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  • 7-氨基-4-甲基-3-香豆素醋酸

    7-Amino-4-methylcoumarin

    7-氨基-4-甲基-3-香豆素醋酸
    产品编号 CFN90420
    CAS编号 106562-32-7
    分子式 = 分子量 C12H11NO4 = 233.22
    产品纯度 >=98%
    物理属性 Cryst.
    化合物类型 Coumarins
    植物来源 The herbs of Guazuma ulmifolia
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    7-氨基-4-甲基-3-香豆素醋酸 CFN90420 106562-32-7 1mg QQ客服:2056216494
    7-氨基-4-甲基-3-香豆素醋酸 CFN90420 106562-32-7 5mg QQ客服:2056216494
    7-氨基-4-甲基-3-香豆素醋酸 CFN90420 106562-32-7 10mg QQ客服:2056216494
    7-氨基-4-甲基-3-香豆素醋酸 CFN90420 106562-32-7 20mg QQ客服:2056216494
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
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  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Ind. J. Pharm. Edu. Res.2023; 57(3):1132-1139.
  • Universite de Bordeaux2017, 2017BORD0867
  • Toxicol In Vitro.2019, 59:161-178
  • Front Plant Sci.2022, 13: 905275.
  • Front Aging Neurosci.2018, 10:269
  • Biomed Pharmacother.2023, 163:114785.
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  • Mol Biol Rep.2022, doi: 10.1007
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  • Phytomedicine.2019, 58:152893
  • Pharmacognosy Journal2019, 11,6:1235-1241
  • J Ethnopharmacol.2022, 291:115159.
  • Onco Targets Ther.2017, 10:3467-3474
  • Korean Journal of Pharmacognosy2014, 113-120
  • Molecules.2022, 27(2):451.
  • Toxicol In Vitro.2022, 81:105346.
  • J Ethnopharmacol.2019, 236:31-41
  • Sci Adv.2018, 4(10)
  • Front Pharmacol.2021, 12:761922.
  • ARPN Journal of Eng.& Applied Sci.2016, 2199-2204
  • ...
  • 生物活性
    Description: 7-Amino-4-methylcoumarin is more suitable as a substrate for enteropeptidase than GD(4)K-NA.
    In vitro:
    BMB Rep. 2011 Jul;44(7):458-61.
    A fluorogenic method for measuring enteropeptidase activity: spectral shift in the emission of GD4K-conjugated 7-amino-4-methylcoumarin.[Pubmed: 21777516]
    Enteropeptidase is a serine protease secreted by the pancreas and converts inactive trypsinogen to active trypsin. Enteropeptidase cleaves the C-terminal end of the substrate recognition sequence Asp-Asp-Asp-Asp-Lys (D(4)K). The assay for enteropeptidase has utilized GD(4)K-conjugated 2-naphthylamine (GD(4)K-NA) as a fluorogenic probe over the last 30 years. However, no other D(4)K-conjugated fluorogenic substrates of enteropeptidase have been reported. Furthermore, naphthalene is known as carcinogenic to humans.
    METHODS AND RESULTS:
    In this study, we used shift in the emission spectrum of GD(4)K-conjugated 7-Amino-4-methylcoumarin (GD(4)K-AMC) as a fluorogenic method to measure enteropeptidase activity. The kinetic analysis revealed that enteropeptidase has a K(M) of 0.025 mM and a k(cat) of 65 sec(-1) for 7-Amino-4-methylcoumarin, whereas it has a K(M) of 0.5 to 0.6 mM and a k(cat) of 25 sec(-1) for GD(4)K-NA. The optimum pH of 7-Amino-4-methylcoumarin hydrolysis was pH 8.0.
    CONCLUSIONS:
    Our data indicate that 7-Amino-4-methylcoumarin is more suitable as a substrate for enteropeptidase than GD(4)K-NA.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 4.2878 mL 21.439 mL 42.878 mL 85.7559 mL 107.1949 mL
    5 mM 0.8576 mL 4.2878 mL 8.5756 mL 17.1512 mL 21.439 mL
    10 mM 0.4288 mL 2.1439 mL 4.2878 mL 8.5756 mL 10.7195 mL
    50 mM 0.0858 mL 0.4288 mL 0.8576 mL 1.7151 mL 2.1439 mL
    100 mM 0.0429 mL 0.2144 mL 0.4288 mL 0.8576 mL 1.0719 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    7-羟基-3-异戊烯基香豆素; 7-Hydroxy-3-prenylcoumarin CFN97429 86654-26-4 C14H14O3 = 230.3 5mg QQ客服:2159513211
    7-羟基-6-甲氧基-3-异戊烯基香豆素; 7-Hydroxy-6-methoxy-3-prenylcoumarin CFN98374 299159-90-3 C15H16O4 = 260.3 5mg QQ客服:1457312923
    3-(1,1-Dimethylallyl)-8-hydroxy-7-methoxycoumarin; 3-(1,1-Dimethylallyl)-8-hydroxy-7-methoxycoumarin CFN89287 61899-42-1 C15H16O4 = 260.28 5mg QQ客服:1413575084
    状芸香素 ; Chalepensin CFN89033 13164-03-9 C16H14O3 = 254.28 5mg QQ客服:2056216494
    芸香内酯; Rutamarin CFN89223 14882-94-1 C21H24O5 = 356.41 5mg QQ客服:2056216494
    三叉苦甲素; Evodosin A CFN89021 1291053-38-7 C14H16O6 = 280.27 5mg QQ客服:3257982914
    12-氧代四环香豆素A; 12-Oxocalanolide A CFN97812 161753-49-7 C22H24O5 = 368.43 5mg QQ客服:1457312923
    胡桐素E; Calanolide E CFN99466 142566-61-8 C22H28O6 = 388.5 5mg QQ客服:2159513211
    7-氨基-4-甲基-3-香豆素醋酸; 7-Amino-4-methylcoumarin CFN90420 106562-32-7 C12H11NO4 = 233.22 5mg QQ客服:2159513211

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