4-甲氧基肉桂酸

4-Methoxycinnamic acid

	产品编号	CFN98191
	CAS编号	830-09-1
	分子式 = 分子量	C₁₀H₁₀O₃ = 178.18
	产品纯度	>=98%
	物理属性	White powder
	化合物类型	Phenylpropanoids
	植物来源	The barks of Cinnamomum cassia Presl.
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产品名称	产品编号	CAS编号	包装	QQ客服
4-甲氧基肉桂酸	CFN98191	830-09-1	10mg	QQ客服：2159513211
4-甲氧基肉桂酸	CFN98191	830-09-1	20mg	QQ客服：2159513211
4-甲氧基肉桂酸	CFN98191	830-09-1	50mg	QQ客服：2159513211
4-甲氧基肉桂酸	CFN98191	830-09-1	100mg	QQ客服：2159513211

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Description:

4-Methoxycinnamic acid is a photosensitive compound, it shows various pharmacologic actions such as anti-cancer, hepatoprotective and antihyperglycemic activities, it also can stimulate insulin secretion from pancreatic β-cells by increasing Ca2+ influx via the L-type Ca2+ channels, but not through the closure of ATP-sensitive K+ channels. 4-Methoxycinnamic acid can strongly inhibit the diphenolase activity of mushroom tyrosinase, with the IC 50 value of 0.42 mM, and the inhibition is reversible.

Targets:

Calcium Channel | ATPase | Potassium Channel | P450 (e.g. CYP17) | NADPH-oxidase

In vitro:

J Med Microbiol. 2011 Nov;60(Pt 11):1626-32.

Natural products modulate Shigella-host-cell interaction.[Pubmed: 21719574]

This study focused on identifying possible new options derived from natural sources for the treatment of bacterial infections. Several natural products were investigated for their potential in modulating Shigella-host-cell interactions.
METHODS AND RESULTS:
The proliferation of Shigella sonnei was effectively inhibited inside HEp-2 cells in the presence of 4-methoxycinnamic acid and propolin D. Propolin D also significantly reduced the apoptosis of infected macrophage-like U937 cells and moderately reduced the secretion of interleukin (IL)-1β and IL-18, which probably resulted from the inhibition of invasion plasmid antigen B secretion by this compound. Further characterization showed that propolin D did not prevent escape of Shigella from phagocytic vacuoles, as evidenced by actin-based motility and by the fact that addition of chloroquine did not further reduce the number of intracellular c.f.u. The role of propolin D in modulating autophagy could not be established under the experimental conditions used.
CONCLUSIONS:
As these compounds had no direct anti-Shigella activity in vitro, it was concluded that these compounds modulated Shigella-host-cell interactions by targeting yet-to-be defined mechanisms that provide benefits to host cells.

US 8758864 B2[P]. 2014.

Photosensitive semiconductor nanocrystals, photosensitive composition comprising semiconductor nanocrystals and method for forming semiconductor nanocrystal pattern using the same[Reference: WebLink]

4. The organic-inorganic hybrid electroluminescent device according to claim 1, wherein the compound containing a photosensitive functional group is selected from a group consisting of methacrylic acid, crotonic acid, vinylacetic acid, tiglic acid, 3,3-dimethylacrylic acid, trans-2-pentenoic acid, 4-pentenoic acid, trans-2-methyl-2-pentenoic acid, 2,2-dimethyl-4-pentenoic acid, trans-2-hexenoic acid, trans-3-hexenoic acid, 2-ethyl-2-hexenoic acid, 6-heptenoic acid, 2-octenoic acid, citronellic acid, undecylenic acid, myristoleic acid, palmitoleic acid, oleic acid, elaidic acid, cis-11-elcosenoic acid, euric acid, nervonic acid, trans-2,4-pentadienoic acid, 2,4-hexadienoic acid, 2,6-heptadienoic acid, geranic acid, linoleic acid, 11,14-eicosadienoic acid, cis-8,11,14-eicosatrienoic acid, arachidonic acid, cis-5,8,11,14,17-eicosapentaenoic acid, cis-4,7,10,13,16,19-docosahexaenoic acid, fumaric acid, maleic acid, itaconic acid, ciraconic acid, mesaconic acid, trans-glutaconic acid, trans-beta-hydromuconic acid, trans-traumatic acid, trans-muconic acid, cis-aconitic acid, trans-aconitic acid, cis-3-chloroacrylic acid, trans-3-chloroacrylic acid, 2-bromoacrylic acid, 2-(trifluoromethyl)acryl-ic acid, trans-styrylacetic acid, trans-cinnamic acid, alpha.-methylcinnamic acid, 2-methylcinnamic acid, 2-fluorocinnamic acid, 2-(trifluoromethyl)cinnamic acid, 2-chlorocinnamic acid, 2-methoxycinnamic acid, 2-hydroxycinnamic acid, 2-nitrocinnamic acid, 2-carboxycinnamic acid, trans-3-fluorocinnamic acid, 3-(trifluoromethyl)cinnamic acid, 3-chlorocinnamic acid, 3-bromocinnamic acid, 3-methoxycinnamic acid, 3-hydroxycinnamic acid, 3-nitrocinnamic acid, 4-methylcinnamic acid, 4-fluorocinnamic acid, trans-4-(trifluoromethyl)-cinnamic acid, 4-chlorocinnamic acid, 4-bromocinnamic acid, 4-methoxycinnamic acid, 4-hydroxycinnamic acid, 4-nitrocinnamic acid, 3,3-dimethoxycinnamic acid, 4-vinylbenzoic acid, allyl methyl sulfide, allyl disulfide, diallyl amine, oleylamine, 3-amino-1-propanol vinyl ether, 4-chlorocinnamonitrile, 4-methoxycinnamonitrile, 3,4-dimethoxycinnamonitrile, 4-dimethylaminocinnamonitrile, acrylonitrile, allyl cyanide, crotononitrile, methacrylonitrile, cis-2-pentenenitrile, trans-3-pentenenitrile, 3,7-dimethyl-2,6-octadienenitrile, and 1,4-dicyano-2-butene.

In vivo:

Mol Cell Biochem. 2014 Sep;394(1-2):187-98.

Protective effect of p-methoxycinnamic acid, an active phenolic acid against 1,2-dimethylhydrazine-induced colon carcinogenesis: modulating biotransforming bacterial enzymes and xenobiotic metabolizing enzymes.[Pubmed: 24908112 ]

Objective of the study is to evaluate the modifying potential of p-methoxycinnamic acid (4-Methoxycinnamic acid,p-MCA), an active rice bran phenolic acid on biotransforming bacterial enzymes and xenobiotic metabolizing enzymes in 1,2-dimethylhydrazine-induced rat colon carcinogenesis.
METHODS AND RESULTS:
48 male albino wistar rats were divided into six groups. Group1 (control) received modified pellet diet and 0.1 % carboxymethylcellulose; group2 received modified pellet diet along with p-MCA (80 mg/kg b.wt. p.o.) everyday for 16 weeks; groups 3-6 received 1,2-dimethylhydrazine (DMH) (20 mg/kg b.wt.) subcutaneous injection once a week for the first 4 weeks, while groups 4-6 received p-MCA at three different doses of 20, 40 and 80 mg/kg b.wt. p.o. everyday for 16 weeks. A significant increase in carcinogen-activating enzymes (cytochrome P450, cytochrome b5, cytochrome P4502E1, NADH-cytochrome-b5-reductase and NADPH-cytochrome-P450 reductase) with concomitant decrease in phaseII enzymes, DT-Diaphorase, glutathione S-transferase, UDP-glucuronyl-transferase and gamma glutamyltransferase were observed in group3 compared to control. DMH treatment significantly increased the activities of feacal and colonic bacterial enzymes (β-glucosidase, β-galactosidase, β-glucuronidase, nitroreductase, sulphatase and mucinase). p-MCA supplementation (40 mg/kg b.wt) to carcinogen exposed rats inhibited these enzymes, which were near those of control rats.
CONCLUSIONS:
The formation of dysplastic aberrant crypt foci in the colon and the histopathological observations of the liver also supports our biochemical findings. p-MCA (40 mg/kg b.wt.) offers remarkable modulating efficacy of biotransforming bacterial and xenobiotic metabolizing enzymes in colon carcinogenesis.

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	5.6123 mL	28.0615 mL	56.123 mL	112.246 mL	140.3076 mL
5 mM	1.1225 mL	5.6123 mL	11.2246 mL	22.4492 mL	28.0615 mL
10 mM	0.5612 mL	2.8062 mL	5.6123 mL	11.2246 mL	14.0308 mL
50 mM	0.1122 mL	0.5612 mL	1.1225 mL	2.2449 mL	2.8062 mL
100 mM	0.0561 mL	0.2806 mL	0.5612 mL	1.1225 mL	1.4031 mL

产品名称	产品编号	CAS编号	分子式 = 分子量	位单	联系QQ
新化合物VIII; New compound 8	CFN95341	N/A	C₁₇H₂₄O₁₀ = 388.4	5mg	QQ客服：215959384
对羟基苯丙酸; Phloretic acid	CFN90888	501-97-3	C₉H₁₀O₃ = 166.2	20mg	QQ客服：2056216494
对羟基肉桂酸; p-Hydroxy-cinnamic acid	CFN98179	7400-08-0	C₉H₈O₃ = 164.16	20mg	QQ客服：2159513211
反式对羟基肉桂酸; trans-4-Hydroxycinnamic acid	CFN98794	501-98-4	C₉H₈O₃ = 164.2	20mg	QQ客服：2056216494
对乙氧基肉桂酸; 4-Acetoxycinnamic acid	CFN98178	15486-19-8	C₁₁H₁₀O₄ = 206.19	20mg	QQ客服：2159513211
4-甲氧基肉桂酸; 4-Methoxycinnamic acid	CFN98191	830-09-1	C₁₀H₁₀O₃ = 178.18	20mg	QQ客服：3257982914
顺式-香豆酸-4-葡萄糖苷; 4-O-beta-Glucopyranosyl-cis-coumaric acid	CFN93803	117405-48-8	C₁₅H₁₈O₈ = 326.29	5mg	QQ客服：215959384
4-羟基肉桂酸甲酯; Methyl 4-hydroxycinnamate	CFN96113	19367-38-5	C₁₀H₁₀O₃ = 178.2	20mg	QQ客服：3257982914
对香豆酸乙酯; p-Coumaric acid ethyl ester	CFN97218	7362-39-2	C₁₁H₁₂O₃ = 192.2	20mg	QQ客服：215959384
对甲氧基肉桂酸乙酯; Ethyl 4-methoxycinnamate	CFN98180	24393-56-4	C₁₂H₁₄O₃ = 206.24	20mg	QQ客服：1457312923

4-甲氧基肉桂酸

4-Methoxycinnamic acid

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