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  • 3-O-顺式对香豆酰委陵菜酸

    3-O-cis-p-Coumaroyltormentic acid

    3-O-顺式对香豆酰委陵菜酸
    产品编号 CFN92211
    CAS编号 121072-40-0
    分子式 = 分子量 C39H54O7 = 634.9
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Triterpenoids
    植物来源 The herbs of Potentilla chinensis Ser.
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    3-O-顺式对香豆酰委陵菜酸 CFN92211 121072-40-0 1mg QQ客服:1413575084
    3-O-顺式对香豆酰委陵菜酸 CFN92211 121072-40-0 5mg QQ客服:1413575084
    3-O-顺式对香豆酰委陵菜酸 CFN92211 121072-40-0 10mg QQ客服:1413575084
    3-O-顺式对香豆酰委陵菜酸 CFN92211 121072-40-0 20mg QQ客服:1413575084
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • Universidad de La Salle (Mexico)
  • Institute of Bioorganic Chemistry Polish Academy of Sciences (Poland)
  • Sanford Burnham Prebys Medical Discovery Institute (USA)
  • University of South Australia (Australia)
  • Molecular Biology Institute of Barcelona (IBMB)-CSIC (Spain)
  • Complutense University of Madrid (Spain)
  • Sapienza University of Rome (Italy)
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  • University of Hertfordshire (United Kingdom)
  • Institute of Chinese Materia Medica (China)
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  • Helmholtz Zentrum München (Germany)
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  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Front Pharmacol.2023, 14:1244655.
  • Sci Rep.2021, 11(1):14180.
  • Front Pharmacol.2021, 12:652860.
  • Sci. Rep.2015, 14-23
  • Oncotarget.2016, 8(51):88386-88400
  • Plos One.2019, 15(2):e0220084
  • Int. J. Mol. Sci.2022, 23(19), 11900.
  • J Sep Sci.2018, 41(9):1938-1946
  • Food Chem. 2020, 320:126530
  • Sci Rep.2019, 9(1):4342
  • National University of Pharmacy2022, 1:73-76
  • Crystals2020, 10(3), 206.
  • Int J Mol Sci.2020, 21(22):8816.
  • Molecules.2019, 24(16):E3003
  • J Ethnopharmacol.2022, 282:114574.
  • Mol Pharm.2018, 15(8):3285-3296
  • In Vitro Cellular & Developmental Biology - Plant2022, 58:972-988.
  • Life Sci.2021, 286:120019.
  • J Korean Med Obes Res.2023, 23:10-7
  • BMC Complement Med Ther.2023, 23(1):264.
  • Int Immunopharmacol.2021, 101(Pt A):108181.
  • Pharmaceutics.2021, 13(7):1028.
  • Antioxidants (Basel).2022, 11(12):2496.
  • ...
  • 生物活性
    Description: 3beta-O-cis-p-Coumaroyltormentic acid, and 3beta-O-trans-p-coumaroyltormentic acid are weakly selective for vancomycin-resistant Enterococcus (VRE) compared with eukaryotic cells, with an MIC of 59.4microg/mL and a 50% inhibitory concentration (IC50) of 72.0microg/mL for monkey kidney epithelial (MA104) cells. A mixture of 3-O-cis-p-coumaroyltormentic acid and 3-O-trans-p-coumaroyltormentic acid shows an inhibitory effect comparable to (-)-epigallocatechin gallate (EGCG) of green tea on the activation of Epstein-Barr virus early antigen (EBV-EA) induced by 12-O-tetradeca-noylphorbol-13-acetate (TPA).
    In vitro:
    J. Ethnopharmacol.,2008 Mar 28;116(3):554- 60.
    Antibacterial compounds from Planchonia careya leaf extracts.[Pubmed: 18289814 ]

    METHODS AND RESULTS:
    Six known compounds were isolated from the leaf extracts and were identified as 1, (+)-gallocatechin; 2, gallocatechin-(4alpha-->8)-gallocatechin; 3, 9(S)-hydroxy-10E,12Z-octadecadienoic acid (alpha-dimorphecolic acid); 4, 2alpha,3beta,24-trihydroxyolean-12-en-28-oic acid (hyptatic acid-A); 5, 3beta-O-cis-p-coumaroyltormentic acid(3-O-cis-p-Coumaroyltormentic acid ); and 6, 3beta-O-trans-p-coumaroyltormentic acid.
    CONCLUSIONS:
    Compounds 5 and 6 were weakly selective for vancomycin-resistant Enterococcus (VRE) compared with eukaryotic cells, with an MIC of 59.4microg/mL and a 50% inhibitory concentration (IC(50)) of 72.0microg/mL for MA104 cells.
    Phytochemistry,2002 Feb;59(3):315-23.
    Production of bioactive triterpenes by Eriobotrya japonica calli.[Pubmed: 11830140]
    Callus tissue cultures induced from an axenic leaf of Eriobotrya japonica (Rosaceae) produced triterpenes in large amounts (ca. 50 mg/g dry wt).
    METHODS AND RESULTS:
    Nine triterpenes were characterized as ursolic acid, oleanolic acid, 2alpha-hydoxyursolic acid, maslinic acid, tormentic acid, 2alpha, 19alpha-dihydroxy-3-oxo-urs-12-en-28-oic acid, hyptadienic acid and a mixture of 3-O-cis-p-Coumaroyltormentic acid and 3-O-trans-p-coumaroyltormentic acid. The triterpene composition in the callus tissues was noticeably different from that in intact leaves. The contents of tormentic acid with antidiabetic action, and 2alpha, 19alpha-dihydroxy-3-oxo-urs-12-en-28-oic acid with anti-HIV activity, were much larger than those in the intact leaves.
    CONCLUSIONS:
    All of the triterpenes isolated from the callus tissues showed an inhibitory effect comparable to (-)-epigallocatechin gallate (EGCG) of green tea on the activation of Epstein-Barr virus early antigen (EBV-EA) induced by 12-O-tetradecanoylphorbol-13-acetate (TPA). 2alpha, 19alpha-Dihydroxy-3-oxo-urs-12-en-28-oic acid was the most potent inhibitor among them and caused a significant delay of two-stage carcinogenesis on mouse skin.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 1.5751 mL 7.8753 mL 15.7505 mL 31.501 mL 39.3763 mL
    5 mM 0.315 mL 1.5751 mL 3.1501 mL 6.3002 mL 7.8753 mL
    10 mM 0.1575 mL 0.7875 mL 1.5751 mL 3.1501 mL 3.9376 mL
    50 mM 0.0315 mL 0.1575 mL 0.315 mL 0.63 mL 0.7875 mL
    100 mM 0.0158 mL 0.0788 mL 0.1575 mL 0.315 mL 0.3938 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    2alpha,19alpha-Dihydroxy-3-oxo-urs-12-en-28-oic acid; 2alpha,19alpha-Dihydroxy-3-oxo-urs-12-en-28-oic acid CFN89112 176983-21-4 C30H46O5 = 486.69 5mg QQ客服:215959384
    覆盆子酸; Fupenzic acid CFN99311 119725-20-1 C30H44O5 = 484.7 5mg QQ客服:3257982914
    Negundonorin A; Negundonorin A CFN96848 1401618-51-6 C29H40O5 = 468.63 5mg QQ客服:2056216494
    1-beta-羟基蔷薇酸; 1beta-Hydroxyeuscaphic acid CFN92609 120211-98-5 C30H48O6 = 504.7 5mg QQ客服:3257982914
    1,2,3,19-四羟基-12-乌苏烯-28-酸; 1,2,3,19-Tetrahydroxy-12-ursen-28-oic acid CFN99233 113558-03-5 C30H48O6 = 504.7 5mg QQ客服:3257982914
    1-羟基-2-氧代果树酸; 1-Hydroxy-2-oxopomolic acid CFN98080 217466-37-0 C30H46O6 = 502.7 5mg QQ客服:1413575084
    3-O-顺式对香豆酰委陵菜酸; 3-O-cis-p-Coumaroyltormentic acid CFN92211 121072-40-0 C39H54O7 = 634.9 5mg QQ客服:2159513211
    蔷薇酸; 野鸦椿酸; Euscaphic acid CFN98888 53155-25-2 C30H48O5 = 488.7 5mg QQ客服:2159513211
    2,3-Di-O-methylthiomethyleuscaphic acid; 2,3-Di-O-methylthiomethyleuscaphic acid CFN97578 N/A C34H56O5S2 = 609.0 5mg QQ客服:2159513211
    2,3-O-异亚丙基刺梨酸; 2,3-O-Isopropylidenyl euscaphic acid CFN98095 220880-90-0 C33H52O5 = 528.8 5mg QQ客服:1413575084

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