7,8-二羟基升麻醇

7,8-Didehydrocimigenol

	产品编号	CFN92381
	CAS编号	150972-72-8
	分子式 = 分子量	C₃₀H₄₆O₅ = 486.7
	产品纯度	>=98%
	物理属性	Cryst.
	化合物类型	Triterpenoids
	植物来源	The roots of Cimicifuga foetida L.
ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用

提供自定义包装

产品名称	产品编号	CAS编号	包装	QQ客服
7,8-二羟基升麻醇	CFN92381	150972-72-8	1mg	QQ客服：1457312923
7,8-二羟基升麻醇	CFN92381	150972-72-8	5mg	QQ客服：1457312923
7,8-二羟基升麻醇	CFN92381	150972-72-8	10mg	QQ客服：1457312923
7,8-二羟基升麻醇	CFN92381	150972-72-8	20mg	QQ客服：1457312923

存储与注意事项

1. 在您收到产品后请检查产品。如无问题，请将产品存入冰霜并且样品瓶保持密封，产品可以存放长达24个月（2-8摄氏度）。

2. 只要有可能，产品溶解后，您应该在同一天应用于您的实验。但是，如果您需要提前做预实验，或者需要全部溶解，我们建议您将溶液以等分试样的形式存放在-20℃的密封小瓶中。通常，这些可用于长达两周。使用前，打开样品瓶前，我们建议您将产品平衡至室温至少1小时。

3. 需要更多关于溶解度，使用和处理的建议？请发送电子邮件至：service@chemfaces.com

订购流程

1. 在线订购

请联系我们QQ客服

2. 电话订购

请拨打电话：
027-84237683 或 027-84237783

3. 邮件或传真订购

发送电子邮件到: manager@chemfaces.com 或
发送传真到：027-84254680

提供订购信息

为了方便客户的订购，请需要订购ChemFaces产品的客户，在下单的时候请提供下列信息，以供我们快速为您建立发货信息。

1. 产品编号（CAS No.或产品名称）

2. 发货地址

3. 联系方法 (联系人，电话）

4. 开票抬头 (如果需要发票的客户）

5. 发票地址（发货地址与发票地址不同）

发货时间

1. 付款方式为100%预付款客户，我们将在确认收到货款后当天或1-3个工作日发货。

2. 付款方式为月结的客户，我们承诺在收到订单后当天或1-3个工作日内发货。

3. 如果客户所需要的产品，需要重新生产，我们有权告知客户，交货时间需要延期。

ChemFaces的产品在许多优秀和顶级科学期刊中被引用

Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6.
doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)

PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206.
doi: 10.1038/nplants.2016.205.
IF=13.297(2019)

PMID: 28005066

Sci Adv. 2018 Oct 24;4(10): eaat6994.
doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)

PMID: 30417089

University of Zurich (Switzerland)

Mahatma Gandhi University (India)

Instytut Nawozów Sztucznych w Pu?awach (Poland)

FORTH-IMBB (Greece)

University of Liège (Belgium)

University of the Basque Country (Spain)

Sri Ramachandra University (India)

University of Wisconsin-Madison (USA)

University of Toulouse (France)

University of Padjajaran (Indonesia)

Nicolaus Copernicus Uniwersity (Poland)

Technical University of Denmark (Denmark)

Korea Intitute of Science and Technology (KIST) (Korea)

University of Stirling (United Kingdom)

More...

Description:

7,8-Didehydrocimigenol can be used for the treatment of cardiovascular disorders such as atherosclerosis. It upregulates PPAR-γ in EC inhibits NF-kB activity of TNF-α-activated EC which leads to selective inhibition of VCAM-1 expression.

Targets:

TNF-α | PPAR | NF-kB | ERK | Akt | IkB | IKK

In vitro:

Food Chem Toxicol. 2011 Jan;49(1):166-72.

7,8-didehydrocimigenol from Cimicifugae rhizoma inhibits TNF-α-induced VCAM-1 but not ICAM-1expression through upregulation of PPAR-γ in human endothelial cells.[Pubmed: 20946932]

Activators of PPAR have been demonstrated to inhibit the induction of VCAM-1 but not ICAM-1 in human endothelial cells (EC). During the screening of anti-inflammatory activity of traditional herbs, we found 7,8-Didehydrocimigenol (7,8-DHC), one of active triterpenoids of Cimicifugae rhizoma (C. rhizoma) increases PPAR-γ expression in EC in a time- and dose-dependent manner.
METHODS AND RESULTS:
Therefore, we asked whether 7,8-Didehydrocimigenol selectively inhibits the expression of VCAM-1 but not ICAM-1 in TNF-α-activated EC via upregulation of PPAR-γ. Treatment with 7,8-Didehydrocimigenol or PPAR-γ agonists (GW1929, troglitazone) inhibited the expression of VCAM-1 but not ICAM-1. 7,8-Didehydrocimigenol significantly inhibited NF-kB activity via inhibition of phosphorylation of IkB and it also inhibited phosphorylation of ERK1/2 and Akt but not PKC. Finally, attachment of monocytes (U937) to EC by TNF-α was significantly reduced by 7,8-Didehydrocimigenol .
CONCLUSIONS:
These results indicate that upregualtion of PPAR-γ by 7,8-Didehydrocimigenol in EC inhibits NF-kB activity of TNF-α-activated EC which leads to selective inhibition of VCAM-1 expression. In addition, ERK1/2 and Akt signal pathways are involved in differential regulation by 7,8-Didehydrocimigenol. We concluded that 7,8-Didehydrocimigenol can be used for the treatment of cardiovascular disorders such as atherosclerosis.

产品名称	产品编号	CAS编号	分子式 = 分子量	位单	联系QQ
24-表-7,8-二羟基升麻醇 3-O-木糖苷; 24-epi-7,8-Didehydrocimigenol 3-xyloside	CFN95627	150972-77-3	C₃₅H₅₄O₉ = 618.8	5mg	QQ客服：1457312923
升麻环氧醇苷; Cimigenoside	CFN98340	27994-11-2	C₃₅H₅₆O₉ = 620.8	20mg	QQ客服：1413575084
升麻酮醇 3-O-alpha-L-拉伯糖苷; Cimiracemoside C	CFN98288	256925-92-5	C₃₅H₅₆O₉ = 620.8	10mg	QQ客服：1413575084
升麻苷B; Cimiside B	CFN99637	152685-91-1	C₄₀H₆₄O₁₃ = 752.9	5mg	QQ客服：215959384
Cimiracemoside D; Cimiracemoside D	CFN90649	290821-39-5	C₃₇H₅₈O₁₁ = 678.39	10mg	QQ客服：1413575084
Cimiaceroside A; Cimiaceroside A	CFN70310	210643-83-7	C₃₅H₅₄O₉ = 618.8	5mg	QQ客服：2056216494
Cimiracemoside F; Cimiracemoside F	CFN70324	264875-61-8	C₃₇H₅₆O₁₁ = 676.9	5mg	QQ客服：1457312923
乙酰升麻醇-3-O-α-L-阿拉伯糖苷; Acetylcimigenol 3-O-alpha-L-arabinopyranside	CFN90682	402513-88-6	C₃₇H₅₈O₁₀ = 662.9	10mg	QQ客服：2159513211
25-O-甲基升麻醇-3-O-β-D-吡喃木糖苷; 25-O-methylcimigenol-3-O-beta-D-xylopyranoside	CFN92380	27994-13-4	C₃₆H₅₈O₉ = 634.9	5mg	QQ客服：3257982914
25-O-乙基升麻醇-3-O-β-D-吡喃木糖苷; 25-O-ethylcimigenol-3-O-beta-D-xylopyranoside	CFN92379	914086-57-0	C₃₇H₆₀O₉ = 648.9	5mg	QQ客服：2056216494

信息支持

公司简介
订购流程
付款方式
退换货政策

ChemFaces提供的产品仅用于科学研究使用，不用于诊断或治疗程序。

联系方式

电机：027-84237783
传真：027-84254680
在线QQ: 1413575084
E-Mail：manager@chemfaces.com

湖北省武汉沌口经济技术开区车城南路83号1号楼第三层厂房

ChemFaces为科学家，科研人员与企业提供快速的产品递送。我们通过瑞士SGS ISO 9001:2008质量体系认证天然化合物与对照品的研发和生产。

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	2.0547 mL	10.2733 mL	20.5465 mL	41.0931 mL	51.3663 mL
5 mM	0.4109 mL	2.0547 mL	4.1093 mL	8.2186 mL	10.2733 mL
10 mM	0.2055 mL	1.0273 mL	2.0547 mL	4.1093 mL	5.1366 mL
50 mM	0.0411 mL	0.2055 mL	0.4109 mL	0.8219 mL	1.0273 mL
100 mM	0.0205 mL	0.1027 mL	0.2055 mL	0.4109 mL	0.5137 mL