Info: Read More
  • 中药标准品生产商,产品定制服务
  • 3alpha-木通萜酸

    3alpha-Akebonoic acid

    3alpha-木通萜酸
    产品编号 CFN99067
    CAS编号 104777-61-9
    分子式 = 分子量 C29H44O3 = 440.7
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Triterpenoids
    植物来源 The herbs of Akebia trifoliata
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    3alpha-木通萜酸 CFN99067 104777-61-9 1mg QQ客服:215959384
    3alpha-木通萜酸 CFN99067 104777-61-9 5mg QQ客服:215959384
    3alpha-木通萜酸 CFN99067 104777-61-9 10mg QQ客服:215959384
    3alpha-木通萜酸 CFN99067 104777-61-9 20mg QQ客服:215959384
    存储与注意事项
    1. 在您收到产品后请检查产品。如无问题,请将产品存入冰霜并且样品瓶保持密封,产品可以存放长达24个月(2-8摄氏度)。

    2. 只要有可能,产品溶解后,您应该在同一天应用于您的实验。 但是,如果您需要提前做预实验,或者需要全部溶解,我们建议您将溶液以等分试样的形式存放在-20℃的密封小瓶中。 通常,这些可用于长达两周。 使用前,打开样品瓶前,我们建议您将产品平衡至室温至少1小时。

    3. 需要更多关于溶解度,使用和处理的建议? 请发送电子邮件至:service@chemfaces.com
    订购流程
  • 1. 在线订购
  • 请联系我们QQ客服

  • 2. 电话订购
  • 请拨打电话:
    027-84237683 或 027-84237783

  • 3. 邮件或传真订购
  • 发送电子邮件到: manager@chemfaces.com 或
    发送传真到:027-84254680

  • 提供订购信息
  • 为了方便客户的订购,请需要订购ChemFaces产品的客户,在下单的时候请提供下列信息,以供我们快速为您建立发货信息。
  •  
  • 1. 产品编号(CAS No.或产品名称)
  • 2. 发货地址
  • 3. 联系方法 (联系人,电话)
  • 4. 开票抬头 (如果需要发票的客户)
  • 5. 发票地址(发货地址与发票地址不同)
  • 发货时间
    1. 付款方式为100%预付款客户,我们将在确认收到货款后当天或1-3个工作日发货。

    2. 付款方式为月结的客户,我们承诺在收到订单后当天或1-3个工作日内发货。

    3. 如果客户所需要的产品,需要重新生产,我们有权告知客户,交货时间需要延期。
    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • Fraunhofer-Institut für Molekularbiologie und Angewandte ?kologie IME (Germany)
  • Mendel University in Brno (Czech Republic)
  • Cornell University (USA)
  • The University of Newcastle (Australia)
  • University of Eastern Finland (Finland)
  • Worcester Polytechnic Institute (USA)
  • Sanford Burnham Prebys Medical Discovery Institute (USA)
  • Shanghai University of TCM (China)
  • University of Liège (Belgium)
  • University of Vigo (Spain)
  • Florida A&M University (USA)
  • Harvard University (USA)
  • University of Brasilia (Brazil)
  • University of Toulouse (France)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Molecules.2022, 27(22):7887.
  • Biochem Pharmacol. 2020, 177:114014.
  • Mediators Inflamm.2016, 2016:7216912
  • Saf Health Work.2019, 10(2):196-204
  • SCOPUS.2020, 836-847.
  • Food Chem.2019, 278:683-691
  • Chin J Pharm Anal.2019, 39(7):1217-1228
  • Biochem Biophys Res Commun.2020, 522(1):40-46
  • Biomed Chromatogr.2016, 30(10):1573-81
  • Molecules.2020, 25(9):2081.
  • Cell Signal.2022, 99:110433.
  • Ecol Evol.2022, 12(11):e9459.
  • VNU Journal of Science2023, 39(2):24-33.
  • Asian Journal of Chemistry2014, 26(8):2425
  • J Chromatogr Sci.2015, 53(5):824-9
  • J Immunol.2023, ji2200727.
  • Mol Pharm.2017, 14(9):3164-3177
  • Molecules.2021, 26(13):4081.
  • J of Dentistry & Oral Health2019, 2641-1962
  • Horticulturae2022, 8(10), 975.
  • Universidade Estadual Paulista2017, 42785
  • Front Pharmacol.2021, 12:765521.
  • Biol Pharm Bull.2018, 41(11):1685-1693
  • ...
  • 生物活性
    Description: 3α-Akebonoic acid shows interesting in vitro growth inhibitory activity against human tumor A549 and HeLa cell lines, it also shows significant in vitro α-glucosidase inhibitory activity. 3α-Akebonoic acid can interfer with presenilin-1 (PS1)/ β-site APP-cleaving enzyme 1 (BACE1) interaction and reduces Aβ production, the chemical interference of PS1/BACE1 interaction is a promising strategy for Alzheimer’s disease therapeutics.
    Targets: Beta Amyloid | BACE
    In vitro:
    Molecules. 2014 Apr 4;19(4):4301-12
    Bioactive 30-noroleanane triterpenes from the pericarps of Akebia trifoliata.[Pubmed: 24714192]

    METHODS AND RESULTS:
    Two new 30-noroleanane triterpenes, 2α,3β,20α-trihydroxy-30-norolean-12-en-28-oic acid (1), 2α,3β-dihydroxy-23-oxo-30-norolean-12,20(29)-dien-28-oic acid (2), were isolated from the pericarps of Akebia trifoliata, together with four known ones, 3β-akebonoic acid (3), 2α,3β-dihydroxy-30-noroleana-12,20(29)-dien-28-oic acid (4), 3alpha-Akebonoic acid (5) and quinatic acid (6). Their structures were established on the basis of detailed spectroscopic analysis, and they were all isolated from the pericarps of A. trifoliata for the first time. Compounds 3-6 showed in vitro bacteriostatic activity against four assayed Gram-positive bacterial strains. In particular 3 showed antibacterial activity toward MRSA with a MIC value 25 μg/mL, which was more potent than kanamycin (MIC 125 μg/mL). No compounds showed antibacterial activity toward the three Gram-negative bacteria tested.
    CONCLUSIONS:
    Compounds 4 and 5 showed interesting in vitro growth inhibitory activity against human tumor A549 and HeLa cell lines, with IC50 values ranging from 8.8 and 5.6 μM, respectively. Compounds 1, 2, 5 and 6 were further revealed to show significant in vitro α-glucosidase inhibitory activity with IC50 values from 0.035 to 0.367 mM, which were more potent than the reference compound acarbose (IC50 0.409 mM).
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 2.2691 mL 11.3456 mL 22.6912 mL 45.3823 mL 56.7279 mL
    5 mM 0.4538 mL 2.2691 mL 4.5382 mL 9.0765 mL 11.3456 mL
    10 mM 0.2269 mL 1.1346 mL 2.2691 mL 4.5382 mL 5.6728 mL
    50 mM 0.0454 mL 0.2269 mL 0.4538 mL 0.9076 mL 1.1346 mL
    100 mM 0.0227 mL 0.1135 mL 0.2269 mL 0.4538 mL 0.5673 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    Sebiferenic acid; Sebiferenic acid CFN97523 94390-09-7 C30H48O4 = 472.7 5mg QQ客服:3257982914
    3,4-开环-齐墩果-12-烯-4-醇-3,28-二酸; 3,4-seco-Olean-12-en-4-ol-3,28-dioic acid CFN96849 182249-69-0 C30H48O5 = 488.70 5mg QQ客服:3257982914
    3-氧代-24-去甲齐墩果-12-烯-28-酸 ; Hedragonic acid CFN96602 466-02-4 C29H44O3 = 440.66 5mg QQ客服:2056216494
    齐墩果酸; Oleanolic acid CFN98800 508-02-1 C30H48O3 = 456.7 20mg QQ客服:3257982914
    齐墩果酸3-乙酸酯; 3-O-Acetyloleanolic acid CFN98668 4339-72-4 C32H50O4 = 498.8 10mg QQ客服:1457312923
    3-O-对香豆酰齐墩果酸; 3-O-p-Coumaroyloleanolic acid CFN96043 151334-06-4 C39H54O5 = 602.9 5mg QQ客服:3257982914
    3-O-咖啡酰基齐墩果酸; 3-O-Caffeoyloleanolic acid CFN96050 97534-10-6 C39H54O6 = 618.9 5mg QQ客服:2056216494
    3alpha-Acetyloxy-25-hydroxyolean-12-en-28-oic acid; 3alpha-Acetyloxy-25-hydroxyolean-12-en-28-oic acid CFN95710 469895-08-7 C32H50O5 = 514.8 5mg QQ客服:2056216494
    3-氧代-12-烯-28-齐墩果酸; 3-oxo-Olean-12-en-28-oic acid CFN92194 17990-42-0 C30H46O3 = 454.7 20mg QQ客服:1457312923
    3-Keto-齐墩果酸-28-甲酯; 3-Oxo-olean-12-en-28-oic acid methyl ester CFN91814 1721-58-0 C31H48O3 = 468.7 5mg QQ客服:2159513211

    信息支持


    公司简介
    订购流程
    付款方式
    退换货政策

    ChemFaces提供的产品仅用于科学研究使用,不用于诊断或治疗程序。

    联系方式


    电机:027-84237783
    传真:027-84254680
    在线QQ: 1413575084
    E-Mail:manager@chemfaces.com

    湖北省武汉沌口经济技术开区车城南路83号1号楼第三层厂房


    ChemFaces为科学家,科研人员与企业提供快速的产品递送。我们通过瑞士SGS ISO 9001:2008质量体系认证天然化合物与对照品的研发和生产