Hydroxycalabaxanthone hydrate CFN97580 N/A C24H26O7 = 426.5 5mg QQ客服:215959384
    3-异倒捻子素水合物; 3-Isomangostin hydrate CFN98295 26063-96-7 C24H28O7 = 428.5 5mg QQ客服:1457312923
    3-异倒捻子素水合甲酸; 3-Isomangostin hydrate formate CFN97490 925705-36-8 C25H28O8 = 456.5 5mg QQ客服:2159513211
    氧杂蒽酮I; 9-Hydroxycalabaxanthone CFN98467 35349-68-9 C24H24O6 = 408.5 5mg QQ客服:2056216494
    3-异倒捻子素; 3-Isomangostin CFN99724 19275-46-8 C24H26O6 = 410.46 10mg QQ客服:2056216494

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