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  • 8-表黄药子素E乙酸酯

    8-Epidiosbulbin E acetate

    8-表黄药子素E乙酸酯
    产品编号 CFN90907
    CAS编号 91095-48-6
    分子式 = 分子量 C21H24O7 = 388.40
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Diterpenoids
    植物来源 The rhizomes of Dioscorea bulbifera.
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    8-表黄药子素E乙酸酯 CFN90907 91095-48-6 10mg QQ客服:3257982914
    8-表黄药子素E乙酸酯 CFN90907 91095-48-6 20mg QQ客服:3257982914
    8-表黄药子素E乙酸酯 CFN90907 91095-48-6 50mg QQ客服:3257982914
    8-表黄药子素E乙酸酯 CFN90907 91095-48-6 100mg QQ客服:3257982914
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • National Hellenic Research Foundation (Greece)
  • Hamdard University (India)
  • Universidad Miguel Hernández (Spain)
  • University of Vienna (Austria)
  • Sri Sai Aditya Institute of Pharmaceutical Sciences and Research (India)
  • Uniwersytet Medyczny w ?odzi (Poland)
  • University of Maryland School of Medicine (USA)
  • Complutense University of Madrid (Spain)
  • University Medical Center Mainz (Germany)
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  • Institute of Bioorganic Chemistry Polish Academy of Sciences (Poland)
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  • Auburn University (USA)
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  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Evid Based Complement Alternat Med.2021, 2021:5319584.
  • Journal of Physiology & Pathology in Korean Medicine.2018, 32(2): 106-112
  • Molecules2022, 27(9):2827.
  • Int J Cosmet Sci.2019, 41(1):12-20
  • Journal of Life Science2017, 233-240
  • Evid Based Complement Alternat Med.2018, 2018:4259603
  • Univerzita Karlova2022, 173245.
  • Applied Biological Chemistry2020, 63:37.
  • University of Limpopo2016, 1777
  • PLoS One.2017, 12(8):e0181191
  • Univerzita Karlova2022, 228192.
  • Int J Mol Sci.2020, 21(19):7209.
  • Phytomedicine.2021, 93:153796.
  • Preprints2022, 202211.0388.v1.
  • J Pharm Biomed Anal2016, 118:183-194
  • Plants (Basel).2021, 10(7):1376.
  • J Sci Food Agric.2022, 102(4):1628-1639
  • Int J Mol Sci.2018, 19(9):E2601
  • Int J Mol Sci.2019, 20(8):E1855
  • J Korean Soc Food Sci Nutr2020, doi: 10.3746.
  • Appl. Sci.2020, 10(8),2804
  • Chemistry of Plant Materials.2019, 215-222
  • Korean j.of Pharm.2017, 70-76
  • ...
  • 生物活性
    Description: 8-Epidiosbulbin E acetate exhibits broad-spectrum plasmid-curing activity against multidrug-resistant (MDR) bacteria, including vancomycin-resistant enterococci. It also exhibits time-and dose-dependent liver injury in mice.
    Targets: Antifection
    In vitro:
    Int J Antimicrob Agents. 2008 Nov;32(5):405-10.
    A potential plasmid-curing agent, 8-epidiosbulbin E acetate, from Dioscorea bulbifera L. against multidrug-resistant bacteria.[Pubmed: 18718743]
    Bioassay-guided fractionation of an aqueous methanolic extract of Dioscorea bulbifera L. bulbs was performed using organic solvents.
    METHODS AND RESULTS:
    A novel plasmid-curing compound was identified as 8-Epidiosbulbin E acetate (EEA) (norditerpene) on the basis of modern spectroscopic analysis and X-ray crystallography. EEA exhibited broad-spectrum plasmid-curing activity against multidrug-resistant (MDR) bacteria, including vancomycin-resistant enterococci. EEA cured antibiotic resistance plasmids (R-plasmids) from clinical isolates of Enterococcus faecalis, Escherichia coli, Shigella sonnei and Pseudomonas aeruginosa with 12-48% curing efficiency. The reference plasmids of Bacillus subtilis (pUB110), E. coli (RP4), P. aeruginosa (RIP64) and Salmonella typhi (R136) were cured with efficiency ranging from 16% to 64%. EEA-mediated R-plasmid curing decreased the minimal inhibitory concentration of antibiotics against MDR bacteria, thus making antibiotic treatment more effective.
    CONCLUSIONS:
    The antibiotic resistance pattern revealed that the compound was effective in the reversal of bacterial resistance to various antibiotics. In addition, the compound did not show any cytotoxicity against a broad range of human cancer cell lines, namely MCF-7 (breast cancer), SiHa (cervical cancer) and A431 (epidermal carcinoma), and hence has the potential to be used as a lead compound for drug discovery programmes.
    In vivo:
    Chem Res Toxicol. 2016 Mar 21;29(3):359-66.
    Role of Metabolic Activation in 8-Epidiosbulbin E Acetate-Induced Liver Injury: Mechanism of Action of the Hepatotoxic Furanoid.[Pubmed: 26886724 ]
    8-Epidiosbulbin E acetate (EEA), a furanoid, was unexpectedly found to be the most abundant diterpenoid lactone in certain varieties of Dioscorea bulbifera L. (DB), a traditional herbal medicine widely used in Asian nations. This herb has been reported to cause liver injury in humans and experimental animals. The occurrence of EEA in DB was dependent on its commercial source.
    METHODS AND RESULTS:
    The present study shows that EEA exhibits time- and dose-dependent liver injury in mice. Pretreatment with ketoconazole prevented the animals from developing EEA-induced liver injury, caused 7- and 13-fold increases in the plasma Cmax and AUC of EEA, and decreased urinary excretion of glutathione conjugates derived from EEA. Pretreatment with buthionine sulfoximine exacerbated EEA-induced hepatotoxicity. In order to define the role of EEA's furan moiety in EEA-induced hepatotoxicity, we synthesized tetrahydro-EEA by catalytic hydrogenation of the furan moiety. No liver injury was observed in the animals given the same doses of tetrahydro-EEA as those used with EAA.
    CONCLUSIONS:
    The results indicate that EEA itself does not appear to be hepatotoxic but that the electrophilic intermediate generated by the metabolic activation of the furan ring mediated by cytochromes P450 is responsible for EEA-induced liver injury.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 2.5747 mL 12.8733 mL 25.7467 mL 51.4933 mL 64.3666 mL
    5 mM 0.5149 mL 2.5747 mL 5.1493 mL 10.2987 mL 12.8733 mL
    10 mM 0.2575 mL 1.2873 mL 2.5747 mL 5.1493 mL 6.4367 mL
    50 mM 0.0515 mL 0.2575 mL 0.5149 mL 1.0299 mL 1.2873 mL
    100 mM 0.0257 mL 0.1287 mL 0.2575 mL 0.5149 mL 0.6437 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    黄独素I; Diosbulbin I CFN99288 1187951-05-8 C29H30O8 = 506.6 5mg QQ客服:1413575084
    黄独素 L; Diosbulbin L CFN89003 1236285-87-2 C19H22O7 = 362.37 5mg QQ客服:1457312923
    黄独素J; Diosbulbin J CFN99289 1187951-06-9 C19H22O8 = 378.4 5mg QQ客服:2159513211
    Borapetoside A; Borapetoside A CFN95658 100202-29-7 C26H34O12 = 538.6 10mg QQ客服:1457312923
    Borapetoside B; Borapetoside B CFN96298 104901-05-5 C27H36O12 = 552.6 5mg QQ客服:1457312923
    Dehydroborapetoside B; Dehydroborapetoside B CFN96306 1221178-16-0 C27H34O12 = 550.6 5mg QQ客服:2159513211
    Borapetoside F; Borapetoside F CFN96279 151200-50-9 C27H34O11 = 534.6 5mg QQ客服:2159513211
    Borapetoside E; Borapetoside E CFN96274 151200-49-6 C27H36O11 = 536.6 10mg QQ客服:215959384
    Borapetoside D; Borapetoside D CFN96317 151200-48-5 C33H46O16 = 698.7 5mg QQ客服:215959384
    黄独素C; Diosbulbin C CFN98015 20086-07-1 C19H22O7 = 362.4 5mg QQ客服:2159513211

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