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  • 4,5-二甲氧基铁屎米酮

    4,5-Dimethoxycanthin-6-one

    4,5-二甲氧基铁屎米酮
    产品编号 CFN99847
    CAS编号 18110-87-7
    分子式 = 分子量 C16H12N2O3 = 280.3
    产品纯度 >=98%
    物理属性 Yellow powder
    化合物类型 Alkaloids
    植物来源 The barks of Picrasma quassioides (D.Don) Benn
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    4,5-二甲氧基铁屎米酮 CFN99847 18110-87-7 1mg QQ客服:2159513211
    4,5-二甲氧基铁屎米酮 CFN99847 18110-87-7 5mg QQ客服:2159513211
    4,5-二甲氧基铁屎米酮 CFN99847 18110-87-7 10mg QQ客服:2159513211
    4,5-二甲氧基铁屎米酮 CFN99847 18110-87-7 20mg QQ客服:2159513211
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
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  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • SBRAS2016, 12
  • J Med Food.2016, 19(12):1155-1165
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  • Sci Adv.2018, 4(10)
  • J Nat Med.2018, 72(3):734-744
  • Front Immunol.2018, 9:2091
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  • Microb Pathog.2019, 131:128-134
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  • Chem Biol Interact.2019, 298:1-7
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  • Food Funct.2020, 10.1039
  • ...
  • 生物活性
    Description: 4,5-Dimethoxycanthin-6-one has antibacterial actiyity, it exhibits inhibition against Staphylococcus aureus and its drug-resistant strains. 4,5-Dimethoxycanthin-6-one has a strong inhibitory effect on cyclic adenosine monophosphate (cAMP) phosphodiesterase. It also shows cytotoxicity against the tumor cell lines, U937 and HepG2.
    Targets: cAMP | Antifection
    In vitro:
    J. Korean Soc. Appl. Biol. Chem.,2009, 52(6):663-7.
    Cytotoxic alkaloids from the wood of Picrasma quassioides.[Reference: WebLink]
    Six alkaloid compounds were isolated from the chloroform soluble fraction of the methanolic extract of the wood of Picrasma quassioides Benn (Simarobaceae) as the cytotoxic components against the tumor cell lines, U937 and HepG2.
    METHODS AND RESULTS:
    The compounds were identified as 4,9-dimethoxy-1-vinyl-γ-carboline (1), 1-carbomethoxy-β-carboline (2), 4,5-Dimethoxycanthin-6-one (3), 5-hydroxy-4-methoxycanthin-6-one (4), 3-methoxycanthin-5,6-dione (5) and 4,8-dimethoxy-1-vinyl-β-carboline (6) by spectroscopic analysis. Among them, compound 5 showed the most potent cytotoxicity in a dose-dependent manner against the two tumor cell lines.
    CONCLUSIONS:
    This is the first report of the cytotoxic effect of those isolated compounds 1-5 on U937 and HepG2 cell lines.
    Chem Pharm Bull (Tokyo). 1984 May;32(5):1872-7.
    Inhibitors of cyclic AMP phosphodiesterase in Picrasma quassioides Bennet, and inhibitory activities of related .BETA.-carboline alkaloids.[Reference: WebLink]

    METHODS AND RESULTS:
    Cyclic adenosine monophosphate (cAMP) phosphodiesterase inhibitors present in Picrasma quassioides BENN. were identified as 1-methoxycarbonyl-β-carboline, 4,5-Dimethoxycanthin-6-one and 5-hydroxy-4-methoxycanthin-6-one. The structure-inhibitory activity relationships were studied in 31 derivatives of β-carboline, 2 dimeric derivatives of β-carboline and 12 derivatives of canthin-6-one.
    CONCLUSIONS:
    β-Carboline derivatives with a methoxycarbonyl group and canthin-6-one derivatives with a methoxyl group generally had a strong inhibitory effect on cAMP phosphodiesterase.
    Yao Xue Xue Bao,1979, 14(3):167-77.
    Chemical investigation of the alkaloids of Ku-Mu [Picrasma quassioides (D. Don) Benn.[Reference: WebLink]
    Some preparation of the total alkaloids of Ku-Mu (Picrasma quassioides (D. Don) Benn.) was Shown to have antibacterial actiyity in clinical trial. For the exploration of the active principles, the present paper deals with the studies of the alkaloids of this medicinal plant.
    METHODS AND RESULTS:
    From an alcohol extract of heartwood of Ku-Mu seven alkaloids were isolated through silica gel and alumina column chromatography as well as preparative thin layer chromatography. Beside the known alkaloids 1-carbomethoxy-β-carboline (Ⅱ), 4,5-Dimethoxycanthin-6-one (Ⅳ), canthin-6-one (Ⅴ), and 4-methoxy-5-hydroxycanthin-6-one (Ⅵ), three new alkaloids, named Kumujian A, Kumujian G, and Kumujian G, were ident fied as 1-carboethoxy-β-carbotine (Ⅰ), 1-formyl-β-carboline(Ⅲ) and 1-vinyl-4,8-dimethoxy-β-carboline (Ⅶ), respectively. In vitro screening of the above alkaloids demonstrated that 1-carbomethoxy-β-carboline (Ⅱ), 4,5-Dimethoxycanthin-6-one (Ⅳ), 4-methoxy-5-hydroxycanthin-6-one (Ⅵ) and 1-vinyl-4,8-dimethoxy-β-carboline (Ⅶ) exhibited inhibition against Staphylococcus aureus and its drug-resistant strains.
    CONCLUSIONS:
    Tests for the antibacterial activity of three other alkaloids were hampered by scarcity of material.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 3.5676 mL 17.838 mL 35.6761 mL 71.3521 mL 89.1902 mL
    5 mM 0.7135 mL 3.5676 mL 7.1352 mL 14.2704 mL 17.838 mL
    10 mM 0.3568 mL 1.7838 mL 3.5676 mL 7.1352 mL 8.919 mL
    50 mM 0.0714 mL 0.3568 mL 0.7135 mL 1.427 mL 1.7838 mL
    100 mM 0.0357 mL 0.1784 mL 0.3568 mL 0.7135 mL 0.8919 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    4,9-二甲氧基铁屎米酮; 4,9-Dimethoxycanthin-6-one CFN92128 1270001-72-3 C16H12N2O3 = 280.3 5mg QQ客服:2159513211
    5-羟基-6-铁屎米酮; 5-Hydroxy-canthin-6-one CFN92930 64118-73-6 C14H8N2O2 = 236.23 5mg QQ客服:2932563308
    5-甲氧基铁屎米酮; 5-Methoxycanthin-6-one CFN92362 15071-56-4 C15H10N2O2 = 250.3 5mg QQ客服:2932563308
    苦木西碱Q; Picrasidine Q CFN92205 101219-61-8 C15H10N2O3 = 266.3 10mg QQ客服:215959384
    5-羟基-4-甲氧基铁屎米酮; 5-Hydroxy-4-methoxycanthin-6-one CFN99846 18110-86-6 C15H10N2O3 = 266.3 5mg QQ客服:2932563308
    4,5-二甲氧基铁屎米酮; 4,5-Dimethoxycanthin-6-one CFN99847 18110-87-7 C16H12N2O3 = 280.3 5mg QQ客服:3257982914

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