Info: Read More
  • 中药标准品生产商,产品定制服务
  • 7β-羟基胆固醇

    7Beta-Hydroxycholesterol

    7β-羟基胆固醇
    产品编号 CFN90610
    CAS编号 566-27-8
    分子式 = 分子量 C27H46O2 = 402.65
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Steroids
    植物来源 From Cliona copiosa
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    7β-羟基胆固醇 CFN90610 566-27-8 1mg QQ客服:2056216494
    7β-羟基胆固醇 CFN90610 566-27-8 5mg QQ客服:2056216494
    7β-羟基胆固醇 CFN90610 566-27-8 10mg QQ客服:2056216494
    7β-羟基胆固醇 CFN90610 566-27-8 20mg QQ客服:2056216494
    存储与注意事项
    1. 在您收到产品后请检查产品。如无问题,请将产品存入冰霜并且样品瓶保持密封,产品可以存放长达24个月(2-8摄氏度)。

    2. 只要有可能,产品溶解后,您应该在同一天应用于您的实验。 但是,如果您需要提前做预实验,或者需要全部溶解,我们建议您将溶液以等分试样的形式存放在-20℃的密封小瓶中。 通常,这些可用于长达两周。 使用前,打开样品瓶前,我们建议您将产品平衡至室温至少1小时。

    3. 需要更多关于溶解度,使用和处理的建议? 请发送电子邮件至:service@chemfaces.com
    订购流程
  • 1. 在线订购
  • 请联系我们QQ客服

  • 2. 电话订购
  • 请拨打电话:
    027-84237683 或 027-84237783

  • 3. 邮件或传真订购
  • 发送电子邮件到: manager@chemfaces.com 或
    发送传真到:027-84254680

  • 提供订购信息
  • 为了方便客户的订购,请需要订购ChemFaces产品的客户,在下单的时候请提供下列信息,以供我们快速为您建立发货信息。
  •  
  • 1. 产品编号(CAS No.或产品名称)
  • 2. 发货地址
  • 3. 联系方法 (联系人,电话)
  • 4. 开票抬头 (如果需要发票的客户)
  • 5. 发票地址(发货地址与发票地址不同)
  • 发货时间
    1. 付款方式为100%预付款客户,我们将在确认收到货款后当天或1-3个工作日发货。

    2. 付款方式为月结的客户,我们承诺在收到订单后当天或1-3个工作日内发货。

    3. 如果客户所需要的产品,需要重新生产,我们有权告知客户,交货时间需要延期。
    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • Aveiro University (Portugal)
  • Hamdard University (India)
  • Universidad Veracuzana (Mexico)
  • Celltrion Chemical Research Institute (Korea)
  • Stanford University (USA)
  • Sant Gadge Baba Amravati University (India)
  • Centrum Menselijke Erfelijkheid (Belgium)
  • University of Parma (Italy)
  • Chang Gung University (Taiwan)
  • Heinrich-Heine-University Düsseldorf (Germany)
  • Uniwersytet Jagielloński w Krakowie (Poland)
  • Instytut Nawozów Sztucznych w Pu?awach (Poland)
  • University of Indonesia (Indonesia)
  • Anna University (India)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Molecules.2023, 28(9):3685.
  • Int Immunopharmacol.2020, 90:107268.
  • Plant Cell,Tissue & Organ Culture2016, 127(1):115-121
  • Heliyon.2023, 9(12):e22932.
  • Anal Bioanal Chem.2016, 408(1):177-90.
  • Int J Mol Sci.2019, 20(21):E5488
  • Nutrients.2022, 14(23):4997.
  • J Applied Biological Chemistry2021, 64(2):185-192
  • Int J Cosmet Sci.2022, doi:10.1111/ics.12827.
  • Antioxidants (Basel).2022, 11(1):171.
  • Front Plant Sci.2020, 10:1705
  • J Liq Chromatogr R T2018, 41(12):761-769
  • Food Chem.2016, 191:81-90
  • Microb Pathog.2019, 131:128-134
  • Industrial Food Engineering2015, 19(4):408-413
  • Antioxidants.2022, 11(3):592.
  • Phytochemistry Letters2015, 243-247
  • Int J Biol Macromol.2020, 169:342-351
  • Evid Based Complement Alternat Med.2022, 9767292,2.
  • Molecules.2021, 26(2):313.
  • J Agric Food Chem.2020, 68(43):12164-12172.
  • Univerzita Karlova2021, 20.500.11956.
  • Food Res Int.2018, 106:909-919
  • ...
  • 生物活性
    Description: 7beta-Hydroxycholesterol, a major cytotoxin in oxidized LDL, induces Ca(2+) oscillations, MAP kinase activation and apoptosis in human aortic smooth muscle cells. 7beta-Hydroxycholesterol and 7-ketocholesterol have dual cytotoxic effects on the cells of the vascular wall by their ability to induce apoptosis in endothelial and smooth muscle cells and necrosis in fibroblasts. 7beta-Hydroxycholesterol can inhibit the proliferation of NCI-H460 cells through apoptosis via caspase activation. It can reinforce the susceptibility of K562 adriamycin-resistant cells to this drug, it also can enhance radiosensitivity in RDM4 cells.
    Targets: LDL | Calcium Channel | MAPK | Caspase | ROS
    In vitro:
    Biol. Pharm. Bull., 2005, 28(8):1377-80.
    Cytotoxic effect of 7beta-hydroxycholesterol on human NCI-H460 lung cancer cells.[Pubmed: 16079477]
    The cytotoxic activity of 7Beta-Hydroxycholesterol (7beta-OHC) was evaluated on human NCI-H460 lung cancer cells.
    METHODS AND RESULTS:
    7beta-OHC decreased clonogenic survival of NCI-H460 in a dose dependent pattern. 7beta-OHC induced apoptosis in NCI-H460, with the characteristic features like increase in sub-G(1) hypodiploid (apoptotic) cells, and apoptotic body formation, as evidenced by flow cytometry and fluorescence microscope, respectively. Apoptosis was also associated with loss of mitochondrial transmembrane potential, and the activation of caspases 9 and 3. 7beta-OHC resulted in generation of reactive oxygen species (ROS) during apoptosis.
    CONCLUSIONS:
    On the whole, the results indicated that 7beta-OHC inhibited the proliferation of NCI-H460 cells through apoptosis via caspase activation.
    Anticancer Res., 2002, 22(2A):943-8.
    Effects of combinations of 7beta-hydroxycholesterol and anticancer drugs or ionizing radiation on the proliferation of cultured tumor cells.[Pubmed: 12014676]
    Oxysterols compose a large class of natural substances endowed in a number of cases with marked antiproliferative and cytotoxic activities.
    METHODS AND RESULTS:
    The consequences of treatments combining 7Beta-Hydroxycholesterol (7beta-OHC) or XG-142 (a galactose-linked hydrosoluble derivative of 7beta-OHC) with drugs used in cancer chemotherapy or gamma radiation has been evaluated upon a variety of tumor cell lines: Hep-G2, U937, K562 cells, its adriamycin-resistant variant K562 Adr+ and RDM4. Proliferation was assessed by the Uptiblue assay and the [3H]Thymidine incorporation test.
    CONCLUSIONS:
    Results indicated that 7beta-OHC increased the sensitivity of tumor cells to adriamycin, VP-16, 5-FU and bleomycin to various degrees. 7beta-OHC was found to reinforce the susceptibility of K562 adriamycin-resistant cells to this drug. In RDM4 cells, an enhanced radiosensitivity by 7beta-OHC was also obtained, whereas XG-142 was less efficient in provoking such an effect.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 2.4835 mL 12.4177 mL 24.8355 mL 49.6709 mL 62.0887 mL
    5 mM 0.4967 mL 2.4835 mL 4.9671 mL 9.9342 mL 12.4177 mL
    10 mM 0.2484 mL 1.2418 mL 2.4835 mL 4.9671 mL 6.2089 mL
    50 mM 0.0497 mL 0.2484 mL 0.4967 mL 0.9934 mL 1.2418 mL
    100 mM 0.0248 mL 0.1242 mL 0.2484 mL 0.4967 mL 0.6209 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    20-羟基蜕皮甾酮; 20-Hydroxyecdysone CFN98873 5289-74-7 C27H44O7 = 480.6 20mg QQ客服:215959384
    水龙骨甾酮B; Polypodine B CFN89545 18069-14-2 C27H44O8 = 496.63 5mg QQ客服:2159513211
    蜕皮甾酮-20,22-单丙酮化物; Ecdysterone 20,22-monoacetonide CFN98229 22798-96-5 C30H48O7 = 520.7 5mg QQ客服:2056216494
    蜕皮甾酮2,3:20,22- 二缩丙酮; Ecdysterone 2,3:20,22-diacetonide CFN98230 22798-98-7 C33H52O7 = 560.8 5mg QQ客服:1413575084
    维生素D3; Vitamin D3 CFN90027 67-97-0 C27H44O = 384.64 20mg QQ客服:2056216494
    维生素D2; Ergocalciferol CFN90049 50-14-6 C28H44O = 396.65 20mg QQ客服:2056216494
    二氢胆固醇; Dihydrocholesterol CFN90608 80-97-7 C27H48O = 388.67 20mg QQ客服:3257982914
    胆固醇; 胆甾醇; Cholesterol CFN90040 57-88-5 C27H46O = 386.67 20mg QQ客服:1457312923
    4β-羟基胆固醇; 4-Beta-Hydroxycholesterol CFN90611 17320-10-4 C27H46O2 = 402.66 5mg QQ客服:1457312923
    7β-羟基胆固醇; 7Beta-Hydroxycholesterol CFN90610 566-27-8 C27H46O2 = 402.65 5mg QQ客服:215959384

    信息支持


    公司简介
    订购流程
    付款方式
    退换货政策

    ChemFaces提供的产品仅用于科学研究使用,不用于诊断或治疗程序。

    联系方式


    电机:027-84237783
    传真:027-84254680
    在线QQ: 1413575084
    E-Mail:manager@chemfaces.com

    湖北省武汉沌口经济技术开区车城南路83号1号楼第三层厂房


    ChemFaces为科学家,科研人员与企业提供快速的产品递送。我们通过瑞士SGS ISO 9001:2008质量体系认证天然化合物与对照品的研发和生产