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  • 6-羟基山奈酚

    6-Hydroxykaempferol

    6-羟基山奈酚
    产品编号 CFN92370
    CAS编号 4324-55-4
    分子式 = 分子量 C15H10O7 = 302.2
    产品纯度 >=98%
    物理属性 Yellow powder
    化合物类型 Flavonoids
    植物来源 The herbs of Inula japonica Thunb.
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    6-羟基山奈酚 CFN92370 4324-55-4 1mg QQ客服:215959384
    6-羟基山奈酚 CFN92370 4324-55-4 5mg QQ客服:215959384
    6-羟基山奈酚 CFN92370 4324-55-4 10mg QQ客服:215959384
    6-羟基山奈酚 CFN92370 4324-55-4 20mg QQ客服:215959384
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
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  • Kyung Hee University (Korea)
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  • Instytut Nawozów Sztucznych w Pu?awach (Poland)
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  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Int J Mol Sci. 2014, 15(5):8443-57
  • Acta Physiologiae Plantarum2015, 37:1736
  • FEBS Lett.2015, 589(1):182-7
  • Phytother Res.2016, 30(12):2020-2026
  • Free Radic Biol Med.2016, 97:307-319
  • Evid Based Complement Alternat Med.2017, 2017:7383104
  • J Ethnopharmacol.2017, 209:305-316
  • Cell Physiol Biochem.2017, 43(4):1425-1435
  • Pharmacol Rep.2017, 69(6):1224-1231
  • BMC Complement Altern Med.2018, 18(1):303
  • European Journal of Integrative Medicine2018, 20:165-172
  • Cell Biochem Funct.2018, 36(6):303-311
  • The Journal of Agromedicine and Medical Sciences2018, 4(1)
  • Phytomedicine.2018, 41:62-66
  • Primary and Industrial.2018, 52(11)
  • Eur J Pharmacol.2018, 832:96-103
  • Front Pharmacol.2018, 9:756
  • Wageningen University & Research2018, January 2018
  • J Ethnopharmacol.2019, 235:406-414
  • Molecules.2019, 24(10):E1926
  • Chin J Pharm Anal.2019, 39(7):1217-1228
  • J Nat Prod.2019, 82(4):1002-1008
  • Drug Des Devel Ther.2020, 14:61-71
  • ...
  • 生物活性
    Description: 6-Hydroxykaempferol is a competitive inhibitor of tyrosinase compared to L-DOPA, it shows also high antioxidant activities.
    Targets: Tyrosinase
    In vitro:
    Molecules, 2007, 12(1):86-97.
    Inhibitory effects of 5,6,7-trihydroxyflavones on tyrosinase.[Pubmed: 17693955]

    METHODS AND RESULTS:
    Baicalein (1), 6-Hydroxyapigenin (6), 6-hydroxygalangin (13) and 6-hydroxy-kaempferol (14), which are naturally occurring flavonoids from a set of 14 hydroxy-flavones tested, exhibited high inhibitory effects on tyrosinase with respect to L-DOPA, while each of the 5,6,7-trihydroxyflavones 1, 6, 13 or 14 acted as a cofactor to monophenolase. Moreover, 6-Hydroxykaempferol (14) showed the highest activity and was a competitive inhibitor of tyrosinase compared to L-DOPA. 5,6,7-Trihydroxyflavones 1, 6, 13 or 14 showed also high antioxidant activities.
    CONCLUSIONS:
    Hence, we conclude that the 5,6,7-trihydroxy-flavones are useful as good depigmentation agents with inhibitory effects in addition to their antioxidant properties.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 3.3091 mL 16.5453 mL 33.0907 mL 66.1813 mL 82.7267 mL
    5 mM 0.6618 mL 3.3091 mL 6.6181 mL 13.2363 mL 16.5453 mL
    10 mM 0.3309 mL 1.6545 mL 3.3091 mL 6.6181 mL 8.2727 mL
    50 mM 0.0662 mL 0.3309 mL 0.6618 mL 1.3236 mL 1.6545 mL
    100 mM 0.0331 mL 0.1655 mL 0.3309 mL 0.6618 mL 0.8273 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    3,5,7-三羟基-8,4'-二甲氧基黄酮; Prudomestin CFN98453 3443-28-5 C17H14O7 = 330.3 5mg QQ客服:3257982914
    5,7-二羟基-3,4',8-三甲氧基黄酮; 5,7-Dihydroxy-3,4',8-trimethoxyflavone CFN99666 1570-09-8 C18H16O7 = 344.3 5mg QQ客服:1413575084
    5,7-二乙酰氧基-3,4',8-三甲氧基黄酮; 5,7-Diacetoxy-3,4',8-trimethoxyflavone CFN98818 5128-43-8 C22H20O9 = 428.4 5mg QQ客服:2932563308
    4',5,7-三羟基 3,6,8-三甲氧基黄酮; 4',5,7-Trihydroxy 3,6,8-trimethoxyflavone CFN70413 57393-71-2 C18H16O8 = 360.3 5mg QQ客服:3257982914
    Calycopterin; Calycopterin CFN70374 481-52-7 C19H18O8 = 374.4 5mg QQ客服:1148253675
    5,7-二羟基-3,4',6,8-四甲氧基黄酮; Araneosol CFN98797 50461-86-4 C19H18O8 = 374.4 5mg QQ客服:3257982914
    2',3,5,7-四羟基黄酮; 2',3,5,7-Tetrahydroxyflavone CFN70373 480-15-9 C15H10O6 = 286.2 5mg QQ客服:1413575084
    山奈酚; Kaempferol CFN98838 520-18-3 C15H10O6 = 286.2 20mg QQ客服:2159513211
    3,4',7-三乙酰山奈酚; 3,4',7-三乙酸堪非醇酯; Kaempferol 3,4,7-triacetate CFN99479 143724-69-0 C21H16O9 = 412.4 5mg QQ客服:1148253675
    四乙酰山奈酚; 四乙酸堪非醇酯; Kaempferol tetraacetate CFN99686 16274-11-6 C23H18O10 = 454.4 5mg QQ客服:2932563308

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