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  • 5,6,7-三甲氧基香豆素

    5,6,7-Trimethoxycoumarin

    5,6,7-三甲氧基香豆素
    产品编号 CFN89309
    CAS编号 55085-47-7
    分子式 = 分子量 C12H12O5 = 236.22
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Coumarins
    植物来源 The roots of Angelica glauca.
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    5,6,7-三甲氧基香豆素 CFN89309 55085-47-7 1mg QQ客服:215959384
    5,6,7-三甲氧基香豆素 CFN89309 55085-47-7 5mg QQ客服:215959384
    5,6,7-三甲氧基香豆素 CFN89309 55085-47-7 10mg QQ客服:215959384
    5,6,7-三甲氧基香豆素 CFN89309 55085-47-7 20mg QQ客服:215959384
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • Universite Libre de Bruxelles (Belgium)
  • Chungnam National University (Korea)
  • Fraunhofer-Institut für Molekularbiologie und Angewandte ?kologie IME (Germany)
  • University of Lodz (Poland)
  • University of Vienna (Austria)
  • Sri Ramachandra University (India)
  • Technical University of Denmark (Denmark)
  • Chiang Mai University (Thailand)
  • Charles Sturt University (Denmark)
  • University Medical Center Mainz (Germany)
  • Korea Intitute of Science and Technology (KIST) (Korea)
  • Massachusetts General Hospital (USA)
  • University of Indonesia (Indonesia)
  • Universit?t Basel (Switzerland)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Tumour Biol.2015, 36(9):7027-34
  • Cancers (Basel).2023, 15(1):37.
  • J Chromatogr A.2022, 1685:463640.
  • Phytomedicine.2022, 102:154183.
  • Planta Med.2019, 85(4):347-355
  • Int J Mol Sci.2020, 21(24):9369.
  • Evid Based Complement Alternat Med.2021, 2021:5585692.
  • Evid Based Complement Alternat Med.2016, 2016:1230294
  • Anal Bioanal Chem.2023, 415(9):1641-1655.
  • Int J Mol Sci.2022, 23(13):7115.
  • Korean J. Medicinal Crop Sci.2021, 29(1):45-50.
  • Asian J of Pharmaceutical&Clinical 2018, 11(2)
  • Asian J Beauty Cosmetol2020, 18(3): 265-272.
  • Am J Chin Med.2023, 51(4):1019-1039.
  • Nutrients.2021, 13(3):978.
  • Biosci Biotechnol Biochem.2021, 85(10):2153-2160.
  • J Ethnopharmacol.2024, 318:116863.
  • Archives of Biological sciences2022, 00:21-21
  • Biomed Chromatogr.2020, e5021.
  • J Nat Prod.2018, 81(4):966-975
  • Appl. Sci. 2021, 11(10),4666.
  • JABS2020, 14:2(2020)
  • Phytomedicine.2018, 47:48-57
  • ...
  • 生物活性
    Description: 5,6,7-Trimethoxycoumarin shows moderate inhibitory activity against Micrococcus luteus, it also displays an intermediate cytotoxic effects against brine shrimp larvae. 5,6,7-Trimethoxycoumarin can improve gastroprotective effects, and it has low toxicity and minimal effects on drug-metabolizing enzymes.
    Targets: P450 (e.g. CYP17) | Antifection
    In vivo:
    Nutrients. 2015 Mar 13;7(3):1945-64.
    Gastroprotective efficacy and safety evaluation of scoparone derivatives on experimentally induced gastric lesions in rodents.[Pubmed: 25781220 ]
    Pharmacological studies suggest that the presence of a methoxy group at position C-5 or C-8 of the scoparone's phenyl ring significantly improves gastroprotective activity, whereas the presence of a dioxolane ring at C-6, C-7, or C-8 was found to have decreased activity.
    METHODS AND RESULTS:
    In order to assess toxicological safety, two of the potent gastroprotective scoparone derivatives-5,6,7-Trimethoxycoumarin and 6,7,8-trimethoxycoumarin-were examined for their acute toxicity in mice as well as their effect on cytochrome P450 (CYP) enzyme activity. These two compounds showed low acute oral toxicity in adult male and female mice, and caused minimal changes to CYP3A4 and CYP2C9 enzyme activity.
    CONCLUSIONS:
    These results indicate that compared to other scoparone derivatives, 5,6,7-Trimethoxycoumarin and 6,7,8-trimethoxycoumarin can improve gastroprotective effects, and they have low toxicity and minimal effects on drug-metabolizing enzymes.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 4.2333 mL 21.1667 mL 42.3334 mL 84.6668 mL 105.8335 mL
    5 mM 0.8467 mL 4.2333 mL 8.4667 mL 16.9334 mL 21.1667 mL
    10 mM 0.4233 mL 2.1167 mL 4.2333 mL 8.4667 mL 10.5834 mL
    50 mM 0.0847 mL 0.4233 mL 0.8467 mL 1.6933 mL 2.1167 mL
    100 mM 0.0423 mL 0.2117 mL 0.4233 mL 0.8467 mL 1.0583 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    8-乙酰基-7-甲氧基香豆素; 8-Acetyl-7-methoxycoumarin CFN70467 89019-07-8 C12H10O4 = 218.2 5mg QQ客服:2056216494
    5,7,8-三甲氧基香豆素; 5,7,8-Trimethoxycoumarin CFN97036 60796-65-8 C12H12O5 = 236.2 5mg QQ客服:2159513211
    Artanin; Artanin CFN97547 96917-26-9 C16H18O5 = 290.3 5mg QQ客服:1413575084
    Neoartanin; Neoartanin CFN91660 104196-69-2 C16H18O5 = 290.31 5mg QQ客服:2159513211
    8-香叶基氧基-5,7-二甲氧基香豆素; 8-Geranyloxy-5,7-dimethoxycoumarin CFN99344 1228175-65-2 C21H26O5 = 358.4 5mg QQ客服:1413575084
    Arteminin; Arteminin CFN92736 466639-11-2 C11H10O5 = 222.2 5mg QQ客服:215959384
    白蜡树精; Fraxinol CFN98768 486-28-2 C11H10O5 = 222.2 5mg QQ客服:2159513211
    5-甲氧基莨菪亭; Umckalin CFN70362 43053-62-9 C11H10O5 = 222.2 5mg QQ客服:1413575084
    5-羟基-6,7-二甲氧基香豆素; Tomentin CFN98347 28449-62-9 C11H10O5 = 222.2 5mg QQ客服:3257982914
    5,6,7-三甲氧基香豆素; 5,6,7-Trimethoxycoumarin CFN89309 55085-47-7 C12H12O5 = 236.22 5mg QQ客服:3257982914

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