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  • 3-O-咖啡酰基齐墩果酸

    3-O-Caffeoyloleanolic acid

    3-O-咖啡酰基齐墩果酸
    产品编号 CFN96050
    CAS编号 97534-10-6
    分子式 = 分子量 C39H54O6 = 618.9
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Triterpenoids
    植物来源 The stem barks of Physocarpus intermedius
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    3-O-咖啡酰基齐墩果酸 CFN96050 97534-10-6 1mg QQ客服:2056216494
    3-O-咖啡酰基齐墩果酸 CFN96050 97534-10-6 5mg QQ客服:2056216494
    3-O-咖啡酰基齐墩果酸 CFN96050 97534-10-6 10mg QQ客服:2056216494
    3-O-咖啡酰基齐墩果酸 CFN96050 97534-10-6 20mg QQ客服:2056216494
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • University of Malaya (Malaysia)
  • Technical University of Denmark (Denmark)
  • Amity University (India)
  • Instituto Politécnico de Bragan?a (Portugal)
  • Mahatma Gandhi University (India)
  • Max Rubner-Institut (MRI) (Germany)
  • Uniwersytet Gdański (Poland)
  • The Ohio State University (USA)
  • Warszawski Uniwersytet Medyczny (Poland)
  • University of Wisconsin-Madison (USA)
  • Universidade Federal de Santa Catarina (Brazil)
  • Semmelweis Unicersity (Hungary)
  • Worcester Polytechnic Institute (USA)
  • University of Parma (Italy)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • J Ethnopharmacol.2017, 196:75-83
  • Srinagarind Medical Journal2019, 34(1)
  • Korean Journal of Pharmacognosy2018, 49(3):270-277
  • Applied Biological Chemistry 2021, 64(75)
  • Pharmaceutics.2021, 13(2):187.
  • Crystals2020, 10(3), 206.
  • Nutraceutical Research . 2021, 19(1),p90-105.
  • Biochemical Systematics and Ecology2018, 81
  • Drug Des Devel Ther.2020, 14:61-71
  • Plos One.2020, 10.1371
  • Molecules.2022, 27(22):7887.
  • Antibiotics.2022, 11(4), 510.
  • Chemistry of Plant Raw Materials2019, 4:135-147
  • Front. Pharmacol.2022, 901563.
  • Nutrients.2022, 14(16):3393.
  • Plant Foods Hum Nutr.2021, 76(4):472-477.
  • Int J Mol Sci.2015, 16(8):18396-411
  • Nutrients.2021, 13(1):254.
  • Korean J. Crop Sci.2018, 63(2):131-139
  • Oncotarget.2017, 8(53):90925-90947
  • Food Science and Human Wellness2022, 11(4):965-974
  • Cardiovasc Toxicol.2019, 19(4):297-305
  • J Cell Mol Med.2022, 26(23):5807-5819.
  • ...
  • 生物活性
    Description: 3-O-Caffeoyl oleanolic acid exhibits in vitro cytotoxicity against the A549 cell line with the CC50 values of less than 20 ug/mL.
    In vitro:
    Planta Med. 2000 Jun;66(5):485-6.
    Cytotoxic triterpenes from stem bark of Physocarpus intermedius.[Pubmed: 10909277]

    METHODS AND RESULTS:
    Seven triterpenes (1-7), i.e., betulinic acid 1, ursolic acid 2, oleanolic acid 3, 3-O-caffeoyloleanolic acid 4, euscaphic acid 5, 2 alpha-hydroxyursolic acid 6 and maslinic acid 7 were isolated from the stem bark extract of P. intermedius as active principles responsible for the cytotoxicity against five cultured human tumor cell lines, i.e., A549 (non small cell lung), SK-OV-3 (ovary), SK-MEL-2 (melanoma), XF498 (central nerve system) and HCT-15 (colon), in vitro.
    Molecules. 2014 Jul 4;19(7):9515-34.
    Studies on cytotoxic constituents from the leaves of Elaeagnus oldhamii Maxim. in non-small cell lung cancer A549 cells.[Pubmed: 25000464 ]
    Elaeagnus oldhamii Maxim. is a commonly used traditional herbal medicine. In Taiwan the leaves of E. oldhamii Maxim. are mainly used for treating lung disorders. Twenty five compounds were isolated from the leaves of E. oldhamii Maxim. in the present study.
    METHODS AND RESULTS:
    These included oleanolic acid (1), 3-O-(Z)-coumaroyl oleanolic acid (2), 3-O-(E)-coumaroyl oleanolic acid (3), 3-O-Caffeoyloleanolic acid (4), ursolic acid (5), 3-O-(Z)-coumaroyl ursolic acid (6), 3-O-(E)-coumaroyl ursolic acid (7), 3-O-caffeoyl ursolic acid (8), 3β, 13β-dihydroxyolean-11-en-28-oic acid (9), 3β, 13β-dihydroxyurs-11-en-28-oic acid (10), uvaol (11), betulin (12), lupeol (13), kaempferol (14), aromadendrin (15), epigallocatechin (16), cis-tiliroside (17), trans-tiliroside (18), isoamericanol B (19), trans-p-coumaric acid (20), protocatechuic acid (21), salicylic acid (22), trans-ferulic acid (23), syringic acid (24) and 3-O-methylgallic acid (25). Of the 25 isolated compounds, 21 compounds were identified for the first time in E. oldhamii Maxim. These included compounds 1, 4, 5 and 8-25. These 25 compounds were evaluated for their inhibitory activity against the growth of non-small cell lung cancer A549 cells by the MTT assay, and the corresponding structure-activity relationships were discussed. Among these 25 compounds, compound 6 displayed the best activity against the A549 cell line in vitro (CC50=8.56±0.57 μg/mL, at 48 h of MTT asssay). Furthermore, compound 2, 4, 8 and 18 exhibited in vitro cytotoxicity against the A549 cell line with the CC50 values of less than 20 μg/mL at 48 h of MTT asssay.
    CONCLUSIONS:
    These five compounds 2, 4, 6, 8 and 18 exhibited better cytotoxic activity compared with cisplatin (positive control, CC50 value of 14.87±1.94 μg/mL, at 48 h of MTT asssay). The result suggested that the five compounds might be responsible for its clinical anti-lung cancer effect.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 1.6158 mL 8.0788 mL 16.1577 mL 32.3154 mL 40.3942 mL
    5 mM 0.3232 mL 1.6158 mL 3.2315 mL 6.4631 mL 8.0788 mL
    10 mM 0.1616 mL 0.8079 mL 1.6158 mL 3.2315 mL 4.0394 mL
    50 mM 0.0323 mL 0.1616 mL 0.3232 mL 0.6463 mL 0.8079 mL
    100 mM 0.0162 mL 0.0808 mL 0.1616 mL 0.3232 mL 0.4039 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    Virgatic acid; Virgatic acid CFN96451 14356-51-5 C30H46O4 = 470.70 5mg QQ客服:1413575084
    刺囊酸; Echinocystic acid CFN98812 510-30-5 C30H48O4 = 472.7 20mg QQ客服:215959384
    3alpha-木通萜酸; 3alpha-Akebonoic acid CFN99067 104777-61-9 C29H44O3 = 440.7 5mg QQ客服:2159513211
    Sebiferenic acid; Sebiferenic acid CFN97523 94390-09-7 C30H48O4 = 472.7 5mg QQ客服:3257982914
    3,4-开环-齐墩果-12-烯-4-醇-3,28-二酸; 3,4-seco-Olean-12-en-4-ol-3,28-dioic acid CFN96849 182249-69-0 C30H48O5 = 488.70 5mg QQ客服:1413575084
    3-氧代-24-去甲齐墩果-12-烯-28-酸 ; Hedragonic acid CFN96602 466-02-4 C29H44O3 = 440.66 5mg QQ客服:1457312923
    齐墩果酸; Oleanolic acid CFN98800 508-02-1 C30H48O3 = 456.7 20mg QQ客服:215959384
    齐墩果酸3-乙酸酯; 3-O-Acetyloleanolic acid CFN98668 4339-72-4 C32H50O4 = 498.8 10mg QQ客服:3257982914
    3-O-对香豆酰齐墩果酸; 3-O-p-Coumaroyloleanolic acid CFN96043 151334-06-4 C39H54O5 = 602.9 5mg QQ客服:215959384
    3-O-咖啡酰基齐墩果酸; 3-O-Caffeoyloleanolic acid CFN96050 97534-10-6 C39H54O6 = 618.9 5mg QQ客服:2159513211

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