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  • 4-甲基伞形酮

    4-Methylumbelliferone

    4-甲基伞形酮
    产品编号 CFN90421
    CAS编号 90-33-5
    分子式 = 分子量 C10H8O3 = 176.17
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Coumarins
    植物来源 The herbs of Ruta graveolens L.
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    4-甲基伞形酮 CFN90421 90-33-5 10mg QQ客服:2056216494
    4-甲基伞形酮 CFN90421 90-33-5 20mg QQ客服:2056216494
    4-甲基伞形酮 CFN90421 90-33-5 50mg QQ客服:2056216494
    4-甲基伞形酮 CFN90421 90-33-5 100mg QQ客服:2056216494
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • University of Amsterdam (Netherlands)
  • Calcutta University (India)
  • Universite de Lille1 (France)
  • University of Maryland School of Medicine (USA)
  • University of Perugia (Italy)
  • Chiang Mai University (Thailand)
  • University of Wisconsin-Madison (USA)
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  • University of Padjajaran (Indonesia)
  • Northeast Normal University Changchun (China)
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  • Agricultural Research Organization (ARO) (Israel)
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  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Enzyme Microb Technol.2019, 122:64-73
  • Journal of Ginseng Research2021, 3 June.
  • Appl. Sci. 2021, 11(1),14.
  • Academic J of Second Military Medical University2018, 39(11)
  • Food Chemistry: X.2022, 2022.100270
  • Drug Des Devel Ther.2020, 14:61-71
  • Food Sci Nutr.2023, 11(9):5532-5542.
  • Braz J Biol.2023, 82:e266573.
  • Metabolites2023, 13(1), 3.
  • Phytother Res.2019, 33(4):1104-1113
  • Free Radic Biol Med.2017, 112:191-199
  • Drug Dev Res.2022, 83(7):1673-1682.
  • Eur J Pharmacol.2018, 832:96-103
  • Molecules.2023, 28(16):6025.
  • J Neuroinflammation.2020, 17(1):75.
  • Int J Med Sci.2021, 18(10):2155-2161.
  • Bioorg Med Chem.2018, 26(14):4201-4208
  • Evid Based Complement Alternat Med.2018, 2018:8565132
  • Phytother Res.2022, 10.1002:ptr.7592.
  • J. Soc. Cosmet. Sci. Korea2016, 163-171
  • Anal Bioanal Chem.2020, 412(12):3005-3015.
  • Plant Physiol Biochem.2021, 160:166-174.
  • J Ethnopharmacol.2016, 192:370-381
  • ...
  • 生物活性
    Description: 4-Methylumbelliferone is a hyaluronic acid (HA) synthesis inhibitor with an IC50 of 0.4 mM, which has antitumoral and antimetastatic effects. 4-Methylumbelliferone may inhibit the phosphorylation of HAS2 by PKC through the stimulation of O-GlcNAcylation; it also similarly ameliorates hypertriglyceridemia and hyperglycemia partly by modulating hepatic lipid metabolism and the antioxidant defense system along with increasing adiponectin levels.
    Targets: P450 (e.g. CYP17) | NADPH-oxidase | PKC | ROS
    In vivo:
    Chem Biol Interact. 2014 Jun 5;216:9-16.
    Long-term supplementation of umbelliferone and 4-methylumbelliferone alleviates high-fat diet induced hypertriglyceridemia and hyperglycemia in mice.[Pubmed: 24661945]
    This study was conducted to evaluate the effects of umbelliferone (UF) and 4-Methylumbelliferone (mUF) on high-fat diet-induced hypertriglyceridemia and hyperglycemia in mice.
    METHODS AND RESULTS:
    The mice were assigned to normal control, high-fat control, and high-fat with UF or 4-Methylumbelliferone groups. For UF or mUF groups, the high-fat diet was supplemented with UF or 4-Methylumbelliferone at 0.02% (wt/wt) for 12weeks. Both UF and 4-Methylumbelliferone significantly decreased plasma triglyceride, free fatty acid and glucose levels, adipocyte size, white adipose tissue weights, and hepatic phosphatidate phosphohydrolase activity and significantly increased plasma adiponectin levels and hepatic fatty acid β-oxidation activity compared with the high-fat control group. UF and 4-Methylumbelliferone improved glucose intolerance and hepatic steatosis in the high-fat fed mice. Long-term high-fat diet intake induced an increase in hepatic CYP2E1 activity and lipid peroxide and cytosolic hydrogen peroxide contents and suppressed superoxide dismutase and glutathione peroxidase activities, which were reversed by UF and 4-Methylumbelliferone supplementation.
    CONCLUSIONS:
    These results indicate that UF and 4-Methylumbelliferone similarly ameliorate hypertriglyceridemia and hyperglycemia partly by modulating hepatic lipid metabolism and the antioxidant defense system along with increasing adiponectin levels.
    J Comp Physiol B. 2014 Aug;184(6):699-708.
    Antioxidative properties of 4-methylumbelliferone are related to antibacterial activity in the silkworm (Bombyx mori) digestive tract.[Pubmed: 24997539]
    Umbelliferones have gained significant attention due to their tumor-inhibitory effects in vitro. This study was undertaken to examine the impact of umbelliferones in an invertebrate model organism, Bombyx mori, to assess the underlying antimicrobial activities via antioxidation in vivo.
    METHODS AND RESULTS:
    Oral administration of 4 mM 4-methylumbelliferone (4-MU), a model umbelliferone drug, in B. Mori larvae caused a rapid increase in reactive oxygen species, such as hydrogen peroxide (H2O2) and antimicrobial activity in the digestive tract. In addition, a significant increase in total antioxidant capacity as well as superoxide anion radical-inhibiting activity and reduced glutathione were detected. The antioxidant defense system was activated following induction of H2O2, resulting in a significant rise in catalase (50-66 %) and glutathione peroxidase (175 %) activities, which were helpful in defending digestive tract cells against oxidative injury.
    CONCLUSIONS:
    These results help in understanding the anticancer mechanism of 4-MU based on its antioxidation in organisms.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 5.6763 mL 28.3817 mL 56.7634 mL 113.5267 mL 141.9084 mL
    5 mM 1.1353 mL 5.6763 mL 11.3527 mL 22.7053 mL 28.3817 mL
    10 mM 0.5676 mL 2.8382 mL 5.6763 mL 11.3527 mL 14.1908 mL
    50 mM 0.1135 mL 0.5676 mL 1.1353 mL 2.2705 mL 2.8382 mL
    100 mM 0.0568 mL 0.2838 mL 0.5676 mL 1.1353 mL 1.4191 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    西瑞香素; Daphnoretin CFN90329 2034-69-7 C19H12O7 = 352.3 20mg QQ客服:1413575084
    异西瑞香素 B; Isodaphnoretin B CFN96604 944824-29-7 C20H14O8 = 382.32 5mg QQ客服:215959384
    异双七叶内酯;异千金子素; Isoeuphorbetin CFN95207 50677-55-9 C18H10O8 = 354.3 5mg QQ客服:3257982914
    Triumbelletin; Triumbelletin CFN96473 131559-54-1 C27H14O9 = 482.39 5mg QQ客服:1413575084
    蜂蜜曲菌素; Mellein CFN97913 480-33-1 C10H10O3 = 178.2 5mg QQ客服:2056216494
    飞龙掌血香豆醌; Toddacoumaquinone CFN92734 142878-03-3 C23H18O7 = 406.4 5mg QQ客服:1413575084
    Aflavarin; Aflavarin CFN89117 144429-67-4 C24H22O9 = 454.43 5mg QQ客服:2159513211
    松风草内酯; Matsukaze-lactone CFN89298 3153-73-9 C20H14O6 = 350.32 5mg QQ客服:2159513211
    7-甲氧基-4-甲基香豆素; 7-Methoxy-4-methylcoumarin CFN94405 2555-28-4 C11H10O3 = 190.20 20mg QQ客服:1413575084
    6-甲氧基-4-甲基香豆素; 6-Methoxy-4-methylcoumarin CFN94425 6295-35-8 C11H10O3 = 190.20 20mg QQ客服:1413575084

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